IL13 (interleukin 13) - Rat Genome Database

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Gene: IL13 (interleukin 13) Sus scrofa
Analyze
Symbol: IL13
Name: interleukin 13
RGD ID: 13900625
Description: ENCODES a protein that exhibits interleukin-13 receptor binding (ortholog); INVOLVED IN negative regulation of complement-dependent cytotoxicity; negative regulation of endothelial cell apoptotic process; cellular response to cytokine stimulus (ortholog); PARTICIPATES IN Fc epsilon receptor mediated signaling pathway; ASSOCIATED WITH Acute Lung Injury (ortholog); alcoholic hepatitis (ortholog); allergic conjunctivitis (ortholog); FOUND IN extracellular space (ortholog); INTERACTS WITH cadmium atom; cadmium dichloride; lipopolysaccharide
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: IL-13; interleukin-13; L13
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: Sscrofa11.1 - Pig Sscrofa11.1 Assembly
Position:
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl2134,972,623 - 134,975,093 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.12134,972,099 - 134,976,672 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.22140,441,025 - 140,444,068 (+)NCBISscrofa10.2Sscrofa10.2susScr3
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
Acute Lung Injury  (ISO)
alcoholic hepatitis  (ISO)
allergic conjunctivitis  (ISO)
allergic disease  (ISO)
allergic rhinitis  (ISO)
asthma  (ISO)
atopic dermatitis  (ISO)
autistic disorder  (ISO)
autoimmune hepatitis  (ISO)
Breast Neoplasms  (ISO)
Bronchial Hyperreactivity  (ISO)
bronchiolitis obliterans  (ISO)
chlamydia  (ISO)
Chronic Bronchitis  (ISO)
chronic obstructive pulmonary disease  (ISO)
contact dermatitis  (ISO)
COVID-19  (ISO)
cutaneous leishmaniasis  (ISO)
cystic fibrosis  (ISO)
Delayed Hypersensitivity  (ISO)
dermatitis  (ISO)
diffuse scleroderma  (ISO)
drug allergy  (ISO)
Eczema  (ISO)
egg allergy  (ISO)
Endotoxemia  (ISO)
esophagitis  (ISO)
Experimental Arthritis  (ISO)
Experimental Autoimmune Encephalomyelitis  (ISO)
Experimental Autoimmune Myocarditis  (ISO)
extrinsic allergic alveolitis  (ISO)
familial adenomatous polyposis 1  (ISO)
Fibrosis  (ISO)
food allergy  (ISO)
Fungal Lung Diseases  (ISO)
Graves' disease  (ISO)
hepatitis C  (ISO)
Hereditary Neoplastic Syndromes  (ISO)
Human Influenza  (ISO)
Hyperalgesia  (ISO)
Hyperplasia  (ISO)
Immediate Hypersensitivity  (ISO)
Inflammation  (ISO)
invasive ductal carcinoma  (ISO)
Kawasaki disease  (ISO)
lipoid nephrosis  (ISO)
localized scleroderma  (ISO)
lung disease  (ISO)
Lymphatic Metastasis  (ISO)
mastocytosis  (ISO)
metabolic dysfunction-associated steatotic liver disease  (ISO)
Metaplasia  (ISO)
middle cerebral artery infarction  (ISO)
milk allergy  (ISO)
multiple sclerosis  (ISO)
Mycoplasma pneumoniae pneumonia  (ISO)
Nasal Polyps  (ISO)
Neurodevelopmental Disorders  (ISO)
occupational dermatitis  (ISO)
onchocerciasis  (ISO)
ovarian carcinoma  (ISO)
pancreatic cancer  (ISO)
pancreatitis  (ISO)
peanut allergy  (ISO)
peptic esophagitis  (ISO)
Perennial Allergic Rhinitis  (ISO)
Picornaviridae Infections  (ISO)
Plasmodium falciparum malaria  (ISO)
pneumonia  (ISO)
prostatic hypertrophy  (ISO)
Pseudomonas Infections  (ISO)
psoriasis  (ISO)
psoriatic arthritis  (ISO)
pulmonary edema  (ISO)
pulmonary emphysema  (ISO)
pulmonary eosinophilia  (ISO)
pulmonary fibrosis  (ISO)
pulmonary hypertension  (ISO)
pulmonary tuberculosis  (ISO)
purpura  (ISO)
Radiation Pneumonitis  (ISO)
renal cell carcinoma  (ISO)
Reperfusion Injury  (ISO)
respiratory allergy  (ISO)
Respiratory Sounds  (ISO)
respiratory syncytial virus infectious disease  (ISO)
Respiratory Tract Granuloma  (ISO)
Respiratory Tract Infections  (ISO)
rheumatoid arthritis  (ISO)
rhinitis  (ISO)
Schistosomiasis Mansoni  (ISO)
Sepsis  (ISO)
sinusitis  (ISO)
Sjogren's syndrome  (ISO)
systemic lupus erythematosus  (ISO)
systemic scleroderma  (ISO)
T-cell non-Hodgkin lymphoma  (ISO)
Transplant Rejection  (ISO)
uveitis  (ISO)
vitiligo  (ISO)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
cellular response to cytokine stimulus  (IEA,ISO)
cellular response to mechanical stimulus  (ISO)
immune response  (IEA)
inflammatory response  (IEA,ISO)
interleukin-13-mediated signaling pathway  (IEA)
macrophage activation  (IEA)
microglial cell activation  (ISO)
negative regulation of complement-dependent cytotoxicity  (IEA,IMP)
negative regulation of endothelial cell apoptotic process  (IEA,IMP)
negative regulation of inflammatory response  (IEA)
negative regulation of NAD(P)H oxidase activity  (ISO)
negative regulation of transforming growth factor beta production  (ISO)
positive regulation of B cell proliferation  (ISO)
positive regulation of cold-induced thermogenesis  (IEA)
positive regulation of gene expression  (ISO)
positive regulation of immunoglobulin production  (IEA,ISO)
positive regulation of interleukin-10 production  (IEA)
positive regulation of macrophage activation  (IEA)
positive regulation of mast cell degranulation  (IEA,ISO)
positive regulation of monoatomic ion transport  (ISO)
positive regulation of pancreatic stellate cell proliferation  (ISO)
positive regulation of protein secretion  (ISO)
positive regulation of release of sequestered calcium ion into cytosol  (ISO)
positive regulation of smooth muscle cell proliferation  (ISO)
positive regulation of transcription by RNA polymerase II  (IEA)
regulation of proton transport  (ISO)
response to ethanol  (ISO)
response to lipopolysaccharide  (ISO)
response to mechanical stimulus  (ISO)
response to nematode  (IEA,ISO)
response to nicotine  (ISO)
response to selenium ion  (IEA,ISO)
signal transduction  (IEA)

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:16034134   PMID:22301074  


Genomics

Comparative Map Data
IL13
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl2134,972,623 - 134,975,093 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.12134,972,099 - 134,976,672 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.22140,441,025 - 140,444,068 (+)NCBISscrofa10.2Sscrofa10.2susScr3
IL13
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh385132,656,522 - 132,661,110 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl5132,656,263 - 132,661,110 (+)EnsemblGRCh38hg38GRCh38
GRCh375131,992,214 - 131,996,802 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 365132,021,764 - 132,024,700 (+)NCBINCBI36Build 36hg18NCBI36
Build 345132,021,763 - 132,024,700NCBI
Celera5128,123,995 - 128,126,931 (+)NCBICelera
Cytogenetic Map5q31.1NCBI
HuRef5127,186,169 - 127,189,105 (+)NCBIHuRef
CHM1_15131,427,162 - 131,430,098 (+)NCBICHM1_1
T2T-CHM13v2.05133,176,323 - 133,180,911 (+)NCBIT2T-CHM13v2.0
Il13
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391153,522,150 - 53,525,529 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1153,522,151 - 53,525,529 (-)EnsemblGRCm39 Ensembl
GRCm381153,631,323 - 53,634,702 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1153,631,324 - 53,634,702 (-)EnsemblGRCm38mm10GRCm38
MGSCv371153,444,825 - 53,448,204 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361153,474,747 - 53,478,125 (-)NCBIMGSCv36mm8
Celera1158,210,849 - 58,214,228 (-)NCBICelera
Cytogenetic Map11B1.3NCBI
cM Map1131.98NCBI
Il13
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81038,290,926 - 38,293,483 (-)NCBIGRCr8
mRatBN7.21037,790,130 - 37,792,687 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1037,790,130 - 37,792,737 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1042,482,076 - 42,484,637 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01041,972,140 - 41,974,701 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01037,475,862 - 37,478,423 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01038,982,909 - 38,985,466 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1038,982,909 - 38,985,466 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01038,764,639 - 38,767,196 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41039,093,512 - 39,096,069 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11039,102,758 - 39,105,316 (-)NCBI
Celera1037,134,342 - 37,136,897 (-)NCBICelera
Cytogenetic Map10q22NCBI
Il13
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_0049554084,046,406 - 4,049,795 (+)NCBIChiLan1.0ChiLan1.0
IL13
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v24127,968,733 - 127,973,681 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan15126,108,155 - 126,113,245 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v05128,073,863 - 128,078,453 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.15134,235,788 - 134,240,548 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl5134,235,788 - 134,240,548 (+)Ensemblpanpan1.1panPan2
IL13
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11120,957,870 - 20,961,391 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1120,958,464 - 20,961,388 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1119,759,917 - 19,762,847 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01121,744,389 - 21,747,318 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1121,744,389 - 21,747,315 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11120,462,871 - 20,465,798 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01120,310,464 - 20,313,371 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01120,952,917 - 20,955,847 (+)NCBIUU_Cfam_GSD_1.0
Il13
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024407213115,527,018 - 115,529,671 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366472,530,491 - 2,532,373 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049366472,529,933 - 2,532,503 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
IL13
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12335,475,762 - 35,479,419 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2335,476,490 - 35,478,869 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603442,463,847 - 42,466,277 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Il13
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473339,428,095 - 39,429,843 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462473339,427,189 - 39,430,019 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in IL13
90 total Variants

Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
circulatory system
ectoderm
endocrine system
hemolymphoid system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
5 1 7 3 1 4 2 7 2 3

Sequence


Ensembl Acc Id: ENSSSCT00000033118   ⟹   ENSSSCP00000030285
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl2134,972,623 - 134,975,093 (+)Ensembl
Ensembl Acc Id: ENSSSCT00000067756   ⟹   ENSSSCP00000066932
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl2134,972,672 - 134,975,093 (+)Ensembl
RefSeq Acc Id: NM_213803   ⟹   NP_998968
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.12134,972,623 - 134,975,093 (+)NCBI
Sequence:
RefSeq Acc Id: XM_005661643   ⟹   XP_005661700
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.12134,972,099 - 134,976,672 (+)NCBI
Sequence:
RefSeq Acc Id: XM_021080318   ⟹   XP_020935977
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.12134,972,664 - 134,976,672 (+)NCBI
Sequence:
RefSeq Acc Id: XM_021080328   ⟹   XP_020935987
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.12134,972,664 - 134,976,672 (+)NCBI
Sequence:
RefSeq Acc Id: XP_005661700   ⟸   XM_005661643
- Peptide Label: isoform X3
- UniProtKB: B3GDZ5 (UniProtKB/TrEMBL),   A0A5G2QQC7 (UniProtKB/TrEMBL),   A0A8D1VYU0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_998968   ⟸   NM_213803
- Peptide Label: precursor
- UniProtKB: Q95J68 (UniProtKB/Swiss-Prot),   A0A5G2QQC7 (UniProtKB/TrEMBL),   A0A8D1VYU0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_020935977   ⟸   XM_021080318
- Peptide Label: isoform X1
- UniProtKB: A0A8D1K6G9 (UniProtKB/TrEMBL),   A0A8D0UW48 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_020935987   ⟸   XM_021080328
- Peptide Label: isoform X2
- UniProtKB: A0A8D0UW48 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSSSCP00000066932   ⟸   ENSSSCT00000067756
Ensembl Acc Id: ENSSSCP00000030285   ⟸   ENSSSCT00000033118


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSSCG00000014281 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ENSSSCG00005006874 UniProtKB/Swiss-Prot
  ENSSSCG00015039152 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ENSSSCG00025057113 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ENSSSCG00030055116 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ENSSSCG00035022892 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ENSSSCG00040022699 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ENSSSCG00045014376 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ENSSSCG00050076393 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ENSSSCG00055003836 UniProtKB/Swiss-Prot
  ENSSSCG00060054819 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ENSSSCG00065022117 UniProtKB/Swiss-Prot
  ENSSSCG00070020046 UniProtKB/Swiss-Prot
Ensembl Transcript ENSSSCT00000033118 ENTREZGENE
  ENSSSCT00000033118.3 UniProtKB/Swiss-Prot
  ENSSSCT00000067756.1 UniProtKB/TrEMBL
  ENSSSCT00005010400.1 UniProtKB/Swiss-Prot
  ENSSSCT00015052193.1 UniProtKB/Swiss-Prot
  ENSSSCT00015052282.1 UniProtKB/TrEMBL
  ENSSSCT00025078103.1 UniProtKB/Swiss-Prot
  ENSSSCT00025078206.1 UniProtKB/TrEMBL
  ENSSSCT00025078249.1 UniProtKB/TrEMBL
  ENSSSCT00030076776.1 UniProtKB/Swiss-Prot
  ENSSSCT00030076793.1 UniProtKB/TrEMBL
  ENSSSCT00035029933.1 UniProtKB/Swiss-Prot
  ENSSSCT00035029939.1 UniProtKB/TrEMBL
  ENSSSCT00040030432.1 UniProtKB/Swiss-Prot
  ENSSSCT00040030469.1 UniProtKB/TrEMBL
  ENSSSCT00045024503.1 UniProtKB/Swiss-Prot
  ENSSSCT00045024517.1 UniProtKB/TrEMBL
  ENSSSCT00050104940.1 UniProtKB/Swiss-Prot
  ENSSSCT00050104943.1 UniProtKB/TrEMBL
  ENSSSCT00055007531.1 UniProtKB/Swiss-Prot
  ENSSSCT00060074655.1 UniProtKB/Swiss-Prot
  ENSSSCT00060074661.1 UniProtKB/TrEMBL
  ENSSSCT00065029413.1 UniProtKB/Swiss-Prot
  ENSSSCT00070039741.1 UniProtKB/Swiss-Prot
Gene3D-CATH 1.20.1250.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro 4_helix_cytokine-like_core UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  IL-13 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  IL-4/IL-13 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  IL-4/IL-13_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report ssc:396721 UniProtKB/Swiss-Prot
NCBI Gene IL13 ENTREZGENE
PANTHER INTERLEUKIN-13 UniProtKB/Swiss-Prot
  INTERLEUKIN-13 UniProtKB/Swiss-Prot
  INTERLEUKIN-13 UniProtKB/TrEMBL
  INTERLEUKIN-13 UniProtKB/TrEMBL
Pfam IL13 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PRINTS INTRLEUKIN13 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE INTERLEUKIN_4_13 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART IL4_13 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF47266 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A5G2QQC7 ENTREZGENE, UniProtKB/TrEMBL
  A0A8D0UW48 ENTREZGENE, UniProtKB/TrEMBL
  A0A8D1K6G9 ENTREZGENE, UniProtKB/TrEMBL
  A0A8D1VYU0 ENTREZGENE, UniProtKB/TrEMBL
  B3GDZ5 ENTREZGENE, UniProtKB/TrEMBL
  IL13_PIG UniProtKB/Swiss-Prot, ENTREZGENE
VGNC ID VGNC:99763 ENTREZGENE