RGD Reference Report - Pulmonary T(H)2 response in Pseudomonas aeruginosa-infected patients with cystic fibrosis. - Rat Genome Database

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Pulmonary T(H)2 response in Pseudomonas aeruginosa-infected patients with cystic fibrosis.

Authors: Hartl, D  Griese, M  Kappler, M  Zissel, G  Reinhardt, D  Rebhan, C  Schendel, DJ  Krauss-Etschmann, S 
Citation: Hartl D, etal., J Allergy Clin Immunol. 2006 Jan;117(1):204-11. Epub 2005 Nov 28.
RGD ID: 4145500
Pubmed: PMID:16387607   (View Abstract at PubMed)
DOI: DOI:10.1016/j.jaci.2005.09.023   (Journal Full-text)

BACKGROUND: Pseudomonas aeruginosa infection determines the course of cystic fibrosis (CF) lung disease. Studies in human peripheral blood indicate that P aeruginosa infection is associated with a predominant T(H)2 immune response, whereas T(H)1 responses are accompanied by a better pulmonary outcome. OBJECTIVE: Analyses of peripheral blood may not correspond directly with the local pulmonary immune response. Therefore, we asked whether the T(H)1/T(H)2 response is altered in bronchoalveolar lavage fluid from P aeruginosa-infected patients with CF. METHODS: Bronchoalveolar lavage fluid was obtained from 12 patients with CF chronically infected with P aeruginosa, 11 noninfected patients with CF, and 8 healthy controls. Pulmonary CXCR3(+) (T(H)1) and CCR4(+) (T(H)2) expressing CD4(+) and CD8(+) lymphocytes were quantified by flow cytometry. Levels of T(H)1-associated (IL-2, IFN-gamma, IFN-gamma inducible T cell-alpha chemoattractant, Monokine induced by IFN-gamma, IFN-gamma inducible protein of 10 kd) and T(H)2-associated (IL-4, IL-5, IL-10, thymus and activation-regulated chemokine [TARC], macrophage-derived chemokine) cytokines and chemokines and a panel of proinflammatory molecules were quantified at the protein level. Chemokines mRNA levels were assessed by real time RT-PCR. RESULTS: P aeruginosa-infected patients with CF had significantly higher levels of pulmonary CCR4(+)CD4(+) (T(H)2) cells, IL-4, IL-13, and TARC and lower levels of IFN-gamma compared with noninfected patients with CF and healthy controls. Bronchoalveolar lavage fluid levels of IL-4, IL-13, and TARC correlated inversely with FEV(1) in P aeruginosa-infected patients with CF. CONCLUSION: These results reveal the prevalence of a pulmonary T(H)2 immune response in P aeruginosa-infected patients with CF. The modulation of the pulmonary T(H)2 response in P aeruginosa infection may be an option for the treatment of P aeruginosa lung disease in patients with CF.



RGD Manual Disease Annotations    Click to see Annotation Detail View

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
CCL17HumanPseudomonas Infections  IEP associated with Cystic FibrosisRGD 
Ccl17RatPseudomonas Infections  ISOCCL17 (Homo sapiens)associated with Cystic FibrosisRGD 
Ccl17MousePseudomonas Infections  ISOCCL17 (Homo sapiens)associated with Cystic FibrosisRGD 
IL13HumanPseudomonas Infections  IEP associated with Cystic FibrosisRGD 
Il13RatPseudomonas Infections  ISOIL13 (Homo sapiens)associated with Cystic FibrosisRGD 
Il13MousePseudomonas Infections  ISOIL13 (Homo sapiens)associated with Cystic FibrosisRGD 

Objects Annotated

Genes (Rattus norvegicus)
Ccl17  (C-C motif chemokine ligand 17)
Il13  (interleukin 13)

Genes (Mus musculus)
Ccl17  (C-C motif chemokine ligand 17)
Il13  (interleukin 13)

Genes (Homo sapiens)
CCL17  (C-C motif chemokine ligand 17)
IL13  (interleukin 13)


Additional Information