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Analysis of proinflammatory and anti-inflammatory cytokine serum concentrations in patients with multiple sclerosis by using a multiplexed immunoassay.

Authors: Martins, TB  Rose, JW  Jaskowski, TD  Wilson, AR  Husebye, D  Seraj, HS  Hill, HR 
Citation: Martins TB, etal., Am J Clin Pathol. 2011 Nov;136(5):696-704.
Pubmed: (View Article at PubMed) PMID:22031307
DOI: Full-text: DOI:10.1309/AJCP7UBK8IBVMVNR

We examined cytokines and other inflammatory markers in serum samples from 833 patients with multiple sclerosis and 117 healthy control subjects. A multiplexed immunoassay was used to assess the concentrations of 13 cytokines/inflammatory markers: interferon (IFN)-gamma; interleukins (ILs)-1beta, 2, 4, 5, 6, 8, 10, 12, and 13; tumor necrosis factor (TNF)-alpha; IL-2 receptor; and soluble CD40 ligand. Significant increases between patients and control subjects were found for IFN-gamma (mean, 7.5 vs 0.4 pg/mL; P = .0002), IL-2 (mean 5.7 vs 1.0 pg/mL; P =.0002), IL-1beta (mean, 23.0 vs 11.3 pg/mL; P


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RGD Object Information
RGD ID: 5684368
Created: 2011-12-16
Species: All species
Last Modified: 2011-12-16
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.