RGD Reference Report - Interleukin-13 and its receptors in idiopathic interstitial pneumonia: clinical implications for lung function. - Rat Genome Database

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Interleukin-13 and its receptors in idiopathic interstitial pneumonia: clinical implications for lung function.

Authors: Park, SW  Ahn, MH  Jang, HK  Jang, AS  Kim, DJ  Koh, ES  Park, JS  Uh, ST  Kim, YH 
Citation: Park SW, etal., J Korean Med Sci. 2009 Aug;24(4):614-20. Epub 2009 Jul 29.
RGD ID: 4145627
Pubmed: PMID:19654941   (View Abstract at PubMed)
PMCID: PMC2719183   (View Article at PubMed Central)

Idiopathic interstitial pneumonia (IIP) is characterized by varying degrees of interstitial fibrosis. IL-13 and IL-4 are strong inducers of tissue fibrosis, whereas IFN-gamma has antifibrotic potential. However, the roles of these substances in IIP remain unknown. IL-13, IL-4, and IFN-gamma were measured in the BAL fluid of 16 idiopathic pulmonary fibrosis (IPF) patients, 10 nonspecific interstitial pneumonia (NSIP) patients, and 8 normal controls. The expression of IL-13 and IL-13Ralpha1/alpha2 in lung tissues was analyzed using ELISA and immunohistochemistry. IL-13 levels were significantly higher in IPF patients than the others (P<0.05). IL-4 levels were higher in both IPF and NSIP patients than in normal controls (P<0.05), and IFN-gamma levels were lower in NSIP patients than in normal controls (P=0.047). IL-13 levels correlated inversely with FVC% (r=-0.47, P=0.043) and DLCO% (r=-0.58, P=0.014) in IPF and NSIP patients. IL-13 was strongly expressed in the smooth muscle, bronchial epithelium, alveolar macrophages and endothelium of IPF patients. IL-13Ralpha1, rather than IL-13Ralpha2, was strongly expressed in the smooth muscle, bronchial epithelium, and endothelium of IPF patients. IL-13 and its receptors may contribute to the pathogenesis of fibrosis in IIP and appear to be related to the severity of the disease.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
pulmonary fibrosis  IEP 4145627idiopathic pulmonary fibrosisRGD 
pulmonary fibrosis  ISOIL13 (Homo sapiens)4145627; 4145627idiopathic pulmonary fibrosisRGD 

Objects Annotated

Genes (Rattus norvegicus)
Il13  (interleukin 13)

Genes (Mus musculus)
Il13  (interleukin 13)

Genes (Homo sapiens)
IL13  (interleukin 13)


Additional Information