Arrb1 (arrestin beta 1) - Rat Genome Database

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Gene: Arrb1 (arrestin beta 1) Ictidomys tridecemlineatus
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Symbol: Arrb1
Name: arrestin beta 1
RGD ID: 12674721
Description: ENCODES a protein that exhibits alpha-1A adrenergic receptor binding (ortholog); alpha-1B adrenergic receptor binding (ortholog); AP-2 adaptor complex binding (ortholog); INVOLVED IN endocytosis (ortholog); follicle-stimulating hormone signaling pathway (ortholog); G protein-coupled receptor signaling pathway (ortholog); PARTICIPATES IN angiotensin II signaling pathway via AT1 receptor; calcium signaling pathway via the calcium-sensing receptor; corticotropin-releasing hormone signaling pathway; ASSOCIATED WITH 3-methylglutaconic aciduria type 7b (ortholog); Arteriovenous Fistula (ortholog); colitis (ortholog); FOUND IN basolateral plasma membrane (ortholog); dendritic spine (ortholog); endosome (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: arrestin beta 1, transcript variant X1; arrestin beta 1, transcript variant X2; arrestin beta 1, transcript variant X3; beta-arrestin-1
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: SpeTri2.0 - Squirrel SpeTri2.0 Assembly
Position:
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494762,490,018 - 62,573,146 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364984,094,893 - 4,172,755 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049364984,089,621 - 4,172,749 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
endocytosis  (ISO)
follicle-stimulating hormone signaling pathway  (ISO)
G protein-coupled receptor internalization  (IEA)
G protein-coupled receptor signaling pathway  (ISO)
negative regulation of apoptotic process  (ISO)
negative regulation of cysteine-type endopeptidase activity  (ISO)
negative regulation of ERK1 and ERK2 cascade  (ISO)
negative regulation of GTPase activity  (ISO)
negative regulation of interleukin-6 production  (IEA)
negative regulation of interleukin-8 production  (IEA)
negative regulation of neuron apoptotic process  (ISO)
negative regulation of NF-kappaB transcription factor activity  (ISO)
negative regulation of Notch signaling pathway  (IEA)
negative regulation of protein phosphorylation  (ISO)
negative regulation of protein ubiquitination  (IEA)
negative regulation of signal transduction  (IEA)
phototransduction  (ISO)
positive regulation of cell population proliferation  (ISO)
positive regulation of ERK1 and ERK2 cascade  (IEA,ISO)
positive regulation of insulin secretion involved in cellular response to glucose stimulus  (ISO)
positive regulation of MAPK cascade  (ISO)
positive regulation of peptidyl-serine phosphorylation  (ISO)
positive regulation of protein phosphorylation  (ISO)
positive regulation of protein ubiquitination  (ISO)
positive regulation of receptor internalization  (IEA)
positive regulation of Rho protein signal transduction  (IEA)
positive regulation of transcription by RNA polymerase II  (IEA)
proteasome-mediated ubiquitin-dependent protein catabolic process  (IEA)
protein transport  (IEA)
protein ubiquitination  (IEA)
regulation of apoptotic process  (ISO)
regulation of DNA-templated transcription  (ISO)
regulation of G protein-coupled receptor signaling pathway  (ISO)
regulation of inositol trisphosphate biosynthetic process  (ISO)
regulation of transcription by RNA polymerase II  (IEA)
response to morphine  (ISO)
response to xenobiotic stimulus  (ISO)
signal transduction  (IEA)
stress fiber assembly  (IEA)
ubiquitin-dependent protein catabolic process  (IEA)

Cellular Component

References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
Arrb1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494762,490,018 - 62,573,146 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364984,094,893 - 4,172,755 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049364984,089,621 - 4,172,749 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ARRB1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381175,260,122 - 75,351,661 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1175,260,122 - 75,351,705 (-)EnsemblGRCh38hg38GRCh38
GRCh371174,971,166 - 75,062,705 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361174,654,130 - 74,740,521 (-)NCBINCBI36Build 36hg18NCBI36
Build 341174,654,129 - 74,740,521NCBI
Celera1172,283,036 - 72,369,427 (-)NCBICelera
Cytogenetic Map11q13.4NCBI
HuRef1171,268,798 - 71,360,118 (-)NCBIHuRef
CHM1_11174,854,770 - 74,946,464 (-)NCBICHM1_1
T2T-CHM13v2.01175,189,729 - 75,281,255 (-)NCBIT2T-CHM13v2.0
Arrb1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39799,184,356 - 99,255,979 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl799,184,673 - 99,255,978 (+)EnsemblGRCm39 Ensembl
GRCm38799,535,147 - 99,606,772 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl799,535,466 - 99,606,771 (+)EnsemblGRCm38mm10GRCm38
MGSCv377106,683,996 - 106,755,281 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36799,409,569 - 99,480,854 (+)NCBIMGSCv36mm8
Celera799,859,615 - 99,932,041 (+)NCBICelera
Cytogenetic Map7E1NCBI
cM Map754.09NCBI
Arrb1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81163,249,654 - 163,321,711 (+)NCBIGRCr8
mRatBN7.21153,837,964 - 153,912,111 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1153,838,078 - 153,904,061 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1161,833,965 - 161,899,728 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01169,014,116 - 169,079,853 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01161,887,644 - 161,953,403 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01164,502,099 - 164,573,947 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1164,502,389 - 164,593,139 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01170,705,795 - 170,777,617 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41156,871,564 - 156,937,540 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11156,949,969 - 157,015,946 (+)NCBI
Celera1151,924,752 - 151,989,492 (+)NCBICelera
Cytogenetic Map1q32NCBI
Arrb1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541416,478,843 - 16,562,135 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495541416,478,843 - 16,568,050 (+)NCBIChiLan1.0ChiLan1.0
ARRB1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2976,190,602 - 76,281,939 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11177,233,278 - 77,324,616 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01170,319,935 - 70,411,276 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11173,624,254 - 73,670,495 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1173,630,276 - 73,654,155 (-)Ensemblpanpan1.1panPan2
ARRB1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12123,261,020 - 23,304,448 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2123,235,711 - 23,297,786 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2122,990,721 - 23,068,006 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02123,428,040 - 23,505,333 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2123,428,093 - 23,507,491 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12123,226,359 - 23,303,832 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02123,422,622 - 23,499,929 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02123,340,581 - 23,417,904 (+)NCBIUU_Cfam_GSD_1.0
ARRB1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl99,516,947 - 9,597,976 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.199,516,944 - 9,597,446 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2910,659,892 - 10,767,092 (+)NCBISscrofa10.2Sscrofa10.2susScr3
ARRB1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1166,489,358 - 66,580,167 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl166,490,102 - 66,580,154 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604359,230,347 - 59,326,828 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Arrb1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248171,750,156 - 1,823,309 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248171,750,448 - 1,828,399 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSSTOT00000004554   ⟹   ENSSTOP00000004086
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
SpeTri2.0 EnsemblNW_0049364984,095,499 - 4,172,755 (-)Ensembl
Ensembl Acc Id: ENSSTOT00000032167   ⟹   ENSSTOP00000024362
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
SpeTri2.0 EnsemblNW_0049364984,095,499 - 4,116,553 (-)Ensembl
Ensembl Acc Id: ENSSTOT00000035599   ⟹   ENSSTOP00000024223
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
SpeTri2.0 EnsemblNW_0049364984,094,893 - 4,172,755 (-)Ensembl
RefSeq Acc Id: XM_005323202   ⟹   XP_005323259
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_02440494762,490,018 - 62,573,146 (-)NCBI
SpeTri2.0NW_0049364984,089,621 - 4,172,749 (-)NCBI
Sequence:
RefSeq Acc Id: XM_021725096   ⟹   XP_021580771
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_02440494762,490,018 - 62,521,338 (-)NCBI
SpeTri2.0NW_0049364984,089,621 - 4,121,122 (-)NCBI
Sequence:
RefSeq Acc Id: XM_021725097   ⟹   XP_021580772
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_02440494762,490,018 - 62,521,338 (-)NCBI
SpeTri2.0NW_0049364984,089,621 - 4,121,123 (-)NCBI
Sequence:
RefSeq Acc Id: XM_040284955   ⟹   XP_040140889
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_02440494762,490,018 - 62,531,256 (-)NCBI
RefSeq Acc Id: XM_040284956   ⟹   XP_040140890
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_02440494762,497,148 - 62,521,338 (-)NCBI
RefSeq Acc Id: XM_040284958   ⟹   XP_040140892
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_02440494762,490,018 - 62,521,338 (-)NCBI
RefSeq Acc Id: XP_005323259   ⟸   XM_005323202
- Peptide Label: isoform X3
- UniProtKB: A0A287CSH7 (UniProtKB/TrEMBL),   A0A287CSW1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_021580772   ⟸   XM_021725097
- Peptide Label: isoform X2
- UniProtKB: A0A287CSW1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_021580771   ⟸   XM_021725096
- Peptide Label: isoform X1
- UniProtKB: A0A287CSW1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_040140889   ⟸   XM_040284955
- Peptide Label: isoform X4
- UniProtKB: A0A287CSW1 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_040140892   ⟸   XM_040284958
- Peptide Label: isoform X6
- UniProtKB: A0A287CSW1 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_040140890   ⟸   XM_040284956
- Peptide Label: isoform X5
- UniProtKB: A0A287CSW1 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSSTOP00000024223   ⟸   ENSSTOT00000035599
Ensembl Acc Id: ENSSTOP00000024362   ⟸   ENSSTOT00000032167
Ensembl Acc Id: ENSSTOP00000004086   ⟸   ENSSTOT00000004554
Protein Domains
Arrestin C-terminal-like


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSTOG00000004545 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSSTOT00000004554.3 UniProtKB/TrEMBL
  ENSSTOT00000032167.1 UniProtKB/TrEMBL
  ENSSTOT00000035599.1 UniProtKB/TrEMBL
Gene3D-CATH 2.60.40.640 UniProtKB/TrEMBL
  2.60.40.840 UniProtKB/TrEMBL
InterPro Arrestin UniProtKB/TrEMBL
  Arrestin-like_C UniProtKB/TrEMBL
  Arrestin-like_N UniProtKB/TrEMBL
  Arrestin_C-like UniProtKB/TrEMBL
  Arrestin_CS UniProtKB/TrEMBL
  Arrestin_N UniProtKB/TrEMBL
  Ig_E-set UniProtKB/TrEMBL
NCBI Gene Arrb1 ENTREZGENE
PANTHER BETA-ARRESTIN-1 UniProtKB/TrEMBL
  PTHR11792 UniProtKB/TrEMBL
Pfam Arrestin_C UniProtKB/TrEMBL
  Arrestin_N UniProtKB/TrEMBL
PRINTS ARRESTIN UniProtKB/TrEMBL
PROSITE ARRESTINS UniProtKB/TrEMBL
SMART Arrestin_C UniProtKB/TrEMBL
Superfamily-SCOP SSF81296 UniProtKB/TrEMBL
UniProt A0A287CSH7 ENTREZGENE, UniProtKB/TrEMBL
  A0A287CSW1 ENTREZGENE, UniProtKB/TrEMBL
  I3M4G7_ICTTR UniProtKB/TrEMBL