LOC403934 (cell division cycle 42) - Rat Genome Database

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Gene: LOC403934 (cell division cycle 42) Canis lupus familiaris
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Symbol: LOC403934
Name: cell division cycle 42
RGD ID: 12349424
Description: ENCODES a protein that exhibits apolipoprotein A-I receptor binding (ortholog); GBD domain binding (ortholog); GTP binding (ortholog); INVOLVED IN actin cytoskeleton organization (ortholog); actin filament branching (ortholog); actin filament organization (ortholog); PARTICIPATES IN adenosine signaling pathway; c-Jun N-terminal kinases MAPK signaling pathway; E-cadherin signaling pathway; ASSOCIATED WITH Adrenal Gland Neoplasms (ortholog); Alzheimer's disease (ortholog); Animal Mammary Neoplasms (ortholog); FOUND IN apical part of cell (ortholog); cell periphery (ortholog); cell projection (ortholog)
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: CDC42; CDC42 GTP-binding protein; cell division control protein 42 homolog; cell division cycle 42 (GTP binding protein, 25kDa); G25K GTP-binding protein
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1277,153,276 - 77,169,947 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl277,153,095 - 77,199,211 (-)EnsemblCanFam3.1canFam3CanFam3.1
ROS_Cfam_1.044,445,564 - 4,446,293 (+)NCBI
UMICH_Zoey_3.144,457,005 - 4,457,734 (+)NCBI
UNSW_CanFamBas_1.044,574,515 - 4,575,244 (+)NCBI
UU_Cfam_GSD_1.044,796,130 - 4,796,859 (+)NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
actin cytoskeleton organization  (ISO)
actin filament branching  (ISO)
actin filament organization  (ISO,ISS)
adherens junction organization  (ISO)
cardiac conduction system development  (ISO)
Cdc42 protein signal transduction  (IBA)
cell junction assembly  (ISS)
cell migration  (IBA)
cell projection assembly  (IBA)
cellular protein localization  (ISO)
cellular response to interferon-gamma  (ISO)
dendritic cell migration  (ISO)
dendritic spine morphogenesis  (ISS)
endocytosis  (IBA,ISO)
establishment of epithelial cell apical/basal polarity  (ISS)
establishment of Golgi localization  (ISO)
establishment or maintenance of apical/basal cell polarity  (ISO)
filopodium assembly  (ISO)
Golgi organization  (ISO)
heart contraction  (ISO)
integrin-mediated signaling pathway  (ISO)
modification of synaptic structure  (IBA)
negative regulation of protein-containing complex assembly  (ISO)
neuron fate determination  (ISO)
neuropilin signaling pathway  (ISO)
nuclear migration  (ISO)
nucleus localization  (ISO)
organelle transport along microtubule  (ISO)
phagocytosis, engulfment  (ISS)
positive regulation of actin cytoskeleton reorganization  (ISO)
positive regulation of catalytic activity  (ISO)
positive regulation of cell growth  (ISO)
positive regulation of cytokinesis  (ISS)
positive regulation of DNA replication  (ISO)
positive regulation of epithelial cell proliferation involved in lung morphogenesis  (ISO)
positive regulation of filopodium assembly  (ISS)
positive regulation of intracellular protein transport  (ISO)
positive regulation of JNK cascade  (ISO)
positive regulation of lamellipodium assembly  (ISO)
positive regulation of MAPK cascade  (ISO)
positive regulation of neuron apoptotic process  (ISO)
positive regulation of phosphatidylinositol 3-kinase activity  (ISO)
positive regulation of pinocytosis  (ISS)
positive regulation of pseudopodium assembly  (ISO)
positive regulation of stress fiber assembly  (ISO)
positive regulation of substrate adhesion-dependent cell spreading  (ISS)
positive regulation of synapse structural plasticity  (ISO)
regulation of attachment of spindle microtubules to kinetochore  (ISS)
regulation of filopodium assembly  (ISS)
regulation of lamellipodium assembly  (ISO)
regulation of mitotic nuclear division  (ISO)
regulation of modification of postsynaptic structure  (ISO)
regulation of protein binding  (ISO)
regulation of stress fiber assembly  (ISO)
sprouting angiogenesis  (ISO)
submandibular salivary gland formation  (ISO)
substantia nigra development  (ISO)
viral RNA genome replication  (ISO)

References
Additional References at PubMed
PMID:15093747   PMID:15456777   PMID:15834156   PMID:17098962   PMID:27901125   PMID:28554775  


Genomics

Comparative Map Data
LOC403934
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1277,153,276 - 77,169,947 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl277,153,095 - 77,199,211 (-)EnsemblCanFam3.1canFam3CanFam3.1
ROS_Cfam_1.044,445,564 - 4,446,293 (+)NCBI
UMICH_Zoey_3.144,457,005 - 4,457,734 (+)NCBI
UNSW_CanFamBas_1.044,574,515 - 4,575,244 (+)NCBI
UU_Cfam_GSD_1.044,796,130 - 4,796,859 (+)NCBI
CDC42
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl122,025,511 - 22,101,360 (+)EnsemblGRCh38hg38GRCh38
GRCh38122,052,709 - 22,101,360 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh37122,379,202 - 22,427,853 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36122,251,707 - 22,292,023 (+)NCBINCBI36hg18NCBI36
Build 34122,124,487 - 22,164,741NCBI
Celera120,702,109 - 20,742,389 (+)NCBI
Cytogenetic Map1p36.12NCBI
HuRef120,622,960 - 20,663,212 (+)NCBIHuRef
CHM1_1122,491,651 - 22,531,931 (+)NCBICHM1_1
Cdc42
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm394137,047,007 - 137,085,070 (-)NCBIGRCm39mm39
GRCm39 Ensembl4137,047,007 - 137,085,031 (-)Ensembl
GRCm384137,319,696 - 137,357,759 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl4137,319,696 - 137,357,720 (-)EnsemblGRCm38mm10GRCm38
MGSCv374136,875,611 - 136,913,652 (-)NCBIGRCm37mm9NCBIm37
MGSCv364136,591,779 - 136,608,205 (-)NCBImm8
Celera4135,540,002 - 135,577,854 (-)NCBICelera
Cytogenetic Map4D3NCBI
cM Map469.83NCBI
Cdc42
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.25149,555,069 - 149,593,239 (-)NCBI
Rnor_6.0 Ensembl5155,691,390 - 155,728,300 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.05155,690,267 - 155,728,385 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.05159,446,154 - 159,485,163 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.45156,106,123 - 156,143,040 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.15156,116,164 - 156,153,079 (-)NCBI
Celera5147,953,334 - 147,989,998 (-)NCBICelera
Cytogenetic Map5q36NCBI
Cdc42
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554522,255,117 - 2,299,042 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554522,255,940 - 2,299,042 (+)NCBIChiLan1.0ChiLan1.0
CDC42
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1122,188,722 - 22,228,351 (+)NCBIpanpan1.1PanPan1.1panPan2
Mhudiblu_PPA_v0121,245,970 - 21,286,210 (+)NCBIMhudiblu_PPA_v0panPan3
Cdc42
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440505841,731,950 - 41,773,901 (+)NCBI
SpeTri2.0NW_0049364747,556,765 - 7,598,687 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CDC42
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl680,035,122 - 80,089,233 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1680,035,034 - 80,089,243 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2674,057,184 - 74,116,824 (+)NCBISscrofa10.2Sscrofa10.2susScr3
CDC42
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.120110,568,004 - 110,608,318 (-)NCBI
ChlSab1.1 Ensembl20110,569,352 - 110,582,562 (-)Ensembl
Vero_WHO_p1.0NW_0236660335,689,907 - 5,730,175 (+)NCBI
Cdc42
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046247646,874,453 - 6,891,952 (+)NCBI


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system reproductive system respiratory system adipose tissue
High
Medium 5 5 22 6 6 6 6 6 12 8 10 6
Low
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSCAFT00000023350   ⟹   ENSCAFP00000021683
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl277,153,095 - 77,199,195 (-)Ensembl
RefSeq Acc Id: ENSCAFT00000023351   ⟹   ENSCAFP00000021684
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl277,154,524 - 77,199,211 (-)Ensembl
RefSeq Acc Id: NM_001003254   ⟹   NP_001003254
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1277,153,276 - 77,169,947 (-)NCBI
Sequence:
RefSeq Acc Id: NM_001389221   ⟹   NP_001376150
RefSeq Status: VALIDATED
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.044,445,564 - 4,446,293 (+)NCBI
UMICH_Zoey_3.144,457,005 - 4,457,734 (+)NCBI
UNSW_CanFamBas_1.044,574,515 - 4,575,244 (+)NCBI
UU_Cfam_GSD_1.044,796,130 - 4,796,859 (+)NCBI
Protein Sequences
Protein RefSeqs NP_001376150 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein P60952 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: NP_001003254   ⟸   NM_001003254
- Peptide Label: precursor
- Sequence:
RefSeq Acc Id: ENSCAFP00000021684   ⟸   ENSCAFT00000023351
RefSeq Acc Id: ENSCAFP00000021683   ⟸   ENSCAFT00000023350
RefSeq Acc Id: NP_001376150   ⟸   NM_001389221


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000014707 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
  ENSCAFG00030002163 UniProtKB/Swiss-Prot
  ENSCAFG00040001840 UniProtKB/Swiss-Prot
  ENSCAFG00040002443 UniProtKB/Swiss-Prot
Ensembl Protein ENSCAFP00000021683 UniProtKB/Swiss-Prot
  ENSCAFP00000021684 UniProtKB/Swiss-Prot
  ENSCAFP00030003518 UniProtKB/Swiss-Prot
  ENSCAFP00040002961 UniProtKB/Swiss-Prot
  ENSCAFP00040003996 UniProtKB/Swiss-Prot
Ensembl Transcript ENSCAFT00000023350 UniProtKB/Swiss-Prot
  ENSCAFT00000023351 UniProtKB/Swiss-Prot
  ENSCAFT00030003966 UniProtKB/Swiss-Prot
  ENSCAFT00040003456 UniProtKB/Swiss-Prot
  ENSCAFT00040004651 UniProtKB/Swiss-Prot
InterPro Cdc42 UniProtKB/Swiss-Prot
  P-loop_NTPase UniProtKB/Swiss-Prot
  Small_GTP-bd_dom UniProtKB/Swiss-Prot
  Small_GTPase UniProtKB/Swiss-Prot
  Small_GTPase_Rho UniProtKB/Swiss-Prot
KEGG Report cfa:403934 UniProtKB/Swiss-Prot
NCBI Gene CDC42 ENTREZGENE
Pfam Ras UniProtKB/Swiss-Prot
PROSITE RHO UniProtKB/Swiss-Prot
Superfamily-SCOP SSF52540 UniProtKB/Swiss-Prot
TIGRFAMs small_GTP UniProtKB/Swiss-Prot
UniProt CDC42_CANLF UniProtKB/Swiss-Prot, ENTREZGENE
UniProt Secondary P21181 UniProtKB/Swiss-Prot
  P25763 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2021-01-12 LOC403934  cell division cycle 42  CDC42  cell division cycle 42  Symbol and/or name change 5135510 APPROVED