LOC403934 (cell division cycle 42) - Rat Genome Database

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Gene: LOC403934 (cell division cycle 42) Canis lupus familiaris
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Symbol: LOC403934 (Ensembl: CDC42)
Name: cell division cycle 42
RGD ID: 12349424
Description: ENCODES a protein that exhibits apolipoprotein A-I receptor binding (ortholog); GBD domain binding (ortholog); GTP binding (ortholog); INVOLVED IN actin cytoskeleton organization (ortholog); actin filament branching (ortholog); actin filament organization (ortholog); PARTICIPATES IN adenosine signaling pathway; c-Jun N-terminal kinases MAPK signaling pathway; E-cadherin signaling pathway; ASSOCIATED WITH 3-hydroxy-3-methylglutaryl-CoA lyase deficiency (ortholog); Adrenal Gland Neoplasms (ortholog); Alzheimer's disease (ortholog); FOUND IN apical part of cell (ortholog); cell leading edge (ortholog); cell-cell junction (ortholog)
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: CDC42; CDC42 GTP-binding protein; cell division control protein 42 homolog; cell division cycle 42 (GTP binding protein, 25kDa); G25K GTP-binding protein
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1277,153,276 - 77,169,947 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl277,153,095 - 77,199,211 (-)EnsemblCanFam3.1canFam3CanFam3.1
ROS_Cfam_1.044,445,564 - 4,446,293 (+)NCBIROS_Cfam_1.0
UMICH_Zoey_3.144,457,005 - 4,457,734 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.044,574,515 - 4,575,244 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.044,796,130 - 4,796,859 (+)NCBIUU_Cfam_GSD_1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
actin cytoskeleton organization  (ISO)
actin filament branching  (ISO)
actin filament organization  (IBA,ISO,ISS)
adherens junction organization  (ISO)
anatomical structure morphogenesis  (IEA)
cardiac conduction system development  (ISO)
cardiac neural crest cell migration involved in outflow tract morphogenesis  (ISO)
Cdc42 protein signal transduction  (IBA)
cell differentiation  (IEA)
cell junction assembly  (ISS)
cellular response to type II interferon  (ISO)
dendritic cell migration  (ISO)
dendritic spine morphogenesis  (ISS)
embryonic heart tube development  (ISO)
endocytosis  (IBA,ISO)
endothelin receptor signaling pathway involved in heart process  (ISO)
establishment of epithelial cell apical/basal polarity  (ISS)
establishment of Golgi localization  (ISO)
establishment of localization in cell  (ISO)
establishment or maintenance of apical/basal cell polarity  (ISO)
establishment or maintenance of cell polarity  (IBA,IEA)
filopodium assembly  (ISO)
Golgi organization  (ISO)
heart contraction  (ISO)
heart process  (ISO)
integrin-mediated signaling pathway  (ISO)
negative regulation of protein-containing complex assembly  (ISO)
nervous system development  (IEA)
neuron fate determination  (ISO)
neuropilin signaling pathway  (ISO)
nuclear migration  (ISO)
nucleus localization  (ISO)
organelle transport along microtubule  (ISO)
phagocytosis, engulfment  (ISS)
positive regulation of catalytic activity  (ISO)
positive regulation of cell growth  (ISO)
positive regulation of cell migration  (ISO)
positive regulation of cellular component organization  (IEA)
positive regulation of cytokinesis  (ISS)
positive regulation of DNA replication  (ISO)
positive regulation of epithelial cell proliferation involved in lung morphogenesis  (ISO)
positive regulation of filopodium assembly  (ISS)
positive regulation of intracellular protein transport  (ISO)
positive regulation of JNK cascade  (ISO)
positive regulation of lamellipodium assembly  (ISO)
positive regulation of MAPK cascade  (ISO)
positive regulation of neuron apoptotic process  (ISO)
positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction  (ISO)
positive regulation of pinocytosis  (ISS)
positive regulation of pseudopodium assembly  (ISO)
positive regulation of stress fiber assembly  (ISO)
positive regulation of substrate adhesion-dependent cell spreading  (ISS)
positive regulation of synapse structural plasticity  (ISO)
protein localization  (ISO)
protein phosphorylation  (ISO)
regulation of actin cytoskeleton organization  (ISO)
regulation of attachment of spindle microtubules to kinetochore  (ISS)
regulation of filopodium assembly  (IBA,ISS)
regulation of lamellipodium assembly  (ISO)
regulation of mitotic nuclear division  (ISO)
regulation of modification of postsynaptic structure  (ISO)
regulation of postsynapse organization  (ISO)
regulation of stress fiber assembly  (ISO)
small GTPase-mediated signal transduction  (IEA)
sprouting angiogenesis  (ISO)
submandibular salivary gland formation  (ISO)
substantia nigra development  (ISO)

References
Additional References at PubMed
PMID:15093747   PMID:15456777   PMID:15834156   PMID:17098962   PMID:22301074   PMID:27901125   PMID:28554775   PMID:30032202  


Genomics

Comparative Map Data
LOC403934
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1277,153,276 - 77,169,947 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl277,153,095 - 77,199,211 (-)EnsemblCanFam3.1canFam3CanFam3.1
ROS_Cfam_1.044,445,564 - 4,446,293 (+)NCBIROS_Cfam_1.0
UMICH_Zoey_3.144,457,005 - 4,457,734 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.044,574,515 - 4,575,244 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.044,796,130 - 4,796,859 (+)NCBIUU_Cfam_GSD_1.0
CDC42
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38122,052,709 - 22,101,360 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl122,052,627 - 22,101,360 (+)EnsemblGRCh38hg38GRCh38
GRCh37122,379,202 - 22,427,853 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36122,251,707 - 22,292,023 (+)NCBINCBI36Build 36hg18NCBI36
Build 34122,124,487 - 22,164,741NCBI
Celera120,702,109 - 20,742,389 (+)NCBICelera
Cytogenetic Map1p36.12NCBI
HuRef120,622,960 - 20,663,212 (+)NCBIHuRef
CHM1_1122,491,651 - 22,531,931 (+)NCBICHM1_1
T2T-CHM13v2.0121,876,517 - 21,925,101 (+)NCBIT2T-CHM13v2.0
Cdc42
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm394137,047,011 - 137,085,007 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl4137,047,007 - 137,085,031 (-)EnsemblGRCm39 Ensembl
GRCm384137,319,696 - 137,357,759 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl4137,319,696 - 137,357,720 (-)EnsemblGRCm38mm10GRCm38
MGSCv374136,875,611 - 136,913,652 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv364136,591,779 - 136,608,205 (-)NCBIMGSCv36mm8
Celera4135,540,002 - 135,577,854 (-)NCBICelera
Cytogenetic Map4D3NCBI
cM Map469.83NCBI
Cdc42
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr85154,838,478 - 154,876,629 (-)NCBIGRCr8
mRatBN7.25149,555,069 - 149,593,239 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl5149,553,724 - 149,593,111 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx5152,253,400 - 152,289,928 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.05154,027,699 - 154,064,227 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.05154,009,694 - 154,046,226 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.05155,690,267 - 155,728,385 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl5155,691,390 - 155,728,300 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.05159,446,154 - 159,485,163 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.45156,106,123 - 156,143,040 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.15156,116,164 - 156,153,079 (-)NCBI
Celera5147,953,334 - 147,989,998 (-)NCBICelera
Cytogenetic Map5q36NCBI
Cdc42
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554522,255,117 - 2,299,042 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554522,255,940 - 2,299,042 (+)NCBIChiLan1.0ChiLan1.0
CDC42
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21204,846,790 - 204,887,042 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11203,958,664 - 203,998,887 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0121,245,970 - 21,286,210 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1122,188,722 - 22,228,351 (+)NCBIpanpan1.1PanPan1.1panPan2
Cdc42
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440505841,731,950 - 41,773,901 (+)NCBIHiC_Itri_2
SpeTri2.0NW_0049364747,556,765 - 7,598,687 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CDC42
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl680,035,123 - 80,089,233 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1680,035,034 - 80,089,243 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2674,057,184 - 74,116,824 (+)NCBISscrofa10.2Sscrofa10.2susScr3
CDC42
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.120110,568,004 - 110,608,318 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl20110,569,352 - 110,582,562 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660335,689,907 - 5,730,175 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Cdc42
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046247646,874,453 - 6,891,952 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in LOC403934
126 total Variants

Sequence


Ensembl Acc Id: ENSCAFT00000023350   ⟹   ENSCAFP00000021683
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl277,153,095 - 77,199,195 (-)Ensembl
Ensembl Acc Id: ENSCAFT00000023351   ⟹   ENSCAFP00000021684
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl277,154,524 - 77,199,211 (-)Ensembl
RefSeq Acc Id: NM_001389221   ⟹   NP_001376150
RefSeq Status: VALIDATED
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.044,445,564 - 4,446,293 (+)NCBI
UMICH_Zoey_3.144,457,005 - 4,457,734 (+)NCBI
UNSW_CanFamBas_1.044,574,515 - 4,575,244 (+)NCBI
UU_Cfam_GSD_1.044,796,130 - 4,796,859 (+)NCBI
Ensembl Acc Id: ENSCAFP00000021684   ⟸   ENSCAFT00000023351
Ensembl Acc Id: ENSCAFP00000021683   ⟸   ENSCAFT00000023350
RefSeq Acc Id: NP_001376150   ⟸   NM_001389221
- UniProtKB: P60952 (UniProtKB/Swiss-Prot),   A0A8C0NDL5 (UniProtKB/TrEMBL),   A0A8I3P5T9 (UniProtKB/TrEMBL)


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000007554 UniProtKB/TrEMBL
  ENSCAFG00000014707 Ensembl, UniProtKB/Swiss-Prot
  ENSCAFG00030002163 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ENSCAFG00030013659 UniProtKB/TrEMBL
  ENSCAFG00040001840 UniProtKB/Swiss-Prot
  ENSCAFG00040002443 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ENSCAFG00040021272 UniProtKB/TrEMBL
  ENSCAFG00805001040 UniProtKB/Swiss-Prot
  ENSCAFG00845000796 UniProtKB/Swiss-Prot
  ENSCAFG00845003209 ENTREZGENE, UniProtKB/TrEMBL
  ENSCAFG00845018261 UniProtKB/TrEMBL
Ensembl Transcript ENSCAFT00000012099.4 UniProtKB/TrEMBL
  ENSCAFT00000023350.6 UniProtKB/Swiss-Prot
  ENSCAFT00000023351.5 UniProtKB/Swiss-Prot
  ENSCAFT00030003966.1 UniProtKB/Swiss-Prot
  ENSCAFT00030003973.1 UniProtKB/Swiss-Prot
  ENSCAFT00030003992.1 UniProtKB/TrEMBL
  ENSCAFT00030025228.1 UniProtKB/TrEMBL
  ENSCAFT00040003456.1 UniProtKB/Swiss-Prot
  ENSCAFT00040004651.1 UniProtKB/Swiss-Prot
  ENSCAFT00040004656.1 UniProtKB/Swiss-Prot
  ENSCAFT00040004678.1 UniProtKB/TrEMBL
  ENSCAFT00040039469.1 UniProtKB/TrEMBL
  ENSCAFT00805001895 UniProtKB/Swiss-Prot
  ENSCAFT00845001325.1 UniProtKB/Swiss-Prot
  ENSCAFT00845001333.1 UniProtKB/Swiss-Prot
  ENSCAFT00845005638 ENTREZGENE
  ENSCAFT00845005638.1 UniProtKB/TrEMBL
  ENSCAFT00845032290.1 UniProtKB/TrEMBL
Gene3D-CATH 3.40.50.300 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Cdc42 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  P-loop_NTPase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Small_GTP-bd_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Small_GTPase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Small_GTPase_Rho UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene CDC42 ENTREZGENE
PANTHER CDC42 HOMOLOG UniProtKB/TrEMBL, UniProtKB/Swiss-Prot
  CELL DIVISION CONTROL PROTEIN 42 HOMOLOG UniProtKB/TrEMBL
  PTHR24072 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Ras UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PRINTS RASTRNSFRMNG UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE RAB UniProtKB/TrEMBL
  RAS UniProtKB/TrEMBL
  RHO UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART RAB UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RAS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RHO UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF52540 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A8C0LYD7_CANLF UniProtKB/TrEMBL
  A0A8C0NDL5 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I3MRX7_CANLF UniProtKB/TrEMBL
  A0A8I3P5T9 ENTREZGENE, UniProtKB/TrEMBL
  CDC42_CANLF UniProtKB/Swiss-Prot, ENTREZGENE
UniProt Secondary P21181 UniProtKB/Swiss-Prot
  P25763 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2021-01-12 LOC403934  cell division cycle 42  CDC42  cell division cycle 42  Symbol and/or name change 5135510 APPROVED