Cdc42 (cell division cycle 42) - Rat Genome Database

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Pathways
Gene: Cdc42 (cell division cycle 42) Heterocephalus glaber
Analyze
Symbol: Cdc42
Name: cell division cycle 42
RGD ID: 18906111
Description: ENCODES a protein that exhibits apolipoprotein A-I receptor binding (ortholog); GBD domain binding (ortholog); GTP binding (ortholog); INVOLVED IN actin cytoskeleton organization (ortholog); actin filament branching (ortholog); actin filament organization (ortholog); PARTICIPATES IN adenosine signaling pathway; c-Jun N-terminal kinases MAPK signaling pathway; E-cadherin signaling pathway; ASSOCIATED WITH Adrenal Gland Neoplasms (ortholog); Alzheimer's disease (ortholog); anemia (ortholog); FOUND IN apical part of cell (ortholog); cell leading edge (ortholog); cell-cell junction (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: cell division control protein 42 homolog; Cell division control protein 42-like protein
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: HetGla 1.0 - Naked Mole-Rat female 1.0 Assembly
NCBI Annotation Information: Annotation category: partial on reference assembly
Position:
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046247646,874,453 - 6,891,952 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Naked mole-rat maternal Ensembl727,376,888 - 27,428,533 (-)Ensembl
JBrowse:




Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
actin cytoskeleton organization  (ISO)
actin filament branching  (ISO)
actin filament organization  (ISO)
adherens junction organization  (ISO)
anatomical structure morphogenesis  (IEA)
cardiac conduction system development  (ISO)
cardiac neural crest cell migration involved in outflow tract morphogenesis  (ISO)
cell junction assembly  (ISO)
cellular response to type II interferon  (ISO)
dendritic cell migration  (ISO)
dendritic spine morphogenesis  (ISO)
embryonic heart tube development  (ISO)
endocytosis  (ISO)
endothelin receptor signaling pathway  (ISO)
establishment of epithelial cell apical/basal polarity  (ISO)
establishment of Golgi localization  (ISO)
establishment or maintenance of apical/basal cell polarity  (ISO)
filopodium assembly  (ISO)
Golgi organization  (ISO)
heart contraction  (ISO)
heart process  (ISO)
integrin-mediated signaling pathway  (ISO)
intracellular protein localization  (ISO)
negative regulation of protein-containing complex assembly  (ISO)
neuron fate determination  (ISO)
neuropilin signaling pathway  (ISO)
nuclear migration  (ISO)
nucleus localization  (ISO)
organelle transport along microtubule  (ISO)
phagocytosis, engulfment  (ISO)
positive regulation of catalytic activity  (ISO)
positive regulation of cell growth  (ISO)
positive regulation of cell migration  (ISO)
positive regulation of cellular component organization  (IEA)
positive regulation of cytokinesis  (ISO)
positive regulation of DNA replication  (ISO)
positive regulation of epithelial cell proliferation involved in lung morphogenesis  (ISO)
positive regulation of filopodium assembly  (ISO)
positive regulation of intracellular protein transport  (ISO)
positive regulation of JNK cascade  (ISO)
positive regulation of lamellipodium assembly  (ISO)
positive regulation of MAPK cascade  (ISO)
positive regulation of neuron apoptotic process  (ISO)
positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction  (ISO)
positive regulation of pinocytosis  (ISO)
positive regulation of pseudopodium assembly  (ISO)
positive regulation of stress fiber assembly  (ISO)
positive regulation of substrate adhesion-dependent cell spreading  (ISO)
positive regulation of synapse structural plasticity  (ISO)
protein phosphorylation  (ISO)
regulation of actin cytoskeleton organization  (ISO)
regulation of attachment of spindle microtubules to kinetochore  (ISO)
regulation of filopodium assembly  (ISO)
regulation of lamellipodium assembly  (ISO)
regulation of mitotic nuclear division  (ISO)
regulation of modification of postsynaptic structure  (ISO)
regulation of postsynapse organization  (ISO)
regulation of stress fiber assembly  (ISO)
sprouting angiogenesis  (ISO)
submandibular salivary gland formation  (ISO)
substantia nigra development  (ISO)

References
Additional References at PubMed
PMID:21993625   PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
Cdc42
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046247646,874,453 - 6,891,952 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Naked mole-rat maternal Ensembl727,376,888 - 27,428,533 (-)Ensembl
CDC42
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38122,052,709 - 22,101,360 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl122,052,627 - 22,101,360 (+)EnsemblGRCh38.p14 Ensemblhg38GRCh38
GRCh37122,379,202 - 22,427,853 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36122,251,707 - 22,292,023 (+)NCBIBuild 36Build 36hg18NCBI36
Build 34122,124,487 - 22,164,741NCBI
Celera120,702,109 - 20,742,389 (+)NCBICelera
Cytogenetic Map1p36.12NCBI
HuRef120,622,960 - 20,663,212 (+)NCBIHuRef
CHM1_1122,491,651 - 22,531,931 (+)NCBICHM1_1
T2T-CHM13v2.0121,876,517 - 21,925,101 (+)NCBIT2T-CHM13v2.0
Cdc42
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm394137,047,011 - 137,085,007 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl4137,047,002 - 137,101,278 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm384137,319,696 - 137,357,759 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl4137,319,696 - 137,357,720 (-)EnsemblGRCm38.p6 Ensemblmm10GRCm38
MGSCv374136,875,611 - 136,913,652 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv364136,591,779 - 136,608,205 (-)NCBIMGSCv36mm8
Celera4135,540,002 - 135,577,854 (-)NCBICelera
Cytogenetic Map4D3NCBI
cM Map469.83NCBI
Cdc42
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr85154,838,478 - 154,876,629 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl5154,839,631 - 154,876,627 (-)EnsemblGRCr8
mRatBN7.25149,555,069 - 149,593,239 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl5149,553,724 - 149,593,111 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx5152,253,400 - 152,289,928 (-)NCBIUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.05154,027,699 - 154,064,227 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.05154,009,694 - 154,046,226 (-)NCBIUTH_Rnor_WKY_Bbb_1.0
Dahl_SR_JrHsd5154,458,897 - 154,495,386 (-)NCBI
Lyon_Normotensive5156,447,664 - 156,484,153 (-)NCBI
Lyon_Hypertensive5155,624,644 - 155,661,134 (-)NCBI
F344_StmMcwi5149,194,943 - 149,231,435 (-)NCBI
Rnor_6.05155,690,267 - 155,728,385 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl5155,691,390 - 155,728,300 (-)EnsemblRnor_6.0 Ensemblrn6Rnor6.0
Rnor_5.05159,446,154 - 159,485,163 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.45156,106,123 - 156,143,040 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera5147,953,334 - 147,989,998 (-)NCBICelera
RGSC_v3.15156,116,164 - 156,153,079 (-)NCBI
Cytogenetic Map5q36NCBI
Cdc42
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554522,255,117 - 2,299,042 (+)EnsemblChiLan1.0 Ensembl
ChiLan1.0NW_0049554522,255,940 - 2,299,042 (+)NCBIChiLan1.0ChiLan1.0
CDC42
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21204,846,790 - 204,887,042 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11203,958,664 - 203,998,887 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0121,245,970 - 21,286,210 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1122,188,722 - 22,228,351 (+)NCBIPanPan1.1PanPan1.1panPan2
LOC403934
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1277,153,276 - 77,169,947 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl277,153,095 - 77,199,211 (-)EnsemblCanFam3.1 EnsemblcanFam3CanFam3.1
ROS_Cfam_1.044,445,564 - 4,446,293 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
UMICH_Zoey_3.144,457,005 - 4,457,734 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.044,574,515 - 4,575,244 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.044,796,130 - 4,796,859 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Cdc42
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mIctTri1.hap11114,504,478 - 14,546,614 (+)NCBImIctTri1.hap1
HiC_Itri_2NW_02440505841,731,950 - 41,773,901 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364747,556,728 - 7,598,761 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049364747,556,765 - 7,598,687 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CDC42
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl680,035,123 - 80,089,233 (+)EnsemblSscrofa11.1 EnsemblsusScr11Sscrofa11.1
Sscrofa11.1680,035,034 - 80,089,243 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2674,057,184 - 74,116,824 (+)NCBISscrofa10.2Sscrofa10.2susScr3
CDC42
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mChlSab1.0.hap120114,977,887 - 115,017,703 (-)NCBImChlSab1.0.hap1
Vero_WHO_p1.0NW_0236660335,689,907 - 5,730,175 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
ChlSab1.120110,568,004 - 110,608,318 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl20110,569,352 - 110,582,562 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Cdc42
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1120,859,956 - 20,878,384 (+)NCBIRrattus_CSIRO_v1Rrattus_CSIRO_v1


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSHGLT00000016024   ⟹   ENSHGLP00000015858
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
Naked mole-rat maternal Ensembl727,376,888 - 27,428,533 (-)Ensembl
Ensembl Acc Id: ENSHGLT00000016025   ⟹   ENSHGLP00000015859
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
Naked mole-rat maternal Ensembl727,378,351 - 27,395,368 (-)Ensembl
Ensembl Acc Id: ENSHGLT00000072683   ⟹   ENSHGLP00000036671
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
Naked mole-rat maternal Ensembl727,376,888 - 27,419,738 (-)Ensembl
RefSeq Acc Id: XM_021263019   ⟹   XP_021118678
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_0046247646,874,453 - 6,891,952 (+)NCBI
Protein Sequences
Protein RefSeqs XP_021118678 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EHB08914 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSHGLP00000015858
GenBank Protein JAN98284 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: XP_021118678   ⟸   XM_021263019
- UniProtKB: A0AAX6TF34 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSHGLP00000036671   ⟸   ENSHGLT00000072683
Ensembl Acc Id: ENSHGLP00000015859   ⟸   ENSHGLT00000016025
Ensembl Acc Id: ENSHGLP00000015858   ⟸   ENSHGLT00000016024


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSHGLG00000011337 Ensembl, ENTREZGENE
Ensembl Transcript ENSHGLT00000016024 ENTREZGENE
Gene3D-CATH 3.40.50.300 UniProtKB/TrEMBL
InterPro Cdc42 UniProtKB/TrEMBL
  P-loop_NTPase UniProtKB/TrEMBL
  Small_GTP-bd_dom UniProtKB/TrEMBL
  Small_GTPase UniProtKB/TrEMBL
  Small_GTPase_Rho UniProtKB/TrEMBL
NCBI Gene Cdc42 ENTREZGENE
PANTHER PTHR24072 UniProtKB/TrEMBL
Pfam Ras UniProtKB/TrEMBL
PRINTS RASTRNSFRMNG UniProtKB/TrEMBL
PROSITE RAB UniProtKB/TrEMBL
  RAS UniProtKB/TrEMBL
  RHO UniProtKB/TrEMBL
SMART RAB UniProtKB/TrEMBL
  RAS UniProtKB/TrEMBL
  RHO UniProtKB/TrEMBL
Superfamily-SCOP SSF52540 UniProtKB/TrEMBL
UniProt A0AAX6TF34 ENTREZGENE, UniProtKB/TrEMBL