Cdc42 (cell division cycle 42) - Rat Genome Database

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Gene: Cdc42 (cell division cycle 42) Chinchilla lanigera
Analyze
Symbol: Cdc42
Name: cell division cycle 42
RGD ID: 8727298
Description: ENCODES a protein that exhibits apolipoprotein A-I receptor binding (ortholog); GBD domain binding (ortholog); GTP binding (ortholog); INVOLVED IN actin cytoskeleton organization (ortholog); actin filament branching (ortholog); actin filament organization (ortholog); PARTICIPATES IN adenosine signaling pathway; c-Jun N-terminal kinases MAPK signaling pathway; E-cadherin signaling pathway; ASSOCIATED WITH 3-Hydroxy-3-Methylglutaryl-CoA Lyase Deficiency (ortholog); Adrenal Gland Neoplasms (ortholog); Alzheimer's disease (ortholog); FOUND IN apical part of cell (ortholog); cell leading edge (ortholog); cell periphery (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: cell division control protein 42 homolog
RGD Orthologs
Human
Mouse
Rat
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: ChiLan1.0 - Chinchilla ChiLan1.0 Assembly
Position:
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554522,255,117 - 2,299,042 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554522,255,940 - 2,299,042 (+)NCBIChiLan1.0ChiLan1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
actin cytoskeleton organization  (ISO)
actin filament branching  (ISO)
actin filament organization  (ISO)
adherens junction organization  (ISO)
cardiac conduction system development  (ISO)
cardiac neural crest cell migration involved in outflow tract morphogenesis  (ISO)
Cdc42 protein signal transduction  (ISO)
cell junction assembly  (ISO)
cellular response to type II interferon  (ISO)
dendritic cell migration  (ISO)
dendritic spine morphogenesis  (ISO)
embryonic heart tube development  (ISO)
endocytosis  (ISO)
endothelin receptor signaling pathway involved in heart process  (ISO)
establishment of epithelial cell apical/basal polarity  (ISO)
establishment of Golgi localization  (ISO)
establishment of localization in cell  (ISO)
establishment or maintenance of apical/basal cell polarity  (ISO)
filopodium assembly  (ISO)
Golgi organization  (ISO)
heart contraction  (ISO)
integrin-mediated signaling pathway  (ISO)
modification of synaptic structure  (ISO)
negative regulation of protein-containing complex assembly  (ISO)
neuron fate determination  (ISO)
neuropilin signaling pathway  (ISO)
nuclear migration  (ISO)
nucleus localization  (ISO)
organelle transport along microtubule  (ISO)
phagocytosis, engulfment  (ISO)
positive regulation of catalytic activity  (ISO)
positive regulation of cell growth  (ISO)
positive regulation of cell migration  (ISO)
positive regulation of cytokinesis  (ISO)
positive regulation of DNA replication  (ISO)
positive regulation of epithelial cell proliferation involved in lung morphogenesis  (ISO)
positive regulation of filopodium assembly  (ISO)
positive regulation of intracellular protein transport  (ISO)
positive regulation of JNK cascade  (ISO)
positive regulation of lamellipodium assembly  (ISO)
positive regulation of MAPK cascade  (ISO)
positive regulation of neuron apoptotic process  (ISO)
positive regulation of phosphatidylinositol 3-kinase activity  (ISO)
positive regulation of pinocytosis  (ISO)
positive regulation of pseudopodium assembly  (ISO)
positive regulation of stress fiber assembly  (ISO)
positive regulation of substrate adhesion-dependent cell spreading  (ISO)
positive regulation of synapse structural plasticity  (ISO)
protein localization  (ISO)
protein phosphorylation  (ISO)
regulation of actin cytoskeleton organization  (ISO)
regulation of attachment of spindle microtubules to kinetochore  (ISO)
regulation of filopodium assembly  (ISO)
regulation of lamellipodium assembly  (ISO)
regulation of mitotic nuclear division  (ISO)
regulation of modification of postsynaptic structure  (ISO)
regulation of postsynapse organization  (ISO)
regulation of protein binding  (ISO)
regulation of stress fiber assembly  (ISO)
sprouting angiogenesis  (ISO)
submandibular salivary gland formation  (ISO)
substantia nigra development  (ISO)

References

References - curated
# Reference Title Reference Citation
1. Transitive Annotation Pipeline Automated assignment of GO, PW and RDO ISO annotations across species
2. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline

Genomics

Comparative Map Data
Cdc42
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554522,255,117 - 2,299,042 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554522,255,940 - 2,299,042 (+)NCBIChiLan1.0ChiLan1.0
CDC42
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38122,052,709 - 22,101,360 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl122,052,627 - 22,101,360 (+)EnsemblGRCh38hg38GRCh38
GRCh37122,379,202 - 22,427,853 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36122,251,707 - 22,292,023 (+)NCBINCBI36Build 36hg18NCBI36
Build 34122,124,487 - 22,164,741NCBI
Celera120,702,109 - 20,742,389 (+)NCBICelera
Cytogenetic Map1p36.12NCBI
HuRef120,622,960 - 20,663,212 (+)NCBIHuRef
CHM1_1122,491,651 - 22,531,931 (+)NCBICHM1_1
T2T-CHM13v2.0121,876,517 - 21,925,101 (+)NCBIT2T-CHM13v2.0
Cdc42
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm394137,047,007 - 137,085,070 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl4137,047,007 - 137,085,031 (-)EnsemblGRCm39 Ensembl
GRCm384137,319,696 - 137,357,759 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl4137,319,696 - 137,357,720 (-)EnsemblGRCm38mm10GRCm38
MGSCv374136,875,611 - 136,913,652 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv364136,591,779 - 136,608,205 (-)NCBIMGSCv36mm8
Celera4135,540,002 - 135,577,854 (-)NCBICelera
Cytogenetic Map4D3NCBI
cM Map469.83NCBI
Cdc42
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.25149,555,069 - 149,593,239 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl5149,553,724 - 149,593,111 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx5152,253,400 - 152,289,928 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.05154,027,699 - 154,064,227 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.05154,009,694 - 154,046,226 (-)NCBIRnor_WKY
Rnor_6.05155,690,267 - 155,728,385 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl5155,691,390 - 155,728,300 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.05159,446,154 - 159,485,163 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.45156,106,123 - 156,143,040 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.15156,116,164 - 156,153,079 (-)NCBI
Celera5147,953,334 - 147,989,998 (-)NCBICelera
Cytogenetic Map5q36NCBI
CDC42
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan11203,958,664 - 203,998,887 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0121,245,970 - 21,286,210 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1122,188,722 - 22,228,351 (+)NCBIpanpan1.1PanPan1.1panPan2
LOC403934
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1277,153,276 - 77,169,947 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl277,153,095 - 77,199,211 (-)EnsemblCanFam3.1canFam3CanFam3.1
ROS_Cfam_1.044,445,564 - 4,446,293 (+)NCBIROS_Cfam_1.0
UMICH_Zoey_3.144,457,005 - 4,457,734 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.044,574,515 - 4,575,244 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.044,796,130 - 4,796,859 (+)NCBIUU_Cfam_GSD_1.0
Cdc42
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440505841,731,950 - 41,773,901 (+)NCBIHiC_Itri_2
SpeTri2.0NW_0049364747,556,765 - 7,598,687 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CDC42
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl680,035,123 - 80,089,233 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1680,035,034 - 80,089,243 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2674,057,184 - 74,116,824 (+)NCBISscrofa10.2Sscrofa10.2susScr3
CDC42
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.120110,568,004 - 110,608,318 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl20110,569,352 - 110,582,562 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660335,689,907 - 5,730,175 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Cdc42
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046247646,874,453 - 6,891,952 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSCLAT00000016544   ⟹   ENSCLAP00000016380
RefSeq Status:
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0 EnsemblNW_0049554522,255,117 - 2,299,042 (+)Ensembl
RefSeq Acc Id: ENSCLAT00000016545   ⟹   ENSCLAP00000016381
RefSeq Status:
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0 EnsemblNW_0049554522,255,940 - 2,296,258 (+)Ensembl
RefSeq Acc Id: XM_005394731   ⟹   XP_005394788
RefSeq Status:
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_0049554522,255,940 - 2,299,042 (+)NCBI
Sequence:
RefSeq Acc Id: XM_005394732   ⟹   XP_005394789
RefSeq Status:
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_0049554522,255,990 - 2,299,042 (+)NCBI
Sequence:
RefSeq Acc Id: XM_005394733   ⟹   XP_005394790
RefSeq Status:
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_0049554522,255,940 - 2,296,258 (+)NCBI
Sequence:
RefSeq Acc Id: XM_013519580   ⟹   XP_013375034
RefSeq Status:
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_0049554522,269,944 - 2,299,042 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_005394788 (Get FASTA)   NCBI Sequence Viewer  
  XP_005394789 (Get FASTA)   NCBI Sequence Viewer  
  XP_005394790 (Get FASTA)   NCBI Sequence Viewer  
  XP_013375034 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: XP_005394790   ⟸   XM_005394733
- Peptide Label: isoform X2
- UniProtKB: A0A8C2VJ29 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_005394789   ⟸   XM_005394732
- Peptide Label: isoform X1
- UniProtKB: A0A8C2VJ40 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_005394788   ⟸   XM_005394731
- Peptide Label: isoform X1
- UniProtKB: A0A8C2VJ40 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_013375034   ⟸   XM_013519580
- Peptide Label: isoform X1
- UniProtKB: A0A8C2VJ40 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSCLAP00000016381   ⟸   ENSCLAT00000016545
RefSeq Acc Id: ENSCLAP00000016380   ⟸   ENSCLAT00000016544


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCLAG00000011266 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSCLAP00000016380 ENTREZGENE
  ENSCLAP00000016380.1 UniProtKB/TrEMBL
  ENSCLAP00000016381 ENTREZGENE
  ENSCLAP00000016381.1 UniProtKB/TrEMBL
Ensembl Transcript ENSCLAT00000016544 ENTREZGENE
  ENSCLAT00000016544.1 UniProtKB/TrEMBL
  ENSCLAT00000016545 ENTREZGENE
  ENSCLAT00000016545.1 UniProtKB/TrEMBL
Gene3D-CATH 3.40.50.300 UniProtKB/TrEMBL
InterPro Cdc42 UniProtKB/TrEMBL
  P-loop_NTPase UniProtKB/TrEMBL
  Small_GTP-bd_dom UniProtKB/TrEMBL
  Small_GTPase UniProtKB/TrEMBL
  Small_GTPase_Rho UniProtKB/TrEMBL
NCBI Gene Cdc42 ENTREZGENE
PANTHER CELL DIVISION CONTROL PROTEIN 42 HOMOLOG UniProtKB/TrEMBL
  CELL DIVISION CONTROL PROTEIN 42 HOMOLOG UniProtKB/TrEMBL
  PTHR24072 UniProtKB/TrEMBL
Pfam Ras UniProtKB/TrEMBL
PRINTS RASTRNSFRMNG UniProtKB/TrEMBL
PROSITE RAB UniProtKB/TrEMBL
  RAS UniProtKB/TrEMBL
  RHO UniProtKB/TrEMBL
SMART RAB UniProtKB/TrEMBL
  RAS UniProtKB/TrEMBL
  RHO UniProtKB/TrEMBL
Superfamily-SCOP SSF52540 UniProtKB/TrEMBL
TIGRFAMs small_GTP UniProtKB/TrEMBL
UniProt A0A8C2VJ29 ENTREZGENE, UniProtKB/TrEMBL
  A0A8C2VJ40 ENTREZGENE, UniProtKB/TrEMBL