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PATHWAY ONTOLOGY - ANNOTATIONS

The Pathway Ontology (PW), is currently being developed at the Rat Genome Database. For more information about this vocabulary, please see Petri et al. The rat genome database pathway portal. Database (Oxford). 2011 Apr 8;2011:bar010. Print 2011 or contact us (http://rgd.mcw.edu/contact/index.shtml).
Term:transforming growth factor-beta Smad dependent signaling pathway
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Accession:PW:0000490 term browser browse the term
Definition:Transforming growth factor-beta (TGF-beta) signaling is one of the best characterized modules of the Tgf-b superfamily pathways. Binding to the type II receptor leads to activation of the type I receptor and subsequent activation of the Smad pathway. Nuclear translocation of Smad(s) and interaction with transcription factors leads to activation or repression of many genes.
Synonyms:related_synonym: TGF- beta signaling pathway - SMAD dependent;   TGF-beta Smad dependent signaling pathway
 alt_id: PID:200227;   Reactome:R-HSA-170834
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transforming growth factor-beta Smad dependent signaling pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ARRB2 arrestin beta 2 ISO PID PID:200227 NCBI chr16:4,191,040...4,202,382
Ensembl chr16:4,191,172...4,202,385 		JBrowse link
G ATF3 activating transcription factor 3 ISO RGD PMID:16322555 PMID:18061509 RGD:2302137 RGD:5143919 NCBI chr25:16,910,312...16,922,598 JBrowse link
G AXIN1 axin 1 ISO PID PID:200227 NCBI chr 5:233,520...295,134
Ensembl chr 5:234,060...290,575 		JBrowse link
G BAMBI BMP and activin membrane bound inhibitor ISO PID PID:200227 NCBI chr 9:28,279,479...28,284,825
Ensembl chr 9:28,279,523...28,285,937 		JBrowse link
G CAMK2A calcium/calmodulin dependent protein kinase II alpha ISO PID PID:200227 NCBI chr23:52,829,438...52,899,428
Ensembl chr23:52,829,350...52,899,375 		JBrowse link
G CAV1 caveolin 1 ISO PID PID:200227 NCBI chr21:85,222,724...85,258,562
Ensembl chr21:85,222,879...85,258,627 		JBrowse link
G CCN2 cellular communication network factor 2 ISO PID PID:200227 NCBI chr13:41,613,838...41,617,010
Ensembl chr13:41,613,798...41,617,651 		JBrowse link
G CREB1 cAMP responsive element binding protein 1 ISO RGD PMID:16891311 RGD:1625706 NCBI chr10:93,316,774...93,395,187
Ensembl chr10:93,316,840...93,388,832 		JBrowse link
G CREBBP CREB binding protein ISO RGD PMID:16322555 PMID:18061509 RGD:2302137 RGD:5143919 NCBI chr 5:3,415,548...3,570,030
Ensembl chr 5:3,415,412...3,540,943 		JBrowse link
G CTNNB1 catenin beta 1 ISO PID PID:200227 NCBI chr22:2,679,488...2,725,034
Ensembl chr22:2,684,022...2,723,949 		JBrowse link
G DACT2 dishevelled binding antagonist of beta catenin 2 ISO PID PID:200227 NCBI chr13:96,141,847...96,152,677 JBrowse link
G DAXX death domain associated protein ISO PID PID:200227 NCBI chr17:38,754,227...38,758,714
Ensembl chr17:38,754,280...38,759,071 		JBrowse link
G DCN decorin ISO RGD PMID:12809600 RGD:2298922 NCBI chr11:86,552,392...86,590,229
Ensembl chr11:86,551,072...86,586,891 		JBrowse link
G DYNLRB1 dynein light chain roadblock-type 1 ISO PID PID:200227 NCBI chr 2:38,813,852...38,839,905
Ensembl chr 2:38,825,574...38,839,903 		JBrowse link
G EIF2A eukaryotic translation initiation factor 2A ISO PID PID:200227 NCBI chr15:40,112,926...40,146,629
Ensembl chr15:40,111,878...40,146,554 		JBrowse link
G FKBP1A FKBP prolyl isomerase 1A ISO PID
RGD		 PMID:12809600 PID:200227 RGD:2298922 NCBI chr 2:55,170,816...55,195,380 JBrowse link
G FOXH1 forkhead box H1 ISO RGD PMID:16322555 PMID:18061509 RGD:2302137 RGD:5143919 NCBI chr 8:138,685,137...138,688,451
Ensembl chr 8:138,685,626...138,687,144 		JBrowse link
G FOXO1 forkhead box O1 ISO RGD PMID:16322555 PMID:18061509 RGD:2302137 RGD:5143919 NCBI chr 3:18,916,849...19,027,776
Ensembl chr 3:18,920,651...19,027,707 		JBrowse link
G FOXO3 forkhead box O3 ISO RGD PMID:16322555 PMID:18061509 RGD:2302137 RGD:5143919 NCBI chr13:65,175,764...65,303,107
Ensembl chr13:65,195,376...65,301,725 		JBrowse link
G FOXO4 forkhead box O4 ISO RGD PMID:16322555 PMID:18061509 RGD:2302137 RGD:5143919 NCBI chr  X:60,893,711...60,901,134
Ensembl chr  X:60,893,526...60,902,844 		JBrowse link
G GRB2 growth factor receptor bound protein 2 ISO PID PID:200227 NCBI chr16:46,264,818...46,346,426
Ensembl chr16:46,264,825...46,347,156 		JBrowse link
G ITCH itchy E3 ubiquitin protein ligase ISO PID PID:200227 NCBI chr 2:38,671,170...38,808,621
Ensembl chr 2:38,701,396...38,805,005 		JBrowse link
G MAP3K7 mitogen-activated protein kinase kinase kinase 7 ISO PID PID:200227 NCBI chr13:15,284,927...15,360,539
Ensembl chr13:15,284,923...15,360,832 		JBrowse link
G NEDD4L NEDD4 like E3 ubiquitin protein ligase ISO PID PID:200227 NCBI chr18:21,326,276...21,683,817
Ensembl chr18:21,327,567...21,683,905 		JBrowse link
G OCLN occludin ISO PID PID:200227 NCBI chr 4:65,581,943...65,641,516
Ensembl chr 4:65,582,460...65,644,787 		JBrowse link
G PARD6A par-6 family cell polarity regulator alpha ISO PID PID:200227 NCBI chr 5:59,781,890...59,783,990 JBrowse link
G PDPK1 3-phosphoinositide dependent protein kinase 1 ISO PID PID:200227
G PML PML nuclear body scaffold ISO PID PID:200227 NCBI chr26:9,441,998...9,494,949
Ensembl chr26:9,451,112...9,494,931 		JBrowse link
G PPP1CA protein phosphatase 1 catalytic subunit alpha ISO PID PID:200227 NCBI chr 1:6,862,536...6,866,212
Ensembl chr 1:6,862,540...6,865,855 		JBrowse link
G PPP1R15A protein phosphatase 1 regulatory subunit 15A ISO PID PID:200227
G PPP2CA protein phosphatase 2 catalytic subunit alpha ISO PID PID:200227 NCBI chr23:36,999,110...37,028,916
Ensembl chr23:36,997,078...37,029,280 		JBrowse link
G PPP2CB protein phosphatase 2 catalytic subunit beta ISO PID PID:200227 NCBI chr 8:28,903,074...28,930,300
Ensembl chr 8:28,903,240...28,930,376 		JBrowse link
G PPP2R2A protein phosphatase 2 regulatory subunit Balpha ISO PID PID:200227 NCBI chr 8:24,390,751...24,485,657
Ensembl chr 8:24,390,781...24,487,195 		JBrowse link
G RHOA ras homolog family member A ISO PID PID:200227 NCBI chr22:10,757,381...10,809,257
Ensembl chr22:10,757,337...10,772,704 		JBrowse link
G RNF111 ring finger protein 111 ISO PID PID:200227 NCBI chr26:24,416,946...24,528,989
Ensembl chr26:24,416,093...24,528,862 		JBrowse link
G RPS6KB1 ribosomal protein S6 kinase B1 ISO PID PID:200227 NCBI chr16:33,498,098...33,556,553
Ensembl chr16:33,497,392...33,556,453 		JBrowse link
G RUNX1 RUNX family transcription factor 1 ISO RGD PMID:16322555 PMID:18061509 RGD:2302137 RGD:5143919 NCBI chr 2:78,819,189...79,082,491
Ensembl chr 2:78,819,194...78,924,495 		JBrowse link
G RUNX2 RUNX family transcription factor 2 ISO RGD PMID:16322555 PMID:18061509 RGD:2302137 RGD:5143919 NCBI chr17:26,679,386...26,807,812
Ensembl chr17:26,683,175...26,807,319 		JBrowse link
G RUNX3 RUNX family transcription factor 3 ISO RGD PMID:16322555 PMID:18061509 RGD:2302137 RGD:5143919 NCBI chr20:107,769,244...107,802,154
Ensembl chr20:107,736,683...107,802,307 		JBrowse link
G SHC1 SHC adaptor protein 1 ISO PID PID:200227 NCBI chr20:8,854,189...8,866,406
Ensembl chr20:8,858,458...8,866,610 		JBrowse link
G SKIL SKI like proto-oncogene ISO PID PID:200227 NCBI chr15:19,022,167...19,059,117
Ensembl chr15:19,022,017...19,057,004 		JBrowse link
G SMAD2 SMAD family member 2 ISO PID
RGD		 PMID:12809600 PMID:16959941 PMID:18684975 PID:200227 RGD:1599906 RGD:2298922 RGD:2302517 NCBI chr18:33,017,138...33,105,320
Ensembl chr18:33,017,492...33,104,606 		JBrowse link
G SMAD3 SMAD family member 3 ISO RGD
PID		 PMID:12702545 PMID:12809600 PMID:16891311 PID:200227 RGD:1299323 RGD:1625706 RGD:2298922 NCBI chr26:16,319,959...16,446,472
Ensembl chr26:16,320,933...16,446,527 		JBrowse link
G SMAD4 SMAD family member 4 ISO PID
RGD		 PMID:12809600 PMID:16959941 PID:200227 RGD:1599906 RGD:2298922 NCBI chr18:29,894,157...29,951,445
Ensembl chr18:29,897,621...29,934,478 		JBrowse link
G SMAD7 SMAD family member 7 ISO PID
RGD		 PMID:12809600 PID:200227 RGD:2298922 NCBI chr18:31,993,543...32,024,088
Ensembl chr18:31,993,681...32,024,850 		JBrowse link
G SMURF1 SMAD specific E3 ubiquitin protein ligase 1 ISO PID
RGD		 PMID:12809600 PID:200227 RGD:2298922 NCBI chr28:14,019,733...14,141,588
Ensembl chr28:14,019,968...14,141,795 		JBrowse link
G SMURF2 SMAD specific E3 ubiquitin protein ligase 2 ISO RGD
PID		 PMID:12809600 PID:200227 RGD:2298922 NCBI chr16:56,615,171...56,728,239 JBrowse link
G SOS1 SOS Ras/Rac guanine nucleotide exchange factor 1 ISO PID PID:200227 NCBI chr14:68,259,509...68,404,167
Ensembl chr14:68,259,360...68,399,895 		JBrowse link
G SPTBN1 spectrin beta, non-erythrocytic 1 ISO PID PID:200227 NCBI chr14:52,266,197...52,487,111
Ensembl chr14:52,262,416...52,487,112 		JBrowse link
G STRAP serine/threonine kinase receptor associated protein ISO PID PID:200227 NCBI chr11:15,790,449...15,812,964
Ensembl chr11:15,790,798...15,813,585 		JBrowse link
G TAB1 TGF-beta activated kinase 1 (MAP3K7) binding protein 1 ISO PID PID:200227 NCBI chr19:21,971,362...22,004,289 JBrowse link
G TAB2 TGF-beta activated kinase 1 (MAP3K7) binding protein 2 ISO PID PID:200227 NCBI chr13:22,234,736...22,312,985
Ensembl chr13:22,234,012...22,282,562 		JBrowse link
G TGFB1 transforming growth factor beta 1 ISO RGD
PID		 PMID:15109563 PID:200227 RGD:2298921 NCBI chr 6:35,651,583...35,674,387
Ensembl chr 6:35,648,677...35,674,365 		JBrowse link
G TGFB2 transforming growth factor beta 2 ISO RGD
PID		 PMID:15109563 PID:200227 RGD:2298921 NCBI chr25:11,163,651...11,259,868
Ensembl chr25:11,163,100...11,258,470 		JBrowse link
G TGFB3 transforming growth factor beta 3 ISO RGD
PID		 PMID:12809600 PID:200227 RGD:2298922 NCBI chr24:53,203,593...53,227,483
Ensembl chr24:53,203,301...53,227,325 		JBrowse link
G TGFBR1 transforming growth factor beta receptor 1 ISO RGD
PID		 PMID:12809600 PMID:18684975 PID:200227 RGD:2298922 RGD:2302517 NCBI chr12:40,272,507...40,321,740
Ensembl chr12:40,276,916...40,297,372 		JBrowse link
G TGFBR2 transforming growth factor beta receptor 2 ISO PID
RGD		 PMID:12809600 PMID:14729511 PMID:18684975 PID:200227 RGD:1579921 RGD:2298922 RGD:2302517 NCBI chr15:75,112,903...75,200,263
Ensembl chr15:75,112,561...75,197,711 		JBrowse link
G TGFBR3 transforming growth factor beta receptor 3 ISO PID
RGD		 PMID:12809600 PID:200227 RGD:2298922 NCBI chr20:41,353,182...41,565,357
Ensembl chr20:41,353,325...41,565,343 		JBrowse link
G TGFBRAP1 transforming growth factor beta receptor associated protein 1 ISO PID PID:200227 NCBI chr14:8,900,342...8,963,107
Ensembl chr14:8,898,587...8,942,148 		JBrowse link
G WWP1 WW domain containing E3 ubiquitin protein ligase 1 ISO PID PID:200227 NCBI chr 8:81,529,520...81,651,478 JBrowse link
G XIAP X-linked inhibitor of apoptosis ISO PID PID:200227
G YAP1 Yes1 associated transcriptional regulator ISO PID PID:200227 NCBI chr 1:93,479,478...93,605,340
Ensembl chr 1:93,479,135...93,606,808 		JBrowse link
G YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein epsilon ISO PID PID:200227 NCBI chr16:1,031,840...1,086,950
Ensembl chr16:1,035,250...1,087,013 		JBrowse link
G ZFYVE16 zinc finger FYVE-type containing 16 ISO PID PID:200227 NCBI chr 4:74,579,573...74,644,331
Ensembl chr 4:74,579,982...74,644,784 		JBrowse link
G ZFYVE9 zinc finger FYVE-type containing 9 ISO PID
RGD		 PMID:12809600 PID:200227 RGD:2298922 NCBI chr20:80,596,744...80,734,195
Ensembl chr20:80,598,435...80,740,159 		JBrowse link
altered transforming growth factor-beta Smad dependent signaling pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G SMAD2 SMAD family member 2 ISO RGD PMID:17613544 PMID:18662538 RGD:2306282 RGD:2308865 NCBI chr18:33,017,138...33,105,320
Ensembl chr18:33,017,492...33,104,606 		JBrowse link
G SMAD3 SMAD family member 3 ISO RGD PMID:17613544 PMID:18772397 RGD:2306282 RGD:5490966 NCBI chr26:16,319,959...16,446,472
Ensembl chr26:16,320,933...16,446,527 		JBrowse link
G SMAD4 SMAD family member 4 ISO RGD PMID:17613544 PMID:18662538 PMID:18772397 PMID:19506583 RGD:2306282 RGD:2308865 RGD:5490965 RGD:5490966 NCBI chr18:29,894,157...29,951,445
Ensembl chr18:29,897,621...29,934,478 		JBrowse link
G SMAD7 SMAD family member 7 ISO RGD PMID:18662538 RGD:2308865 NCBI chr18:31,993,543...32,024,088
Ensembl chr18:31,993,681...32,024,850 		JBrowse link
G TGFB1 transforming growth factor beta 1 ISO RGD PMID:17613544 PMID:18313409 RGD:2299005 RGD:2306282 NCBI chr 6:35,651,583...35,674,387
Ensembl chr 6:35,648,677...35,674,365 		JBrowse link
G TGFBR1 transforming growth factor beta receptor 1 ISO RGD PMID:17613544 PMID:18313409 RGD:2299005 RGD:2306282 NCBI chr12:40,272,507...40,321,740
Ensembl chr12:40,276,916...40,297,372 		JBrowse link
G TGFBR2 transforming growth factor beta receptor 2 ISO RGD PMID:17613544 PMID:18313409 PMID:18662538 PMID:18772397 PMID:19506583 RGD:2299005 RGD:2306282 RGD:2308865 RGD:5490965 RGD:5490966 NCBI chr15:75,112,903...75,200,263
Ensembl chr15:75,112,561...75,197,711 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  pathway 4028
    signaling pathway 1919
      signaling pathway pertinent to development 458
        transforming growth factor-beta Smad dependent signaling pathway 65
          altered transforming growth factor-beta Smad dependent signaling pathway 7
Path 2
Term Annotations click to browse term
  pathway 4028
    signaling pathway 1919
      growth factor signaling pathway 370
        transforming growth factor-beta superfamily mediated signaling pathway 103
          transforming growth factor-beta signaling pathway 67
            transforming growth factor-beta Smad dependent signaling pathway 65
              altered transforming growth factor-beta Smad dependent signaling pathway 7
paths to the root