BAMBI (BMP and activin membrane bound inhibitor)

Gene: BAMBI (BMP and activin membrane bound inhibitor) Chlorocebus sabaeus

Analyze

Symbol:

BAMBI

Name:

BMP and activin membrane bound inhibitor

RGD ID:

18684609

Description:

ENCODES a protein that exhibits frizzled binding (inferred); INVOLVED IN negative regulation of BMP signaling pathway (ortholog); negative regulation of osteoblast differentiation (ortholog); transforming growth factor beta receptor signaling pathway (ortholog); PARTICIPATES IN Bone morphogenetic proteins signaling pathway; transforming growth factor-beta Smad dependent signaling pathway; ASSOCIATED WITH aortic valve stenosis (ortholog); Cardiomegaly (ortholog); chronic obstructive pulmonary disease (ortholog); FOUND IN cytoplasm (inferred); membrane (inferred); plasma membrane (inferred)

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

BMP and activin membrane-bound inhibitor homolog

RGD Orthologs

Alliance Genes

More Info

more info ...

Latest Assembly:

ChlSab1.1 - Green Monkey 1.1 Assembly

Position:

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	9	28,279,479 - 28,284,825 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	9	28,279,523 - 28,285,937 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666051	34,317,547 - 34,323,212 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

aortic valve stenosis (ISO)

Cardiomegaly (ISO)

chronic obstructive pulmonary disease (ISO)

colorectal cancer (ISO)

congestive heart failure (ISO)

genetic disease (ISO)

liver cirrhosis (ISO)

lung non-small cell carcinoma (ISO)

Lymphatic Metastasis (ISO)

obesity (ISO)

prostatitis (ISO)

Spinal Cord Injuries (ISO)

stomach cancer (ISO)

Ventricular Outflow Obstruction (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

cell migration (IEA)

negative regulation of BMP signaling pathway (IEA,ISO)

negative regulation of osteoblast differentiation (IEA,ISO)

negative regulation of transforming growth factor beta receptor signaling pathway (IEA)

positive regulation of canonical Wnt signaling pathway (IEA)

positive regulation of cell population proliferation (IEA)

positive regulation of DNA-templated transcription (IEA)

positive regulation of epithelial to mesenchymal transition (IEA)

regulation of cell shape (IEA)

transforming growth factor beta receptor signaling pathway (IEA,ISO)

Cellular Component

cytoplasm (IEA)

membrane (IEA)

plasma membrane (IEA)

Molecular Function

frizzled binding (IEA)

protein binding (ISO)

Molecular Pathway Annotations Click to see Annotation Detail View

Bone morphogenetic proteins signaling pathway (ISO)

transforming growth factor-beta Smad dependent signaling pathway (ISO)

References

Additional References at PubMed

PMID:22301074	PMID:30032202

Genomics

Comparative Map Data

BAMBI
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	9	28,279,479 - 28,284,825 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	9	28,279,523 - 28,285,937 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666051	34,317,547 - 34,323,212 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

BAMBI
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	10	28,677,521 - 28,682,932 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	10	28,677,510 - 28,682,932 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	10	28,966,450 - 28,971,861 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	10	29,006,430 - 29,011,874 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	10	29,006,458 - 29,011,702	NCBI
Celera	10	28,731,284 - 28,736,727 (+)	NCBI		Celera
Cytogenetic Map	10	p12.1	NCBI
HuRef	10	28,685,147 - 28,690,591 (+)	NCBI		HuRef
CHM1_1	10	28,966,877 - 28,972,320 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	10	28,708,908 - 28,714,318 (+)	NCBI		T2T-CHM13v2.0

Bambi
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	18	3,507,011 - 3,516,404 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	18	3,507,923 - 3,516,404 (+)	Ensembl		GRCm39 Ensembl
GRCm38	18	3,507,011 - 3,516,404 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	18	3,507,923 - 3,516,404 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	18	3,507,955 - 3,516,402 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	18	3,507,955 - 3,516,402 (+)	NCBI		MGSCv36	mm8
Celera	18	3,558,647 - 3,567,082 (+)	NCBI		Celera
Cytogenetic Map	18	A1	NCBI
cM Map	18	2.3	NCBI

Bambi
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	17	58,816,438 - 58,821,003 (-)	NCBI		GRCr8
mRatBN7.2	17	54,121,251 - 54,125,816 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	17	54,121,255 - 54,126,060 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	17	57,288,277 - 57,292,537 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	17	61,291,313 - 61,295,573 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	17	55,449,123 - 55,453,381 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	17	56,905,419 - 56,909,675 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	17	56,905,112 - 56,909,992 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	17	54,939,068 - 54,943,633 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	17	62,654,385 - 62,658,641 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	17	62,664,912 - 62,669,718 (-)	NCBI
Celera	17	50,102,907 - 50,107,163 (-)	NCBI		Celera
Cytogenetic Map	17	q12.1	NCBI

Bambi
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955429	21,024,374 - 21,025,890 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955429	21,024,396 - 21,025,890 (+)	NCBI	ChiLan1.0	ChiLan1.0

BAMBI
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	8	41,354,018 - 41,359,534 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	10	41,359,721 - 41,364,861 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	10	28,833,690 - 28,839,164 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	10	29,187,857 - 29,193,324 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	10	29,187,857 - 29,193,324 (+)	Ensembl	panpan1.1		panPan2

BAMBI
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	2	17,453,628 - 17,459,812 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	2	17,455,243 - 17,462,346 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	2	14,952,595 - 14,958,681 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	2	15,700,785 - 15,706,918 (-)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	2	15,700,785 - 15,710,019 (-)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	2	15,139,651 - 15,145,733 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	2	15,026,954 - 15,033,049 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	2	15,300,265 - 15,306,392 (-)	NCBI		UU_Cfam_GSD_1.0

Bambi
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024409344	8,547,962 - 8,553,293 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936613	3,098,159 - 3,103,868 (+)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936613	3,098,549 - 3,103,868 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

BAMBI
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	10	40,053,355 - 40,060,319 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	10	40,053,368 - 40,058,590 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	10	44,241,652 - 44,246,876 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

Bambi
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624805	1,967,101 - 1,974,898 (+)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624805	1,967,174 - 1,973,030 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Expression

RNA-SEQ Expression

High: > 1000 TPM value Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM Below Cutoff: < 0.5 TPM

	endocrine system	hemolymphoid system	nervous system
High
Medium	20		4
Low	16	19	56
Below cutoff		1

View RNA-SEQ Expression Data

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_008002666	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	JACDXN010000019	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

ENSCSAT00000009792 ⟹ ENSCSAP00000007902

Type:

CODING

Position:

Green Monkey Assembly	Chr	Position (strand)	Source
ChlSab1.1 Ensembl	9	28,279,523 - 28,285,937 (+)	Ensembl

RefSeq Acc Id:

XM_008002666 ⟹ XP_008000857

Type:

CODING

Position:

Green Monkey Assembly	Chr	Position (strand)	Source
ChlSab1.1	9	28,279,479 - 28,284,825 (+)	NCBI
Vero_WHO_p1.0	NW_023666051	34,317,547 - 34,323,212 (+)	NCBI

Sequence:

show sequence

GGCGCGGAGCCGGCGGGACCTGGGCTGGCGCTGGCGGGAGTTGCGGTAAATGCGCTAGCGCGCT
GGTGATCCCCTGCTCTCTTCGCGGAGAGTGGCCGCTAGCGGGGACTGAAGGCCGGGCGCCCACC
CTGGCCCGCGTCGGTGCCCGGGGCTAGCGTGCGGCCCTAGAGTCGAGTGGGGCAAGGGAGCCGG
TGGCCGCCGAGGCGGGACCGGGAAACTTTTCTGGGCTCCTGGGCGCGCCCTGTAGCCGCGCTCC
ATGCTCCGGCCGCGGCCCGAACCCCAGCCCCGCCGCTGACGGCGCCCGCCGCTCCGGGCAGGGC
CCATGCCCTGCGCGCTCCGGGGGTAGTAGGCTGCCGCCGAGCCGGGGCTCCGGGAGCCGGCGGG
GGCGCCGCGGCTGTGCGGGGCGTCAATGGATCGCCACTCCAGCTACATCTTCATCTGGCTGCAG
CTGGAGCTCTGCGCCATGGCCGTGCTGCTCACCAAAGGTGAAATTCGATGCTACTGTGATGCTG
CCCACTGTGTAGCCACTGGTTATATGTGTAAATCTGAGCTCAGCGCCTGCTTCTCTAGACTTCT
TGATCCTCAGAACTCAAATTCCCCACTCACCCATGGCTGCCTGGACTCTCTTGCAAGCACGGCA
GACATCTGCCAAGCCAAACAGGCCCGAAACCACTCTGGCACCACCATGCCCACATTGGAATGCT
GTCATGAAGACATGTGCAATTACCGAGGGTTGCATGATGTTCTCTCTCCTCCCAAGGGTGAGGC
CTCAGGACAAGGAAACAGGTATCAGCATGATGGTAGCAGAAACCTTATCACCAAGGTGCAGGAG
CTGACTTCTTCCAAAGAGCTGTGGTTCCGGGCCGCAGTCATTGCCGTGCCCATTGCTGGAGGGC
TGATTTTAGTGTTGCTTATTATGTTGGCCCTAAGGATGCTTAGAAGTGAAAACAAGAGGCTGCA
GGATCAGCGGCAACAGATGCTCTCCCGTTTGCACTACAGCTTTCACGGACACCATTCCAAAAAG
GGGCAGGTTGCAAAGTTAGACTTGGAATGCATGGTACCGGTCAGTGGGCACGAGAACTGCTGTC
TGACCTGTGATAAAATGAGACAAGCAGACCTCAGCAATGATAAGATCCTCTCGCTCGTTCACTG
GGGCATGTACAGTGGGCACGGGAAGCTGGAATTCGTATGACCGAGTCTTATCTGAACTACACTT
CTTGAACGCTTGAAGGCCTTTTTGAGTTCTGCTGGACAGGAGCACTTTATCTGAAGACAAACTC
ATTTAATCATCTTTGAGAGACAAAATGACCTCTGCAAACAGAATCTTGGATATTTCTTCTGAAG
GATTATTTGCACAGACTTAAATACAGTCAAATGTGTTATTTGCTTTAAAATTATAGAAAACAAA
GAGAAGACTTTGTACACACTGTCACCAGGGTTATTTGCATCCAAGGGAGATGGAATTGAGTACC
TAAATAAACAAAAATGTGCCCTATGTAAGCTTCTACATCTTGATTTATTGTAAAGATTTAAAAG
AAATATATATATTTTGTCTGAAATTTAA

hide sequence

Protein Sequences


Protein RefSeqs	XP_008000857	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSCSAP00000007902
	ENSCSAP00000007902.1

RefSeq Acc Id:	XP_008000857 ⟸ XM_008002666
- UniProtKB:	A0A0D9RH13 (UniProtKB/TrEMBL)

RefSeq Acc Id:

ENSCSAP00000007902 ⟸ ENSCSAT00000009792

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSCSAG00000011702	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSCSAT00000009792.1	UniProtKB/TrEMBL
Gene3D-CATH	2.10.60.10	UniProtKB/TrEMBL
InterPro	BAMBI	UniProtKB/TrEMBL
	BAMBI_C	UniProtKB/TrEMBL
	BAMBI_N	UniProtKB/TrEMBL
	Snake_toxin-like_sf	UniProtKB/TrEMBL
KEGG Report	csab:103238055	UniProtKB/TrEMBL
NCBI Gene	BAMBI	ENTREZGENE
PANTHER	PTHR15505:SF1	UniProtKB/TrEMBL
	RIIA DOMAIN-CONTAINING PROTEIN 1	UniProtKB/TrEMBL
Pfam	BAMBI	UniProtKB/TrEMBL
	BAMBI_C	UniProtKB/TrEMBL
PIRSF	BAMBI	UniProtKB/TrEMBL
Superfamily-SCOP	SSF57302	UniProtKB/TrEMBL
UniProt	A0A0D9RH13	ENTREZGENE, UniProtKB/TrEMBL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Imported Annotations - PID (archival)

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Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Imported Annotations - PID (archival)