SMURF1 (SMAD specific E3 ubiquitin protein ligase 1) - Rat Genome Database

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Gene: SMURF1 (SMAD specific E3 ubiquitin protein ligase 1) Chlorocebus sabaeus
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Symbol: SMURF1
Name: SMAD specific E3 ubiquitin protein ligase 1
RGD ID: 18441516
Description: ENCODES a protein that exhibits activin receptor binding (inferred); I-SMAD binding (inferred); R-SMAD binding (inferred); INVOLVED IN negative regulation of ossification (ortholog); parkin-mediated stimulation of mitophagy in response to mitochondrial depolarization (ortholog); positive regulation of axon extension (ortholog); PARTICIPATES IN Bone morphogenetic proteins signaling pathway; transforming growth factor-beta Smad dependent signaling pathway; ASSOCIATED WITH Cocaine-Related Disorders (ortholog); genetic disease (ortholog); pleomorphic xanthoastrocytoma (ortholog); FOUND IN axon (ortholog); neuronal cell body (ortholog); plasma membrane (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: E3 ubiquitin-protein ligase SMURF1
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: ChlSab1.1 - Green Monkey 1.1 Assembly
Position:
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12814,019,733 - 14,141,588 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2814,019,968 - 14,141,795 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660702,154,820 - 2,276,911 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
SMURF1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12814,019,733 - 14,141,588 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2814,019,968 - 14,141,795 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660702,154,820 - 2,276,911 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
SMURF1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38799,027,440 - 99,144,108 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl799,027,440 - 99,144,108 (-)EnsemblGRCh38hg38GRCh38
GRCh37798,625,063 - 98,741,731 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36798,463,000 - 98,579,659 (-)NCBINCBI36Build 36hg18NCBI36
Celera793,353,908 - 93,471,364 (-)NCBICelera
Cytogenetic Map7q22.1NCBI
HuRef793,257,804 - 93,374,432 (-)NCBIHuRef
CHM1_1798,555,482 - 98,672,053 (-)NCBICHM1_1
T2T-CHM13v2.07100,260,765 - 100,377,379 (-)NCBIT2T-CHM13v2.0
CRA_TCAGchr7v2797,981,091 - 98,097,765 (-)NCBI
Smurf1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm395144,813,305 - 144,902,657 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl5144,813,305 - 144,902,657 (-)EnsemblGRCm39 Ensembl
GRCm385144,876,495 - 144,965,899 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl5144,876,495 - 144,965,847 (-)EnsemblGRCm38mm10GRCm38
MGSCv375145,637,364 - 145,726,699 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv365145,130,022 - 145,219,357 (-)NCBIMGSCv36mm8
MGSCv365143,961,853 - 144,051,632 (-)NCBIMGSCv36mm8
Celera5141,867,627 - 141,904,898 (-)NCBICelera
Cytogenetic Map5G2NCBI
cM Map584.83NCBI
Smurf1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81214,748,717 - 14,840,273 (+)NCBIGRCr8
mRatBN7.2129,635,009 - 9,726,520 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl129,635,025 - 9,726,519 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1210,438,588 - 10,530,424 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01211,061,801 - 11,153,638 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01210,086,150 - 10,176,124 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01211,433,815 - 11,526,465 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1211,407,213 - 11,526,465 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01213,499,018 - 13,591,105 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4129,950,304 - 10,042,391 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1211,439,779 - 11,530,606 (+)NCBICelera
Cytogenetic Map12p11NCBI
Smurf1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495546014,774,545 - 14,802,879 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495546014,774,545 - 14,860,783 (-)NCBIChiLan1.0ChiLan1.0
SMURF1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v26116,882,049 - 116,998,395 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan17165,146,684 - 165,263,030 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0790,995,923 - 91,112,240 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.17104,500,965 - 104,568,046 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl7104,500,965 - 104,568,046 (-)Ensemblpanpan1.1panPan2
SMURF1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1610,385,781 - 10,498,071 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl610,385,779 - 10,494,922 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha612,010,745 - 12,124,123 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0610,384,720 - 10,498,106 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl610,384,957 - 10,497,052 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1610,254,596 - 10,367,952 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0610,233,259 - 10,346,407 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0610,466,893 - 10,580,346 (+)NCBIUU_Cfam_GSD_1.0
Smurf1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024409344138,531,835 - 138,563,396 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049367501,381,851 - 1,407,323 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049367501,381,864 - 1,406,736 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SMURF1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl36,037,741 - 6,142,575 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.136,037,732 - 6,142,569 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.236,098,677 - 6,149,341 (-)NCBISscrofa10.2Sscrofa10.2susScr3
Smurf1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462474032,483,092 - 32,615,260 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462474032,480,138 - 32,615,436 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

endocrine system hemolymphoid system nervous system
High
Medium 20 22
Low 16 20 38
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSCSAT00000015865   ⟹   ENSCSAP00000013793
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.1 Ensembl2814,019,968 - 14,141,795 (+)Ensembl
RefSeq Acc Id: XM_008018672   ⟹   XP_008016863
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.12814,019,733 - 14,141,588 (+)NCBI
Vero_WHO_p1.0NW_0236660702,154,820 - 2,276,911 (-)NCBI
Sequence:
RefSeq Acc Id: XM_008018674   ⟹   XP_008016865
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.12814,019,733 - 14,141,588 (+)NCBI
Vero_WHO_p1.0NW_0236660702,154,820 - 2,276,911 (-)NCBI
Sequence:
RefSeq Acc Id: XM_008018675   ⟹   XP_008016866
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.12814,019,733 - 14,141,583 (+)NCBI
Vero_WHO_p1.0NW_0236660702,154,820 - 2,276,911 (-)NCBI
Sequence:
RefSeq Acc Id: XM_037990363   ⟹   XP_037846291
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
Vero_WHO_p1.0NW_0236660702,160,218 - 2,276,911 (-)NCBI
RefSeq Acc Id: XM_037990365   ⟹   XP_037846293
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
Vero_WHO_p1.0NW_0236660702,160,218 - 2,276,911 (-)NCBI
Reference Protein Sequences
RefSeq Acc Id: XP_008016863   ⟸   XM_008018672
- Peptide Label: isoform X1
RefSeq Acc Id: XP_008016865   ⟸   XM_008018674
- Peptide Label: isoform X2
- UniProtKB: A0A0D9RYV4 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_008016866   ⟸   XM_008018675
- Peptide Label: isoform X5
RefSeq Acc Id: ENSCSAP00000013793   ⟸   ENSCSAT00000015865
RefSeq Acc Id: XP_037846293   ⟸   XM_037990365
- Peptide Label: isoform X4
RefSeq Acc Id: XP_037846291   ⟸   XM_037990363
- Peptide Label: isoform X3


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCSAG00000017771 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCSAT00000015865.1 UniProtKB/TrEMBL
Gene3D-CATH 2.20.70.10 UniProtKB/TrEMBL
  2.60.40.150 UniProtKB/TrEMBL
  Hect, E3 ligase catalytic domain UniProtKB/TrEMBL
  Hect, E3 ligase catalytic domain UniProtKB/TrEMBL
  Hect, E3 ligase catalytic domains UniProtKB/TrEMBL
InterPro C2_dom UniProtKB/TrEMBL
  C2_domain_sf UniProtKB/TrEMBL
  E3_ub_ligase_SMURF1 UniProtKB/TrEMBL
  HECT_dom UniProtKB/TrEMBL
  Hect_E3_ubiquitin_ligase UniProtKB/TrEMBL
  WW_dom UniProtKB/TrEMBL
  WW_dom_sf UniProtKB/TrEMBL
NCBI Gene SMURF1 ENTREZGENE
PANTHER E3 UBIQUITIN-PROTEIN LIGASE SMURF1 UniProtKB/TrEMBL
  HECT DOMAIN UBIQUITIN-PROTEIN LIGASE UniProtKB/TrEMBL
Pfam HECT UniProtKB/TrEMBL
  PF00168 UniProtKB/TrEMBL
  PF00397 UniProtKB/TrEMBL
PIRSF E3_ub_ligase_SMURF1 UniProtKB/TrEMBL
PROSITE HECT UniProtKB/TrEMBL
  PS50004 UniProtKB/TrEMBL
  WW_DOMAIN_1 UniProtKB/TrEMBL
  WW_DOMAIN_2 UniProtKB/TrEMBL
SMART HECTc UniProtKB/TrEMBL
  SM00239 UniProtKB/TrEMBL
  SM00456 UniProtKB/TrEMBL
Superfamily-SCOP SSF49562 UniProtKB/TrEMBL
  SSF51045 UniProtKB/TrEMBL
  SSF56204 UniProtKB/TrEMBL
UniProt A0A0D9RYV4 ENTREZGENE, UniProtKB/TrEMBL