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Pathways
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PATHWAY ONTOLOGY - ANNOTATIONS

The Pathway Ontology (PW), is currently being developed at the Rat Genome Database. For more information about this vocabulary, please see Petri et al. The rat genome database pathway portal. Database (Oxford). 2011 Apr 8;2011:bar010. Print 2011 or contact us (http://rgd.mcw.edu/contact/index.shtml).
Term:integrin mediated signaling pathway
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Accession:PW:0000286 term browser browse the term
Definition:Integrins signal bi-directionally across the plasma membrane and provide an example of mechanotransduction. Inside-out signaling modulates their interaction with ligands to regulate cell adhesion and ECM organization. Ligand binding initiates and shapes many signaling events and links to the cytoskeleton. Via protein clustering and ECM organization integrins synergize with and/or modulate various growth factor pathways. Integrin signaling regulates multiple processes including gene expression, cell proliferation, differentiation and survival.
Synonyms:related_synonym: Integrin signaling;   integrin-mediated signaling pathway
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integrin mediated signaling pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G APBB1IP amyloid beta precursor protein binding family B member 1 interacting protein ISO RGD PMID:18363565 RGD:2300340 NCBI chr10:26,613,897...26,740,670
Ensembl chr10:27,030,218...27,104,483 		JBrowse link
G FABP3 fatty acid binding protein 3 ISO RGD PMID:23719537 RGD:7364738 NCBI chr 1:30,640,595...30,653,450
Ensembl chr 1:31,665,270...31,673,689 		JBrowse link
G FBLIM1 filamin binding LIM protein 1 ISO RGD PMID:23860236 RGD:7349373 NCBI chr 1:14,898,987...14,928,887
Ensembl chr 1:15,890,600...15,921,558 		JBrowse link
G FERMT1 FERM domain containing kindlin 1 ISO RGD PMID:23860236 RGD:7349373 NCBI chr20:6,063,480...6,120,206
Ensembl chr20:5,856,287...5,902,251 		JBrowse link
G FERMT2 FERM domain containing kindlin 2 ISO RGD PMID:23860236 RGD:7349373 NCBI chr14:33,453,983...33,547,721
Ensembl chr14:51,737,188...51,829,766 		JBrowse link
G FERMT3 FERM domain containing kindlin 3 ISO RGD PMID:23860236 RGD:7349373 NCBI chr11:59,562,861...59,581,054
Ensembl chr11:62,909,030...62,928,191 		JBrowse link
G FLNA filamin A ISO RGD PMID:23719537 RGD:7364738 NCBI chr  X:143,799,088...143,825,282 JBrowse link
G FLNB filamin B ISO RGD PMID:23719537 RGD:7364738 NCBI chr 3:57,943,263...58,107,115
Ensembl chr 3:59,359,234...59,521,989 		JBrowse link
G FLNC filamin C ISO RGD PMID:23719537 RGD:7364738 NCBI chr 7:120,782,584...120,811,504
Ensembl chr 7:133,307,041...133,335,896 		JBrowse link
G ILK integrin linked kinase ISO RGD PMID:8538749 PMID:12629168 PMID:16493410 RGD:2300344 RGD:2302091 RGD:40924646 NCBI chr11:6,735,735...6,742,922
Ensembl chr11:6,418,717...6,425,788 		JBrowse link
G ILKAP ILK associated serine/threonine phosphatase ISO RGD PMID:16493410 RGD:2300344 NCBI chr2B:125,403,220...125,436,614
Ensembl chr2B:244,253,970...244,278,317 		JBrowse link
G ITGA1 integrin subunit alpha 1 ISO RGD PMID:17543136 RGD:5135538 NCBI chr 5:61,073,507...61,247,565
Ensembl chr 5:62,692,673...62,865,769 		JBrowse link
G ITGA10 integrin subunit alpha 10 ISO RGD PMID:12297042 PMID:17543136 RGD:1358329 RGD:5135538 NCBI chr 1:121,847,420...121,866,560
Ensembl chr 1:113,803,019...113,821,908 		JBrowse link
G ITGA11 integrin subunit alpha 11 ISO RGD PMID:12297042 PMID:17543136 RGD:1358329 RGD:5135538 NCBI chr15:47,260,931...47,390,062
Ensembl chr15:66,031,201...66,128,985 		JBrowse link
G ITGA2 integrin subunit alpha 2 ISO RGD PMID:12941079 PMID:17543136 RGD:1302878 RGD:5135538 NCBI chr 5:60,935,452...61,040,726
Ensembl chr 5:62,555,370...62,659,720 		JBrowse link
G ITGA2B integrin subunit alpha 2b ISO RGD PMID:17543136 RGD:5135538 NCBI chr17:13,009,514...13,027,289
Ensembl chr17:13,176,843...13,193,269 		JBrowse link
G ITGA3 integrin subunit alpha 3 ISO RGD PMID:12297042 PMID:17543136 RGD:1358329 RGD:5135538 NCBI chr17:44,145,974...44,181,343
Ensembl chr17:49,019,892...49,055,245 		JBrowse link
G ITGA4 integrin subunit alpha 4 ISO RGD PMID:11782963 PMID:17543136 RGD:1302879 RGD:5135538 NCBI chr2B:68,719,376...68,802,488
Ensembl chr2B:186,530,187...186,612,203 		JBrowse link
G ITGA5 integrin subunit alpha 5 ISO RGD PMID:12821041 PMID:17543136 RGD:1300196 RGD:5135538 NCBI chr12:34,326,182...34,350,050
Ensembl chr12:35,052,994...35,075,835 		JBrowse link
G ITGA6 integrin subunit alpha 6 ISO RGD PMID:12297042 PMID:17543136 RGD:1358329 RGD:5135538 NCBI chr2B:59,714,348...59,794,762
Ensembl chr2B:177,169,536...177,250,143 		JBrowse link
G ITGA7 integrin subunit alpha 7 ISO RGD PMID:1315319 PMID:17543136 RGD:5135538 RGD:70774 NCBI chr12:33,195,602...33,226,796
Ensembl chr12:33,923,549...33,950,886 		JBrowse link
G ITGA8 integrin subunit alpha 8 ISO RGD PMID:9054500 PMID:17543136 RGD:40903006 RGD:5135538 NCBI chr10:15,838,320...16,045,206
Ensembl chr10:16,114,999...16,321,360 		JBrowse link
G ITGA9 integrin subunit alpha 9 ISO RGD PMID:12297042 PMID:17543136 RGD:1358329 RGD:5135538 NCBI chr 3:37,349,120...37,722,572
Ensembl chr 3:37,651,395...38,006,363 		JBrowse link
G ITGAD integrin subunit alpha D ISO RGD PMID:12297042 PMID:17543136 RGD:1358329 RGD:5135538 NCBI chr16:23,539,562...23,572,705
Ensembl chr16:31,724,113...31,797,249 		JBrowse link
G ITGAE integrin subunit alpha E ISO RGD PMID:9394838 PMID:17543136 RGD:5135538 RGD:633077 NCBI chr17:3,763,813...3,851,645
Ensembl chr17:3,758,730...3,844,444 		JBrowse link
G ITGAL integrin subunit alpha L ISO RGD PMID:17543136 RGD:5135538 NCBI chr16:24,445,966...24,496,037
Ensembl chr16:30,843,747...30,892,597 		JBrowse link
G ITGAM integrin subunit alpha M ISO RGD PMID:17543136 PMID:34630381 RGD:329849126 RGD:5135538 NCBI chr16:23,634,476...23,707,147
Ensembl chr16:31,630,146...31,702,406 		JBrowse link
G ITGAV integrin subunit alpha V ISO RGD PMID:12297042 PMID:12639933 PMID:17543136 RGD:1358329 RGD:1625134 RGD:5135538 NCBI chr2B:73,880,962...73,972,486
Ensembl chr2B:191,680,655...191,773,028 		JBrowse link
G ITGAX integrin subunit alpha X ISO RGD PMID:17543136 RGD:5135538 NCBI chr16:23,574,807...23,612,638
Ensembl chr16:31,724,113...31,797,249 		JBrowse link
G ITGB1 integrin subunit beta 1 ISO RGD PMID:12639933 PMID:17543136 RGD:1625134 RGD:5135538 NCBI chr10:33,023,573...33,081,384
Ensembl chr10:33,608,978...33,644,031 		JBrowse link
G ITGB1BP1 integrin subunit beta 1 binding protein 1 ISO RGD PMID:23719537 PMID:23860236 RGD:7349373 RGD:7364738 NCBI chr2A:9,396,553...9,413,408
Ensembl chr2A:9,556,857...9,577,155 		JBrowse link
G ITGB2 integrin subunit beta 2 ISO RGD PMID:12297042 PMID:17543136 RGD:1358329 RGD:5135538 NCBI chr21:31,181,228...31,216,033
Ensembl chr21:44,470,999...44,505,963 		JBrowse link
G ITGB3 integrin subunit beta 3 ISO RGD PMID:12639933 PMID:17543136 RGD:1625134 RGD:5135538 NCBI chr17:10,134,450...10,194,596
Ensembl chr17:10,353,111...10,392,382 		JBrowse link
G ITGB4 integrin subunit beta 4 ISO RGD PMID:8026337 PMID:17543136 RGD:5135538 RGD:729025 NCBI chr17:69,671,252...69,708,520
Ensembl chr17:75,222,376...75,259,401 		JBrowse link
G ITGB5 integrin subunit beta 5 ISO RGD PMID:8799848 PMID:17543136 RGD:41410438 RGD:5135538 NCBI chr 3:121,863,676...122,013,438
Ensembl chr 3:128,762,200...128,877,172 		JBrowse link
G ITGB6 integrin subunit beta 6 ISO RGD PMID:17543136 RGD:5135538 NCBI chr2B:47,386,913...47,496,491
Ensembl chr2B:164,764,251...164,867,426 		JBrowse link
G ITGB7 integrin subunit beta 7 ISO RGD PMID:9233649 PMID:17543136 RGD:5135538 RGD:633040 NCBI chr12:35,546,107...35,562,641
Ensembl chr12:36,328,355...36,344,616 		JBrowse link
G ITGB8 integrin subunit beta 8 ISO RGD PMID:12297042 PMID:17543136 RGD:1358329 RGD:5135538 NCBI chr 7:21,019,917...21,105,143
Ensembl chr 7:20,336,031...20,415,666 		JBrowse link
G KRIT1 KRIT1 ankyrin repeat containing ISO RGD PMID:23719537 PMID:23860236 RGD:7349373 RGD:7364738 NCBI chr 7:84,197,200...84,244,050
Ensembl chr 7:97,794,531...97,840,895 		JBrowse link
G LIMS1 LIM zinc finger domain containing 1 ISO RGD PMID:16493410 RGD:2300344 NCBI chr2A:94,739,338...94,928,835 JBrowse link
G LIMS2 LIM zinc finger domain containing 2 ISO RGD PMID:16493410 RGD:2300344 NCBI chr2B:32,594,330...32,637,697
Ensembl chr2B:128,304,799...128,347,951 		JBrowse link
G NCK2 NCK adaptor protein 2 ISO RGD PMID:16493410 RGD:2300344 NCBI chr2A:95,939,197...96,089,163
Ensembl chr2A:106,898,547...106,976,363 		JBrowse link
G PARVA parvin alpha ISO RGD PMID:16493410 RGD:2300344 NCBI chr11:12,544,232...12,701,517
Ensembl chr11:12,237,446...12,387,584 		JBrowse link
G PARVB parvin beta ISO RGD PMID:16493410 RGD:2300344 NCBI chr22:24,913,710...25,061,603
Ensembl chr22:43,079,786...43,245,932 		JBrowse link
G PARVG parvin gamma ISO RGD PMID:16493410 RGD:2300344 NCBI chr22:25,073,522...25,098,936
Ensembl chr22:43,263,988...43,287,349 		JBrowse link
G PTK2 protein tyrosine kinase 2 ISO RGD PMID:15108811 RGD:2300402 NCBI chr 8:137,330,777...137,677,306
Ensembl chr 8:140,412,773...140,684,898 		JBrowse link
G PXN paxillin ISO RGD PMID:16493410 RGD:2300344 NCBI chr12:117,785,614...117,840,816
Ensembl chr12:121,160,295...121,176,667 		JBrowse link
G SHARPIN SHANK associated RH domain interactor ISO RGD PMID:23719537 PMID:23860236 RGD:7349373 RGD:7364738 NCBI chr 8:140,865,009...140,870,580
Ensembl chr 8:143,854,902...143,862,888 		JBrowse link
G TLN1 talin 1 ISO RGD PMID:18363565 PMID:23860236 RGD:2300340 RGD:7349373 NCBI chr 9:35,549,328...35,583,376
Ensembl chr 9:36,351,836...36,379,228 		JBrowse link
G TLN2 talin 2 ISO RGD PMID:23860236 RGD:7349373 NCBI chr15:41,337,084...41,790,949
Ensembl chr15:59,892,920...60,088,414 		JBrowse link
altered integrin mediated signaling pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ILK integrin linked kinase ISO RGD PMID:18772397 RGD:5490966 NCBI chr11:6,735,735...6,742,922
Ensembl chr11:6,418,717...6,425,788 		JBrowse link
G ITGA1 integrin subunit alpha 1 ISO RGD PMID:10536667 RGD:1302875 NCBI chr 5:61,073,507...61,247,565
Ensembl chr 5:62,692,673...62,865,769 		JBrowse link
G ITGA11 integrin subunit alpha 11 ISO RGD PMID:18772397 RGD:5490966 NCBI chr15:47,260,931...47,390,062
Ensembl chr15:66,031,201...66,128,985 		JBrowse link
G ITGA4 integrin subunit alpha 4 ISO RGD PMID:11782963 PMID:18772397 RGD:1302879 RGD:5490966 NCBI chr2B:68,719,376...68,802,488
Ensembl chr2B:186,530,187...186,612,203 		JBrowse link
G ITGA8 integrin subunit alpha 8 ISO RGD PMID:9054500 RGD:40903006 NCBI chr10:15,838,320...16,045,206
Ensembl chr10:16,114,999...16,321,360 		JBrowse link
G ITGA9 integrin subunit alpha 9 ISO RGD PMID:18772397 RGD:5490966 NCBI chr 3:37,349,120...37,722,572
Ensembl chr 3:37,651,395...38,006,363 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  pathway 4063
    signaling pathway 1929
      mechanotransduction pathway 70
        integrin mediated signaling pathway 50
          altered integrin mediated signaling pathway 6
          integrin mediated cell-cell signaling pathway 0
          integrin mediated cell-extracellular matrix signaling pathway 0
paths to the root