FLNA (filamin A) - Rat Genome Database
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Gene: FLNA (filamin A) Pan paniscus
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Symbol: FLNA
Name: filamin A
RGD ID: 11683532
Description: ENCODES a protein that exhibits actin filament binding (ortholog); Fc-gamma receptor I complex binding (ortholog); G protein-coupled receptor binding (ortholog); INVOLVED IN actin crosslink formation (ortholog); actin cytoskeleton organization (ortholog); actin cytoskeleton reorganization (ortholog); PARTICIPATES IN calcium signaling pathway via the calcium-sensing receptor; integrin mediated signaling pathway; Rho/Rac/Cdc42 mediated signaling pathway; ASSOCIATED WITH adrenoleukodystrophy (ortholog); Aneurysm (ortholog); aortic aneurysm (ortholog); FOUND IN actin cytoskeleton (ortholog); actin filament (ortholog); actin filament bundle (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Also known as: filamin-A; LOW QUALITY PROTEIN: filamin-A
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Mhudiblu_PPA_v0 - Bonobo Mhudiblu_PPA_v0 Assembly
Position:
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Mhudiblu_PPA_v0X143,799,088 - 143,825,282 (+)NCBIMhudiblu_PPA_v0panPan3
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
adrenoleukodystrophy  (ISO)
Aneurysm  (ISO)
aortic aneurysm  (ISO)
Arterial Thrombosis  (ISO)
arterial tortuosity syndrome  (ISO)
autistic disorder  (ISO)
Breast Neoplasms  (ISO)
colitis  (ISO)
connective tissue disease  (ISO)
craniosynostosis  (ISO)
Dwarfism  (ISO)
Ehlers-Danlos syndrome  (ISO)
Ehlers-Danlos syndrome classic type 1  (ISO)
epilepsy  (ISO)
Experimental Liver Cirrhosis  (ISO)
Familial Thoracic Aortic Aneurysm 2  (ISO)
FG syndrome  (ISO)
FG Syndrome 2  (ISO)
frontometaphyseal dysplasia  (ISO)
frontometaphyseal dysplasia 1  (ISO)
genetic disease  (ISO)
hemorrhagic disease  (ISO)
hydronephrosis  (ISO)
intellectual disability  (ISO)
Juberg Hayward Syndrome  (ISO)
Malformations of Cortical Development, Group II  (ISO)
Marfan syndrome  (ISO)
Melnick-Needles syndrome  (ISO)
microcephaly  (ISO)
mitral valve prolapse  (ISO)
osteochondrodysplasia  (ISO)
otopalatodigital syndrome spectrum disorder  (ISO)
otopalatodigital syndrome type 1  (ISO)
otopalatodigital syndrome type 2  (ISO)
periventricular nodular heterotopia  (ISO)
Periventricular Nodular Heterotopia 4  (ISO)
Phyllodes Tumor  (ISO)
prune belly syndrome  (ISO)
scoliosis  (ISO)
severe congenital encephalopathy due to MECP2 mutation  (ISO)
terminal osseous dysplasia  (ISO)
thrombocytopenia  (ISO)
tuberous sclerosis  (ISO)
visual epilepsy  (ISO)
Wolff-Parkinson-White syndrome  (ISO)
X-linked cardiac valvular dysplasia  (ISO)
X-linked chronic idiopathic intestinal pseudo-obstruction  (ISO)
X-linked Emery-Dreifuss muscular dystrophy 1  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
actin crosslink formation  (ISO)
actin cytoskeleton organization  (ISO)
actin cytoskeleton reorganization  (ISO)
adenylate cyclase-inhibiting dopamine receptor signaling pathway  (ISO)
angiogenesis  (ISO)
blood vessel remodeling  (ISO)
cell-cell junction organization  (ISO)
cerebral cortex development  (ISO)
cilium assembly  (ISO)
cytoplasmic sequestering of protein  (ISO)
early endosome to late endosome transport  (ISO)
epithelial to mesenchymal transition  (ISO)
establishment of protein localization  (ISO)
establishment of Sertoli cell barrier  (ISO)
formation of radial glial scaffolds  (ISO)
heart morphogenesis  (ISO)
mitotic spindle assembly  (ISO)
mRNA transcription by RNA polymerase II  (ISO)
negative regulation of apoptotic process  (ISO)
negative regulation of DNA-binding transcription factor activity  (ISO)
negative regulation of neuron projection development  (ISO)
negative regulation of protein catabolic process  (ISO)
negative regulation of transcription by RNA polymerase I  (ISO)
platelet aggregation  (ISO)
positive regulation of actin filament bundle assembly  (ISO)
positive regulation of axon regeneration  (ISO)
positive regulation of I-kappaB kinase/NF-kappaB signaling  (ISO)
positive regulation of integrin-mediated signaling pathway  (ISO)
positive regulation of neural precursor cell proliferation  (ISO)
positive regulation of neuron migration  (ISO)
positive regulation of potassium ion transmembrane transport  (ISO)
positive regulation of protein import into nucleus  (ISO)
positive regulation of substrate adhesion-dependent cell spreading  (ISO)
protein localization to bicellular tight junction  (ISO)
protein localization to cell surface  (ISO)
protein localization to plasma membrane  (ISO)
protein stabilization  (ISO)
receptor clustering  (ISO)
regulation of actin filament bundle assembly  (ISO)
regulation of cell migration  (ISO)
regulation of membrane repolarization during cardiac muscle cell action potential  (ISO)
semaphorin-plexin signaling pathway  (ISO)
synapse organization  (ISO)
tubulin deacetylation  (ISO)
wound healing, spreading of cells  (ISO)

References

Genomics

Comparative Map Data
FLNA
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Mhudiblu_PPA_v0X143,799,088 - 143,825,282 (+)NCBIMhudiblu_PPA_v0panPan3
FLNA
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 EnsemblX154,348,524 - 154,374,634 (-)EnsemblGRCh38hg38GRCh38
GRCh38.p13 EnsemblX154,348,524 - 154,374,638 (-)EnsemblGRCh38hg38GRCh38
GRCh38X154,348,531 - 154,374,634 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh37X153,576,899 - 153,603,002 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36X153,230,091 - 153,252,845 (-)NCBINCBI36hg18NCBI36
Build 34X153,097,811 - 153,123,776NCBI
CeleraX153,737,962 - 153,764,068 (-)NCBI
Cytogenetic MapXq28NCBI
HuRefX142,154,186 - 142,180,218 (-)NCBIHuRef
CHM1_1X153,488,516 - 153,514,622 (-)NCBICHM1_1
Flna
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39X73,267,067 - 73,293,787 (-)NCBIGRCm39mm39
GRCm39 EnsemblX73,267,067 - 73,293,426 (-)Ensembl
GRCm38X74,223,461 - 74,249,854 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 EnsemblX74,223,461 - 74,249,820 (-)EnsemblGRCm38mm10GRCm38
MGSCv37X71,468,800 - 71,491,873 (-)NCBIGRCm37mm9NCBIm37
MGSCv36X71,468,800 - 71,491,873 (-)NCBImm8
CeleraX65,477,570 - 65,500,684 (-)NCBICelera
Cytogenetic MapXA7.3NCBI
cM MapX37.89NCBI
Flna
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2X152,007,758 - 152,034,266 (-)NCBI
Rnor_6.0 EnsemblX156,463,953 - 156,487,245 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.0X156,460,785 - 156,487,245 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01152,200,936 - 152,227,391 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4X160,362,334 - 160,385,626 (+)NCBIRGSC3.4rn4RGSC3.4
Celera1135,865,679 - 135,888,971 (+)NCBICelera
Cytogenetic MapXq37NCBI
Flna
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955580874,233 - 895,232 (+)EnsemblChiLan1.0
ChiLan1.0NW_004955580874,233 - 895,172 (+)NCBIChiLan1.0ChiLan1.0
FLNA
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1X122,058,303 - 122,083,467 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 EnsemblX122,061,455 - 122,083,203 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_TashaX107,387,038 - 107,412,214 (+)NCBI
ROS_Cfam_1.0X125,200,002 - 125,225,183 (+)NCBI
UMICH_Zoey_3.1X120,969,062 - 120,994,237 (+)NCBI
UNSW_CanFamBas_1.0X123,484,172 - 123,509,345 (+)NCBI
UU_Cfam_GSD_1.0X123,246,013 - 123,271,198 (+)NCBI
Flna
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_ltri_2X119,359,521 - 119,385,421 (-)NCBI
SpeTri2.0NW_0049368091,097,288 - 1,123,206 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
FLNA
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 EnsemblX124,890,142 - 124,917,171 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1X124,889,934 - 124,915,000 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
FLNA
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1X128,657,580 - 128,683,812 (-)NCBI
ChlSab1.1 EnsemblX128,657,393 - 128,680,531 (-)Ensembl
Flna
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_004624946812,278 - 836,307 (+)NCBI


Expression


Sequence


Reference Sequences
RefSeq Acc Id: XM_003804718   ⟹   XP_003804766
RefSeq Status:
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
Mhudiblu_PPA_v0X143,799,088 - 143,825,282 (+)NCBI
Sequence:
RefSeq Acc Id: XM_034950347   ⟹   XP_034806238
RefSeq Status:
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
Mhudiblu_PPA_v0X143,799,088 - 143,825,282 (+)NCBI
Protein Sequences
Protein RefSeqs XP_003804766 (Get FASTA)   NCBI Sequence Viewer  
  XP_034806238 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: XP_003804766   ⟸   XM_003804718
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_034806238   ⟸   XM_034950347
- Peptide Label: isoform X2


Additional Information

Database Acc Id Source(s)
NCBI Gene FLNA ENTREZGENE