ITGA8 (integrin subunit alpha 8) - Rat Genome Database

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Gene: ITGA8 (integrin subunit alpha 8) Pan paniscus
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Symbol: ITGA8
Name: integrin subunit alpha 8
RGD ID: 11958551
Description: ENCODES a protein that exhibits integrin binding (inferred); metal ion binding (inferred); INVOLVED IN cell projection organization (ortholog); establishment of protein localization (ortholog); extracellular matrix organization (ortholog); PARTICIPATES IN altered integrin mediated signaling pathway; glomerulonephritis pathway; integrin mediated signaling pathway; ASSOCIATED WITH autosomal dominant polycystic kidney disease (ortholog); end stage renal disease (ortholog); genetic disease (ortholog); FOUND IN apical part of cell (ortholog); dendritic spine membrane (ortholog); glutamatergic synapse (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: integrin alpha-8
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: Mhudiblu_PPA_v0 - Bonobo Mhudiblu_PPA_v0 Assembly
Position:
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2828,363,781 - 28,573,171 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11028,369,106 - 28,578,498 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01015,838,320 - 16,045,206 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11016,114,999 - 16,321,277 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1016,114,999 - 16,321,360 (-)Ensemblpanpan1.1panPan2
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
ITGA8
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2828,363,781 - 28,573,171 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11028,369,106 - 28,578,498 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01015,838,320 - 16,045,206 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11016,114,999 - 16,321,277 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1016,114,999 - 16,321,360 (-)Ensemblpanpan1.1panPan2
ITGA8
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381015,513,954 - 15,719,922 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1015,513,954 - 15,719,922 (-)EnsemblGRCh38hg38GRCh38
GRCh371015,555,953 - 15,761,921 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361015,599,094 - 15,801,776 (-)NCBINCBI36Build 36hg18NCBI36
Build 341015,599,093 - 15,801,776NCBI
Celera1015,492,319 - 15,695,021 (-)NCBICelera
Cytogenetic Map10p13NCBI
HuRef1015,471,650 - 15,674,184 (-)NCBIHuRef
CHM1_11015,559,210 - 15,761,820 (-)NCBICHM1_1
T2T-CHM13v2.01015,531,985 - 15,737,921 (-)NCBIT2T-CHM13v2.0
Itga8
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39212,111,443 - 12,306,755 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl212,111,443 - 12,306,733 (-)EnsemblGRCm39 Ensembl
GRCm38212,106,632 - 12,301,985 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl212,106,632 - 12,301,922 (-)EnsemblGRCm38mm10GRCm38
MGSCv37212,028,287 - 12,223,547 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36212,024,513 - 12,219,773 (-)NCBIMGSCv36mm8
Celera212,022,433 - 12,215,417 (-)NCBICelera
Cytogenetic Map2A1NCBI
cM Map29.12NCBI
Itga8
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81780,213,139 - 80,410,633 (-)NCBIGRCr8
mRatBN7.21775,304,004 - 75,501,510 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1775,304,008 - 75,501,510 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1778,764,688 - 78,961,155 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01782,600,048 - 82,796,494 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01776,647,995 - 76,844,433 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01779,321,893 - 79,676,927 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1779,321,900 - 79,676,499 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01780,956,109 - 81,030,622 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Rnor_5.01781,190,818 - 81,304,978 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41786,427,191 - 86,649,268 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1774,681,231 - 74,877,691 (-)NCBICelera
Cytogenetic Map17q12.3NCBI
Itga8
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542911,932,570 - 12,120,821 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495542911,932,764 - 12,120,757 (+)NCBIChiLan1.0ChiLan1.0
ITGA8
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1221,034,630 - 21,244,304 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl221,075,653 - 21,241,951 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha218,185,585 - 18,354,528 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0221,368,356 - 21,544,465 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl221,368,171 - 21,542,328 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1218,574,970 - 18,744,463 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0219,409,413 - 19,578,983 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0220,034,706 - 20,203,972 (+)NCBIUU_Cfam_GSD_1.0
Itga8
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934416,485,714 - 16,655,428 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365745,984,939 - 6,155,164 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365745,985,181 - 6,155,067 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ITGA8
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1046,132,913 - 46,303,343 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11046,132,887 - 46,303,659 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21050,827,993 - 51,000,242 (+)NCBISscrofa10.2Sscrofa10.2susScr3
ITGA8
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1915,482,746 - 15,684,161 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl915,482,750 - 15,683,481 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605121,068,023 - 21,273,578 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Itga8
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462479611,908,964 - 12,101,139 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462479611,908,927 - 12,103,806 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSPPAT00000038613   ⟹   ENSPPAP00000015920
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl1016,114,999 - 16,321,360 (-)Ensembl
Ensembl Acc Id: ENSPPAT00000038623   ⟹   ENSPPAP00000015930
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl1016,118,198 - 16,320,717 (-)Ensembl
RefSeq Acc Id: XM_003831184   ⟹   XP_003831232
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v2828,363,781 - 28,573,171 (-)NCBI
NHGRI_mPanPan11028,369,106 - 28,578,498 (-)NCBI
Mhudiblu_PPA_v01015,838,320 - 16,045,206 (-)NCBI
PanPan1.11016,114,999 - 16,321,277 (-)NCBI
Sequence:
RefSeq Acc Id: XM_063607282   ⟹   XP_063463352
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v2828,363,781 - 28,573,171 (-)NCBI
Protein Sequences
Protein RefSeqs XP_003831232 (Get FASTA)   NCBI Sequence Viewer  
  XP_063463352 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSPPAP00000015920.1
  ENSPPAP00000015930.1
RefSeq Acc Id: XP_003831232   ⟸   XM_003831184
- Peptide Label: isoform X2
- UniProtKB: A0A2R9AJX0 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSPPAP00000015930   ⟸   ENSPPAT00000038623
Ensembl Acc Id: ENSPPAP00000015920   ⟸   ENSPPAT00000038613
RefSeq Acc Id: XP_063463352   ⟸   XM_063607282
- Peptide Label: isoform X1
- UniProtKB: A0A2R9AJX0 (UniProtKB/TrEMBL)
Protein Domains
Integrin alpha first immunoglubulin-like   Integrin alpha second immunoglobulin-like   Integrin alpha third immunoglobulin-like


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSPPAG00000031070 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSPPAT00000038613.1 UniProtKB/TrEMBL
  ENSPPAT00000038623.1 UniProtKB/TrEMBL
Gene3D-CATH 2.130.10.130 UniProtKB/TrEMBL
  Bicelle-embedded integrin alpha(iib) transmembrane segment UniProtKB/TrEMBL
  Integrin domains. Chain A, domain 2 UniProtKB/TrEMBL
  ntegrin, alpha v. Chain A, domain 3 UniProtKB/TrEMBL
  ntegrin, alpha v. Chain A, domain 4 UniProtKB/TrEMBL
InterPro FG-GAP UniProtKB/TrEMBL
  Int_alpha_beta-p UniProtKB/TrEMBL
  Integrin_alpha UniProtKB/TrEMBL
  Integrin_alpha-2 UniProtKB/TrEMBL
  Integrin_alpha_C_CS UniProtKB/TrEMBL
  Integrin_alpha_Ig-like_2 UniProtKB/TrEMBL
  Integrin_alpha_Ig-like_3 UniProtKB/TrEMBL
  Integrin_alpha_N UniProtKB/TrEMBL
  Integrin_dom_sf UniProtKB/TrEMBL
KEGG Report pps:100967547 UniProtKB/TrEMBL
NCBI Gene ITGA8 ENTREZGENE
PANTHER INTEGRIN ALPHA UniProtKB/TrEMBL
  INTEGRIN ALPHA-8 UniProtKB/TrEMBL
Pfam FG-GAP UniProtKB/TrEMBL
  Integrin_A_Ig_2 UniProtKB/TrEMBL
  Integrin_A_Ig_3 UniProtKB/TrEMBL
  Integrin_alpha UniProtKB/TrEMBL
  Integrin_alpha2 UniProtKB/TrEMBL
PRINTS INTEGRINA UniProtKB/TrEMBL
PROSITE FG_GAP UniProtKB/TrEMBL
  INTEGRIN_ALPHA UniProtKB/TrEMBL
SMART Int_alpha UniProtKB/TrEMBL
Superfamily-SCOP SSF69179 UniProtKB/TrEMBL
  SSF69318 UniProtKB/TrEMBL
UniProt A0A2R9AJX0 ENTREZGENE, UniProtKB/TrEMBL
  A0A2R9AJY0_PANPA UniProtKB/TrEMBL