ITGA4 (integrin subunit alpha 4) - Rat Genome Database

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Gene: ITGA4 (integrin subunit alpha 4) Pan paniscus
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Symbol: ITGA4
Name: integrin subunit alpha 4
RGD ID: 11753710
Description: ENCODES a protein that exhibits antigen binding (ortholog); C-X3-C chemokine binding (ortholog); cell adhesion molecule binding (ortholog); INVOLVED IN axonogenesis involved in innervation (ortholog); blood vessel remodeling (ortholog); cell adhesion (ortholog); PARTICIPATES IN altered integrin mediated signaling pathway; integrin mediated signaling pathway; pancreatic cancer pathway; ASSOCIATED WITH anti-basement membrane glomerulonephritis (ortholog); autism spectrum disorder (ortholog); autistic disorder (ortholog); FOUND IN cell surface (ortholog); cell-cell junction (ortholog); growth cone (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: integrin alpha-4
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: Mhudiblu_PPA_v0 - Bonobo Mhudiblu_PPA_v0 Assembly
Position:
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21384,105,824 - 84,188,542 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12B84,120,824 - 84,202,578 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02B68,719,376 - 68,802,488 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12B186,530,187 - 186,613,398 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2B186,530,187 - 186,612,203 (+)Ensemblpanpan1.1panPan2
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
axonogenesis involved in innervation  (ISO)
blood vessel remodeling  (ISO)
cell adhesion  (IEA,ISO)
cell adhesion mediated by integrin  (IEA)
cell migration  (ISO)
cell-cell adhesion  (IEA)
cell-cell adhesion mediated by integrin  (IEA)
cell-matrix adhesion  (IEA)
cell-matrix adhesion involved in ameboidal cell migration  (IEA)
cellular response to amyloid-beta  (IEA)
cellular response to cytokine stimulus  (ISO)
chorio-allantoic fusion  (ISO)
clathrin-dependent extracellular exosome endocytosis  (ISO)
diapedesis  (ISO)
endodermal cell differentiation  (IEA)
face development  (ISO)
heart development  (ISO)
heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules  (ISO)
heterotypic cell-cell adhesion  (IEA)
import into cell  (ISO)
integrin-mediated signaling pathway  (IEA)
leukocyte cell-cell adhesion  (IEA,ISO)
leukocyte tethering or rolling  (IEA)
negative regulation of protein homodimerization activity  (IEA)
negative regulation of vasoconstriction  (IEA)
neuron projection extension  (ISO)
pericyte cell migration  (ISO)
positive regulation of endothelial cell apoptotic process  (IEA)
positive regulation of leukocyte cell-cell adhesion  (ISO)
positive regulation of leukocyte migration  (ISO)
positive regulation of leukocyte tethering or rolling  (ISO)
positive regulation of T cell migration  (ISO)
positive regulation of vascular endothelial cell proliferation  (IEA)
receptor clustering  (IEA)
substrate adhesion-dependent cell spreading  (IEA)
T cell migration  (ISO)
vascular associated smooth muscle cell migration  (ISO)

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
ITGA4
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21384,105,824 - 84,188,542 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12B84,120,824 - 84,202,578 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02B68,719,376 - 68,802,488 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12B186,530,187 - 186,613,398 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2B186,530,187 - 186,612,203 (+)Ensemblpanpan1.1panPan2
ITGA4
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382181,457,205 - 181,538,940 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2181,457,202 - 181,538,940 (+)EnsemblGRCh38hg38GRCh38
GRCh372182,321,932 - 182,403,667 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362182,029,864 - 182,110,719 (+)NCBINCBI36Build 36hg18NCBI36
Build 342182,146,716 - 182,226,420NCBI
Celera2175,917,712 - 175,998,559 (+)NCBICelera
Cytogenetic Map2q31.3NCBI
HuRef2174,178,675 - 174,259,339 (+)NCBIHuRef
CHM1_12182,327,169 - 182,407,679 (+)NCBICHM1_1
T2T-CHM13v2.02181,947,690 - 182,029,083 (+)NCBIT2T-CHM13v2.0
Itga4
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39279,084,767 - 79,163,458 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl279,085,770 - 79,163,467 (+)EnsemblGRCm39 Ensembl
GRCm38279,255,426 - 79,333,114 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl279,255,426 - 79,333,123 (+)EnsemblGRCm38mm10GRCm38
MGSCv37279,095,583 - 79,173,271 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36279,056,484 - 79,131,613 (+)NCBIMGSCv36mm8
Celera280,914,099 - 80,991,875 (+)NCBICelera
Cytogenetic Map2C3NCBI
cM Map247.38NCBI
Itga4
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8384,569,487 - 84,646,276 (+)NCBIGRCr8
mRatBN7.2364,162,764 - 64,235,010 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl364,163,085 - 64,233,715 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx367,514,517 - 67,585,195 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0376,098,129 - 76,168,804 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0373,844,839 - 73,915,642 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0366,178,745 - 66,265,547 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl366,193,059 - 66,263,960 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0372,754,339 - 72,825,872 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4362,024,747 - 62,097,456 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera363,623,691 - 63,694,098 (+)NCBICelera
Cytogenetic Map3q24NCBI
Itga4
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540315,723,785 - 15,807,111 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495540315,726,296 - 15,807,055 (-)NCBIChiLan1.0ChiLan1.0
ITGA4
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13624,670,464 - 24,686,719 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3624,653,408 - 24,729,057 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3624,675,932 - 24,755,430 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.03624,815,313 - 24,895,039 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3624,815,333 - 24,893,581 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13624,904,710 - 24,984,278 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03624,869,937 - 24,949,662 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03625,004,898 - 25,084,914 (+)NCBIUU_Cfam_GSD_1.0
Itga4
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405303141,661,380 - 141,739,750 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493650910,215,283 - 10,292,252 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493650910,215,283 - 10,293,653 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ITGA4
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1586,947,240 - 87,030,364 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11586,942,054 - 87,028,428 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21596,521,473 - 96,602,512 (+)NCBISscrofa10.2Sscrofa10.2susScr3
ITGA4
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11066,984,687 - 67,063,158 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1066,984,887 - 67,061,636 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666040132,515,440 - 132,595,887 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Itga4
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248443,265,110 - 3,354,087 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248443,264,794 - 3,353,355 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Sequence


Ensembl Acc Id: ENSPPAT00000049542   ⟹   ENSPPAP00000026707
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl2B186,530,187 - 186,612,203 (+)Ensembl
Ensembl Acc Id: ENSPPAT00000049549   ⟹   ENSPPAP00000026713
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl2B186,530,962 - 186,549,136 (+)Ensembl
RefSeq Acc Id: XM_003823539   ⟹   XP_003823587
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v21384,105,824 - 84,186,657 (+)NCBI
NHGRI_mPanPan12B84,120,824 - 84,202,578 (+)NCBI
Mhudiblu_PPA_v02B68,719,824 - 68,802,488 (+)NCBI
PanPan1.12B186,530,187 - 186,613,398 (+)NCBI
Sequence:
RefSeq Acc Id: XR_010109400
Type: NON-CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v21384,105,824 - 84,188,542 (+)NCBI
Protein Sequences
Protein RefSeqs XP_003823587 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSPPAP00000026707.1
  ENSPPAP00000026713.1
RefSeq Acc Id: XP_003823587   ⟸   XM_003823539
- UniProtKB: A0A2R9BC59 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSPPAP00000026713   ⟸   ENSPPAT00000049549
Ensembl Acc Id: ENSPPAP00000026707   ⟸   ENSPPAT00000049542
Protein Domains
Integrin alpha first immunoglubulin-like   Integrin alpha second immunoglobulin-like   Integrin alpha third immunoglobulin-like


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSPPAG00000036435 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSPPAT00000049542.1 UniProtKB/TrEMBL
  ENSPPAT00000049549.1 UniProtKB/TrEMBL
Gene3D-CATH 2.130.10.130 UniProtKB/TrEMBL
  Bicelle-embedded integrin alpha(iib) transmembrane segment UniProtKB/TrEMBL
  Integrin domains. Chain A, domain 2 UniProtKB/TrEMBL
  ntegrin, alpha v. Chain A, domain 3 UniProtKB/TrEMBL
  ntegrin, alpha v. Chain A, domain 4 UniProtKB/TrEMBL
InterPro FG-GAP UniProtKB/TrEMBL
  Int_alpha_beta-p UniProtKB/TrEMBL
  Integrin_alpha UniProtKB/TrEMBL
  Integrin_alpha-2 UniProtKB/TrEMBL
  Integrin_alpha_C_CS UniProtKB/TrEMBL
  Integrin_alpha_Ig-like_2 UniProtKB/TrEMBL
  Integrin_alpha_Ig-like_3 UniProtKB/TrEMBL
  Integrin_alpha_N UniProtKB/TrEMBL
  Integrin_dom_sf UniProtKB/TrEMBL
KEGG Report pps:100983460 UniProtKB/TrEMBL
NCBI Gene ITGA4 ENTREZGENE
PANTHER INTEGRIN ALPHA UniProtKB/TrEMBL
  INTEGRIN ALPHA-4 UniProtKB/TrEMBL
Pfam FG-GAP UniProtKB/TrEMBL
  Integrin_A_Ig_2 UniProtKB/TrEMBL
  Integrin_A_Ig_3 UniProtKB/TrEMBL
  Integrin_alpha2 UniProtKB/TrEMBL
PRINTS INTEGRINA UniProtKB/TrEMBL
PROSITE FG_GAP UniProtKB/TrEMBL
  INTEGRIN_ALPHA UniProtKB/TrEMBL
SMART Int_alpha UniProtKB/TrEMBL
Superfamily-SCOP SSF69179 UniProtKB/TrEMBL
  SSF69318 UniProtKB/TrEMBL
UniProt A0A2R9BAT2_PANPA UniProtKB/TrEMBL
  A0A2R9BC59 ENTREZGENE, UniProtKB/TrEMBL