Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models   new Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources

PATHWAY ONTOLOGY - ANNOTATIONS

The Pathway Ontology (PW), is currently being developed at the Rat Genome Database. For more information about this vocabulary, please see Petri et al. The rat genome database pathway portal. Database (Oxford). 2011 Apr 8;2011:bar010. Print 2011 or contact us (http://rgd.mcw.edu/contact/index.shtml).
Term:phosphatidylinositol 3-kinase-Akt signaling pathway
go back to main search page
Accession:PW:0000232 term browser browse the term
Definition:The phosphatidylinositol 3-kinase-Akt signaling pathway, involving PI3K class I enzymes, particularly class IA, controls various processes such as cell growth, proliferation and survival. Class IA enzymes couple to receptor tyrosine kinases or their adaptors; class IB couple to G-protein-coupled receptors mainly via Galphai. Members of the Akt family of protein kinases are activated downstream of class I PI3Ks and collectively (Akt1, 2, and 3) phosphorylate more than 70 cytoplasmic and nuclear substrates. Deregulation of the pathway has been linked to various forms of cancer.
Synonyms:related_synonym: PI3K Cascade;   PI3K-Akt signaling pathway;   PI3K/AKT Signaling;   phosphoinositide 3-kinase-Akt signaling pathway
View Interactive Diagram

GViewer not supported for the selected species.

show annotations for term's descendants           Sort by:
phosphatidylinositol 3-kinase-Akt signaling pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akt1 AKT serine/threonine kinase 1 ISO PID
RGD		 PMID:12084817 PMID:17272396 PMID:17641274 PMID:27188433 PID:200197 RGD:152177689 RGD:152995510 RGD:2290458 RGD:625444 NCBI chrNW_004955538:3,208,711...3,224,386
Ensembl chrNW_004955538:3,208,710...3,229,904 		JBrowse link
G Akt2 AKT serine/threonine kinase 2 ISO PID
RGD		 PMID:12089343 PMID:17641274 PID:200197 RGD:2290458 RGD:632179 NCBI chrNW_004955578:950,258...1,004,438
Ensembl chrNW_004955578:967,593...1,004,438 		JBrowse link
G Akt3 AKT serine/threonine kinase 3 ISO PID
RGD		 PMID:17641274 PID:200197 RGD:2290458 NCBI chrNW_004955406:6,907,876...7,163,672 JBrowse link
G Bad BCL2 associated agonist of cell death ISO PID PID:200197 NCBI chrNW_004955422:20,795,585...20,809,039
Ensembl chrNW_004955422:20,795,676...20,809,245 		JBrowse link
G Casp9 caspase 9 ISO PID PID:200197 NCBI chrNW_004955527:2,613,691...2,630,217
Ensembl chrNW_004955527:2,613,683...2,629,738 		JBrowse link
G Cdkn1a cyclin dependent kinase inhibitor 1A ISO PID PID:200197 NCBI chrNW_004955437:6,254,638...6,261,278
Ensembl chrNW_004955437:6,254,309...6,261,479 		JBrowse link
G Cdkn1b cyclin dependent kinase inhibitor 1B ISO PID PID:200197 NCBI chrNW_004955413:9,615,542...9,620,542
Ensembl chrNW_004955413:9,615,542...9,620,542 		JBrowse link
G Chuk component of inhibitor of nuclear factor kappa B kinase complex ISO PID PID:200197 NCBI chrNW_004955507:6,066,026...6,102,066
Ensembl chrNW_004955507:6,067,203...6,102,001 		JBrowse link
G Ckb creatine kinase B ISO RGD PMID:17272396 RGD:152177689 NCBI chrNW_004955538:2,379,868...2,380,771 JBrowse link
G Esr1 estrogen receptor 1 ISO RGD PMID:17272396 RGD:152177689 NCBI chrNW_004955439:9,588,631...9,953,606
Ensembl chrNW_004955439:9,588,201...9,963,353 		JBrowse link
G Foxo1 forkhead box O1 ISO PID PID:200197 NCBI chrNW_004955431:5,797,359...5,890,758 JBrowse link
G Foxo3 forkhead box O3 ISO PID PID:200197 NCBI chrNW_004955411:33,655,958...33,770,829
Ensembl chrNW_004955411:33,655,958...33,770,829 		JBrowse link
G Foxo4 forkhead box O4 ISO PID PID:200197 NCBI chrNW_004955475:10,666,024...10,673,717
Ensembl chrNW_004955475:10,665,987...10,674,110 		JBrowse link
G Gsk3a glycogen synthase kinase 3 alpha ISO PID PID:200197 NCBI chrNW_004955555:668,641...676,351
Ensembl chrNW_004955555:667,973...676,351 		JBrowse link
G Gsk3b glycogen synthase kinase 3 beta ISO PID PID:200197 NCBI chrNW_004955427:19,489,972...19,671,137
Ensembl chrNW_004955427:19,495,422...19,671,137 		JBrowse link
G Hif1a hypoxia inducible factor 1 subunit alpha ISO RGD PMID:17272396 RGD:152177689 NCBI chrNW_004955466:8,000,311...8,022,497
Ensembl chrNW_004955466:8,000,044...8,022,497 		JBrowse link
G Hsp90aa1 heat shock protein 90 alpha family class A member 1 ISO PID PID:200197 NCBI chrNW_004955538:1,469,544...1,475,010
Ensembl chrNW_004955538:1,469,544...1,475,019 		JBrowse link
G Inpp5d inositol polyphosphate-5-phosphatase D ISO RGD PMID:17371235 RGD:2302068 NCBI chrNW_004955453:2,938,659...3,037,211
Ensembl chrNW_004955453:2,938,659...3,037,211 		JBrowse link
G Inppl1 inositol polyphosphate phosphatase like 1 ISO RGD PMID:17371235 RGD:2302068 NCBI chrNW_004955414:19,146,304...19,163,923
Ensembl chrNW_004955414:19,145,432...19,163,923 		JBrowse link
G Insr insulin receptor ISO RGD PMID:25352008 PMID:29896241 RGD:14700925 RGD:14700927 NCBI chrNW_004955563:1,867,400...2,011,845
Ensembl chrNW_004955563:1,867,400...2,009,149 		JBrowse link
G Kpna1 karyopherin subunit alpha 1 ISO PID PID:200197 NCBI chrNW_004955427:21,705,407...21,764,913
Ensembl chrNW_004955427:21,705,412...21,764,913 		JBrowse link
G Map3k5 mitogen-activated protein kinase kinase kinase 5 ISO PID PID:200197 NCBI chrNW_004955439:162,499...376,919
Ensembl chrNW_004955439:163,103...377,808 		JBrowse link
G Mapkap1 MAPK associated protein 1 ISO PID PID:200197 NCBI chrNW_004955419:2,656,662...2,887,505
Ensembl chrNW_004955419:2,657,741...2,888,607 		JBrowse link
G Mlst8 MTOR associated protein, LST8 homolog ISO PID PID:200197 NCBI chrNW_004955442:15,056,363...15,060,300
Ensembl chrNW_004955442:15,056,363...15,060,300 		JBrowse link
G Mtor mechanistic target of rapamycin kinase ISO PID PID:200197 NCBI chrNW_004955486:2,487,642...2,599,694
Ensembl chrNW_004955486:2,487,642...2,599,694 		JBrowse link
G Pdpk1 3-phosphoinositide dependent protein kinase 1 ISO PID
RGD		 PMID:17641274 PID:200197 RGD:2290458 NCBI chrNW_004955442:14,685,089...14,772,870
Ensembl chrNW_004955442:14,685,153...14,772,870 		JBrowse link
G Pgr progesterone receptor ISO RGD PMID:17272396 RGD:152177689 NCBI chrNW_004955412:4,643,839...4,693,478 JBrowse link
G Phlpp1 PH domain and leucine rich repeat protein phosphatase 1 ISO RGD PMID:24794538 RGD:11535053 NCBI chrNW_004955402:46,563,918...46,773,349
Ensembl chrNW_004955402:46,666,599...46,772,387 		JBrowse link
G Phlpp2 PH domain and leucine rich repeat protein phosphatase 2 ISO RGD PMID:24794538 RGD:11535053 NCBI chrNW_004955484:4,353,950...4,419,891
Ensembl chrNW_004955484:4,353,950...4,420,873 		JBrowse link
G Pik3ca phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha ISO RGD PMID:17641274 PMID:27188433 RGD:152995510 RGD:2290458 NCBI chrNW_004955420:8,355,415...8,427,024
Ensembl chrNW_004955420:8,356,353...8,427,024 		JBrowse link
G Pik3cb phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta ISO RGD PMID:17641274 RGD:2290458 NCBI chrNW_004955501:251,829...381,255
Ensembl chrNW_004955501:259,645...379,909 		JBrowse link
G Pik3cd phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta ISO RGD PMID:17641274 PMID:26311905 PMID:29893841 RGD:2290458 RGD:40890270 RGD:40890274 NCBI chrNW_004955486:3,813,923...3,837,563
Ensembl chrNW_004955486:3,813,923...3,838,119 		JBrowse link
G Pik3cg phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma ISO RGD PMID:21665152 PMID:29323718 PMID:29666415 RGD:38599151 RGD:38599159 RGD:38599216 NCBI chrNW_004955410:11,402,476...11,433,335
Ensembl chrNW_004955410:11,402,520...11,437,422 		JBrowse link
G Pik3r1 phosphoinositide-3-kinase regulatory subunit 1 ISO RGD PMID:17641274 RGD:2290458 NCBI chrNW_004955446:1,020,707...1,098,327
Ensembl chrNW_004955446:1,020,043...1,098,820 		JBrowse link
G Pik3r2 phosphoinositide-3-kinase regulatory subunit 2 ISO RGD PMID:17641274 RGD:2290458 NCBI chrNW_004955524:3,234,111...3,241,445
Ensembl chrNW_004955524:3,234,111...3,241,173 		JBrowse link
G Ppp2ca protein phosphatase 2 catalytic subunit alpha ISO RGD PMID:23454242 RGD:11535052 NCBI chrNW_004955408:5,435,117...5,460,361
Ensembl chrNW_004955408:5,433,268...5,460,361 		JBrowse link
G Ppp2cb protein phosphatase 2 catalytic subunit beta ISO RGD PMID:23454242 RGD:11535052 NCBI chrNW_004955463:7,229,717...7,249,490
Ensembl chrNW_004955463:7,226,912...7,249,490 		JBrowse link
G Ppp2r1a protein phosphatase 2 scaffold subunit Aalpha ISO RGD PMID:23454242 RGD:11535052 NCBI chrNW_004955558:381,794...410,485
Ensembl chrNW_004955558:381,794...410,485 		JBrowse link
G Ppp2r1b protein phosphatase 2 scaffold subunit Abeta ISO RGD PMID:23454242 RGD:11535052 NCBI chrNW_004955412:13,458,078...13,494,583
Ensembl chrNW_004955412:13,458,136...13,494,585 		JBrowse link
G Ppp2r2a protein phosphatase 2 regulatory subunit Balpha ISO RGD PMID:23454242 RGD:11535052 NCBI chrNW_004955403:49,042,188...49,113,743
Ensembl chrNW_004955403:49,042,185...49,113,737 		JBrowse link
G Prkaca protein kinase cAMP-activated catalytic subunit alpha ISO PID PID:200197 NCBI chrNW_004955415:32,794,172...32,807,944
Ensembl chrNW_004955415:32,793,718...32,812,930 		JBrowse link
G Prkdc protein kinase, DNA-activated, catalytic subunit ISO PID PID:200197 NCBI chrNW_004955454:7,733,697...7,890,896
Ensembl chrNW_004955454:7,733,978...7,890,867 		JBrowse link
G Pten phosphatase and tensin homolog ISO RGD PMID:17641274 PMID:27188433 RGD:152995510 RGD:2290458 NCBI chrNW_004955425:5,007,811...5,091,829
Ensembl chrNW_004955425:5,014,147...5,091,829 		JBrowse link
G Raf1 Raf-1 proto-oncogene, serine/threonine kinase ISO PID PID:200197 NCBI chrNW_004955429:17,980,956...18,049,723
Ensembl chrNW_004955429:18,025,932...18,049,723 		JBrowse link
G Rictor RPTOR independent companion of MTOR complex 2 ISO PID PID:200197 NCBI chrNW_004955426:23,468,112...23,582,587
Ensembl chrNW_004955426:23,468,112...23,582,587 		JBrowse link
G Sfn stratifin ISO PID PID:200197 NCBI chrNW_004955452:6,217,519...6,218,481
Ensembl chrNW_004955452:6,217,698...6,218,444 		JBrowse link
G Slc2a4 solute carrier family 2 member 4 ISO PID PID:200197 NCBI chrNW_004955467:9,630,304...9,636,005
Ensembl chrNW_004955467:9,630,304...9,636,005 		JBrowse link
G Sp1 Sp1 transcription factor ISO RGD PMID:17272396 RGD:152177689 NCBI chrNW_004955458:644,435...677,360
Ensembl chrNW_004955458:644,378...677,441 		JBrowse link
G Src SRC proto-oncogene, non-receptor tyrosine kinase ISO PID PID:200197 NCBI chrNW_004955445:19,213,210...19,227,670
Ensembl chrNW_004955445:19,215,161...19,228,695 		JBrowse link
G Tbc1d4 TBC1 domain family member 4 ISO PID PID:200197 NCBI chrNW_004955404:31,516,727...31,691,414
Ensembl chrNW_004955404:31,622,102...31,691,517 		JBrowse link
G Vegfa vascular endothelial growth factor A ISO RGD PMID:17272396 RGD:152177689 NCBI chrNW_004955437:9,527,445...9,541,908 JBrowse link
G Ywhab tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein beta ISO PID PID:200197 NCBI chrNW_004955445:12,451,644...12,474,251
Ensembl chrNW_004955445:12,448,760...12,474,251 		JBrowse link
G Ywhae tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein epsilon ISO PID PID:200197 NCBI chrNW_004955481:1,752,778...1,805,700
Ensembl chrNW_004955481:1,752,778...1,808,583 		JBrowse link
G Ywhag tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein gamma ISO PID PID:200197 NCBI chrNW_004955456:14,939,130...14,970,248
Ensembl chrNW_004955456:14,939,084...14,970,248 		JBrowse link
G Ywhah tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein eta ISO PID PID:200197 NCBI chrNW_004955455:6,045,919...6,057,729
Ensembl chrNW_004955455:6,045,919...6,057,729 		JBrowse link
G Ywhaq tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein theta ISO PID PID:200197 NCBI chrNW_004955487:5,229,485...5,263,749
Ensembl chrNW_004955487:5,230,506...5,263,752 		JBrowse link
G Ywhaz tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta ISO PID PID:200197 NCBI chrNW_004955417:16,047,263...16,070,506
Ensembl chrNW_004955417:16,047,263...16,072,854 		JBrowse link
altered phosphatidylinositol 3-kinase-Akt signaling pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akt1 AKT serine/threonine kinase 1 ISO RGD PMID:18955974 PMID:21277552 RGD:2313763 RGD:5133243 NCBI chrNW_004955538:3,208,711...3,224,386
Ensembl chrNW_004955538:3,208,710...3,229,904 		JBrowse link
G Akt2 AKT serine/threonine kinase 2 ISO RGD PMID:15166380 PMID:18955974 PMID:19506583 RGD:2313408 RGD:2313763 RGD:5490965 NCBI chrNW_004955578:950,258...1,004,438
Ensembl chrNW_004955578:967,593...1,004,438 		JBrowse link
G Akt3 AKT serine/threonine kinase 3 ISO RGD PMID:18955974 RGD:2313763 NCBI chrNW_004955406:6,907,876...7,163,672 JBrowse link
G Pik3ca phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha ISO RGD PMID:18955974 PMID:19078924 PMID:20951313 PMID:21277552 RGD:2313763 RGD:4143515 RGD:5133242 RGD:5133243 NCBI chrNW_004955420:8,355,415...8,427,024
Ensembl chrNW_004955420:8,356,353...8,427,024 		JBrowse link
G Pten phosphatase and tensin homolog ISO RGD PMID:18008377 PMID:18955974 PMID:19078924 PMID:19506583 PMID:20951313 RGD:2313763 RGD:2326139 RGD:4143515 RGD:5133242 RGD:5490965 NCBI chrNW_004955425:5,007,811...5,091,829
Ensembl chrNW_004955425:5,014,147...5,091,829 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  pathway 3923
    signaling pathway 1878
      kinase mediated signaling pathway 310
        serine/threonine-specific kinase mediated signaling pathway 286
          phosphatidylinositol 3-kinase-Akt signaling pathway 57
            altered phosphatidylinositol 3-kinase-Akt signaling pathway 5
Path 2
Term Annotations click to browse term
  pathway 3923
    signaling pathway 1878
      signaling pathway involving second messengers 262
        phosphatidylinositol 3-kinase signaling pathway 91
          phosphatidylinositol 3-kinase class I signaling pathway 90
            phosphatidylinositol 3-kinase-Akt signaling pathway 57
              altered phosphatidylinositol 3-kinase-Akt signaling pathway 5
paths to the root