Prkaca (protein kinase cAMP-activated catalytic subunit alpha) - Rat Genome Database

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Pathways
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Gene: Prkaca (protein kinase cAMP-activated catalytic subunit alpha) Chinchilla lanigera
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Symbol: Prkaca
Name: protein kinase cAMP-activated catalytic subunit alpha
RGD ID: 9005513
Description: ENCODES a protein that exhibits ATP binding (ortholog); cAMP-dependent protein kinase activity (ortholog); magnesium ion binding (ortholog); INVOLVED IN adenylate cyclase-activating G protein-coupled receptor signaling pathway (ortholog); adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway (ortholog); cAMP/PKA signal transduction (ortholog); PARTICIPATES IN acebutolol pharmacodynamics pathway; adrenergic beta receptor agonist and beta-blocker pharmacodynamics pathway; amiodarone pharmacodynamics pathway; ASSOCIATED WITH ACTH-independent macronodular adrenal hyperplasia 1 (ortholog); adrenal cortical adenoma (ortholog); Adrenal Gland Neoplasms (ortholog); FOUND IN acrosomal vesicle (ortholog); axoneme (ortholog); cAMP-dependent protein kinase complex (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: cAMP-dependent protein kinase catalytic subunit alpha
RGD Orthologs
Human
Mouse
Rat
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: ChiLan1.0 - Chinchilla ChiLan1.0 Assembly
NCBI Annotation Information: Annotation category: partial on reference assembly
Position:
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541532,793,718 - 32,812,930 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495541532,794,172 - 32,807,944 (-)NCBIChiLan1.0ChiLan1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
adenylate cyclase-activating G protein-coupled receptor signaling pathway  (ISO)
adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway  (ISO)
cAMP/PKA signal transduction  (ISO)
cellular response to cold  (ISO)
cellular response to glucagon stimulus  (ISO)
cellular response to glucose stimulus  (ISO)
cellular response to heat  (ISO)
cellular response to parathyroid hormone stimulus  (ISO)
mesoderm formation  (ISO)
modulation of chemical synaptic transmission  (ISO)
mRNA processing  (ISO)
negative regulation of glycolytic process through fructose-6-phosphate  (ISO)
negative regulation of meiotic cell cycle  (ISO)
negative regulation of meiotic cell cycle process involved in oocyte maturation  (ISO)
negative regulation of smoothened signaling pathway  (ISO)
negative regulation of TORC1 signaling  (ISO)
neural tube closure  (ISO)
peptidyl-serine phosphorylation  (ISO)
peptidyl-threonine phosphorylation  (ISO)
positive regulation of cell population proliferation  (ISO)
positive regulation of cholesterol biosynthetic process  (ISO)
positive regulation of gluconeogenesis  (ISO)
positive regulation of insulin secretion  (ISO)
positive regulation of protein export from nucleus  (ISO)
postsynaptic modulation of chemical synaptic transmission  (ISO)
protein autophosphorylation  (ISO)
protein export from nucleus  (ISO)
protein localization to lipid droplet  (ISO)
protein phosphorylation  (ISO)
regulation of bicellular tight junction assembly  (ISO)
regulation of cell cycle  (ISO)
regulation of cellular respiration  (ISO)
regulation of osteoblast differentiation  (ISO)
regulation of proteasomal protein catabolic process  (ISO)
regulation of protein processing  (ISO)
regulation of synaptic transmission, glutamatergic  (ISO)
sperm capacitation  (ISO)
spontaneous exocytosis of neurotransmitter  (ISO)

Molecular Pathway Annotations     Click to see Annotation Detail View
acebutolol pharmacodynamics pathway   (ISO)
adrenergic beta receptor agonist and beta-blocker pharmacodynamics pathway  (ISO)
amiodarone pharmacodynamics pathway  (ISO)
amlodipine pharmacodynamics pathway  (ISO)
atenolol pharmacodynamics pathway  (ISO)
betaxolol pharmacodynamics pathway  (ISO)
bisoprolol pharmacodynamics pathway  (ISO)
bupranolol drug pathway  (ISO)
bupranolol pharmacodynamics pathway  (ISO)
carvedilol pharmacodynamics pathway  (ISO)
diltiazem pharmacodynamics pathway  (ISO)
disopyramide pharmacodynamics pathway  (ISO)
dobutamine pharmacodynamics pathway   (ISO)
dopamine signaling pathway  (ISO)
eicosanoid signaling pathway  (ISO)
esmolol pharmacodynamics pathway  (ISO)
flecainde pharmacodynamics pathway  (ISO)
fosphenytoin pharmacodynamics pathway  (ISO)
granulocyte-macrophage colony-stimulating factor signaling pathway   (ISO)
Hedgehog signaling pathway  (ISO)
ibutilide pharmacodynamics pathway  (ISO)
interleukin-3 signaling pathway  (ISO)
isoprenaline pharmacodynamics pathway  (ISO)
isradipine pharmacodynamics pathway  (ISO)
levobunolol pharmacodynamics pathway  (ISO)
lidocaine pharmacodynamics pathway  (ISO)
metoprolol pharmacodynamics pathway  (ISO)
mexiletine pharmacodynamics pathway  (ISO)
nadolol pharmacodynamics pathway  (ISO)
nebivolol pharmacodynamics pathway  (ISO)
nifedipine pharmacodynamics pathway  (ISO)
nimodipine pharmacodynamics pathway  (ISO)
nisoldipine pharmacodynamics pathway  (ISO)
nitrendipine pharmacodynamics pathway  (ISO)
penbutolol pharmacodynamics pathway  (ISO)
phenytoin pharmacodynamics pathway   (ISO)
phosphatidylinositol 3-kinase-Akt signaling pathway  (ISO)
pindolol pharmacodynamics pathway  (ISO)
procainamide pharmacodynamics pathway  (ISO)
propranolol pharmacodynamics pathway   (ISO)
protein kinase A (PKA) signaling pathway  (ISO)
quinidine pharmacodynamics pathway  (ISO)
sotalol pharmacodynamics pathway  (ISO)
syndecan signaling pathway  (ISO)
timolol pharmacodynamics pathway   (ISO)
vascular endothelial growth factor signaling pathway  (ISO)
verapamil pharmacodynamics pathway  (ISO)

References

References - curated
# Reference Title Reference Citation
1. Transitive Annotation Pipeline Automated assignment of GO, PW and RDO ISO annotations across species
2. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
Prkaca
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541532,793,718 - 32,812,930 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495541532,794,172 - 32,807,944 (-)NCBIChiLan1.0ChiLan1.0
PRKACA
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381914,091,688 - 14,117,762 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1914,091,688 - 14,118,084 (-)EnsemblGRCh38hg38GRCh38
GRCh371914,202,500 - 14,228,574 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361914,063,500 - 14,089,559 (-)NCBINCBI36Build 36hg18NCBI36
Build 341914,063,508 - 14,085,992NCBI
Celera1914,096,777 - 14,122,833 (-)NCBICelera
Cytogenetic Map19p13.12NCBI
HuRef1913,774,379 - 13,800,126 (-)NCBIHuRef
CHM1_11914,202,926 - 14,228,985 (-)NCBICHM1_1
T2T-CHM13v2.01914,218,299 - 14,244,374 (-)NCBIT2T-CHM13v2.0
Prkaca
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39884,699,607 - 84,723,073 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl884,699,622 - 84,723,072 (+)EnsemblGRCm39 Ensembl
GRCm38883,972,978 - 83,996,444 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl883,972,993 - 83,996,443 (+)EnsemblGRCm38mm10GRCm38
MGSCv37886,496,877 - 86,520,344 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36886,863,093 - 86,886,544 (+)NCBIMGSCv36mm8
Celera888,266,474 - 88,289,645 (+)NCBICelera
Cytogenetic Map8C2NCBI
cM Map840.22NCBI
Prkaca
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81941,059,843 - 41,083,189 (-)NCBIGRCr8
mRatBN7.21924,155,081 - 24,178,430 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1924,155,090 - 24,178,430 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1930,976,206 - 30,999,561 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01931,630,613 - 31,653,968 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01933,853,335 - 33,876,684 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01925,095,089 - 25,118,869 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1925,095,089 - 25,118,860 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01936,073,104 - 36,096,884 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41925,840,795 - 25,864,786 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11925,845,620 - 25,861,927 (-)NCBI
Celera1923,703,180 - 23,726,723 (-)NCBICelera
Cytogenetic Map19q11NCBI
PRKACA
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22019,024,152 - 19,050,193 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11918,025,838 - 18,051,874 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01913,657,344 - 13,683,864 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11914,385,183 - 14,406,205 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1914,385,191 - 14,406,205 (-)Ensemblpanpan1.1panPan2
PRKACA
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12048,416,730 - 48,425,237 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2048,409,045 - 48,426,669 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2048,283,546 - 48,299,768 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02048,926,811 - 48,944,065 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2048,926,580 - 48,944,481 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12048,138,017 - 48,154,228 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02048,564,570 - 48,580,793 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02048,807,387 - 48,823,603 (+)NCBIUU_Cfam_GSD_1.0
Prkaca
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118207,588,938 - 207,605,559 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366592,750,537 - 2,765,753 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049366592,750,015 - 2,765,914 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PRKACA
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl265,074,870 - 65,095,551 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1265,074,876 - 65,095,564 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2265,350,544 - 65,371,236 (+)NCBISscrofa10.2Sscrofa10.2susScr3
PRKACA
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1612,743,752 - 12,759,155 (-)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_0236660746,888,080 - 6,914,845 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Prkaca
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046249011,319,062 - 1,336,744 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046249011,319,426 - 1,336,848 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSCLAT00000022968   ⟹   ENSCLAP00000022759
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0 EnsemblNW_00495541532,793,718 - 32,812,930 (-)Ensembl
RefSeq Acc Id: XM_013512354   ⟹   XP_013367808
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_00495541532,794,172 - 32,807,944 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_013367808 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSCLAP00000008288.1
  ENSCLAP00000022759
  ENSCLAP00000022759.1
RefSeq Acc Id: XP_013367808   ⟸   XM_013512354
- UniProtKB: A0A8C2V554 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSCLAP00000022759   ⟸   ENSCLAT00000022968
Protein Domains
AGC-kinase C-terminal   Protein kinase


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCLAG00000005809 UniProtKB/TrEMBL
  ENSCLAG00000015604 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCLAT00000008415.1 UniProtKB/TrEMBL
  ENSCLAT00000022968 ENTREZGENE
  ENSCLAT00000022968.1 UniProtKB/TrEMBL
Gene3D-CATH Transferase(Phosphotransferase) domain 1 UniProtKB/TrEMBL
InterPro AGC-kinase_C UniProtKB/TrEMBL
  Kinase-like_dom_sf UniProtKB/TrEMBL
  Prot_kinase_dom UniProtKB/TrEMBL
  Protein_kinase_ATP_BS UniProtKB/TrEMBL
  Ser/Thr_kinase_AS UniProtKB/TrEMBL
  STKc_PKA UniProtKB/TrEMBL
NCBI Gene Prkaca ENTREZGENE
PANTHER CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA UniProtKB/TrEMBL
  CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT BETA UniProtKB/TrEMBL
  CYCLIC NUCLEOTIDE-DEPENDENT PROTEIN KINASE UniProtKB/TrEMBL
Pfam Pkinase UniProtKB/TrEMBL
PROSITE AGC_KINASE_CTER UniProtKB/TrEMBL
  PROTEIN_KINASE_ATP UniProtKB/TrEMBL
  PROTEIN_KINASE_DOM UniProtKB/TrEMBL
  PROTEIN_KINASE_ST UniProtKB/TrEMBL
SMART S_TK_X UniProtKB/TrEMBL
  S_TKc UniProtKB/TrEMBL
Superfamily-SCOP SSF56112 UniProtKB/TrEMBL
UniProt A0A8C2V554 ENTREZGENE, UniProtKB/TrEMBL
  A0A8C2YTS6_CHILA UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-08-03 Prkaca  protein kinase cAMP-activated catalytic subunit alpha    protein kinase, cAMP-dependent, catalytic, alpha  Symbol and/or name change 5135510 APPROVED