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ONTOLOGY REPORT - ANNOTATIONS

Term:amyloid fibril formation
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Accession:GO:1990000 term browser browse the term
Definition:The generation of amyloid fibrils, insoluble fibrous protein aggregates exhibiting beta sheet structure, from proteins.
Comment:Although deposition of amyloid fibrils is associated with diseases, e.g. Alzheimer's disease, amyloid formation is a normal process. Disease occurs when the balance between amyloid formation and clearance is disrupted (reviewed e.g. in PMID:29654159 and PMID:28937655). An example of a normal amyloid complex is composed of human RIP1 and RIP3 kinases (PMID:22817896).
Synonyms:related_synonym: amyloid fibril assembly;   amyloid structure assembly;   amyloid structure formation


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amyloid fibril formation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G APP amyloid beta precursor protein involved_in IEA Ensembl GO_REF:0000107 NCBI chr21:12,324,455...12,608,594
Ensembl chr21:25,684,355...25,995,072 		JBrowse link
G B2M beta-2-microglobulin involved_in IEA Ensembl GO_REF:0000107 NCBI chr15:23,668,108...23,674,791
Ensembl chr15:41,836,345...41,842,991 		JBrowse link
G CAMP cathelicidin antimicrobial peptide involved_in IEA Ensembl GO_REF:0000107 NCBI chr 3:48,137,785...48,139,893
Ensembl chr 3:49,222,110...49,224,250 		JBrowse link
G CD36 CD36 molecule (CD36 blood group) involved_in IEA Ensembl GO_REF:0000107 NCBI chr 7:72,566,478...72,643,517
Ensembl chr 7:86,265,114...86,305,865 		JBrowse link
G CDKN2A cyclin dependent kinase inhibitor 2A involved_in ISO (PMID:12630860) DisProt PMID:12630860 NCBI chr 9:21,803,862...21,831,322 JBrowse link
G CDSN corneodesmosin involved_in ISO (PMID:20448140) DisProt PMID:20448140 NCBI chr 6:30,861,199...30,867,082
Ensembl chr 6:31,727,090...31,731,976 		JBrowse link
G CSTB cystatin B involved_in ISO (PMID:16155205) DisProt PMID:16155205 NCBI chr21:30,030,359...30,032,899 JBrowse link
G FKBP1A FKBP prolyl isomerase 1A involved_in ISO (PMID:18346205) BHF-UCL PMID:18346205 NCBI chr20:1,519,330...1,548,473 JBrowse link
G FUS FUS RNA binding protein involved_in IEA Ensembl GO_REF:0000107 NCBI chr16:23,775,389...23,786,881
Ensembl chr16:31,551,135...31,562,327 		JBrowse link
G GSN gelsolin involved_in IEA Ensembl GO_REF:0000107 NCBI chr 9:92,413,819...92,460,483
Ensembl chr 9:120,741,148...120,805,831 		JBrowse link
G IAPP islet amyloid polypeptide involved_in ISO (PMID:22944668) UniProt PMID:22944668 NCBI chr12:64,918,000...64,925,191
Ensembl chr12:67,520,986...67,528,103 		JBrowse link
G LOC100983684 small EDRK-rich factor 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 5:44,273,813...44,295,715
Ensembl chr 5:45,850,338...45,867,036 		JBrowse link
G MAPT microtubule associated protein tau involved_in ISO (PMID:7929085)
(PMID:14769047), (PMID:7929085)		 CAFA
DisProt		 PMID:7929085 PMID:14769047 NCBI chr17:11,373,220...11,506,669
Ensembl chr17:11,458,159...11,523,129 		JBrowse link
G MDM2 MDM2 proto-oncogene involved_in ISO (PMID:12630860) CAFA PMID:12630860 NCBI chr12:66,322,340...66,357,010
Ensembl chr12:69,102,084...69,133,278 		JBrowse link
G NUP153 nucleoporin 153 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 6:17,468,826...17,561,064
Ensembl chr 6:17,826,769...17,917,992 		JBrowse link
G RIPK1 receptor interacting serine/threonine kinase 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 6:2,893,802...2,943,162
Ensembl chr 6:2,997,343...3,045,078 		JBrowse link
G RIPK3 receptor interacting serine/threonine kinase 3 involved_in IEA Ensembl GO_REF:0000107 NCBI chr14:5,112,512...5,116,486
Ensembl chr14:23,235,796...23,239,821 		JBrowse link
G SNCA synuclein alpha involved_in ISO (PMID:8901511) DisProt PMID:8901511 NCBI chr 4:82,018,585...82,132,938
Ensembl chr 4:92,737,608...92,850,600 		JBrowse link
G TARDBP TAR DNA binding protein involved_in IEA Ensembl GO_REF:0000107 NCBI chr 1:9,775,084...9,786,710
Ensembl chr 1:10,996,006...11,008,732 		JBrowse link
G VHL von Hippel-Lindau tumor suppressor involved_in IEA Ensembl GO_REF:0000107 NCBI chr 3:10,077,630...10,089,499
Ensembl chr 3:10,430,143...10,440,234 		JBrowse link
negative regulation of amyloid fibril formation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G APOE apolipoprotein E involved_in IEA Ensembl GO_REF:0000107 NCBI chr19:41,853,669...41,857,252
Ensembl chr19:50,459,906...50,463,490 		JBrowse link
G CLU clusterin involved_in IEA Ensembl GO_REF:0000107 NCBI chr 8:26,867,973...26,884,838
Ensembl chr 8:24,070,053...24,083,523 		JBrowse link
G CRYAB crystallin alpha B involved_in IEA Ensembl GO_REF:0000107 NCBI chr11:106,795,406...106,800,019
Ensembl chr11:110,639,442...110,644,272 		JBrowse link
G HSPG2 heparan sulfate proteoglycan 2 involved_in ISO (PMID:21126803) ARUK-UCL PMID:21126803 NCBI chr 1:21,014,951...21,129,937
Ensembl chr 1:21,979,504...22,053,400 		JBrowse link
G LDLR low density lipoprotein receptor involved_in IEA Ensembl GO_REF:0000107 NCBI chr19:10,640,225...10,683,728
Ensembl chr19:11,357,311...11,396,791 		JBrowse link
G PFDN1 prefoldin subunit 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 5:135,611,791...135,669,895
Ensembl chr 5:141,729,128...141,786,822 		JBrowse link
G PFDN2 prefoldin subunit 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 1:136,512,982...136,530,524
Ensembl chr 1:140,426,205...140,443,773 		JBrowse link
G PFDN4 prefoldin subunit 4 involved_in IEA Ensembl GO_REF:0000107 NCBI chr20:50,554,477...50,566,496
Ensembl chr20:51,775,932...51,788,389 		JBrowse link
G PFDN5 prefoldin subunit 5 involved_in IEA Ensembl GO_REF:0000107 NCBI chr12:35,454,680...35,458,667
Ensembl chr12:36,235,552...36,239,706 		JBrowse link
G PFDN6 prefoldin subunit 6 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 6:32,861,793...32,863,234
Ensembl chr 6:33,975,992...33,983,245 		JBrowse link
G TREM2 triggering receptor expressed on myeloid cells 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 6:40,735,483...40,740,208
Ensembl chr 6:42,043,900...42,048,578 		JBrowse link
G VBP1 VHL binding protein 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr  X:144,685,548...144,709,136
Ensembl chr  X:154,504,795...154,547,773 		JBrowse link
positive regulation of amyloid fibril formation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G APP amyloid beta precursor protein involved_in IEA Ensembl GO_REF:0000107 NCBI chr21:12,324,455...12,608,594
Ensembl chr21:25,684,355...25,995,072 		JBrowse link
G PSEN1 presenilin 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr14:53,718,299...53,802,684
Ensembl chr14:72,579,024...72,663,876 		JBrowse link
G USP8 ubiquitin specific peptidase 8 involved_in IEA Ensembl GO_REF:0000107 NCBI chr15:29,374,945...29,451,235
Ensembl chr15:47,713,997...47,790,624 		JBrowse link
regulation of amyloid fibril formation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G APOE apolipoprotein E involved_in IEA Ensembl GO_REF:0000107 NCBI chr19:41,853,669...41,857,252
Ensembl chr19:50,459,906...50,463,490 		JBrowse link
G APP amyloid beta precursor protein involved_in ISO (PMID:11140685) ARUK-UCL PMID:11140685 NCBI chr21:12,324,455...12,608,594
Ensembl chr21:25,684,355...25,995,072 		JBrowse link
G LOC100977072 neuronal acetylcholine receptor subunit alpha-7 involved_in ISO (MGI:4437154|PMID:20164328) ARUK-UCL PMID:20164328 MGI:4437154 NCBI chr15:10,525,535...10,667,227
Ensembl chr15:29,565,885...29,705,194 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 16447
    metabolic process 10323
      primary metabolic process 8935
        protein metabolic process 3941
          amyloid fibril formation 35
            negative regulation of amyloid fibril formation 12
            positive regulation of amyloid fibril formation 3
            regulation of amyloid fibril formation + 16
Path 2
Term Annotations click to browse term
  biological_process 16447
    metabolic process 10323
      organic substance metabolic process 9890
        macromolecule metabolic process 8360
          protein metabolic process 3941
            amyloid fibril formation 35
              negative regulation of amyloid fibril formation 12
              positive regulation of amyloid fibril formation 3
              regulation of amyloid fibril formation + 16
paths to the root