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ONTOLOGY REPORT - ANNOTATIONS


Term:regulation of amyloid fibril formation
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Accession:GO:1905906 term browser browse the term
Definition:Any process that modulates the frequency, rate or extent of amyloid fibril formation.
Comment:Although deposition of amyloid fibrils is associated with diseases, e.g. Alzheimer's disease, amyloid formation is a normal process. Disease occurs when the balance between amyloid formation and clearance is disrupted (reviewed e.g. in PMID:29654159 and PMID:28937655). An example of a normal amyloid complex is composed of human RIP1 and RIP3 kinases (PMID:22817896).
Synonyms:related_synonym: regulation of amyloid fibril assembly;   regulation of amyloid structure assembly;   regulation of amyloid structure formation



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regulation of amyloid fibril formation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Apoe apolipoprotein E involved_in IEA
ISO
GO_REF:0000107
(PMID:25207746)
Ensembl
RGD
PMID:25207746 GO_REF:0000107 NCBI chr 1:79,353,924...79,357,852
Ensembl chr 1:79,353,916...79,357,932
JBrowse link
G App amyloid beta precursor protein involved_in ISO ComplexPortal:CPX-1134 (PMID:11140685) RGD PMID:11140685 NCBI chr11:24,019,774...24,236,584
Ensembl chr11:24,019,778...24,236,561
JBrowse link
G Chrna7 cholinergic receptor nicotinic alpha 7 subunit involved_in IEA
ISO
GO_REF:0000107
UniProtKB:P05067 (MGI:4437154|PMID:20164328)
Ensembl
RGD
PMID:20164328 GO_REF:0000107 MGI:4437154 NCBI chr 1:116,715,286...116,837,223
Ensembl chr 1:116,714,711...116,837,240
JBrowse link
negative regulation of amyloid fibril formation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Apoe apolipoprotein E involved_in ISS
ISO
GO_REF:0000024
(MGI:3621689|PMID:14741101)
UniProt
RGD
PMID:14741101 GO_REF:0000024 MGI:3621689 NCBI chr 1:79,353,924...79,357,852
Ensembl chr 1:79,353,916...79,357,932
JBrowse link
G Clu clusterin involved_in ISO
ISS
IEA
(PMID:22179788)
(MGI:3621689|PMID:14741101)
GO_REF:0000024
GO_REF:0000107
RGD
UniProt
Ensembl
PMID:14741101 PMID:22179788 GO_REF:0000024 GO_REF:0000107 MGI:3621689 NCBI chr15:40,161,068...40,200,315
Ensembl chr15:40,174,617...40,200,315
JBrowse link
G Cryab crystallin, alpha B involved_in ISO (PMID:23106396) RGD PMID:23106396 NCBI chr 8:51,093,441...51,099,161
Ensembl chr 8:51,093,441...51,099,157
JBrowse link
G Hspg2 heparan sulfate proteoglycan 2 involved_in ISO UniProtKB:P05067:PRO_0000000093 (PMID:21126803) RGD PMID:21126803 NCBI chr 5:149,677,437...149,778,594
Ensembl chr 5:149,677,476...149,778,594
JBrowse link
G Ldlr low density lipoprotein receptor involved_in ISO UniProtKB:P05067|UniProtKB:P49768 (MGI:4415751|PMID:20005821) RGD PMID:20005821 MGI:4415751 NCBI chr 8:20,270,020...20,292,981
Ensembl chr 8:20,270,041...20,294,580
JBrowse link
G Mir31 microRNA 31 acts_upstream_of ISO UniProtKB:P05067 (PMID:32069773) RGD PMID:32069773 NCBI chr 5:103,599,038...103,599,143 JBrowse link
G Pfdn1 prefoldin subunit 1 involved_in ISO (PMID:23614719) RGD PMID:23614719 NCBI chr18:28,014,145...28,067,148
Ensembl chr18:28,014,145...28,067,064
JBrowse link
G Pfdn2 prefoldin subunit 2 involved_in ISO (PMID:23614719) RGD PMID:23614719 NCBI chr13:83,772,301...83,791,367
Ensembl chr13:83,753,877...83,790,504
JBrowse link
G Pfdn4 prefoldin subunit 4 involved_in ISO (PMID:23614719) RGD PMID:23614719 NCBI chr 3:159,303,064...159,311,221
Ensembl chr 3:159,303,071...159,311,219
JBrowse link
G Pfdn5 prefoldin subunit 5 involved_in ISO (PMID:23614719) RGD PMID:23614719 NCBI chr 7:133,451,778...133,456,516
Ensembl chr 7:133,451,453...133,456,516
JBrowse link
G Pfdn6 prefoldin subunit 6 involved_in ISO (PMID:23614719) RGD PMID:23614719 NCBI chr20:4,945,959...4,947,433
Ensembl chr20:4,945,959...4,947,433
JBrowse link
G Trem2 triggering receptor expressed on myeloid cells 2 involved_in ISO (MGI:6313424|PMID:30617257) RGD PMID:30617257 MGI:6313424 NCBI chr 9:12,647,605...12,654,190
Ensembl chr 9:12,647,259...12,654,170
JBrowse link
G Vbp1 VHL binding protein 1 involved_in ISO (PMID:23614719) RGD PMID:23614719
positive regulation of amyloid fibril formation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G App amyloid beta precursor protein involved_in ISO (PMID:19660551) RGD PMID:19660551 NCBI chr11:24,019,774...24,236,584
Ensembl chr11:24,019,778...24,236,561
JBrowse link
G Psen1 presenilin 1 involved_in ISO UniProtKB:P05067 (PMID:11880515) RGD PMID:11880515 NCBI chr 6:103,323,014...103,375,088
Ensembl chr 6:103,323,120...103,371,650
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 18734
    metabolic process 11458
      primary metabolic process 10260
        protein metabolic process 5768
          regulation of protein metabolic process 2743
            regulation of amyloid fibril formation 16
              negative regulation of amyloid fibril formation 13
              positive regulation of amyloid fibril formation 2
Path 2
Term Annotations click to browse term
  biological_process 18734
    metabolic process 11458
      organic substance metabolic process 11020
        organonitrogen compound metabolic process 6710
          protein metabolic process 5768
            amyloid fibril formation 28
              regulation of amyloid fibril formation 16
                negative regulation of amyloid fibril formation 13
                positive regulation of amyloid fibril formation 2
paths to the root