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ONTOLOGY REPORT - ANNOTATIONS


Term:regulation of amyloid fibril formation
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Accession:GO:1905906 term browser browse the term
Definition:Any process that modulates the frequency, rate or extent of amyloid fibril formation.
Comment:Although deposition of amyloid fibrils is associated with diseases, e.g. Alzheimer's disease, amyloid formation is a normal process. Disease occurs when the balance between amyloid formation and clearance is disrupted (reviewed e.g. in PMID:29654159 and PMID:28937655). An example of a normal amyloid complex is composed of human RIP1 and RIP3 kinases (PMID:22817896).
Synonyms:related_synonym: regulation of amyloid fibril assembly;   regulation of amyloid structure assembly;   regulation of amyloid structure formation


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regulation of amyloid fibril formation term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Apoe apolipoprotein E IEA
ISO
GO_REF:0000107
(PMID:25207746)
Ensembl
RGD
PMID:25207746 GO_REF:0000107 NCBI chr 1:80,612,894...80,616,820
Ensembl chr 1:80,612,895...80,617,057
JBrowse link
G App amyloid beta precursor protein ISO ComplexPortal:CPX-1134 (PMID:11140685) RGD PMID:11140685 NCBI chr11:24,425,013...24,641,872
Ensembl chr11:24,425,005...24,641,858
JBrowse link
G Chrna7 cholinergic receptor nicotinic alpha 7 subunit IEA
ISO
GO_REF:0000107
UniProtKB:P05067 (MGI:MGI:4437154|PMID:20164328)
Ensembl
RGD
PMID:20164328 GO_REF:0000107, MGI:MGI:4437154 NCBI chr 1:123,897,341...124,039,263
Ensembl chr 1:123,899,657...124,039,196
JBrowse link
negative regulation of amyloid fibril formation term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Apoe apolipoprotein E ISO
ISS
(MGI:MGI:3621689|PMID:14741101)
GO_REF:0000024
RGD
UniProt
PMID:14741101 GO_REF:0000024, MGI:MGI:3621689 NCBI chr 1:80,612,894...80,616,820
Ensembl chr 1:80,612,895...80,617,057
JBrowse link
G Clu clusterin ISO
ISS
IEA
(PMID:22179788)
GO_REF:0000024
(MGI:MGI:3621689|PMID:14741101)
GO_REF:0000107
RGD
UniProt
Ensembl
PMID:14741101, PMID:22179788 GO_REF:0000024, GO_REF:0000107, MGI:MGI:3621689 NCBI chr15:42,626,612...42,665,858
Ensembl chr15:42,640,146...42,665,857
JBrowse link
G Cryab crystallin, alpha B ISO (PMID:23106396) RGD PMID:23106396 NCBI chr 8:55,178,543...55,182,546
Ensembl chr 8:55,178,289...55,182,545
JBrowse link
G Hspg2 heparan sulfate proteoglycan 2 ISO UniProtKB:P05067:PRO_0000000093 (PMID:21126803) RGD PMID:21126803 NCBI chr 5:155,812,096...155,913,751 JBrowse link
G Ldlr low density lipoprotein receptor IEA
ISO
GO_REF:0000107
UniProtKB:P05067|UniProtKB:P49768 (MGI:MGI:4415751|PMID:20005821)
Ensembl
RGD
PMID:20005821 GO_REF:0000107, MGI:MGI:4415751 NCBI chr 8:22,750,425...22,773,305
Ensembl chr 8:22,750,336...22,774,903
JBrowse link
positive regulation of amyloid fibril formation term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G App amyloid beta precursor protein ISO (PMID:19660551) RGD PMID:19660551 NCBI chr11:24,425,013...24,641,872
Ensembl chr11:24,425,005...24,641,858
JBrowse link
G Psen1 presenilin 1 ISO UniProtKB:P05067 (PMID:11880515) RGD PMID:11880515 NCBI chr 6:107,169,514...107,221,000
Ensembl chr 6:107,169,528...107,216,798
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20022
    metabolic process 12274
      primary metabolic process 10915
        protein metabolic process 6226
          regulation of protein metabolic process 2955
            regulation of amyloid fibril formation 8
              negative regulation of amyloid fibril formation 5
              positive regulation of amyloid fibril formation 2
Path 2
Term Annotations click to browse term
  biological_process 20022
    metabolic process 12274
      organic substance metabolic process 11657
        organonitrogen compound metabolic process 7151
          protein metabolic process 6226
            amyloid fibril formation 19
              regulation of amyloid fibril formation 8
                negative regulation of amyloid fibril formation 5
                positive regulation of amyloid fibril formation 2
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.