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ONTOLOGY REPORT - ANNOTATIONS

Term:regulation of amyloid fibril formation
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Accession:GO:1905906 term browser browse the term
Definition:Any process that modulates the frequency, rate or extent of amyloid fibril formation.
Comment:Although deposition of amyloid fibrils is associated with diseases, e.g. Alzheimer's disease, amyloid formation is a normal process. Disease occurs when the balance between amyloid formation and clearance is disrupted (reviewed e.g. in PMID:29654159 and PMID:28937655). An example of a normal amyloid complex is composed of human RIP1 and RIP3 kinases (PMID:22817896).
Synonyms:related_synonym: regulation of amyloid fibril assembly;   regulation of amyloid structure assembly;   regulation of amyloid structure formation


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regulation of amyloid fibril formation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Apoe apolipoprotein E involved_in IEA
ISO		 GO_REF:0000107
(PMID:25207746)		 Ensembl
RGD		 PMID:25207746 GO_REF:0000107 NCBI chr 1:79,353,924...79,357,852
Ensembl chr 1:79,353,916...79,357,932 		JBrowse link
G App amyloid beta precursor protein involved_in ISO ComplexPortal:CPX-1134 (PMID:11140685) RGD PMID:11140685 NCBI chr11:24,019,774...24,236,584
Ensembl chr11:24,019,778...24,236,561 		JBrowse link
G Chrna7 cholinergic receptor nicotinic alpha 7 subunit involved_in IEA
ISO		 GO_REF:0000107
UniProtKB:P05067 (MGI:4437154|PMID:20164328)		 Ensembl
RGD		 PMID:20164328 GO_REF:0000107 MGI:4437154 NCBI chr 1:116,715,286...116,837,223
Ensembl chr 1:116,714,711...116,837,240 		JBrowse link
negative regulation of amyloid fibril formation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Apoe apolipoprotein E involved_in ISS
ISO		 GO_REF:0000024
(MGI:3621689|PMID:14741101)		 UniProt
RGD		 PMID:14741101 GO_REF:0000024 MGI:3621689 NCBI chr 1:79,353,924...79,357,852
Ensembl chr 1:79,353,916...79,357,932 		JBrowse link
G Clu clusterin involved_in ISO
ISS
IEA		 (PMID:22179788)
(MGI:3621689|PMID:14741101)
GO_REF:0000024
GO_REF:0000107		 RGD
UniProt
Ensembl		 PMID:14741101 PMID:22179788 GO_REF:0000024 GO_REF:0000107 MGI:3621689 NCBI chr15:40,161,068...40,200,315
Ensembl chr15:40,174,617...40,200,315 		JBrowse link
G Cryab crystallin, alpha B involved_in ISO (PMID:23106396) RGD PMID:23106396 NCBI chr 8:51,093,441...51,099,161
Ensembl chr 8:51,093,441...51,099,157 		JBrowse link
G Hspg2 heparan sulfate proteoglycan 2 involved_in ISO UniProtKB:P05067:PRO_0000000093 (PMID:21126803) RGD PMID:21126803 NCBI chr 5:149,677,437...149,778,594
Ensembl chr 5:149,677,476...149,778,594 		JBrowse link
G Ldlr low density lipoprotein receptor involved_in ISO
IEA		 UniProtKB:P05067|UniProtKB:P49768 (MGI:4415751|PMID:20005821)
GO_REF:0000107		 RGD
Ensembl		 PMID:20005821 GO_REF:0000107 MGI:4415751 NCBI chr 8:20,270,020...20,292,981
Ensembl chr 8:20,270,041...20,294,580 		JBrowse link
G Mir31 microRNA 31 acts_upstream_of ISO UniProtKB:P05067 (PMID:32069773) RGD PMID:32069773 NCBI chr 5:103,599,038...103,599,143 JBrowse link
G Pfdn1 prefoldin subunit 1 involved_in ISO (PMID:23614719) RGD PMID:23614719 NCBI chr18:28,014,145...28,067,148
Ensembl chr18:28,014,145...28,067,064 		JBrowse link
G Pfdn2 prefoldin subunit 2 involved_in ISO (PMID:23614719) RGD PMID:23614719 NCBI chr13:83,772,301...83,791,367
Ensembl chr13:83,753,877...83,790,504 		JBrowse link
G Pfdn4 prefoldin subunit 4 involved_in ISO (PMID:23614719) RGD PMID:23614719 NCBI chr 3:159,303,064...159,311,221
Ensembl chr 3:159,303,071...159,311,219 		JBrowse link
G Pfdn5 prefoldin subunit 5 involved_in ISO (PMID:23614719) RGD PMID:23614719 NCBI chr 7:133,451,778...133,456,516
Ensembl chr 7:133,451,453...133,456,516 		JBrowse link
G Pfdn6 prefoldin subunit 6 involved_in ISO (PMID:23614719) RGD PMID:23614719 NCBI chr20:4,945,959...4,947,433
Ensembl chr20:4,945,959...4,947,433 		JBrowse link
G Trem2 triggering receptor expressed on myeloid cells 2 involved_in ISO (MGI:6313424|PMID:30617257) RGD PMID:30617257 MGI:6313424 NCBI chr 9:12,647,605...12,654,190
Ensembl chr 9:12,647,259...12,654,170 		JBrowse link
G Vbp1 VHL binding protein 1 involved_in ISO (PMID:23614719) RGD PMID:23614719
positive regulation of amyloid fibril formation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G App amyloid beta precursor protein involved_in ISO
IEA		 (PMID:19660551)
GO_REF:0000107		 RGD
Ensembl		 PMID:19660551 GO_REF:0000107 NCBI chr11:24,019,774...24,236,584
Ensembl chr11:24,019,778...24,236,561 		JBrowse link
G Psen1 presenilin 1 involved_in ISO UniProtKB:P05067 (PMID:11880515) RGD PMID:11880515 NCBI chr 6:103,323,014...103,375,088
Ensembl chr 6:103,323,120...103,371,650 		JBrowse link
G Usp8 ubiquitin specific peptidase 8 involved_in ISO (PMID:27444016) RGD PMID:27444016 NCBI chr 3:113,962,136...114,009,683
Ensembl chr 3:113,962,164...114,009,666 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 19818
    regulation of biological process 13074
      regulation of metabolic process 6861
        regulation of primary metabolic process 3596
          regulation of protein metabolic process 2580
            regulation of amyloid fibril formation 17
              negative regulation of amyloid fibril formation 13
              positive regulation of amyloid fibril formation 3
Path 2
Term Annotations click to browse term
  biological_process 19818
    metabolic process 12096
      nitrogen compound metabolic process 8258
        organonitrogen compound metabolic process 6766
          protein metabolic process 5776
            regulation of protein metabolic process 2580
              regulation of amyloid fibril formation 17
                negative regulation of amyloid fibril formation 13
                positive regulation of amyloid fibril formation 3
paths to the root