CSTB (cystatin B) - Rat Genome Database

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Gene: CSTB (cystatin B) Pan paniscus
Analyze
Symbol: CSTB
Name: cystatin B
RGD ID: 11676548
Description: ENCODES a protein that exhibits protease binding (ortholog); INVOLVED IN adult locomotory behavior (ortholog); amyloid fibril formation (ortholog); negative regulation of proteolysis (ortholog); ASSOCIATED WITH autistic disorder (ortholog); benign epilepsy with centrotemporal spikes (ortholog); cataract 9 multiple types (ortholog); FOUND IN extracellular space (ortholog); nucleolus (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: Cystatin-B; Stefin-B; STFB
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: Mhudiblu_PPA_v0 - Bonobo Mhudiblu_PPA_v0 Assembly
Position:
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22239,780,301 - 39,783,181 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12134,630,903 - 34,633,448 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02130,030,359 - 30,032,899 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12143,329,002 - 43,343,874 (-)NCBIpanpan1.1PanPan1.1panPan2
JBrowse: View Region in Genome Browser (JBrowse)
Model



  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
CSTBBonoboExperimental Seizures  ISOCstb (Rattus norvegicus)9068941mRNA and protein:increased expression:brainRGDPMID:10792446 and REF_RGD_ID:729930
1 to 17 of 17 rows
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
CSTBBonoboautistic disorder  ISOCSTB (Homo sapiens)8554872ClinVar Annotator: match by term: AutismClinVarPMID:21681106 and PMID:30208311
CSTBBonobobenign epilepsy with centrotemporal spikes  ISOCSTB (Homo sapiens)8554872ClinVar Annotator: match by term: Rolandic epilepsyClinVarPMID:15329070 more ...
CSTBBonobocataract 9 multiple types  ISOCSTB (Homo sapiens)8554872ClinVar Annotator: match by term: Cataract 9 multiple typesClinVarPMID:28492532
CSTBBonobodevelopmental and epileptic encephalopathy 30  ISOCSTB (Homo sapiens)8554872ClinVar Annotator: match by term: Developmental and epileptic encephalopathy and 30ClinVarPMID:25839329 more ...
CSTBBonoboDyskinesias  ISOCSTB (Homo sapiens)8554872ClinVar Annotator: match by term: DyskinesiaClinVarPMID:15329070 more ...
CSTBBonobodystonia  ISOCSTB (Homo sapiens)8554872ClinVar Annotator: match by term: DystoniaClinVarPMID:15329070 more ...
CSTBBonobogenetic disease  ISOCSTB (Homo sapiens)8554872ClinVar Annotator: match by term: Inborn genetic diseasesClinVarPMID:15483648 more ...
CSTBBonobohomocystinuria  ISOCSTB (Homo sapiens)8554872ClinVar Annotator: match by term: HYPERHOMOCYSTEINEMIA more ...ClinVarPMID:10338090 more ...
CSTBBonobointellectual disability  ISOCSTB (Homo sapiens)8554872ClinVar Annotator: match by term: Intellectual disabilityClinVarPMID:15329070 more ...
CSTBBonobointellectual disability  ISOCSTB (Homo sapiens)8554872ClinVar Annotator: match by term: Intellectual disability and severeClinVarPMID:15329070 more ...
CSTBBonobomicrocephaly  ISOCSTB (Homo sapiens)8554872ClinVar more ...ClinVarPMID:15329070 more ...
CSTBBonoboMyoclonic Epilepsies  ISOCSTB (Homo sapiens)8554872ClinVar Annotator: match by term: Myoclonus epilepsyClinVarPMID:15329070 more ...
CSTBBonoboNeurodevelopmental Disorders  ISOCSTB (Homo sapiens)8554872ClinVar Annotator: match by term: Neurodevelopmental disorderClinVarPMID:25741868
CSTBBonoboprimary ciliary dyskinesia  ISOCSTB (Homo sapiens)8554872ClinVar Annotator: match by term: Primary ciliary dyskinesiaClinVarPMID:28492532
CSTBBonoboprogressive myoclonus epilepsy  ISOCSTB (Homo sapiens)8554872ClinVar more ...ClinVarPMID:15329070 more ...
CSTBBonoboUnverricht-Lundborg syndrome  ISOCSTB (Homo sapiens)8554872ClinVar Annotator: match by term: Unverricht-Lundborg syndromeClinVarPMID:11814737 more ...
CSTBBonobovisual epilepsy  ISOCSTB (Homo sapiens)8554872ClinVar Annotator: match by term: SeizureClinVarPMID:25741868 more ...
1 to 17 of 17 rows
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
CSTBBonoboesophagus squamous cell carcinoma  ISOCSTB (Homo sapiens)9068941CTD Direct Evidence: marker/mechanismCTDPMID:21517111
CSTBBonoboglioblastoma  ISOCSTB (Homo sapiens)9068941CTD Direct Evidence: marker/mechanismCTDPMID:22287159
CSTBBonobomeningioma  ISOCSTB (Homo sapiens)9068941CTD Direct Evidence: marker/mechanismCTDPMID:19747051
CSTBBonoboNeoplasm Invasiveness  ISOCSTB (Homo sapiens)9068941CTD Direct Evidence: marker/mechanismCTDPMID:19747051 and PMID:22287159
CSTBBonoboRecurrence  ISOCSTB (Homo sapiens)9068941CTD Direct Evidence: marker/mechanismCTDPMID:19747051
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
CSTBBonoboprogressive myoclonus epilepsy 1A  ISOCSTB (Homo sapiens)7240710 OMIM 
CSTBBonoboUnverricht-Lundborg syndrome  ISOCSTB (Homo sapiens)7240710 OMIM 


Biological Process

  

Cellular Component

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
CSTBBonobocytoplasm located_inIEAUniProtKB-SubCell:SL-0086150520179 UniProtGO_REF:0000044
CSTBBonobocytoplasm located_inIEAUniProtKB-KW:KW-0963150520179 UniProtGO_REF:0000043
CSTBBonobocytosol located_inIEAPANTHER:PTN000151761150520179 TreeGrafterGO_REF:0000118
CSTBBonoboextracellular space located_inISOCSTB (Homo sapiens)9068941 PMID:3488317UniProtPMID:3488317
CSTBBonobonucleolus located_inISOCSTB (Homo sapiens)9068941 HPAGO_REF:0000052
CSTBBonobonucleus located_inIEAUniProtKB-SubCell:SL-0191150520179 UniProtGO_REF:0000044
CSTBBonobonucleus located_inIEAUniProtKB-KW:KW-0539150520179 UniProtGO_REF:0000043

Molecular Function
1 to 9 of 9 rows

  
1 to 9 of 9 rows

PMID:22301074   PMID:30032202  



CSTB
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22239,780,301 - 39,783,181 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12134,630,903 - 34,633,448 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02130,030,359 - 30,032,899 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12143,329,002 - 43,343,874 (-)NCBIpanpan1.1PanPan1.1panPan2
CSTB
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382143,773,950 - 43,776,308 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2143,772,511 - 43,776,330 (-)EnsemblGRCh38hg38GRCh38
GRCh372145,193,831 - 45,196,189 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362144,018,259 - 44,020,687 (-)NCBINCBI36Build 36hg18NCBI36
Build 342144,018,259 - 44,020,687NCBI
Celera2130,299,423 - 30,301,851 (-)NCBICelera
Cytogenetic Map21q22.3NCBI
HuRef2130,561,944 - 30,564,654 (-)NCBIHuRef
CHM1_12144,754,030 - 44,756,740 (-)NCBICHM1_1
T2T-CHM13v2.02142,129,562 - 42,131,920 (-)NCBIT2T-CHM13v2.0
Cstb
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391078,261,504 - 78,263,456 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1078,261,503 - 78,263,456 (+)EnsemblGRCm39 Ensembl
GRCm381078,425,670 - 78,427,622 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1078,425,669 - 78,427,622 (+)EnsemblGRCm38mm10GRCm38
MGSCv371077,888,415 - 77,890,367 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361077,828,799 - 77,830,751 (+)NCBIMGSCv36mm8
Celera1079,447,767 - 79,449,719 (+)NCBICelera
Cytogenetic Map10C1NCBI
cM Map1039.72NCBI
Cstb
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82010,245,157 - 10,247,199 (-)NCBIGRCr8
mRatBN7.22010,245,462 - 10,247,505 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2010,245,462 - 10,247,526 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx2010,945,142 - 10,947,182 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02010,306,047 - 10,308,087 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02010,777,526 - 10,779,568 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.02010,966,357 - 10,968,399 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2010,966,331 - 10,968,432 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02013,137,896 - 13,139,938 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42010,576,664 - 10,578,706 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.12010,576,891 - 10,578,923 (-)NCBI
Celera2011,756,111 - 11,758,153 (-)NCBICelera
Cytogenetic Map20p12NCBI
Cstb
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540741,475,533 - 41,479,150 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495540741,475,533 - 41,478,943 (+)NCBIChiLan1.0ChiLan1.0
CSTB
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Dog10K_Boxer_Tasha3136,873,130 - 36,876,156 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.03137,261,684 - 37,264,733 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3137,261,716 - 37,264,743 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13137,129,434 - 37,132,462 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03137,115,288 - 37,118,267 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03137,607,453 - 37,610,501 (-)NCBIUU_Cfam_GSD_1.0
Cstb
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440497136,964,516 - 36,965,388 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936500502,237 - 503,578 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936500502,444 - 503,307 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CSTB
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl13206,706,063 - 206,710,646 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.113206,706,060 - 206,710,598 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
CSTB
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1287,551,341 - 87,555,145 (-)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366605415,620,453 - 15,625,359 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Cstb
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462474530,153,023 - 30,155,712 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462474530,152,988 - 30,155,704 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

.





RefSeq Transcripts XM_034947958 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AB083087 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JARIFH020000022 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

RefSeq Acc Id: XM_034947958   ⟹   XP_034803849
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v22239,780,301 - 39,783,181 (-)NCBI
NHGRI_mPanPan12134,630,903 - 34,633,448 (-)NCBI
Mhudiblu_PPA_v02130,030,359 - 30,032,899 (-)NCBI
Protein RefSeqs XP_034803849 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein BAC20306 (Get FASTA)   NCBI Sequence Viewer  
  P60575 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: XP_034803849   ⟸   XM_034947958
- UniProtKB: P60575 (UniProtKB/Swiss-Prot)



1 to 14 of 14 rows
Database
Acc Id
Source(s)
Gene3D-CATH 3.10.450.10 UniProtKB/Swiss-Prot
InterPro Cystatin_dom UniProtKB/Swiss-Prot
  Cystatin_sf UniProtKB/Swiss-Prot
  Prot_inh_cystat_CS UniProtKB/Swiss-Prot
  Prot_inh_stefin UniProtKB/Swiss-Prot
NCBI Gene CSTB ENTREZGENE
PANTHER CYSTATIN-B UniProtKB/Swiss-Prot
  PTHR11414 UniProtKB/Swiss-Prot
Pfam Cystatin UniProtKB/Swiss-Prot
PRINTS STEFINA UniProtKB/Swiss-Prot
PROSITE CYSTATIN UniProtKB/Swiss-Prot
SMART SM00043 UniProtKB/Swiss-Prot
Superfamily-SCOP SSF54403 UniProtKB/Swiss-Prot
UniProt CYTB_PANPA UniProtKB/Swiss-Prot, ENTREZGENE
1 to 14 of 14 rows