CSTB (cystatin B) - Rat Genome Database

Name: CSTB
Creator: Rat Genome Database
License: Creative Commons CC BY 4.0
Keywords: Rat Gene RGD Genome

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Gene: CSTB (cystatin B) Pan paniscus

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Symbol:

CSTB

Name:

cystatin B

RGD ID:

11676548

Description:

ENCODES a protein that exhibits endopeptidase inhibitor activity (ortholog); protease binding (ortholog); INVOLVED IN adult locomotory behavior (ortholog); amyloid fibril formation (ortholog); negative regulation of peptidase activity (ortholog); ASSOCIATED WITH autistic disorder (ortholog); benign epilepsy with centrotemporal spikes (ortholog); cataract 9 multiple types (ortholog); FOUND IN extracellular space (ortholog); nucleolus (ortholog)

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

Cystatin-B; Stefin-B; STFB

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	CSTB (cystatin B)	NCBI	Ortholog
Mus musculus (house mouse):	Cstb (cystatin B)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Rattus norvegicus (Norway rat):	Cstb (cystatin B)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Cstb (cystatin B)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	CSTB (cystatin B)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Cstb (cystatin B)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	CSTB (cystatin B)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	CSTB (cystatin B)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Cstb (cystatin B)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline

Latest Assembly:

Mhudiblu_PPA_v0 - Bonobo Mhudiblu_PPA_v0 Assembly

Position:

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	22	39,780,301 - 39,783,181 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	21	34,630,903 - 34,633,448 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	21	30,030,359 - 30,032,899 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	21	43,329,002 - 43,343,874 (-)	NCBI	panpan1.1	PanPan1.1	panPan2

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

autistic disorder (ISO)

benign epilepsy with centrotemporal spikes (ISO)

cataract 9 multiple types (ISO)

developmental and epileptic encephalopathy 30 (ISO)

Dyskinesias (ISO)

dystonia (ISO)

esophagus squamous cell carcinoma (ISO)

Experimental Seizures (ISO)

genetic disease (ISO)

glioblastoma (ISO)

homocystinuria (ISO)

intellectual disability (ISO)

meningioma (ISO)

microcephaly (ISO)

Myoclonic Epilepsies (ISO)

Neoplasm Invasiveness (ISO)

Neurodevelopmental Disorders (ISO)

primary ciliary dyskinesia (ISO)

progressive myoclonus epilepsy (ISO)

progressive myoclonus epilepsy 1A (ISO)

Recurrence (ISO)

Unverricht-Lundborg syndrome (ISO)

visual epilepsy (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

adult locomotory behavior (ISO)

amyloid fibril formation (ISO)

negative regulation of peptidase activity (ISO)

negative regulation of proteolysis (ISO)

Cellular Component

cytoplasm (IEA)

cytosol (IEA)

extracellular space (ISO)

nucleolus (ISO)

nucleus (IEA)

Molecular Function

cysteine-type endopeptidase inhibitor activity (IEA)

endopeptidase inhibitor activity (ISO)

protease binding (ISO)

protein binding (ISO)

References

Additional References at PubMed

PMID:22301074	PMID:30032202

Genomics

Comparative Map Data

CSTB
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	22	39,780,301 - 39,783,181 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	21	34,630,903 - 34,633,448 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	21	30,030,359 - 30,032,899 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	21	43,329,002 - 43,343,874 (-)	NCBI	panpan1.1	PanPan1.1	panPan2

CSTB
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	21	43,773,950 - 43,776,308 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	21	43,772,511 - 43,776,330 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	21	45,193,831 - 45,196,189 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	21	44,018,259 - 44,020,687 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	21	44,018,259 - 44,020,687	NCBI
Celera	21	30,299,423 - 30,301,851 (-)	NCBI		Celera
Cytogenetic Map	21	q22.3	NCBI
HuRef	21	30,561,944 - 30,564,654 (-)	NCBI		HuRef
CHM1_1	21	44,754,030 - 44,756,740 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	21	42,129,562 - 42,131,920 (-)	NCBI		T2T-CHM13v2.0

Cstb
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	10	78,261,504 - 78,263,456 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	10	78,261,503 - 78,263,456 (+)	Ensembl		GRCm39 Ensembl
GRCm38	10	78,425,670 - 78,427,622 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	10	78,425,669 - 78,427,622 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	10	77,888,415 - 77,890,367 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	10	77,828,799 - 77,830,751 (+)	NCBI		MGSCv36	mm8
Celera	10	79,447,767 - 79,449,719 (+)	NCBI		Celera
Cytogenetic Map	10	C1	NCBI
cM Map	10	39.72	NCBI

Cstb
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	20	10,245,157 - 10,247,199 (-)	NCBI		GRCr8
mRatBN7.2	20	10,245,462 - 10,247,505 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	20	10,245,462 - 10,247,526 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	20	10,945,142 - 10,947,182 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	20	10,306,047 - 10,308,087 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	20	10,777,526 - 10,779,568 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	20	10,966,357 - 10,968,399 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	20	10,966,331 - 10,968,432 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	20	13,137,896 - 13,139,938 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	20	10,576,664 - 10,578,706 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	20	10,576,891 - 10,578,923 (-)	NCBI
Celera	20	11,756,111 - 11,758,153 (-)	NCBI		Celera
Cytogenetic Map	20	p12	NCBI

Cstb
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955407	41,475,533 - 41,479,150 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955407	41,475,533 - 41,478,943 (+)	NCBI	ChiLan1.0	ChiLan1.0

CSTB
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Dog10K_Boxer_Tasha	31	36,873,130 - 36,876,156 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	31	37,261,684 - 37,264,733 (-)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	31	37,261,716 - 37,264,743 (-)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	31	37,129,434 - 37,132,462 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	31	37,115,288 - 37,118,267 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	31	37,607,453 - 37,610,501 (-)	NCBI		UU_Cfam_GSD_1.0

Cstb
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024404971	36,964,516 - 36,965,388 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936500	502,237 - 503,578 (+)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936500	502,444 - 503,307 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

CSTB
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	13	206,706,063 - 206,710,646 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	13	206,706,060 - 206,710,598 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1

CSTB
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	2	87,551,341 - 87,555,145 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
Vero_WHO_p1.0	NW_023666054	15,620,453 - 15,625,359 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Cstb
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624745	30,153,023 - 30,155,712 (+)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624745	30,152,988 - 30,155,704 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_034947958	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AB083087	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JARIFH020000022	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

XM_034947958 ⟹ XP_034803849

Type:

CODING

Position:

Bonobo Assembly	Chr	Position (strand)	Source
NHGRI_mPanPan1-v2	22	39,780,301 - 39,783,181 (-)	NCBI
NHGRI_mPanPan1	21	34,630,903 - 34,633,448 (-)	NCBI
Mhudiblu_PPA_v0	21	30,030,359 - 30,032,899 (-)	NCBI

Protein Sequences


Protein RefSeqs	XP_034803849	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	BAC20306	(Get FASTA)	NCBI Sequence Viewer
	P60575	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:	XP_034803849 ⟸ XM_034947958
- UniProtKB:	P60575 (UniProtKB/Swiss-Prot)

Additional Information

External Database Links

Database	Acc Id	Source(s)
Gene3D-CATH	3.10.450.10	UniProtKB/Swiss-Prot
InterPro	Cystatin_dom	UniProtKB/Swiss-Prot
	Cystatin_sf	UniProtKB/Swiss-Prot
	Prot_inh_cystat_CS	UniProtKB/Swiss-Prot
	Prot_inh_stefin	UniProtKB/Swiss-Prot
NCBI Gene	CSTB	ENTREZGENE
PANTHER	CYSTATIN-B	UniProtKB/Swiss-Prot
	PTHR11414	UniProtKB/Swiss-Prot
Pfam	Cystatin	UniProtKB/Swiss-Prot
PRINTS	STEFINA	UniProtKB/Swiss-Prot
PROSITE	CYSTATIN	UniProtKB/Swiss-Prot
SMART	SM00043	UniProtKB/Swiss-Prot
Superfamily-SCOP	SSF54403	UniProtKB/Swiss-Prot
UniProt	CYTB_PANPA	UniProtKB/Swiss-Prot, ENTREZGENE

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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