Cstb (cystatin B) - Rat Genome Database

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Gene: Cstb (cystatin B) Chinchilla lanigera
Analyze
Symbol: Cstb
Name: cystatin B
RGD ID: 8886265
Description: ENCODES a protein that exhibits cysteine-type endopeptidase inhibitor activity (ortholog); endopeptidase inhibitor activity (ortholog); protease binding (ortholog); INVOLVED IN adult locomotory behavior (ortholog); amyloid fibril formation (ortholog); negative regulation of proteolysis (ortholog); ASSOCIATED WITH autistic disorder (ortholog); benign epilepsy with centrotemporal spikes (ortholog); cataract 9 multiple types (ortholog); FOUND IN cytoplasm (ortholog); cytosol (ortholog); extracellular space (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: cystatin B (stefin B); cystatin-B
RGD Orthologs
Human
Mouse
Rat
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: ChiLan1.0 - Chinchilla ChiLan1.0 Assembly
NCBI Annotation Information: Annotation category: partial on reference assembly
Position:
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540741,475,533 - 41,479,150 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495540741,475,533 - 41,478,943 (+)NCBIChiLan1.0ChiLan1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model



  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
CstbChinchillaExperimental Seizures  ISOCstb (Rattus norvegicus)9068941mRNA and protein:increased expression:brainRGDPMID:10792446 and REF_RGD_ID:729930
1 to 17 of 17 rows
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
CstbChinchillaautistic disorder  ISOCSTB (Homo sapiens)8554872ClinVar Annotator: match by term: AutismClinVarPMID:21681106 and PMID:30208311
CstbChinchillabenign epilepsy with centrotemporal spikes  ISOCSTB (Homo sapiens)8554872ClinVar Annotator: match by term: Rolandic epilepsyClinVarPMID:15329070 more ...
CstbChinchillacataract 9 multiple types  ISOCSTB (Homo sapiens)8554872ClinVar Annotator: match by term: Cataract 9 multiple typesClinVarPMID:28492532
CstbChinchilladevelopmental and epileptic encephalopathy 30  ISOCSTB (Homo sapiens)8554872ClinVar Annotator: match by term: Developmental and epileptic encephalopathy and 30ClinVarPMID:25839329 more ...
CstbChinchillaDyskinesias  ISOCSTB (Homo sapiens)8554872ClinVar Annotator: match by term: DyskinesiaClinVarPMID:15329070 more ...
CstbChinchilladystonia  ISOCSTB (Homo sapiens)8554872ClinVar Annotator: match by term: DystoniaClinVarPMID:15329070 more ...
CstbChinchillagenetic disease  ISOCSTB (Homo sapiens)8554872ClinVar Annotator: match by term: Inborn genetic diseasesClinVarPMID:15483648 more ...
CstbChinchillahomocystinuria  ISOCSTB (Homo sapiens)8554872ClinVar Annotator: match by term: HYPERHOMOCYSTEINEMIA more ...ClinVarPMID:10338090 more ...
CstbChinchillaintellectual disability  ISOCSTB (Homo sapiens)8554872ClinVar Annotator: match by term: Intellectual disabilityClinVarPMID:15329070 more ...
CstbChinchillaintellectual disability  ISOCSTB (Homo sapiens)8554872ClinVar Annotator: match by term: Intellectual disability and severeClinVarPMID:15329070 more ...
CstbChinchillamicrocephaly  ISOCSTB (Homo sapiens)8554872ClinVar more ...ClinVarPMID:15329070 more ...
CstbChinchillaMyoclonic Epilepsies  ISOCSTB (Homo sapiens)8554872ClinVar Annotator: match by term: Myoclonus epilepsyClinVarPMID:15329070 more ...
CstbChinchillaNeurodevelopmental Disorders  ISOCSTB (Homo sapiens)8554872ClinVar Annotator: match by term: Neurodevelopmental disorderClinVarPMID:25741868
CstbChinchillaprimary ciliary dyskinesia  ISOCSTB (Homo sapiens)8554872ClinVar Annotator: match by term: Primary ciliary dyskinesiaClinVarPMID:28492532
CstbChinchillaprogressive myoclonus epilepsy  ISOCSTB (Homo sapiens)8554872ClinVar more ...ClinVarPMID:15329070 more ...
CstbChinchillaUnverricht-Lundborg syndrome  ISOCSTB (Homo sapiens)8554872ClinVar Annotator: match by term: Unverricht-Lundborg syndromeClinVarPMID:11814737 more ...
CstbChinchillavisual epilepsy  ISOCSTB (Homo sapiens)8554872ClinVar Annotator: match by term: SeizureClinVarPMID:25741868 more ...
1 to 17 of 17 rows
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
CstbChinchillaesophagus squamous cell carcinoma  ISOCSTB (Homo sapiens)9068941CTD Direct Evidence: marker/mechanismCTDPMID:21517111
CstbChinchillaglioblastoma  ISOCSTB (Homo sapiens)9068941CTD Direct Evidence: marker/mechanismCTDPMID:22287159
CstbChinchillameningioma  ISOCSTB (Homo sapiens)9068941CTD Direct Evidence: marker/mechanismCTDPMID:19747051
CstbChinchillaNeoplasm Invasiveness  ISOCSTB (Homo sapiens)9068941CTD Direct Evidence: marker/mechanismCTDPMID:19747051 and PMID:22287159
CstbChinchillaRecurrence  ISOCSTB (Homo sapiens)9068941CTD Direct Evidence: marker/mechanismCTDPMID:19747051
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
CstbChinchillaprogressive myoclonus epilepsy 1A  ISOCSTB (Homo sapiens)7240710 OMIM 
CstbChinchillaUnverricht-Lundborg syndrome  ISOCSTB (Homo sapiens)7240710 OMIM 


Biological Process

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
CstbChinchillaadult locomotory behavior acts_upstream_of_or_withinISOMGI:18619159068941 PMID:9806543MGIPMID:9806543
CstbChinchillaamyloid fibril formation involved_inISOCSTB (Homo sapiens)9068941 PMID:16155205DisProtPMID:16155205
CstbChinchillanegative regulation of proteolysis involved_inISOCSTB (Homo sapiens)9068941 PMID:3488317 and PMID:6203523BHF-UCLPMID:3488317 and PMID:6203523

Cellular Component

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
CstbChinchillacytoplasm located_inISOCSTB (Homo sapiens)9068941 PMID:11139332UniProtPMID:11139332
CstbChinchillacytosol located_inISOCSTB (Homo sapiens)9068941 HPAGO_REF:0000052
CstbChinchillaextracellular space located_inISOCSTB (Homo sapiens)9068941 PMID:3488317UniProtPMID:3488317
CstbChinchillanucleolus located_inISOCSTB (Homo sapiens)9068941 HPAGO_REF:0000052
CstbChinchillanucleus located_inISOCSTB (Homo sapiens)9068941 PMID:11139332MGIPMID:11139332

Molecular Function

  


#
Reference Title
Reference Citation
1. Transitive Annotation Pipeline Automated assignment of GO, PW and RDO ISO annotations across species
2. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
PMID:22301074   PMID:30032202  



Cstb
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540741,475,533 - 41,479,150 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495540741,475,533 - 41,478,943 (+)NCBIChiLan1.0ChiLan1.0
CSTB
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382143,773,950 - 43,776,308 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2143,772,511 - 43,776,330 (-)EnsemblGRCh38hg38GRCh38
GRCh372145,193,831 - 45,196,189 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362144,018,259 - 44,020,687 (-)NCBINCBI36Build 36hg18NCBI36
Build 342144,018,259 - 44,020,687NCBI
Celera2130,299,423 - 30,301,851 (-)NCBICelera
Cytogenetic Map21q22.3NCBI
HuRef2130,561,944 - 30,564,654 (-)NCBIHuRef
CHM1_12144,754,030 - 44,756,740 (-)NCBICHM1_1
T2T-CHM13v2.02142,129,562 - 42,131,920 (-)NCBIT2T-CHM13v2.0
Cstb
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391078,261,504 - 78,263,456 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1078,261,503 - 78,263,456 (+)EnsemblGRCm39 Ensembl
GRCm381078,425,670 - 78,427,622 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1078,425,669 - 78,427,622 (+)EnsemblGRCm38mm10GRCm38
MGSCv371077,888,415 - 77,890,367 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361077,828,799 - 77,830,751 (+)NCBIMGSCv36mm8
Celera1079,447,767 - 79,449,719 (+)NCBICelera
Cytogenetic Map10C1NCBI
cM Map1039.72NCBI
Cstb
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82010,245,157 - 10,247,199 (-)NCBIGRCr8
mRatBN7.22010,245,462 - 10,247,505 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2010,245,462 - 10,247,526 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx2010,945,142 - 10,947,182 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02010,306,047 - 10,308,087 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02010,777,526 - 10,779,568 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.02010,966,357 - 10,968,399 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2010,966,331 - 10,968,432 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02013,137,896 - 13,139,938 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42010,576,664 - 10,578,706 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.12010,576,891 - 10,578,923 (-)NCBI
Celera2011,756,111 - 11,758,153 (-)NCBICelera
Cytogenetic Map20p12NCBI
CSTB
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22239,780,301 - 39,783,181 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12134,630,903 - 34,633,448 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02130,030,359 - 30,032,899 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12143,329,002 - 43,343,874 (-)NCBIpanpan1.1PanPan1.1panPan2
CSTB
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Dog10K_Boxer_Tasha3136,873,130 - 36,876,156 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.03137,261,684 - 37,264,733 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3137,261,716 - 37,264,743 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13137,129,434 - 37,132,462 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03137,115,288 - 37,118,267 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03137,607,453 - 37,610,501 (-)NCBIUU_Cfam_GSD_1.0
Cstb
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440497136,964,516 - 36,965,388 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936500502,237 - 503,578 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936500502,444 - 503,307 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CSTB
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl13206,706,063 - 206,710,646 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.113206,706,060 - 206,710,598 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
CSTB
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1287,551,341 - 87,555,145 (-)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366605415,620,453 - 15,625,359 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Cstb
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462474530,153,023 - 30,155,712 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462474530,152,988 - 30,155,704 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

.






Ensembl Acc Id: ENSCLAT00000014610   ⟹   ENSCLAP00000014452
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0 EnsemblNW_00495540741,475,533 - 41,479,150 (+)Ensembl
RefSeq Acc Id: XM_005375884   ⟹   XP_005375941
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_00495540741,475,533 - 41,478,943 (+)NCBI
Sequence:
Protein RefSeqs XP_005375941 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSCLAP00000014452
  ENSCLAP00000014452.1
RefSeq Acc Id: XP_005375941   ⟸   XM_005375884
- UniProtKB: A0A8C2VLR8 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSCLAP00000014452   ⟸   ENSCLAT00000014610
Cystatin



1 to 15 of 15 rows
Database
Acc Id
Source(s)
Ensembl Genes ENSCLAG00000009970 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCLAT00000014610 ENTREZGENE
  ENSCLAT00000014610.1 UniProtKB/TrEMBL
Gene3D-CATH 3.10.450.10 UniProtKB/TrEMBL
InterPro Cystatin_dom UniProtKB/TrEMBL
  Cystatin_sf UniProtKB/TrEMBL
  Prot_inh_stefin UniProtKB/TrEMBL
NCBI Gene Cstb ENTREZGENE
PANTHER CYSTATIN-B UniProtKB/TrEMBL
  PTHR11414 UniProtKB/TrEMBL
Pfam Cystatin UniProtKB/TrEMBL
PRINTS STEFINA UniProtKB/TrEMBL
SMART SM00043 UniProtKB/TrEMBL
Superfamily-SCOP SSF54403 UniProtKB/TrEMBL
UniProt A0A8C2VLR8 ENTREZGENE, UniProtKB/TrEMBL
1 to 15 of 15 rows


Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-08-16 Cstb  cystatin B    cystatin B (stefin B)  Symbol and/or name change 5135510 APPROVED