CSTB (cystatin B) - Rat Genome Database

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Gene: CSTB (cystatin B) Sus scrofa
Analyze
Symbol: CSTB
Name: cystatin B
RGD ID: 13916290
Description: ENCODES a protein that exhibits protease binding (ortholog); INVOLVED IN adult locomotory behavior (ortholog); amyloid fibril formation (ortholog); negative regulation of proteolysis (ortholog); ASSOCIATED WITH autistic disorder (ortholog); benign epilepsy with centrotemporal spikes (ortholog); cataract 9 multiple types (ortholog); FOUND IN extracellular space (ortholog); nucleolus (ortholog); nucleus (ortholog); INTERACTS WITH deoxynivalenol
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: CST6; cystatin B protein; Cystatin-B; Stefin-B; STFB
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Sscrofa11.1 - Pig Sscrofa11.1 Assembly
Position:
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl13206,706,063 - 206,710,646 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.113206,706,060 - 206,710,598 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
cytoplasm  (IEA)
cytosol  (IBA,IEA)
extracellular space  (ISO)
nucleolus  (ISO)
nucleus  (ISO)

Molecular Function

References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
CSTB
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl13206,706,063 - 206,710,646 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.113206,706,060 - 206,710,598 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
CSTB
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382143,773,950 - 43,776,308 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2143,772,511 - 43,776,330 (-)EnsemblGRCh38hg38GRCh38
GRCh372145,193,831 - 45,196,189 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362144,018,259 - 44,020,687 (-)NCBINCBI36Build 36hg18NCBI36
Build 342144,018,259 - 44,020,687NCBI
Celera2130,299,423 - 30,301,851 (-)NCBICelera
Cytogenetic Map21q22.3NCBI
HuRef2130,561,944 - 30,564,654 (-)NCBIHuRef
CHM1_12144,754,030 - 44,756,740 (-)NCBICHM1_1
T2T-CHM13v2.02142,129,562 - 42,131,920 (-)NCBIT2T-CHM13v2.0
Cstb
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391078,261,504 - 78,263,456 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1078,261,503 - 78,263,456 (+)EnsemblGRCm39 Ensembl
GRCm381078,425,670 - 78,427,622 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1078,425,669 - 78,427,622 (+)EnsemblGRCm38mm10GRCm38
MGSCv371077,888,415 - 77,890,367 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361077,828,799 - 77,830,751 (+)NCBIMGSCv36mm8
Celera1079,447,767 - 79,449,719 (+)NCBICelera
Cytogenetic Map10C1NCBI
cM Map1039.72NCBI
Cstb
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82010,245,157 - 10,247,199 (-)NCBIGRCr8
mRatBN7.22010,245,462 - 10,247,505 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2010,245,462 - 10,247,526 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx2010,945,142 - 10,947,182 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02010,306,047 - 10,308,087 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02010,777,526 - 10,779,568 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.02010,966,357 - 10,968,399 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2010,966,331 - 10,968,432 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02013,137,896 - 13,139,938 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42010,576,664 - 10,578,706 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.12010,576,891 - 10,578,923 (-)NCBI
Celera2011,756,111 - 11,758,153 (-)NCBICelera
Cytogenetic Map20p12NCBI
Cstb
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540741,475,533 - 41,479,150 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495540741,475,533 - 41,478,943 (+)NCBIChiLan1.0ChiLan1.0
CSTB
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22239,780,301 - 39,783,181 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12134,630,903 - 34,633,448 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02130,030,359 - 30,032,899 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12143,329,002 - 43,343,874 (-)NCBIpanpan1.1PanPan1.1panPan2
CSTB
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Dog10K_Boxer_Tasha3136,873,130 - 36,876,156 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.03137,261,684 - 37,264,733 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3137,261,716 - 37,264,743 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13137,129,434 - 37,132,462 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03137,115,288 - 37,118,267 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03137,607,453 - 37,610,501 (-)NCBIUU_Cfam_GSD_1.0
Cstb
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440497136,964,516 - 36,965,388 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936500502,237 - 503,578 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936500502,444 - 503,307 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CSTB
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1287,551,341 - 87,555,145 (-)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366605415,620,453 - 15,625,359 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Cstb
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462474530,153,023 - 30,155,712 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462474530,152,988 - 30,155,704 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in CSTB
152 total Variants

Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system hemolymphoid system musculoskeletal system nervous system renal system reproductive system respiratory system
High
Medium 10 2 3 5 2 22 2 3 3
Low 2 1
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSSSCT00000023178   ⟹   ENSSSCP00000021841
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl13206,706,063 - 206,710,646 (-)Ensembl
RefSeq Acc Id: NM_001097496   ⟹   NP_001090965
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.113206,706,060 - 206,710,598 (-)NCBI
Sequence:
Reference Protein Sequences
RefSeq Acc Id: NP_001090965   ⟸   NM_001097496
- UniProtKB: A4USB5 (UniProtKB/TrEMBL),   A0A8D1XLZ9 (UniProtKB/TrEMBL),   A3RG87 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSSSCP00000021841   ⟸   ENSSSCT00000023178
Protein Domains
Cystatin


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSSCG00000027357 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
  ENSSSCG00015047373 UniProtKB/TrEMBL
  ENSSSCG00025009470 UniProtKB/Swiss-Prot
  ENSSSCG00030015231 UniProtKB/TrEMBL
  ENSSSCG00035017614 UniProtKB/Swiss-Prot
  ENSSSCG00040056028 UniProtKB/TrEMBL
  ENSSSCG00045018269 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ENSSSCG00050032913 UniProtKB/TrEMBL
  ENSSSCG00055020262 UniProtKB/Swiss-Prot
  ENSSSCG00065010330 UniProtKB/TrEMBL
  ENSSSCG00070008242 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENSSSCT00000023178 ENTREZGENE
  ENSSSCT00000023178.3 UniProtKB/Swiss-Prot
  ENSSSCT00015063351.1 UniProtKB/TrEMBL
  ENSSSCT00025012535.1 UniProtKB/Swiss-Prot
  ENSSSCT00030021024.1 UniProtKB/TrEMBL
  ENSSSCT00035022666.1 UniProtKB/Swiss-Prot
  ENSSSCT00040075928.1 UniProtKB/TrEMBL
  ENSSSCT00040075979.1 UniProtKB/TrEMBL
  ENSSSCT00045031108.1 UniProtKB/Swiss-Prot
  ENSSSCT00045031158.1 UniProtKB/TrEMBL
  ENSSSCT00050044169.1 UniProtKB/TrEMBL
  ENSSSCT00055039725.1 UniProtKB/Swiss-Prot
  ENSSSCT00065013723.1 UniProtKB/TrEMBL
  ENSSSCT00070015906.1 UniProtKB/Swiss-Prot
  ENSSSCT00070015921.1 UniProtKB/TrEMBL
Gene3D-CATH 3.10.450.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Cystatin_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Cystatin_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Prot_inh_cystat_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Prot_inh_stefin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report ssc:100038020 UniProtKB/TrEMBL
NCBI Gene CSTB ENTREZGENE
PANTHER CYSTATIN-B UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR11414 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Cystatin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PRINTS STEFINA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE CYSTATIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART SM00043 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF54403 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A4X1TD05_PIG UniProtKB/TrEMBL
  A0A8D1F5B8_PIG UniProtKB/TrEMBL
  A0A8D1XLZ9 ENTREZGENE, UniProtKB/TrEMBL
  A3RG87 ENTREZGENE, UniProtKB/TrEMBL
  A4USB5 ENTREZGENE, UniProtKB/TrEMBL
  CYTB_PIG UniProtKB/Swiss-Prot
  Q19A58_PIG UniProtKB/TrEMBL
  Q29290 ENTREZGENE
  Q95KQ9_PIG UniProtKB/TrEMBL
  Q95KR0_PIG UniProtKB/TrEMBL
  Q95KR1_PIG UniProtKB/TrEMBL
VGNC ID VGNC:97952 ENTREZGENE