MAPT (microtubule associated protein tau) - Rat Genome Database

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Pathways
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Gene: MAPT (microtubule associated protein tau) Pan paniscus
Analyze
Symbol: MAPT
Name: microtubule associated protein tau
RGD ID: 11773069
Description: ENCODES a protein that exhibits apolipoprotein binding (ortholog); DNA binding (ortholog); enzyme binding (ortholog); INVOLVED IN adult walking behavior (ortholog); amyloid fibril formation (ortholog); axo-dendritic transport (ortholog); PARTICIPATES IN Reelin signaling pathway; ASSOCIATED WITH Alzheimer's disease (ortholog); Animal Disease Models (ortholog); anxiety disorder (ortholog); FOUND IN axolemma (ortholog); axon (ortholog); axonal growth cone (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: microtubule-associated protein tau; microtubule-associated protein tau pseudogene
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: Mhudiblu_PPA_v0 - Bonobo Mhudiblu_PPA_v0 Assembly
Position:
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21918,882,648 - 19,016,175 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11720,851,436 - 20,984,844 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01711,373,220 - 11,506,669 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11711,458,159 - 11,590,626 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1711,458,159 - 11,523,129 (-)Ensemblpanpan1.1panPan2
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
Alzheimer's disease  (ISO)
Animal Disease Models  (ISO)
anxiety disorder  (ISO)
Ataxia  (ISO)
atrial fibrillation  (ISO)
Brain Hypoxia-Ischemia  (ISO)
brain ischemia  (ISO)
breast cancer  (ISO)
cardiomyopathy  (ISO)
cognitive disorder  (ISO)
Cognitive Dysfunction  (ISO)
Creutzfeldt-Jakob disease  (ISO)
dementia  (ISO)
Drug-Induced Dyskinesia  (ISO)
epilepsy  (ISO)
essential tremor  (ISO)
Experimental Autoimmune Encephalomyelitis  (ISO)
Experimental Diabetes Mellitus  (ISO)
frontotemporal dementia  (ISO)
genetic disease  (ISO)
Gliosis  (ISO)
hepatocellular carcinoma  (ISO)
intellectual disability  (ISO)
Iron Overload  (ISO)
Koolen de Vries syndrome  (ISO)
late onset Parkinson's disease  (ISO)
learning disability  (ISO)
Memory Disorders  (ISO)
middle cerebral artery infarction  (ISO)
multiple system atrophy  (ISO)
Multiple System Atrophy (MSA) with Orthostatic Hypotension  (ISO)
neurodegenerative disease  (ISO)
obesity  (ISO)
Osteoarthritis, Hip  (ISO)
Parkinson's disease  (ISO)
Parkinsonism  (ISO)
Pick's disease  (ISO)
Premature Aging  (ISO)
progressive supranuclear palsy  (ISO)
Progressive Supranuclear Palsy Atypical  (ISO)
prostate cancer  (ISO)
Psychomotor Agitation  (ISO)
respiratory failure  (ISO)
Shy-Drager Syndrome  (ISO)
Spinal Cord Injuries  (ISO)
Splenomegaly  (ISO)
Sporadic Creutzfeldt-Jakob Disease  (ISO)
syndromic intellectual disability  (ISO)
tauopathy  (ISO)
temporal lobe epilepsy  (ISO)
traumatic brain injury  (ISO)
vascular dementia  (ISO)
Weight Gain  (ISO)
Weight Loss  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
adult walking behavior  (ISO)
amyloid fibril formation  (ISO)
axo-dendritic transport  (ISO)
axon extension  (ISO)
axonogenesis  (ISO)
DNA damage response  (ISO)
female pregnancy  (ISO)
intracellular distribution of mitochondria  (ISO)
intracellular transport  (ISO)
intrinsic apoptotic signaling pathway in response to oxidative stress  (ISO)
learning or memory  (ISO)
memory  (ISO)
microtubule cytoskeleton organization  (IEA,ISO)
microtubule polymerization  (ISO)
mitochondrion transport along microtubule  (ISO)
mRNA transport  (ISO)
negative regulation of establishment of protein localization to mitochondrion  (ISO)
negative regulation of gene expression  (ISO)
negative regulation of intracellular transport  (ISO)
negative regulation of mitochondrial fission  (ISO)
negative regulation of mitochondrial membrane potential  (ISO)
negative regulation of tubulin deacetylation  (ISO)
neuron migration  (ISO)
neuron projection development  (IEA)
positive regulation of axon extension  (ISO)
positive regulation of long-term synaptic depression  (ISO)
positive regulation of microtubule polymerization  (ISO)
positive regulation of neuron projection development  (ISO)
positive regulation of protein localization  (ISO)
positive regulation of protein localization to synapse  (ISO)
positive regulation of superoxide anion generation  (ISO)
protein homooligomerization  (ISO)
protein polymerization  (ISO)
regulation of autophagy  (ISO)
regulation of calcium-mediated signaling  (ISO)
regulation of cellular response to heat  (ISO)
regulation of microtubule cytoskeleton organization  (ISO)
regulation of microtubule polymerization or depolymerization  (ISO)
regulation of microtubule-based movement  (ISO)
response to lead ion  (ISO)
response to nutrient  (ISO)
supramolecular fiber organization  (ISO)
synapse assembly  (ISO)
synapse organization  (ISO)

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
MAPT
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21918,882,648 - 19,016,175 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11720,851,436 - 20,984,844 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01711,373,220 - 11,506,669 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11711,458,159 - 11,590,626 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1711,458,159 - 11,523,129 (-)Ensemblpanpan1.1panPan2
MAPT
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381745,894,554 - 46,028,334 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1745,894,527 - 46,028,334 (+)EnsemblGRCh38hg38GRCh38
GRCh371743,971,920 - 44,105,700 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361741,327,624 - 41,461,547 (+)NCBINCBI36Build 36hg18NCBI36
Build 341741,327,623 - 41,458,611NCBI
Celera1740,619,037 - 40,753,014 (+)NCBICelera
Cytogenetic Map17q21.31NCBI
HuRef1739,635,406 - 39,768,427 (+)NCBIHuRef
CHM1_11744,218,591 - 44,352,524 (+)NCBICHM1_1
T2T-CHM13v2.01746,756,177 - 46,889,953 (+)NCBIT2T-CHM13v2.0
Mapt
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3911104,120,235 - 104,222,916 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl11104,122,216 - 104,222,916 (+)EnsemblGRCm39 Ensembl
GRCm3811104,229,409 - 104,332,090 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl11104,231,390 - 104,332,090 (+)EnsemblGRCm38mm10GRCm38
MGSCv3711104,092,750 - 104,193,410 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3611104,047,526 - 104,148,186 (+)NCBIMGSCv36mm8
Celera11115,951,246 - 116,057,990 (+)NCBICelera
Cytogenetic Map11E1NCBI
cM Map1167.79NCBI
Mapt
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81089,638,618 - 89,736,108 (+)NCBIGRCr8
mRatBN7.21089,138,644 - 89,236,137 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1089,138,627 - 89,236,129 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1094,176,204 - 94,273,767 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01093,639,716 - 93,737,291 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01089,042,500 - 89,139,907 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01092,289,002 - 92,386,517 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1092,288,910 - 92,386,517 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01092,050,754 - 92,147,840 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41093,411,098 - 93,508,762 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11093,425,375 - 93,523,128 (+)NCBI
Celera1087,832,730 - 87,930,191 (+)NCBICelera
Cytogenetic Map10q32.1NCBI
Mapt
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495547810,225,823 - 10,271,442 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495547810,222,439 - 10,271,439 (-)NCBIChiLan1.0ChiLan1.0
MAPT
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.199,572,174 - 9,674,082 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl99,570,557 - 9,674,349 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha910,679,514 - 10,725,761 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0911,161,388 - 11,263,326 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl911,159,768 - 11,263,320 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1910,175,159 - 10,221,409 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0917,303,033 - 17,349,281 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0917,249,716 - 17,295,984 (+)NCBIUU_Cfam_GSD_1.0
Mapt
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440560216,714,614 - 16,813,155 (-)NCBIHiC_Itri_2
SpeTri2.0NW_0049365412,381,411 - 2,479,984 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
MAPT
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1217,095,587 - 17,211,373 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11217,098,259 - 17,211,483 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21217,123,502 - 17,234,041 (-)NCBISscrofa10.2Sscrofa10.2susScr3
MAPT
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11659,894,400 - 60,020,723 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1659,890,221 - 59,955,612 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366607730,612,597 - 30,742,938 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Mapt
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046248492,320,887 - 2,421,099 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSPPAT00000007531   ⟹   ENSPPAP00000001538
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl1711,458,159 - 11,523,129 (-)Ensembl
RefSeq Acc Id: ENSPPAT00000007535   ⟹   ENSPPAP00000001542
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl1711,458,159 - 11,523,129 (-)Ensembl
RefSeq Acc Id: ENSPPAT00000007541   ⟹   ENSPPAP00000001545
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl1711,458,159 - 11,523,129 (-)Ensembl
RefSeq Acc Id: ENSPPAT00000007614   ⟹   ENSPPAP00000001552
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl1711,462,318 - 11,523,129 (-)Ensembl
RefSeq Acc Id: ENSPPAT00000007682   ⟹   ENSPPAP00000001565
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl1711,462,318 - 11,523,129 (-)Ensembl
RefSeq Acc Id: ENSPPAT00000007731   ⟹   ENSPPAP00000001570
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl1711,462,318 - 11,523,129 (-)Ensembl
RefSeq Acc Id: ENSPPAT00000007744   ⟹   ENSPPAP00000001579
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl1711,462,318 - 11,507,297 (-)Ensembl
RefSeq Acc Id: XM_008965217   ⟹   XP_008963465
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v21918,882,705 - 19,016,175 (+)NCBI
NHGRI_mPanPan11720,851,436 - 20,984,844 (+)NCBI
Mhudiblu_PPA_v01711,373,220 - 11,506,669 (+)NCBI
PanPan1.11711,458,159 - 11,590,575 (-)NCBI
Sequence:
RefSeq Acc Id: XM_008965223   ⟹   XP_008963471
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v21918,882,648 - 19,016,175 (+)NCBI
NHGRI_mPanPan11720,851,436 - 20,984,844 (+)NCBI
Mhudiblu_PPA_v01711,373,387 - 11,506,669 (+)NCBI
PanPan1.11711,458,159 - 11,590,626 (-)NCBI
Sequence:
RefSeq Acc Id: XM_008965232   ⟹   XP_008963480
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v21918,882,709 - 19,016,175 (+)NCBI
NHGRI_mPanPan11720,851,436 - 20,984,844 (+)NCBI
Mhudiblu_PPA_v01711,373,387 - 11,506,669 (+)NCBI
PanPan1.11711,458,159 - 11,590,575 (-)NCBI
Sequence:
RefSeq Acc Id: XM_008965235   ⟹   XP_008963483
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v21918,882,648 - 19,016,175 (+)NCBI
NHGRI_mPanPan11720,851,436 - 20,984,844 (+)NCBI
Mhudiblu_PPA_v01711,373,370 - 11,506,669 (+)NCBI
PanPan1.11711,458,159 - 11,590,626 (-)NCBI
Sequence:
RefSeq Acc Id: XM_014341976   ⟹   XP_014197462
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v21918,882,672 - 19,016,175 (+)NCBI
NHGRI_mPanPan11720,851,436 - 20,984,844 (+)NCBI
Mhudiblu_PPA_v01711,373,389 - 11,506,669 (+)NCBI
PanPan1.11711,458,159 - 11,590,563 (-)NCBI
Sequence:
Reference Protein Sequences
RefSeq Acc Id: XP_008963483   ⟸   XM_008965235
- Peptide Label: isoform X4
- UniProtKB: A0A2R8Z9B6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008963471   ⟸   XM_008965223
- Peptide Label: isoform X2
- UniProtKB: A0A2R8Z9J4 (UniProtKB/TrEMBL),   A0A2R8Z9B6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008963480   ⟸   XM_008965232
- Peptide Label: isoform X3
- UniProtKB: A0A2R8Z9B6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008963465   ⟸   XM_008965217
- Peptide Label: isoform X1
- UniProtKB: A0A2R8ZFY4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_014197462   ⟸   XM_014341976
- Peptide Label: isoform X5
- UniProtKB: A0A2R8Z985 (UniProtKB/TrEMBL),   A0A2R8ZFZ1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSPPAP00000001570   ⟸   ENSPPAT00000007731
RefSeq Acc Id: ENSPPAP00000001579   ⟸   ENSPPAT00000007744
RefSeq Acc Id: ENSPPAP00000001542   ⟸   ENSPPAT00000007535
RefSeq Acc Id: ENSPPAP00000001538   ⟸   ENSPPAT00000007531
RefSeq Acc Id: ENSPPAP00000001545   ⟸   ENSPPAT00000007541
RefSeq Acc Id: ENSPPAP00000001552   ⟸   ENSPPAT00000007614
RefSeq Acc Id: ENSPPAP00000001565   ⟸   ENSPPAT00000007682


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSPPAG00000005022 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSPPAT00000007531.1 UniProtKB/TrEMBL
  ENSPPAT00000007535.1 UniProtKB/TrEMBL
  ENSPPAT00000007541.1 UniProtKB/TrEMBL
  ENSPPAT00000007614.1 UniProtKB/TrEMBL
  ENSPPAT00000007682.1 UniProtKB/TrEMBL
  ENSPPAT00000007731.1 UniProtKB/TrEMBL
  ENSPPAT00000007744.1 UniProtKB/TrEMBL
InterPro MAP2/MAP4/Tau UniProtKB/TrEMBL
  MAP_tubulin-bd_rpt UniProtKB/TrEMBL
  Tau UniProtKB/TrEMBL
KEGG Report pps:100987023 UniProtKB/TrEMBL
NCBI Gene MAPT ENTREZGENE
PANTHER MICROTUBULE-ASSOCIATED PROTEIN UniProtKB/TrEMBL
  MICROTUBULE-ASSOCIATED PROTEIN TAU UniProtKB/TrEMBL
Pfam Tubulin-binding UniProtKB/TrEMBL
PRINTS TAUPROTEIN UniProtKB/TrEMBL
PROSITE TAU_MAP_1 UniProtKB/TrEMBL
  TAU_MAP_2 UniProtKB/TrEMBL
UniProt A0A2R8Z985 ENTREZGENE, UniProtKB/TrEMBL
  A0A2R8Z9A6_PANPA UniProtKB/TrEMBL
  A0A2R8Z9B0_PANPA UniProtKB/TrEMBL
  A0A2R8Z9B6 ENTREZGENE, UniProtKB/TrEMBL
  A0A2R8Z9J4 ENTREZGENE, UniProtKB/TrEMBL
  A0A2R8ZFY4 ENTREZGENE, UniProtKB/TrEMBL
  A0A2R8ZFZ1 ENTREZGENE, UniProtKB/TrEMBL