RGD Reference Report - Microtubule-associated protein tau is essential for long-term depression in the hippocampus. - Rat Genome Database

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Microtubule-associated protein tau is essential for long-term depression in the hippocampus.

Authors: Kimura, T  Whitcomb, DJ  Jo, J  Regan, P  Piers, T  Heo, S  Brown, C  Hashikawa, T  Murayama, M  Seok, H  Sotiropoulos, I  Kim, E  Collingridge, GL  Takashima, A  Cho, K 
Citation: Kimura T, etal., Philos Trans R Soc Lond B Biol Sci. 2013 Dec 2;369(1633):20130144. doi: 10.1098/rstb.2013.0144. Print 2014 Jan 5.
RGD ID: 10412705
Pubmed: PMID:24298146   (View Abstract at PubMed)
PMCID: PMC3843876   (View Article at PubMed Central)
DOI: DOI:10.1098/rstb.2013.0144   (Journal Full-text)

The microtubule-associated protein tau is a principal component of neurofibrillary tangles, and has been identified as a key molecule in Alzheimer's disease and other tauopathies. However, it is unknown how a protein that is primarily located in axons is involved in a disease that is believed to have a synaptic origin. To investigate a possible synaptic function of tau, we studied synaptic plasticity in the hippocampus and found a selective deficit in long-term depression (LTD) in tau knockout mice in vivo and in vitro, an effect that was replicated by RNAi knockdown of tau in vitro. We found that the induction of LTD is associated with the glycogen synthase kinase-3-mediated phosphorylation of tau. These observations demonstrate that tau has a critical physiological function in LTD.



Gene Ontology Annotations    Click to see Annotation Detail View

Biological Process

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
MaptRatpositive regulation of long-term synaptic depression  IMP  RGD 

Cellular Component

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
MaptRatdendrite  IDA  RGD 

Objects Annotated

Genes (Rattus norvegicus)
Mapt  (microtubule-associated protein tau)


Additional Information