RGD Reference Report - Genetic analysis of MAPT haplotype diversity in frontotemporal dementia. - Rat Genome Database

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Genetic analysis of MAPT haplotype diversity in frontotemporal dementia.

Authors: Laws, SM  Friedrich, P  Diehl-Schmid, J  Muller, J  Ibach, B  Bauml, J  Eisele, T  Forstl, H  Kurz, A  Riemenschneider, M 
Citation: Laws SM, etal., Neurobiol Aging. 2008 Aug;29(8):1276-8. Epub 2007 Mar 26.
RGD ID: 8158108
Pubmed: PMID:17386961   (View Abstract at PubMed)
DOI: DOI:10.1016/j.neurobiolaging.2007.02.019   (Journal Full-text)

The H1 haplotype of the tau gene, MAPT, has been linked to the sporadic tauopathies corticobasal degeneration and progressive supranuclear palsy; however, there have been inconsistent findings regarding association with frontotemporal dementia (FTD). We investigated MAPT haplotype diversity, in 171 sporadic FTD and 186 healthy controls individuals, and report no single marker or haplotype association with increased risk or changes in age at onset. These findings do not support an association of MAPT with FTD but do not rule out its association with other tauopathies.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
frontotemporal dementia no_associationIAGP 8158108DNA:haplotypeRGD 
frontotemporal dementia no_associationISOMAPT (Homo sapiens)8158108; 8158108DNA:haplotypeRGD 

Objects Annotated

Genes (Rattus norvegicus)
Mapt  (microtubule-associated protein tau)

Genes (Mus musculus)
Mapt  (microtubule-associated protein tau)

Genes (Homo sapiens)
MAPT  (microtubule associated protein tau)


Additional Information