RGD Reference Report - Transient cerebral ischemia induces site-specific hyperphosphorylation of tau protein. - Rat Genome Database

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Transient cerebral ischemia induces site-specific hyperphosphorylation of tau protein.

Authors: Wen, Y  Yang, S  Liu, R  Simpkins, JW 
Citation: Wen Y, etal., Brain Res. 2004 Oct 1;1022(1-2):30-8.
RGD ID: 1599927
Pubmed: PMID:15353210   (View Abstract at PubMed)
DOI: DOI:10.1016/j.brainres.2004.05.106   (Journal Full-text)

Neurofibrillary tangles (NFTs) are a pathological hallmark of many neurodegenerative diseases including Alzheimer's disease (AD), Parkinson's disease (PD), and frontotemporal dementia with parkinsonism linked to chromosome 17 (FTDP17). However, the cellular origin and the consequence of the NFT formation are poorly understood. Epidemiological evidence suggests a much higher occurrence of dementia in stroke patients. This may represent the pathogenesis of sporadic AD, which accounts for the majority of AD occurrence. Here we show that after a transient cerebral ischemia, hyperphosphorylated tau accumulates in cortical neurons in a site-specific manner. The hyperphosphorylated tau presents a conformation similar to those present in human tauopathies, and colocalizes largely with signs of apoptosis. Our current study suggests that tau hyperphosphorylation may contribute to the brain damage induced by transient cerebral ischemia, and may be involved in the pathogenesis of neurodegenerative disorders in patients after stroke. Further, these results indicate that ischemic neuronal damage and apoptosis associates with tau hyperphosphorylation, and potentially NFTs formation. Finally, our results also suggest that neuronal apoptosis may be a therapeutic target in preventing tauopathy-related neurodegenerative diseases.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
brain ischemia  IDA 1599927protein:increased phosphorylationRGD 
brain ischemia  ISOMapt (Rattus norvegicus)1599927protein:increased phosphorylationRGD 

Objects Annotated

Genes (Rattus norvegicus)
Mapt  (microtubule-associated protein tau)

Genes (Mus musculus)
Mapt  (microtubule-associated protein tau)


Additional Information