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ONTOLOGY REPORT - ANNOTATIONS


Term:positive regulation of amyloid fibril formation
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Accession:GO:1905908 term browser browse the term
Definition:Any process that activates or increases the frequency, rate or extent of amyloid fibril formation.
Comment:Although deposition of amyloid fibrils is associated with diseases, e.g. Alzheimer's disease, amyloid formation is a normal process. Disease occurs when the balance between amyloid formation and clearance is disrupted (reviewed e.g. in PMID:29654159 and PMID:28937655). An example of a normal amyloid complex is composed of human RIP1 and RIP3 kinases (PMID:22817896).
Synonyms:exact_synonym: up regulation of amyloid fibril formation;   upregulation of amyloid fibril formation
 narrow_synonym: activation of amyloid fibril formation
 related_synonym: activation of amyloid fibril assembly;   activation of amyloid structure assembly;   activation of amyloid structure formation;   positive regulation of amyloid fibril assembly;   positive regulation of amyloid structure assembly;   positive regulation of amyloid structure formation;   up regulation of amyloid fibril assembly;   up regulation of amyloid structure assembly;   up regulation of amyloid structure formation;   upregulation of amyloid fibril assembly;   upregulation of amyloid structure assembly;   upregulation of amyloid structure formation


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positive regulation of amyloid fibril formation term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G App amyloid beta precursor protein ISO (PMID:19660551) RGD PMID:19660551 NCBI chr11:24,425,013...24,641,872
Ensembl chr11:24,425,005...24,641,858
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G Psen1 presenilin 1 ISO UniProtKB:P05067 (PMID:11880515) RGD PMID:11880515 NCBI chr 6:107,169,514...107,221,000
Ensembl chr 6:107,169,528...107,216,798
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20027
    metabolic process 12278
      positive regulation of metabolic process 4057
        positive regulation of macromolecule metabolic process 3759
          positive regulation of protein metabolic process 1815
            positive regulation of amyloid fibril formation 2
Path 2
Term Annotations click to browse term
  biological_process 20027
    biological regulation 13773
      regulation of biological process 13075
        regulation of metabolic process 6985
          positive regulation of metabolic process 4057
            positive regulation of macromolecule metabolic process 3759
              positive regulation of protein metabolic process 1815
                positive regulation of amyloid fibril formation 2
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.