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ONTOLOGY REPORT - ANNOTATIONS

Term:positive regulation of amyloid fibril formation
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Accession:GO:1905908 term browser browse the term
Definition:Any process that activates or increases the frequency, rate or extent of amyloid fibril formation.
Comment:Although deposition of amyloid fibrils is associated with diseases, e.g. Alzheimer's disease, amyloid formation is a normal process. Disease occurs when the balance between amyloid formation and clearance is disrupted (reviewed e.g. in PMID:29654159 and PMID:28937655). An example of a normal amyloid complex is composed of human RIP1 and RIP3 kinases (PMID:22817896).
Synonyms:exact_synonym: up regulation of amyloid fibril formation;   upregulation of amyloid fibril formation
 narrow_synonym: activation of amyloid fibril formation
 related_synonym: activation of amyloid fibril assembly;   activation of amyloid structure assembly;   activation of amyloid structure formation;   positive regulation of amyloid fibril assembly;   positive regulation of amyloid structure assembly;   positive regulation of amyloid structure formation;   up regulation of amyloid fibril assembly;   up regulation of amyloid structure assembly;   up regulation of amyloid structure formation;   upregulation of amyloid fibril assembly;   upregulation of amyloid structure assembly;   upregulation of amyloid structure formation


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positive regulation of amyloid fibril formation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G App amyloid beta precursor protein involved_in ISO
IEA		 (PMID:19660551)
GO_REF:0000107		 RGD
Ensembl		 PMID:19660551 GO_REF:0000107 NCBI chr11:24,019,774...24,236,584
Ensembl chr11:24,019,778...24,236,561 		JBrowse link
G Psen1 presenilin 1 involved_in ISO UniProtKB:P05067 (PMID:11880515) RGD PMID:11880515 NCBI chr 6:103,323,052...103,375,088
Ensembl chr 6:103,323,120...103,371,650 		JBrowse link
G Usp8 ubiquitin specific peptidase 8 involved_in ISO (PMID:27444016) RGD PMID:27444016 NCBI chr 3:113,962,136...114,009,683
Ensembl chr 3:113,962,164...114,009,666 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20292
    metabolic process 11720
      positive regulation of metabolic process 3799
        positive regulation of macromolecule metabolic process 3474
          positive regulation of protein metabolic process 1080
            positive regulation of amyloid fibril formation 3
Path 2
Term Annotations click to browse term
  biological_process 20292
    biological regulation 13633
      regulation of biological process 13220
        regulation of metabolic process 6575
          positive regulation of metabolic process 3799
            positive regulation of macromolecule metabolic process 3474
              positive regulation of protein metabolic process 1080
                positive regulation of amyloid fibril formation 3
paths to the root