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ONTOLOGY REPORT - ANNOTATIONS


Term:negative regulation of amyloid fibril formation
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Accession:GO:1905907 term browser browse the term
Definition:Any process that stops, prevents or reduces the frequency, rate or extent of amyloid fibril formation.
Comment:Although deposition of amyloid fibrils is associated with diseases, e.g. Alzheimer's disease, amyloid formation is a normal process. Disease occurs when the balance between amyloid formation and clearance is disrupted (reviewed e.g. in PMID:29654159 and PMID:28937655). An example of a normal amyloid complex is composed of human RIP1 and RIP3 kinases (PMID:22817896).
Synonyms:exact_synonym: down regulation of amyloid fibril formation;   downregulation of amyloid fibril formation
 narrow_synonym: inhibition of amyloid fibril formation
 related_synonym: down regulation of amyloid fibril assembly;   down regulation of amyloid structure assembly;   down regulation of amyloid structure formation;   downregulation of amyloid fibril assembly;   downregulation of amyloid structure assembly;   downregulation of amyloid structure formation;   inhibition of amyloid fibril assembly;   inhibition of amyloid structure assembly;   inhibition of amyloid structure formation;   negative regulation of amyloid fibril assembly;   negative regulation of amyloid structure assembly;   negative regulation of amyloid structure formation


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negative regulation of amyloid fibril formation term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Apoe apolipoprotein E ISO
ISS
(MGI:MGI:3621689|PMID:14741101)
GO_REF:0000024
RGD
UniProt
PMID:14741101 GO_REF:0000024, MGI:MGI:3621689 NCBI chr 1:80,612,894...80,616,820
Ensembl chr 1:80,612,895...80,617,057
JBrowse link
G Clu clusterin ISO
IEA
ISS
(PMID:22179788)
GO_REF:0000107
(MGI:MGI:3621689|PMID:14741101)
GO_REF:0000024
RGD
Ensembl
UniProt
PMID:14741101, PMID:22179788 GO_REF:0000024, GO_REF:0000107, MGI:MGI:3621689 NCBI chr15:42,626,612...42,665,858
Ensembl chr15:42,640,146...42,665,857
JBrowse link
G Cryab crystallin, alpha B ISO (PMID:23106396) RGD PMID:23106396 NCBI chr 8:55,178,543...55,182,546
Ensembl chr 8:55,178,289...55,182,545
JBrowse link
G Hspg2 heparan sulfate proteoglycan 2 ISO UniProtKB:P05067:PRO_0000000093 (PMID:21126803) RGD PMID:21126803 NCBI chr 5:155,812,096...155,913,751 JBrowse link
G Ldlr low density lipoprotein receptor IEA
ISO
GO_REF:0000107
UniProtKB:P05067|UniProtKB:P49768 (MGI:MGI:4415751|PMID:20005821)
Ensembl
RGD
PMID:20005821 GO_REF:0000107, MGI:MGI:4415751 NCBI chr 8:22,750,425...22,773,305
Ensembl chr 8:22,750,336...22,774,903
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20027
    metabolic process 12278
      negative regulation of metabolic process 3307
        negative regulation of macromolecule metabolic process 3043
          negative regulation of protein metabolic process 1197
            negative regulation of amyloid fibril formation 5
Path 2
Term Annotations click to browse term
  biological_process 20027
    biological regulation 13773
      regulation of biological process 13075
        regulation of metabolic process 6985
          negative regulation of metabolic process 3307
            negative regulation of macromolecule metabolic process 3043
              negative regulation of protein metabolic process 1197
                negative regulation of amyloid fibril formation 5
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.