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ONTOLOGY REPORT - ANNOTATIONS


Term:negative regulation of amyloid fibril formation
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Accession:GO:1905907 term browser browse the term
Definition:Any process that stops, prevents or reduces the frequency, rate or extent of amyloid fibril formation.
Comment:Although deposition of amyloid fibrils is associated with diseases, e.g. Alzheimer's disease, amyloid formation is a normal process. Disease occurs when the balance between amyloid formation and clearance is disrupted (reviewed e.g. in PMID:29654159 and PMID:28937655). An example of a normal amyloid complex is composed of human RIP1 and RIP3 kinases (PMID:22817896).
Synonyms:exact_synonym: down regulation of amyloid fibril formation;   downregulation of amyloid fibril formation
 narrow_synonym: inhibition of amyloid fibril formation
 related_synonym: down regulation of amyloid fibril assembly;   down regulation of amyloid structure assembly;   down regulation of amyloid structure formation;   downregulation of amyloid fibril assembly;   downregulation of amyloid structure assembly;   downregulation of amyloid structure formation;   inhibition of amyloid fibril assembly;   inhibition of amyloid structure assembly;   inhibition of amyloid structure formation;   negative regulation of amyloid fibril assembly;   negative regulation of amyloid structure assembly;   negative regulation of amyloid structure formation


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negative regulation of amyloid fibril formation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Apoe apolipoprotein E involved_in ISS
ISO
GO_REF:0000024
(MGI:3621689|PMID:14741101)
UniProt
RGD
PMID:14741101 GO_REF:0000024 MGI:3621689 NCBI chr 1:79,353,924...79,357,852
Ensembl chr 1:79,353,916...79,357,932
JBrowse link
G Clu clusterin involved_in ISO
ISS
IEA
(PMID:22179788)
(MGI:3621689|PMID:14741101)
GO_REF:0000024
GO_REF:0000107
RGD
UniProt
Ensembl
PMID:14741101 PMID:22179788 GO_REF:0000024 GO_REF:0000107 MGI:3621689 NCBI chr15:40,161,068...40,200,315
Ensembl chr15:40,174,617...40,200,315
JBrowse link
G Cryab crystallin, alpha B involved_in ISO (PMID:23106396) RGD PMID:23106396 NCBI chr 8:51,093,441...51,099,161
Ensembl chr 8:51,093,441...51,099,157
JBrowse link
G Hspg2 heparan sulfate proteoglycan 2 involved_in ISO UniProtKB:P05067:PRO_0000000093 (PMID:21126803) RGD PMID:21126803 NCBI chr 5:149,677,437...149,778,594 JBrowse link
G Ldlr low density lipoprotein receptor involved_in IEA
ISO
GO_REF:0000107
UniProtKB:P05067|UniProtKB:P49768 (MGI:4415751|PMID:20005821)
Ensembl
RGD
PMID:20005821 GO_REF:0000107 MGI:4415751 NCBI chr 8:20,270,020...20,292,981
Ensembl chr 8:20,270,041...20,294,580
JBrowse link
G Pfdn1 prefoldin subunit 1 involved_in ISO (PMID:23614719) RGD PMID:23614719 NCBI chr18:28,014,145...28,067,148
Ensembl chr18:28,014,145...28,067,064
JBrowse link
G Pfdn2 prefoldin subunit 2 involved_in ISO (PMID:23614719) RGD PMID:23614719 NCBI chr13:83,772,301...83,791,367
Ensembl chr13:83,753,877...83,790,504
JBrowse link
G Pfdn4 prefoldin subunit 4 involved_in ISO (PMID:23614719) RGD PMID:23614719 NCBI chr 3:159,303,064...159,311,221
Ensembl chr 3:159,303,071...159,311,219
JBrowse link
G Pfdn5 prefoldin subunit 5 involved_in ISO (PMID:23614719) RGD PMID:23614719 NCBI chr 7:133,451,778...133,456,516
Ensembl chr 7:133,451,453...133,456,516
JBrowse link
G Pfdn6 prefoldin subunit 6 involved_in ISO (PMID:23614719) RGD PMID:23614719 NCBI chr20:4,945,959...4,947,433
Ensembl chr20:4,945,959...4,947,433
JBrowse link
G Trem2 triggering receptor expressed on myeloid cells 2 involved_in ISO (MGI:6313424|PMID:30617257) RGD PMID:30617257 MGI:6313424 NCBI chr 9:12,647,605...12,654,190
Ensembl chr 9:12,647,259...12,654,170
JBrowse link
G Vbp1 VHL binding protein 1 involved_in ISO (PMID:23614719) RGD PMID:23614719

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 19492
    metabolic process 11797
      negative regulation of metabolic process 3180
        negative regulation of macromolecule metabolic process 2956
          negative regulation of protein metabolic process 1119
            negative regulation of amyloid fibril formation 12
Path 2
Term Annotations click to browse term
  biological_process 19492
    biological regulation 13513
      regulation of biological process 12769
        regulation of metabolic process 6740
          negative regulation of metabolic process 3180
            negative regulation of macromolecule metabolic process 2956
              negative regulation of protein metabolic process 1119
                negative regulation of amyloid fibril formation 12
paths to the root