negative regulation of amyloid fibril formation - Ontology Report - Rat Genome Database

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ONTOLOGY REPORT - ANNOTATIONS	{{ watchLinkText }}

Term:	negative regulation of amyloid fibril formation	go back to main search page
Accession:	GO:1905907	browse the term
Definition:	Any process that stops, prevents or reduces the frequency, rate or extent of amyloid fibril formation.
Comment:	Although deposition of amyloid fibrils is associated with diseases, e.g. Alzheimer's disease, amyloid formation is a normal process. Disease occurs when the balance between amyloid formation and clearance is disrupted (reviewed e.g. in PMID:29654159 and PMID:28937655). An example of a normal amyloid complex is composed of human RIP1 and RIP3 kinases (PMID:22817896).
Synonyms:	exact_synonym:	down regulation of amyloid fibril formation; downregulation of amyloid fibril formation
	narrow_synonym:	inhibition of amyloid fibril formation
	related_synonym:	down regulation of amyloid fibril assembly; down regulation of amyloid structure assembly; down regulation of amyloid structure formation; downregulation of amyloid fibril assembly; downregulation of amyloid structure assembly; downregulation of amyloid structure formation; inhibition of amyloid fibril assembly; inhibition of amyloid structure assembly; inhibition of amyloid structure formation; negative regulation of amyloid fibril assembly; negative regulation of amyloid structure assembly; negative regulation of amyloid structure formation

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Genes (13)

negative regulation of amyloid fibril formation

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

apolipoprotein E

involved_in

GO_REF:0000024
(MGI:3621689|PMID:14741101)

GO_REF:0000024 MGI:3621689

NCBI chr 1:79,353,924...79,357,852
Ensembl chr 1:79,353,916...79,357,932

G

clusterin

involved_in

GO_REF:0000107
GO_REF:0000024
(MGI:3621689|PMID:14741101)
(PMID:22179788)

Ensembl
UniProt
RGD

PMID:14741101 PMID:22179788

GO_REF:0000024 GO_REF:0000107 MGI:3621689

NCBI chr15:40,161,068...40,200,315
Ensembl chr15:40,174,617...40,200,315

G

crystallin, alpha B

involved_in

(PMID:23106396)

NCBI chr 8:51,093,441...51,099,161
Ensembl chr 8:51,093,441...51,099,157

G

heparan sulfate proteoglycan 2

involved_in

UniProtKB:P05067:PRO_0000000093 (PMID:21126803)

NCBI chr 5:149,677,437...149,778,594
Ensembl chr 5:149,677,476...149,778,594

G

low density lipoprotein receptor

involved_in

UniProtKB:P05067|UniProtKB:P49768 (MGI:4415751|PMID:20005821)

NCBI chr 8:20,270,020...20,292,981
Ensembl chr 8:20,270,041...20,294,580

G

microRNA 31

acts_upstream_of

UniProtKB:P05067 (PMID:32069773)

NCBI chr 5:103,599,038...103,599,143

G

prefoldin subunit 1

involved_in

(PMID:23614719)

NCBI chr18:28,014,145...28,067,148
Ensembl chr18:28,014,145...28,067,064

G

prefoldin subunit 2

involved_in

(PMID:23614719)

NCBI chr13:83,772,301...83,791,367
Ensembl chr13:83,753,877...83,790,504

G

prefoldin subunit 4

involved_in

(PMID:23614719)

NCBI chr 3:159,303,064...159,311,221
Ensembl chr 3:159,303,071...159,311,219

G

prefoldin subunit 5

involved_in

(PMID:23614719)

NCBI chr 7:133,451,778...133,456,516
Ensembl chr 7:133,451,453...133,456,516

G

prefoldin subunit 6

involved_in

(PMID:23614719)

NCBI chr20:4,945,959...4,947,433
Ensembl chr20:4,945,959...4,947,433

G

triggering receptor expressed on myeloid cells 2

involved_in

(MGI:6313424|PMID:30617257)

NCBI chr 9:12,647,605...12,654,190
Ensembl chr 9:12,647,259...12,654,170

G

VHL binding protein 1

involved_in

(PMID:23614719)

Term paths to the root

Path 1
Term	Annotations
biological_process	19746
metabolic process	12044
negative regulation of metabolic process	3296
negative regulation of macromolecule metabolic process	3052
negative regulation of protein metabolic process	1162
negative regulation of amyloid fibril formation	13
Path 2
Term	Annotations
biological_process	19746
biological regulation	13447
regulation of biological process	13040
regulation of metabolic process	6832
negative regulation of metabolic process	3296
negative regulation of macromolecule metabolic process	3052
negative regulation of protein metabolic process	1162
negative regulation of amyloid fibril formation	13

paths to the root