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ONTOLOGY REPORT - ANNOTATIONS

Term:regulation of isotype switching
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Accession:GO:0045191 term browser browse the term
Definition:Any process that modulates the frequency, rate or extent of isotype switching.
Synonyms:exact_synonym: regulation of class switch recombination;   regulation of class switching;   regulation of isotype switch recombination

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regulation of isotype switching term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aplf aprataxin and PNKP like factor acts_upstream_of_or_within ISO (PMID:21211721) MGI PMID:21211721 NCBI chrNW_004955424:16,338,546...16,449,074
Ensembl chrNW_004955424:16,336,228...16,448,766 		JBrowse link
G Supt6h SPT6 homolog, histone chaperone and transcription elongation factor involved_in ISO (MGI:5004983|PMID:21518874) UniProt PMID:21518874 MGI:5004983 NCBI chrNW_004955481:4,462,270...4,497,364
Ensembl chrNW_004955481:4,462,270...4,497,364 		JBrowse link
negative regulation of isotype switching term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Parp3 poly(ADP-ribose) polymerase family member 3 involved_in ISO (MGI:6214451|PMID:26000965) UniProt PMID:26000965 MGI:6214451 NCBI chrNW_004955532:3,591,484...3,597,549
Ensembl chrNW_004955532:3,591,499...3,597,549 		JBrowse link
negative regulation of isotype switching to IgE isotypes term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bcl6 BCL6 transcription repressor acts_upstream_of_or_within ISO (PMID:10490661) MGI PMID:10490661 NCBI chrNW_004955420:19,998,960...20,021,200
Ensembl chrNW_004955420:19,998,742...20,022,259 		JBrowse link
G Foxp3 forkhead box P3 acts_upstream_of_or_within ISO (PMID:16275384) MGI PMID:16275384 NCBI chrNW_004955543:731,707...742,606
Ensembl chrNW_004955543:731,707...742,606 		JBrowse link
G Ndfip1 Nedd4 family interacting protein 1 acts_upstream_of_or_within ISO (PMID:17137798) MGI PMID:17137798 NCBI chrNW_004955415:11,643,846...11,666,131
Ensembl chrNW_004955415:11,643,846...11,666,131 		JBrowse link
positive regulation of interleukin-4-dependent isotype switching to IgE isotypes term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Tnfsf4 TNF superfamily member 4 involved_in ISO (MGI:3763508|PMID:12496423) BHF-UCL PMID:12496423 MGI:3763508 NCBI chrNW_004955406:13,477,077...13,493,309
Ensembl chrNW_004955406:13,477,077...13,493,309 		JBrowse link
positive regulation of isotype switching term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Exosc3 exosome component 3 acts_upstream_of_or_within ISO (PMID:21255825) MGI PMID:21255825 NCBI chrNW_004955419:28,683,896...28,692,006
Ensembl chrNW_004955419:28,683,896...28,693,395 		JBrowse link
G Exosc6 exosome component 6 acts_upstream_of_or_within ISO (PMID:21255825) MGI PMID:21255825 NCBI chrNW_004955484:3,088,133...3,089,551
Ensembl chrNW_004955484:3,088,624...3,089,472 		JBrowse link
G Hmces 5-hydroxymethylcytosine binding, ES cell specific involved_in ISO (MGI:6393148|PMID:31806351) UniProt PMID:31806351 MGI:6393148 NCBI chrNW_004955429:13,616,647...13,638,657
Ensembl chrNW_004955429:13,616,647...13,661,389 		JBrowse link
G Kmt5b lysine methyltransferase 5B involved_in ISO (MGI:6370097|PMID:28114273) UniProt PMID:28114273 MGI:6370097 NCBI chrNW_004955422:17,626,606...17,684,890
Ensembl chrNW_004955422:17,647,530...17,682,132 		JBrowse link
G Kmt5c lysine methyltransferase 5C involved_in ISO (MGI:6370097|PMID:28114273) UniProt PMID:28114273 MGI:6370097 NCBI chrNW_004955567:895,334...901,240
Ensembl chrNW_004955567:894,608...900,578 		JBrowse link
G Mad2l2 mitotic arrest deficient 2 like 2 involved_in ISO (PMID:29656893) UniProt PMID:29656893 NCBI chrNW_004955486:2,191,903...2,197,193
Ensembl chrNW_004955486:2,191,903...2,198,538 		JBrowse link
G Paxip1 PAX interacting protein 1 involved_in ISO (MGI:4821506|PMID:20671152) UniProt PMID:20671152 MGI:4821506 NCBI chrNW_004955491:8,177,422...8,219,764
Ensembl chrNW_004955491:8,177,422...8,219,766 		JBrowse link
G Rif1 replication timing regulatory factor 1 involved_in ISO (MGI:5468036|PMID:23306439), (MGI:5476381|PMID:23333305), (MGI:5490831|PMID:23333306) UniProt PMID:23306439 PMID:23333305 PMID:23333306 MGI:5468036 MGI:5476381 MGI:5490831 NCBI chrNW_004955440:16,977,710...17,047,809
Ensembl chrNW_004955440:16,979,042...17,041,748 		JBrowse link
G Shld1 shieldin complex subunit 1 involved_in ISO (PMID:29656893) UniProt PMID:29656893 NCBI chrNW_004955415:16,180,074...16,282,937
Ensembl chrNW_004955415:16,180,051...16,280,864 		JBrowse link
G Shld2 shieldin complex subunit 2 involved_in ISO (PMID:29656893) UniProt PMID:29656893 NCBI chrNW_004955510:6,021,477...6,114,745
Ensembl chrNW_004955510:6,075,510...6,114,898 		JBrowse link
G Tfrc transferrin receptor involved_in ISO (PMID:26642240) UniProt PMID:26642240 NCBI chrNW_004955420:12,348,392...12,372,714
Ensembl chrNW_004955420:12,348,821...12,372,691 		JBrowse link
G Tp53bp1 tumor protein p53 binding protein 1 involved_in ISO (PMID:23760478)
(MGI:3041657|PMID:15077110), (MGI:3046005|PMID:15159415)
(PMID:23345425)		 UniProt PMID:15077110 PMID:15159415 PMID:23345425 PMID:23760478 MGI:3041657 MGI:3046005 NCBI chrNW_004955416:9,962,736...10,035,433
Ensembl chrNW_004955416:9,962,897...10,035,278 		JBrowse link
positive regulation of isotype switching to IgA isotypes term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Mlh1 mutL homolog 1 involved_in ISO (MGI:1342394|PMID:10430621) CAFA PMID:10430621 MGI:1342394 NCBI chrNW_004955421:3,890,291...3,936,892
Ensembl chrNW_004955421:3,890,306...3,936,526 		JBrowse link
G Msh2 mutS homolog 2 involved_in ISO (MGI:1342394|PMID:10430621) CAFA PMID:10430621 MGI:1342394 NCBI chrNW_004955441:14,188,315...14,247,608
Ensembl chrNW_004955441:14,187,805...14,247,698 		JBrowse link
G Nsd2 nuclear receptor binding SET domain protein 2 acts_upstream_of_or_within ISO (PMID:23241889) MGI PMID:23241889 NCBI chrNW_004955514:1,084,522...1,162,624
Ensembl chrNW_004955514:1,069,085...1,162,624 		JBrowse link
G Pms2 PMS1 homolog 2, mismatch repair system component involved_in ISO (MGI:1342394|PMID:10430621) CAFA PMID:10430621 MGI:1342394 NCBI chrNW_004955460:13,762,854...13,791,462 JBrowse link
G Tgfb1 transforming growth factor beta 1 acts_upstream_of_or_within ISO (PMID:14988498) MGI PMID:14988498 NCBI chrNW_004955555:274,405...288,441
Ensembl chrNW_004955555:270,652...288,441 		JBrowse link
positive regulation of isotype switching to IgE isotypes term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Clcf1 cardiotrophin like cytokine factor 1 involved_in ISO (MGI:3777853|PMID:12023368) BHF-UCL PMID:12023368 MGI:3777853 NCBI chrNW_004955422:18,097,779...18,108,628
Ensembl chrNW_004955422:18,097,779...18,108,628 		JBrowse link
G Il4 interleukin 4 acts_upstream_of_or_within ISO (PMID:14988498) MGI PMID:14988498 NCBI chrNW_004955408:4,058,052...4,065,999 JBrowse link
G Stat6 signal transducer and activator of transcription 6 acts_upstream_of_or_within ISO (PMID:10490661) MGI PMID:10490661 NCBI chrNW_004955458:4,833,417...4,847,956
Ensembl chrNW_004955458:4,833,515...4,843,273 		JBrowse link
positive regulation of isotype switching to IgG isotypes term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Atad5 ATPase family AAA domain containing 5 acts_upstream_of_or_within ISO (PMID:25404367) MGI PMID:25404367 NCBI chrNW_004955481:6,986,128...7,031,113
Ensembl chrNW_004955481:6,986,502...7,030,742 		JBrowse link
G Cd28 CD28 molecule acts_upstream_of_or_within ISO (PMID:7688139) MGI PMID:7688139 NCBI chrNW_004955457:11,159,769...11,253,099
Ensembl chrNW_004955457:11,162,282...11,192,991 		JBrowse link
G Cd40 CD40 molecule acts_upstream_of_or_within ISO (PMID:12882831) MGI PMID:12882831 NCBI chrNW_004955445:11,191,817...11,202,156
Ensembl chrNW_004955445:11,190,603...11,202,093 		JBrowse link
G Ifng interferon gamma acts_upstream_of_or_within ISO (PMID:12882831) MGI PMID:12882831 NCBI chrNW_004955458:14,643,333...14,648,020
Ensembl chrNW_004955458:14,643,313...14,648,045 		JBrowse link
G Il2 interleukin 2 acts_upstream_of_or_within ISO (PMID:1830926) MGI PMID:1830926 NCBI chrNW_004955428:18,163,010...18,168,157
Ensembl chrNW_004955428:18,162,467...18,168,265 		JBrowse link
G Il4 interleukin 4 acts_upstream_of_or_within ISO (PMID:12882831), (PMID:14988498) MGI PMID:12882831 PMID:14988498 NCBI chrNW_004955408:4,058,052...4,065,999 JBrowse link
G Mlh1 mutL homolog 1 involved_in ISO (MGI:1342394|PMID:10430621) CAFA PMID:10430621 MGI:1342394 NCBI chrNW_004955421:3,890,291...3,936,892
Ensembl chrNW_004955421:3,890,306...3,936,526 		JBrowse link
G Msh2 mutS homolog 2 involved_in ISO (MGI:1342394|PMID:10430621) CAFA PMID:10430621 MGI:1342394 NCBI chrNW_004955441:14,188,315...14,247,608
Ensembl chrNW_004955441:14,187,805...14,247,698 		JBrowse link
G Pagr1 PAXIP1 associated glutamate rich protein 1 involved_in ISO (MGI:5752090|PMID:26744420) UniProt PMID:26744420 MGI:5752090 NCBI chrNW_004955493:7,142,048...7,144,836
Ensembl chrNW_004955493:7,142,272...7,144,389 		JBrowse link
G Paxip1 PAX interacting protein 1 involved_in ISO (MGI:5752090|PMID:26744420) UniProt PMID:26744420 MGI:5752090 NCBI chrNW_004955491:8,177,422...8,219,764
Ensembl chrNW_004955491:8,177,422...8,219,766 		JBrowse link
G Pms2 PMS1 homolog 2, mismatch repair system component involved_in ISO (MGI:1342394|PMID:10430621) CAFA PMID:10430621 MGI:1342394 NCBI chrNW_004955460:13,762,854...13,791,462 JBrowse link
G Ptprc protein tyrosine phosphatase receptor type C acts_upstream_of_or_within ISO (PMID:9015183) MGI PMID:9015183 NCBI chrNW_004955406:35,005,577...35,127,395
Ensembl chrNW_004955406:35,005,214...35,129,552 		JBrowse link
G Tbx21 T-box transcription factor 21 acts_upstream_of_or_within ISO (PMID:12882831) MGI PMID:12882831 NCBI chrNW_004955451:13,315,237...13,317,888
Ensembl chrNW_004955451:13,315,859...13,325,937 		JBrowse link
regulation of isotype switching to IgG isotypes term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Foxp3 forkhead box P3 acts_upstream_of_or_within ISO (PMID:16275384) MGI PMID:16275384 NCBI chrNW_004955543:731,707...742,606
Ensembl chrNW_004955543:731,707...742,606 		JBrowse link
G Il27ra interleukin 27 receptor subunit alpha acts_upstream_of_or_within ISO (PMID:11057672) MGI PMID:11057672 NCBI chrNW_004955415:32,749,682...32,762,532
Ensembl chrNW_004955415:32,749,094...32,761,882 		JBrowse link
G Ndfip1 Nedd4 family interacting protein 1 acts_upstream_of_or_within ISO (PMID:17137798) MGI PMID:17137798 NCBI chrNW_004955415:11,643,846...11,666,131
Ensembl chrNW_004955415:11,643,846...11,666,131 		JBrowse link
G Slc15a4 solute carrier family 15 member 4 involved_in ISO (MGI:5649169|PMID:25310967) UniProt PMID:25310967 MGI:5649169 NCBI chrNW_004955482:2,327,137...2,343,980 JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 12362
    immune system process 1980
      production of molecular mediator of immune response 215
        regulation of production of molecular mediator of immune response 186
          regulation of immunoglobulin production 78
            regulation of isotype switching 37
              negative regulation of isotype switching + 4
              positive regulation of isotype switching + 29
              regulation of isotype switching to IgA isotypes + 5
              regulation of isotype switching to IgD isotypes + 0
              regulation of isotype switching to IgE isotypes + 7
              regulation of isotype switching to IgG isotypes + 17
Path 2
Term Annotations click to browse term
  biological_process 12362
    metabolic process 7489
      organic substance metabolic process 7172
        organic cyclic compound metabolic process 4096
          nucleobase-containing compound metabolic process 3737
            nucleic acid metabolic process 3370
              DNA metabolic process 754
                DNA recombination 253
                  somatic cell DNA recombination 72
                    somatic diversification of immune receptors via germline recombination within a single locus 72
                      somatic recombination of immunoglobulin gene segments 60
                        somatic recombination of immunoglobulin genes involved in immune response 53
                          isotype switching 53
                            regulation of isotype switching 37
                              negative regulation of isotype switching + 4
                              positive regulation of isotype switching + 29
                              regulation of isotype switching to IgA isotypes + 5
                              regulation of isotype switching to IgD isotypes + 0
                              regulation of isotype switching to IgE isotypes + 7
                              regulation of isotype switching to IgG isotypes + 17
paths to the root