Supt6h (SPT6 homolog, histone chaperone and transcription elongation factor) - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models   new Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Gene: Supt6h (SPT6 homolog, histone chaperone and transcription elongation factor) Chinchilla lanigera
Analyze
Symbol: Supt6h
Name: SPT6 homolog, histone chaperone and transcription elongation factor
RGD ID: 8791496
Description: ENCODES a protein that exhibits histone binding (ortholog); INVOLVED IN blastocyst formation (ortholog); positive regulation of transcription elongation by RNA polymerase II (ortholog); regulation of isotype switching (ortholog); ASSOCIATED WITH genetic disease (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: SPT6 homolog, histone chaperone; suppressor of Ty 6 homolog (S. cerevisiae); transcription elongation factor SPT6
RGD Orthologs
Human
Mouse
Rat
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: ChiLan1.0 - Chinchilla ChiLan1.0 Assembly
Position:
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554814,462,270 - 4,497,364 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554814,462,270 - 4,497,364 (-)NCBIChiLan1.0ChiLan1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Transitive Annotation Pipeline Automated assignment of GO, PW and RDO ISO annotations across species
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
Supt6h
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554814,462,270 - 4,497,364 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554814,462,270 - 4,497,364 (-)NCBIChiLan1.0ChiLan1.0
SUPT6H
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381728,662,205 - 28,702,679 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1728,662,198 - 28,702,679 (+)EnsemblGRCh38hg38GRCh38
GRCh371726,989,223 - 27,029,697 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361724,013,429 - 24,053,376 (+)NCBINCBI36Build 36hg18NCBI36
Build 341724,013,428 - 24,053,375NCBI
Celera1723,848,329 - 23,888,285 (+)NCBICelera
Cytogenetic Map17q11.2NCBI
HuRef1723,197,936 - 23,237,879 (+)NCBIHuRef
CHM1_11727,051,774 - 27,091,721 (+)NCBICHM1_1
T2T-CHM13v2.01729,604,969 - 29,645,463 (+)NCBIT2T-CHM13v2.0
Supt6
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391178,097,575 - 78,136,798 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1178,097,572 - 78,136,813 (-)EnsemblGRCm39 Ensembl
GRCm381178,206,749 - 78,245,972 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1178,206,746 - 78,245,987 (-)EnsemblGRCm38mm10GRCm38
MGSCv371178,020,251 - 78,059,205 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361178,845,457 - 78,884,252 (-)NCBIMGSCv36mm8
MGSCv361178,023,219 - 78,061,897 (-)NCBIMGSCv36mm8
Cytogenetic Map11B5NCBI
cM Map1146.74NCBI
Supt6h
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81063,601,990 - 63,638,851 (-)NCBIGRCr8
mRatBN7.21063,103,920 - 63,140,780 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1063,103,921 - 63,140,780 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1067,736,213 - 67,773,064 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01067,241,567 - 67,278,419 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01062,712,445 - 62,749,485 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01065,470,470 - 65,507,581 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1065,470,471 - 65,507,581 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01066,129,656 - 66,166,767 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41064,388,961 - 64,425,858 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11064,402,868 - 64,439,227 (+)NCBI
Celera1062,081,610 - 62,118,466 (-)NCBICelera
Cytogenetic Map10q25NCBI
SUPT6H
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21935,757,177 - 35,797,082 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11737,637,681 - 37,677,257 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01728,073,288 - 28,113,041 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11728,578,199 - 28,617,347 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1728,578,199 - 28,617,292 (-)Ensemblpanpan1.1panPan2
SUPT6H
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1942,859,154 - 42,896,044 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl942,859,361 - 42,904,487 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha942,015,365 - 42,052,125 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0943,677,523 - 43,714,296 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl943,677,539 - 43,714,274 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1942,460,966 - 42,497,722 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0942,753,208 - 42,789,947 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0942,830,961 - 42,867,947 (+)NCBIUU_Cfam_GSD_1.0
Supt6h
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440560242,000,694 - 42,032,668 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365384,878,662 - 4,910,597 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365384,878,645 - 4,910,613 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SUPT6H
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1244,917,633 - 44,940,273 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11244,916,716 - 44,940,732 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21246,891,999 - 46,925,640 (+)NCBISscrofa10.2Sscrofa10.2susScr3
SUPT6H
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11622,444,864 - 22,470,248 (+)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_0236660757,653,593 - 7,693,087 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Supt6h
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247861,238,082 - 1,271,875 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247861,226,131 - 1,271,872 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSCLAT00000009357   ⟹   ENSCLAP00000009228
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0 EnsemblNW_0049554814,462,270 - 4,497,364 (-)Ensembl
RefSeq Acc Id: XM_005402740   ⟹   XP_005402797
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_0049554814,462,270 - 4,497,364 (-)NCBI
Sequence:
RefSeq Acc Id: XM_013503386   ⟹   XP_013358840
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_0049554814,462,270 - 4,497,364 (-)NCBI
Sequence:
RefSeq Acc Id: XM_013503387   ⟹   XP_013358841
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_0049554814,462,270 - 4,497,364 (-)NCBI
Sequence:
RefSeq Acc Id: XM_013503388   ⟹   XP_013358842
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_0049554814,462,270 - 4,497,364 (-)NCBI
Sequence:
RefSeq Acc Id: XM_013503389   ⟹   XP_013358843
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_0049554814,462,270 - 4,497,364 (-)NCBI
Sequence:
RefSeq Acc Id: XM_013503390   ⟹   XP_013358844
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_0049554814,462,270 - 4,497,364 (-)NCBI
Sequence:
RefSeq Acc Id: XM_013503391   ⟹   XP_013358845
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_0049554814,462,270 - 4,497,364 (-)NCBI
Sequence:
Reference Protein Sequences
RefSeq Acc Id: XP_005402797   ⟸   XM_005402740
- UniProtKB: A0A8C2YMC6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_013358842   ⟸   XM_013503388
- UniProtKB: A0A8C2YMC6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_013358844   ⟸   XM_013503390
- UniProtKB: A0A8C2YMC6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_013358843   ⟸   XM_013503389
- UniProtKB: A0A8C2YMC6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_013358845   ⟸   XM_013503391
- UniProtKB: A0A8C2YMC6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_013358840   ⟸   XM_013503386
- UniProtKB: A0A8C2YMC6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_013358841   ⟸   XM_013503387
- UniProtKB: A0A8C2YMC6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSCLAP00000009228   ⟸   ENSCLAT00000009357
Protein Domains
S1 motif   SH2


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCLAG00000006422 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCLAT00000009357 ENTREZGENE
  ENSCLAT00000009357.1 UniProtKB/TrEMBL
Gene3D-CATH 1.10.10.2740 UniProtKB/TrEMBL
  1.10.10.650 UniProtKB/TrEMBL
  1.10.3500.10 UniProtKB/TrEMBL
  2.40.50.140 UniProtKB/TrEMBL
  3.30.420.140 UniProtKB/TrEMBL
  3.30.505.10 UniProtKB/TrEMBL
  Spt6, helix-hairpin-helix domain UniProtKB/TrEMBL
InterPro HHH_9 UniProtKB/TrEMBL
  NA-bd_OB-fold UniProtKB/TrEMBL
  RNaseH-like_sf UniProtKB/TrEMBL
  RuvA_2-like UniProtKB/TrEMBL
  S1_domain UniProtKB/TrEMBL
  SH2 UniProtKB/TrEMBL
  SH2_dom_sf UniProtKB/TrEMBL
  Spt6_acidic_N_dom UniProtKB/TrEMBL
  Spt6_death-like UniProtKB/TrEMBL
  Spt6_HHH UniProtKB/TrEMBL
  Spt6_HTH_DNA-bd_dom UniProtKB/TrEMBL
  Spt6_SH2 UniProtKB/TrEMBL
  Spt6_SH2_C UniProtKB/TrEMBL
  Spt6_SH2_N UniProtKB/TrEMBL
  Spt6_YqgF UniProtKB/TrEMBL
  Tex-like_dom_sf UniProtKB/TrEMBL
  Tex-like_HTH_dom_sf UniProtKB/TrEMBL
  TF_Spt6 UniProtKB/TrEMBL
  YqgF/RNaseH-like_dom UniProtKB/TrEMBL
  YqgF/RNaseH-like_dom_sf UniProtKB/TrEMBL
NCBI Gene Supt6h ENTREZGENE
PANTHER PTHR10145 UniProtKB/TrEMBL
  TRANSCRIPTION ELONGATION FACTOR SPT6 UniProtKB/TrEMBL
Pfam HHH_7 UniProtKB/TrEMBL
  HHH_9 UniProtKB/TrEMBL
  HTH_44 UniProtKB/TrEMBL
  PF00575 UniProtKB/TrEMBL
  SH2_2 UniProtKB/TrEMBL
  SPT6_acidic UniProtKB/TrEMBL
  YqgF UniProtKB/TrEMBL
PIRSF Spt6 UniProtKB/TrEMBL
PROSITE PS50126 UniProtKB/TrEMBL
  SH2 UniProtKB/TrEMBL
SMART SH2 UniProtKB/TrEMBL
  SM00316 UniProtKB/TrEMBL
  YqgFc UniProtKB/TrEMBL
Superfamily-SCOP SSF47781 UniProtKB/TrEMBL
  SSF50249 UniProtKB/TrEMBL
  SSF53098 UniProtKB/TrEMBL
  SSF55550 UniProtKB/TrEMBL
  Tex N-terminal region-like UniProtKB/TrEMBL
UniProt A0A8C2YMC6 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2019-11-26 Supt6h  SPT6 homolog, histone chaperone and transcription elongation factor  Supt6h  SPT6 homolog, histone chaperone  Symbol and/or name change 5135510 APPROVED
2016-08-16 Supt6h  SPT6 homolog, histone chaperone    suppressor of Ty 6 homolog (S. cerevisiae)  Symbol and/or name change 5135510 APPROVED