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ONTOLOGY REPORT - ANNOTATIONS


Term:positive regulation of isotype switching
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Accession:GO:0045830 term browser browse the term
Definition:Any process that activates or increases the frequency, rate or extent of isotype switching.
Synonyms:exact_synonym: positive regulation of class switch recombination;   positive regulation of class switching;   positive regulation of isotype switch recombination;   up regulation of isotype switching;   upregulation of isotype switching
 narrow_synonym: activation of isotype switching;   stimulation of isotype switching



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positive regulation of isotype switching term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Exosc3 exosome component 3 acts_upstream_of_or_within ISO (MGI:5009766|PMID:21255825) RGD PMID:21255825 MGI:5009766 NCBI chr 5:59,573,849...59,579,065
Ensembl chr 5:59,573,886...59,579,060
JBrowse link
G Exosc6 exosome component 6 acts_upstream_of_or_within ISO (MGI:5009766|PMID:21255825) RGD PMID:21255825 MGI:5009766 NCBI chr19:39,021,308...39,023,535
Ensembl chr19:39,022,183...39,023,515
JBrowse link
G Hmces 5-hydroxymethylcytosine binding, ES cell specific involved_in ISS
ISO
GO_REF:0000024
(MGI:6393148|PMID:31806351)
UniProt
RGD
PMID:31806351 GO_REF:0000024 MGI:6393148 NCBI chr 4:120,392,812...120,415,616 JBrowse link
G Kmt5b lysine methyltransferase 5B involved_in ISS
ISO
GO_REF:0000024
(MGI:6370097|PMID:28114273)
UniProt
RGD
PMID:28114273 GO_REF:0000024 MGI:6370097 NCBI chr 1:201,000,444...201,049,819
Ensembl chr 1:201,000,444...201,049,819
JBrowse link
G Kmt5c lysine methyltransferase 5C involved_in ISS
ISO
GO_REF:0000024
(MGI:6370097|PMID:28114273)
UniProt
RGD
PMID:28114273 GO_REF:0000024 MGI:6370097 NCBI chr 1:69,099,531...69,107,145
Ensembl chr 1:69,099,539...69,107,145
JBrowse link
G Mad2l2 mitotic arrest deficient 2 like 2 involved_in ISO (PMID:29656893) RGD PMID:29656893 NCBI chr 5:158,563,545...158,576,698
Ensembl chr 5:158,563,567...158,576,693
JBrowse link
G Paxip1 PAX interacting protein 1 involved_in ISO (MGI:4821506|PMID:20671152) RGD PMID:20671152 MGI:4821506 NCBI chr 4:7,524,887...7,576,663
Ensembl chr 4:7,525,004...7,576,548
JBrowse link
G Rif1 replication timing regulatory factor 1 involved_in ISO (MGI:5468036|PMID:23306439), (MGI:5476381|PMID:23333305), (MGI:5490831|PMID:23333306) RGD PMID:23306439 PMID:23333305 PMID:23333306 MGI:5468036 MGI:5476381 MGI:5490831 NCBI chr 3:36,554,689...36,607,961
Ensembl chr 3:36,554,697...36,603,617
JBrowse link
G Shld1 shieldin complex subunit 1 involved_in ISO
IBA
(PMID:29656893)
PMID:21873635
RGD PMID:29656893 PMID:21873635 RGD:13792537 NCBI chr 3:119,938,695...120,011,068
Ensembl chr 3:119,938,833...120,009,550
JBrowse link
G Shld2 shieldin complex subunit 2 involved_in ISO (PMID:29656893) RGD PMID:29656893 NCBI chr16:9,544,940...9,640,323
Ensembl chr16:9,548,660...9,639,965
JBrowse link
G Shld3 shieldin complex subunit 3 involved_in ISO (PMID:29656893) RGD PMID:29656893 NCBI chr 2:35,294,956...35,301,865 JBrowse link
G Tfrc transferrin receptor involved_in ISS
ISO
GO_REF:0000024
(PMID:26642240)
UniProt
RGD
PMID:26642240 GO_REF:0000024 NCBI chr11:68,163,413...68,185,257
Ensembl chr11:68,163,413...68,185,257
JBrowse link
G Tp53bp1 tumor protein p53 binding protein 1 involved_in ISO (PMID:23345425), (PMID:23760478)
(MGI:3041657|PMID:15077110), (MGI:3046005|PMID:15159415)
RGD PMID:15077110 PMID:15159415 PMID:23345425 PMID:23760478 MGI:3041657 MGI:3046005 NCBI chr 3:108,166,574...108,270,229
Ensembl chr 3:108,169,980...108,269,822
JBrowse link
positive regulation of interleukin-4-dependent isotype switching to IgE isotypes term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Tnfsf4 TNF superfamily member 4 involved_in ISO (MGI:3763508|PMID:12496423) RGD PMID:12496423 MGI:3763508 NCBI chr13:73,723,329...73,746,809
Ensembl chr13:73,723,329...73,746,788
JBrowse link
positive regulation of isotype switching to IgA isotypes term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Mlh1 mutL homolog 1 involved_in IEA
ISO
GO_REF:0000107
(MGI:1342394|PMID:10430621)
Ensembl
RGD
PMID:10430621 GO_REF:0000107 MGI:1342394 NCBI chr 8:111,196,468...111,233,721
Ensembl chr 8:111,196,468...111,233,617
JBrowse link
G Msh2 mutS homolog 2 involved_in IEA
ISO
GO_REF:0000107
(MGI:1342394|PMID:10430621)
Ensembl
RGD
PMID:10430621 GO_REF:0000107 MGI:1342394 NCBI chr 6:6,813,793...6,872,960
Ensembl chr 6:6,813,795...6,872,938
JBrowse link
G Nsd2 nuclear receptor binding SET domain protein 2 acts_upstream_of_or_within ISO (MGI:5462481|PMID:23241889) RGD PMID:23241889 MGI:5462481 NCBI chr14:76,833,194...76,911,304
Ensembl chr14:76,835,637...76,913,641
JBrowse link
G Pms2 PMS1 homolog 2, mismatch repair system component involved_in ISO UniProtKB:Q9JK91 (MGI:1342394|PMID:10430621) RGD PMID:10430621 MGI:1342394 NCBI chr12:10,676,819...10,701,161
Ensembl chr12:10,676,764...10,701,066
JBrowse link
G Tgfb1 transforming growth factor, beta 1 involved_in
acts_upstream_of_or_within
ISS
ISO
GO_REF:0000024
(PMID:14988498)
AgBase
RGD
PMID:14988498 GO_REF:0000024 NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847
JBrowse link
G Tnfsf13 TNF superfamily member 13 involved_in
acts_upstream_of_or_within
IBA
ISO
PMID:21873635
(PMID:14988498)
MGI:3038886 (MGI:3037416|PMID:14988498)
RGD PMID:14988498 PMID:21873635 MGI:3037416, RGD:13792537 NCBI chr10:54,400,054...54,403,723
Ensembl chr10:54,400,065...54,403,042
JBrowse link
positive regulation of isotype switching to IgE isotypes term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Clcf1 cardiotrophin-like cytokine factor 1 involved_in ISO (MGI:3777853|PMID:12023368) RGD PMID:12023368 MGI:3777853 NCBI chr 1:201,507,763...201,517,607
Ensembl chr 1:201,507,859...201,517,605
JBrowse link
G Il4 interleukin 4 involved_in
acts_upstream_of_or_within
IBA
ISO
PMID:21873635
(MGI:3037416|PMID:14988498)
RGD PMID:14988498 PMID:21873635 MGI:3037416, RGD:13792537 NCBI chr10:37,771,203...37,776,750
Ensembl chr10:37,771,203...37,776,750
JBrowse link
G Stat6 signal transducer and activator of transcription 6 acts_upstream_of_or_within ISO MGI:107187 (MGI:1345885|PMID:10490661) RGD PMID:10490661 MGI:1345885 NCBI chr 7:63,480,229...63,497,551
Ensembl chr 7:63,479,642...63,498,495
JBrowse link
positive regulation of isotype switching to IgG isotypes term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Atad5 ATPase family, AAA domain containing 5 acts_upstream_of_or_within ISO MGI:4127920 (MGI:5763555|PMID:25404367) RGD PMID:25404367 MGI:5763555 NCBI chr10:65,070,682...65,118,489
Ensembl chr10:65,070,689...65,117,845
JBrowse link
G Cd28 Cd28 molecule involved_in
acts_upstream_of_or_within
IEA
ISO
GO_REF:0000107
MGI:1857150 (MGI:62368|PMID:7688139)
Ensembl
RGD
PMID:7688139 GO_REF:0000107 MGI:62368 NCBI chr 9:62,166,324...62,194,674
Ensembl chr 9:62,166,192...62,194,685
JBrowse link
G Cd40 CD40 molecule involved_in
acts_upstream_of_or_within
IBA
ISO
PMID:21873635
(MGI:2670820|PMID:12882831)
RGD PMID:12882831 PMID:21873635 MGI:2670820, RGD:13792537 NCBI chr 3:153,790,372...153,805,279
Ensembl chr 3:153,790,449...153,805,534
JBrowse link
G Ifng interferon gamma acts_upstream_of_or_within ISO (MGI:2670820|PMID:12882831) RGD PMID:12882831 MGI:2670820 NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375
JBrowse link
G Il2 interleukin 2 acts_upstream_of_or_within ISO MGI:1857191 (MGI:87443|PMID:1830926) RGD PMID:1830926 MGI:87443 NCBI chr 2:120,004,862...120,009,566
Ensembl chr 2:120,004,862...120,009,566
JBrowse link
G Il4 interleukin 4 involved_in
acts_upstream_of_or_within
IBA
ISO
PMID:21873635
(MGI:2670820|PMID:12882831), (MGI:3037416|PMID:14988498)
RGD PMID:12882831 PMID:14988498 PMID:21873635 MGI:2670820 MGI:3037416, RGD:13792537 NCBI chr10:37,771,203...37,776,750
Ensembl chr10:37,771,203...37,776,750
JBrowse link
G Mlh1 mutL homolog 1 involved_in IEA
ISO
GO_REF:0000107
(MGI:1342394|PMID:10430621)
Ensembl
RGD
PMID:10430621 GO_REF:0000107 MGI:1342394 NCBI chr 8:111,196,468...111,233,721
Ensembl chr 8:111,196,468...111,233,617
JBrowse link
G Msh2 mutS homolog 2 involved_in IEA
ISO
GO_REF:0000107
(MGI:1342394|PMID:10430621)
Ensembl
RGD
PMID:10430621 GO_REF:0000107 MGI:1342394 NCBI chr 6:6,813,793...6,872,960
Ensembl chr 6:6,813,795...6,872,938
JBrowse link
G Pagr1 Paxip1-associated glutamate-rich protein 1 involved_in ISO (MGI:5752090|PMID:26744420) RGD PMID:26744420 MGI:5752090 NCBI chr 1:181,622,708...181,624,996 JBrowse link
G Paxip1 PAX interacting protein 1 involved_in ISO (MGI:5752090|PMID:26744420) RGD PMID:26744420 MGI:5752090 NCBI chr 4:7,524,887...7,576,663
Ensembl chr 4:7,525,004...7,576,548
JBrowse link
G Pms2 PMS1 homolog 2, mismatch repair system component involved_in ISO UniProtKB:Q9JK91 (MGI:1342394|PMID:10430621) RGD PMID:10430621 MGI:1342394 NCBI chr12:10,676,819...10,701,161
Ensembl chr12:10,676,764...10,701,066
JBrowse link
G Ptprc protein tyrosine phosphatase, receptor type, C acts_upstream_of_or_within ISO MGI:2181288 (MGI:85031|PMID:9015183) RGD PMID:9015183 MGI:85031 NCBI chr13:49,596,193...49,708,283
Ensembl chr13:49,596,193...49,708,692
JBrowse link
G Tbx21 T-box transcription factor 21 acts_upstream_of_or_within ISO MGI:2180194 (MGI:2670820|PMID:12882831) RGD PMID:12882831 MGI:2670820 NCBI chr10:82,082,322...82,098,831
Ensembl chr10:82,082,322...82,098,831
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 19497
    developmental process 6889
      positive regulation of developmental process 1504
        positive regulation of isotype switching 31
          positive regulation of isotype switching to IgA isotypes 6
          positive regulation of isotype switching to IgD isotypes 0
          positive regulation of isotype switching to IgE isotypes + 4
          positive regulation of isotype switching to IgG isotypes 13
Path 2
Term Annotations click to browse term
  biological_process 19497
    metabolic process 11824
      cellular metabolic process 10719
        cellular aromatic compound metabolic process 5635
          nucleobase-containing compound metabolic process 5410
            nucleic acid metabolic process 4926
              DNA metabolic process 913
                DNA recombination 329
                  somatic cell DNA recombination 78
                    somatic diversification of immune receptors via germline recombination within a single locus 78
                      somatic recombination of immunoglobulin gene segments 66
                        somatic recombination of immunoglobulin genes involved in immune response 58
                          isotype switching 58
                            regulation of isotype switching 43
                              positive regulation of isotype switching 31
                                positive regulation of isotype switching to IgA isotypes 6
                                positive regulation of isotype switching to IgD isotypes 0
                                positive regulation of isotype switching to IgE isotypes + 4
                                positive regulation of isotype switching to IgG isotypes 13
paths to the root