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ONTOLOGY REPORT - ANNOTATIONS

Term:positive regulation of isotype switching
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Accession:GO:0045830 term browser browse the term
Definition:Any process that activates or increases the frequency, rate or extent of isotype switching.
Synonyms:exact_synonym: positive regulation of class switch recombination;   positive regulation of class switching;   positive regulation of isotype switch recombination;   up regulation of isotype switching;   upregulation of isotype switching
 narrow_synonym: activation of isotype switching;   stimulation of isotype switching

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positive regulation of isotype switching term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Exosc3 exosome component 3 ISO (MGI:5009766|PMID:21255825) RGD PMID:21255825 MGI:5009766 NCBI chr 5:60,866,498...60,871,734
Ensembl chr 5:60,868,502...60,871,705 		JBrowse link
G Exosc6 exosome component 6 ISO (MGI:5009766|PMID:21255825) RGD PMID:21255825 MGI:5009766 NCBI chr19:43,190,879...43,193,164
Ensembl chr19:43,191,390...43,192,208 		JBrowse link
G Hmces 5-hydroxymethylcytosine binding, ES cell specific involved_in ISS
ISO		 GO_REF:0000024
(MGI:6393148|PMID:31806351)		 UniProt
RGD		 PMID:31806351 GO_REF:0000024 MGI:6393148 NCBI chr 4:119,841,088...119,864,115
Ensembl chr 4:119,815,139...119,864,114 		JBrowse link
G Kmt5b lysine methyltransferase 5B involved_in ISS
ISO		 GO_REF:0000024
(MGI:6370097|PMID:28114273)		 UniProt
RGD		 PMID:28114273 GO_REF:0000024 MGI:6370097 NCBI chr 1:219,000,844...219,050,211
Ensembl chr 1:219,000,844...219,050,211 		JBrowse link
G Kmt5c lysine methyltransferase 5C involved_in ISS
ISO		 GO_REF:0000024
(MGI:6370097|PMID:28114273)		 UniProt
RGD		 PMID:28114273 GO_REF:0000024 MGI:6370097 NCBI chr 1:72,666,662...72,674,271
Ensembl chr 1:72,666,665...72,674,271 		JBrowse link
G Mad2l2 mitotic arrest deficient 2 like 2 involved_in ISO (PMID:29656893) RGD PMID:29656893 NCBI chr 5:164,943,183...164,956,255
Ensembl chr 5:164,950,917...164,956,255 		JBrowse link
G Paxip1 PAX interacting protein 1 ISO (MGI:4821506|PMID:20671152) RGD PMID:20671152 MGI:4821506 NCBI chr 4:3,956,931...4,008,326
Ensembl chr 4:3,959,640...4,008,326 		JBrowse link
G Rif1 replication timing regulatory factor 1 ISO (MGI:5468036|PMID:23306439), (MGI:5476381|PMID:23333305), (MGI:5490831|PMID:23333306) RGD PMID:23306439 PMID:23333305 PMID:23333306 MGI:5468036 MGI:5476381 MGI:5490831 NCBI chr 3:37,599,540...37,648,818
Ensembl chr 3:37,599,728...37,647,631 		JBrowse link
G Shld1 shieldin complex subunit 1 involved_in ISO
IBA		 (PMID:29656893)
PMID:21873635		 RGD PMID:29656893, PMID:21873635, PMID:21873635 RGD:13792537, RGD:13792537 NCBI chr 3:125,318,682...125,396,705
Ensembl chr 3:125,320,680...125,396,821 		JBrowse link
G Shld2 shieldin complex subunit 2 involved_in ISO (PMID:29656893) RGD PMID:29656893 NCBI chr16:10,570,307...10,661,528
Ensembl chr16:10,570,314...10,661,528 		JBrowse link
G Shld3 shieldin complex subunit 3 involved_in ISO (PMID:29656893) RGD PMID:29656893
G Tfrc transferrin receptor involved_in ISO
ISS		 (PMID:26642240)
GO_REF:0000024		 RGD
UniProt		 PMID:26642240 GO_REF:0000024 NCBI chr11:71,397,423...71,419,263
Ensembl chr11:71,397,383...71,419,223 		JBrowse link
G Tp53bp1 tumor protein p53 binding protein 1 involved_in ISO (PMID:23345425), (PMID:23760478)
(MGI:3041657|PMID:15077110), (MGI:3046005|PMID:15159415)		 RGD PMID:15077110 PMID:15159415 PMID:23345425 PMID:23760478 MGI:3041657 MGI:3046005 NCBI chr 3:113,160,030...113,259,701
Ensembl chr 3:113,160,000...113,231,790 		JBrowse link
positive regulation of interleukin-4-dependent isotype switching to IgE isotypes term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Tnfsf4 TNF superfamily member 4 ISO (MGI:3763508|PMID:12496423) RGD PMID:12496423 MGI:3763508 NCBI chr13:79,269,973...79,293,775
Ensembl chr13:79,269,973...79,293,778 		JBrowse link
positive regulation of isotype switching to IgA isotypes term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Mlh1 mutL homolog 1 involved_in IEA
ISO		 GO_REF:0000107
(MGI:1342394|PMID:10430621)		 Ensembl
RGD		 PMID:10430621 GO_REF:0000107 MGI:1342394 NCBI chr 8:119,486,655...119,523,716
Ensembl chr 8:119,486,691...119,523,964 		JBrowse link
G Msh2 mutS homolog 2 involved_in IEA
ISO		 GO_REF:0000107
(MGI:1342394|PMID:10430621)		 Ensembl
RGD		 PMID:10430621 GO_REF:0000107 MGI:1342394 NCBI chr 6:11,215,951...11,274,916
Ensembl chr 6:11,215,963...11,274,932 		JBrowse link
G Nsd2 nuclear receptor binding SET domain protein 2 ISO (MGI:5462481|PMID:23241889) RGD PMID:23241889 MGI:5462481 NCBI chr14:82,119,210...82,196,501
Ensembl chr14:82,119,210...82,171,480 		JBrowse link
G Pms2 PMS1 homolog 2, mismatch repair system component ISO UniProtKB:Q9JK91 (MGI:1342394|PMID:10430621) RGD PMID:10430621 MGI:1342394 NCBI chr12:12,714,394...12,738,654
Ensembl chr12:12,714,394...12,738,641 		JBrowse link
G Tgfb1 transforming growth factor, beta 1 involved_in ISO
ISS		 (PMID:14988498)
GO_REF:0000024		 RGD
AgBase		 PMID:14988498 GO_REF:0000024 NCBI chr 1:82,480,875...82,497,196
Ensembl chr 1:82,480,195...82,497,199 		JBrowse link
G Tnfsf13 TNF superfamily member 13 involved_in ISO
IBA		 (PMID:14988498)
PMID:21873635
MGI:3038886 (MGI:3037416|PMID:14988498)		 RGD PMID:14988498, PMID:21873635, PMID:21873635 MGI:3037416, RGD:13792537, RGD:13792537 NCBI chr10:56,286,964...56,290,680
Ensembl chr10:56,286,887...56,289,952 		JBrowse link
positive regulation of isotype switching to IgE isotypes term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Clcf1 cardiotrophin-like cytokine factor 1 ISO (MGI:3777853|PMID:12023368) RGD PMID:12023368 MGI:3777853 NCBI chr 1:219,468,866...219,472,445
Ensembl chr 1:219,468,675...219,472,654 		JBrowse link
G Il4 interleukin 4 involved_in ISO
IBA		 (MGI:3037416|PMID:14988498)
PMID:21873635		 RGD PMID:14988498, PMID:21873635, PMID:21873635 MGI:3037416, RGD:13792537, RGD:13792537 NCBI chr10:38,963,979...38,969,531
Ensembl chr10:38,963,979...38,969,531 		JBrowse link
G Stat6 signal transducer and activator of transcription 6 ISO MGI:107187 (MGI:1345885|PMID:10490661) RGD PMID:10490661 MGI:1345885 NCBI chr 7:70,946,228...70,963,542
Ensembl chr 7:70,946,228...70,964,484 		JBrowse link
positive regulation of isotype switching to IgG isotypes term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Atad5 ATPase family, AAA domain containing 5 ISO MGI:4127920 (MGI:5763555|PMID:25404367) RGD PMID:25404367 MGI:5763555 NCBI chr10:67,427,042...67,475,825
Ensembl chr10:67,427,066...67,473,649 		JBrowse link
G Cd28 Cd28 molecule IEA
ISO		 GO_REF:0000107
MGI:1857150 (MGI:62368|PMID:7688139)		 Ensembl
RGD		 PMID:7688139 GO_REF:0000107 MGI:62368 NCBI chr 9:67,546,408...67,573,858
Ensembl chr 9:67,546,408...67,571,871 		JBrowse link
G Cd40 CD40 molecule involved_in ISO
IBA		 (MGI:2670820|PMID:12882831)
PMID:21873635		 RGD PMID:12882831, PMID:21873635, PMID:21873635 MGI:2670820, RGD:13792537, RGD:13792537 NCBI chr 3:161,519,789...161,534,943
Ensembl chr 3:161,519,743...161,534,704 		JBrowse link
G Ifng interferon gamma ISO (MGI:2670820|PMID:12882831) RGD PMID:12882831 MGI:2670820 NCBI chr 7:61,337,383...61,341,419
Ensembl chr 7:61,337,381...61,341,419 		JBrowse link
G Il2 interleukin 2 ISO MGI:1857191 (MGI:87443|PMID:1830926) RGD PMID:1830926 MGI:87443 NCBI chr 2:123,847,150...123,851,854
Ensembl chr 2:123,847,150...123,851,854 		JBrowse link
G Il4 interleukin 4 involved_in ISO
IBA		 (MGI:2670820|PMID:12882831), (MGI:3037416|PMID:14988498)
PMID:21873635		 RGD PMID:12882831 PMID:14988498, PMID:21873635, PMID:21873635 MGI:2670820 MGI:3037416, RGD:13792537, RGD:13792537 NCBI chr10:38,963,979...38,969,531
Ensembl chr10:38,963,979...38,969,531 		JBrowse link
G Mlh1 mutL homolog 1 involved_in IEA
ISO		 GO_REF:0000107
(MGI:1342394|PMID:10430621)		 Ensembl
RGD		 PMID:10430621 GO_REF:0000107 MGI:1342394 NCBI chr 8:119,486,655...119,523,716
Ensembl chr 8:119,486,691...119,523,964 		JBrowse link
G Msh2 mutS homolog 2 involved_in IEA
ISO		 GO_REF:0000107
(MGI:1342394|PMID:10430621)		 Ensembl
RGD		 PMID:10430621 GO_REF:0000107 MGI:1342394 NCBI chr 6:11,215,951...11,274,916
Ensembl chr 6:11,215,963...11,274,932 		JBrowse link
G Pagr1 Paxip1-associated glutamate-rich protein 1 ISO (MGI:5752090|PMID:26744420) RGD PMID:26744420 MGI:5752090 NCBI chr 1:198,448,790...198,451,078
Ensembl chr 1:198,449,040...198,450,688 		JBrowse link
G Paxip1 PAX interacting protein 1 ISO (MGI:5752090|PMID:26744420) RGD PMID:26744420 MGI:5752090 NCBI chr 4:3,956,931...4,008,326
Ensembl chr 4:3,959,640...4,008,326 		JBrowse link
G Pms2 PMS1 homolog 2, mismatch repair system component ISO UniProtKB:Q9JK91 (MGI:1342394|PMID:10430621) RGD PMID:10430621 MGI:1342394 NCBI chr12:12,714,394...12,738,654
Ensembl chr12:12,714,394...12,738,641 		JBrowse link
G Ptprc protein tyrosine phosphatase, receptor type, C ISO MGI:2181288 (MGI:85031|PMID:9015183) RGD PMID:9015183 MGI:85031 NCBI chr13:55,061,561...55,174,150
Ensembl chr13:55,061,562...55,173,692 		JBrowse link
G Tbx21 T-box transcription factor 21 ISO MGI:2180194 (MGI:2670820|PMID:12882831) RGD PMID:12882831 MGI:2670820 NCBI chr10:85,032,799...85,049,331
Ensembl chr10:85,032,799...85,049,331 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20078
    developmental process 6848
      positive regulation of developmental process 1488
        positive regulation of isotype switching 31
          positive regulation of isotype switching to IgA isotypes 6
          positive regulation of isotype switching to IgD isotypes 0
          positive regulation of isotype switching to IgE isotypes + 4
          positive regulation of isotype switching to IgG isotypes 13
Path 2
Term Annotations click to browse term
  biological_process 20078
    metabolic process 12140
      cellular metabolic process 11076
        cellular aromatic compound metabolic process 5725
          nucleobase-containing compound metabolic process 5512
            nucleic acid metabolic process 5002
              DNA metabolic process 897
                DNA recombination 305
                  somatic cell DNA recombination 76
                    somatic diversification of immune receptors via germline recombination within a single locus 76
                      somatic recombination of immunoglobulin gene segments 64
                        somatic recombination of immunoglobulin genes involved in immune response 58
                          isotype switching 58
                            regulation of isotype switching 43
                              positive regulation of isotype switching 31
                                positive regulation of isotype switching to IgA isotypes 6
                                positive regulation of isotype switching to IgD isotypes 0
                                positive regulation of isotype switching to IgE isotypes + 4
                                positive regulation of isotype switching to IgG isotypes 13
paths to the root