Mad2l2 (mitotic arrest deficient 2 like 2)

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Gene: Mad2l2 (mitotic arrest deficient 2 like 2) Chinchilla lanigera

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Symbol:

Mad2l2

Name:

mitotic arrest deficient 2 like 2

RGD ID:

9043725

Description:

ENCODES a protein that exhibits JUN kinase binding (ortholog); RNA polymerase II-specific DNA-binding transcription factor binding (ortholog); INVOLVED IN actin filament organization (ortholog); DNA damage response, signal transduction resulting in transcription (ortholog); double-strand break repair (ortholog); ASSOCIATED WITH Charcot-Marie-Tooth disease type 2 (ortholog); chromosome 1p36 deletion syndrome (ortholog); Familial Atrial Fibrillation 6 (ortholog); FOUND IN anaphase-promoting complex (ortholog); nucleoplasm (ortholog); nucleus (ortholog)

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

MAD2 mitotic arrest deficient-like 2; MAD2 mitotic arrest deficient-like 2 (yeast); mitotic spindle assembly checkpoint protein MAD2B

RGD Orthologs

Alliance Orthologs

More Info

more info ...

Latest Assembly:

ChiLan1.0 - Chinchilla ChiLan1.0 Assembly

Position:

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955486	2,191,903 - 2,198,538 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955486	2,191,903 - 2,197,193 (+)	NCBI	ChiLan1.0	ChiLan1.0

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

Charcot-Marie-Tooth disease type 2 (ISO)

chromosome 1p36 deletion syndrome (ISO)

Familial Atrial Fibrillation 6 (ISO)

Fanconi anemia complementation group V (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

actin filament organization (ISO)

DNA damage response, signal transduction resulting in transcription (ISO)

double-strand break repair (ISO)

error-prone translesion synthesis (ISO)

negative regulation of canonical Wnt signaling pathway (ISO)

negative regulation of cell-cell adhesion mediated by cadherin (ISO)

negative regulation of DNA-binding transcription factor activity (ISO)

negative regulation of double-strand break repair via homologous recombination (ISO)

negative regulation of epithelial to mesenchymal transition (ISO)

negative regulation of protein catabolic process (ISO)

negative regulation of transcription by competitive promoter binding (ISO)

negative regulation of transcription by RNA polymerase II (ISO)

negative regulation of ubiquitin protein ligase activity (ISO)

positive regulation of DNA-templated transcription (ISO)

positive regulation of double-strand break repair via nonhomologous end joining (ISO)

positive regulation of epithelial to mesenchymal transition (ISO)

positive regulation of extracellular matrix assembly (ISO)

positive regulation of gene expression (ISO)

positive regulation of isotype switching (ISO)

positive regulation of peptidyl-serine phosphorylation (ISO)

regulation of cell growth (ISO)

Cellular Component

anaphase-promoting complex (ISO)

nucleoplasm (ISO)

nucleus (ISO)

spindle (ISO)

zeta DNA polymerase complex (ISO)

Molecular Function

JUN kinase binding (ISO)

protein binding (ISO)

RNA polymerase II-specific DNA-binding transcription factor binding (ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	Transitive Annotation Pipeline	Automated assignment of GO, PW and RDO ISO annotations across species

Additional References at PubMed

PMID:30032202

Genomics

Comparative Map Data

Mad2l2
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955486	2,191,903 - 2,198,538 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955486	2,191,903 - 2,197,193 (+)	NCBI	ChiLan1.0	ChiLan1.0

MAD2L2
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	1	11,674,480 - 11,691,830 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	1	11,657,230 - 11,691,811 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	1	11,734,537 - 11,751,616 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	1	11,657,124 - 11,663,780 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	1	11,668,802 - 11,675,459	NCBI
Celera	1	10,846,601 - 10,863,739 (-)	NCBI		Celera
Cytogenetic Map	1	p36.22	NCBI
HuRef	1	10,888,642 - 10,905,769 (-)	NCBI		HuRef
CHM1_1	1	11,722,539 - 11,739,685 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	1	11,218,548 - 11,235,917 (-)	NCBI		T2T-CHM13v2.0

Mad2l2
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	4	148,214,615 - 148,230,161 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	4	148,214,841 - 148,230,156 (+)	Ensembl		GRCm39 Ensembl
GRCm38	4	148,130,158 - 148,145,704 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	4	148,130,384 - 148,145,699 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	4	147,514,599 - 147,519,805 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	4	146,984,290 - 146,989,496 (+)	NCBI		MGSCv36	mm8
Celera	4	150,401,823 - 150,407,027 (+)	NCBI		Celera
Cytogenetic Map	4	E2	NCBI
cM Map	4	78.67	NCBI

Mad2l2
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	5	163,846,678 - 163,859,851 (+)	NCBI		GRCr8
mRatBN7.2	5	158,563,545 - 158,576,698 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	5	158,563,567 - 158,576,693 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	5	161,288,790 - 161,293,471 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	5	163,110,607 - 163,115,262 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	5	163,066,954 - 163,071,609 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	5	164,943,183 - 164,956,255 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	5	164,950,917 - 164,956,255 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	5	168,601,233 - 168,614,293 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	5	165,218,362 - 165,222,828 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	5	165,228,549 - 165,233,014 (+)	NCBI
Celera	5	156,851,516 - 156,855,981 (+)	NCBI		Celera
Cytogenetic Map	5	q36	NCBI

MAD2L2
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	1	216,532,737 - 216,550,231 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	1	215,178,858 - 215,196,364 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	1	10,436,532 - 10,454,023 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	1	11,654,963 - 11,671,364 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	1	11,654,963 - 11,661,526 (-)	Ensembl	panpan1.1		panPan2

MAD2L2
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	2	84,539,724 - 84,549,402 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	2	84,545,226 - 84,549,356 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	2	81,076,962 - 81,081,699 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	2	85,207,730 - 85,212,516 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	2	85,201,068 - 85,212,508 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	2	81,956,536 - 81,961,266 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	2	82,957,166 - 82,961,884 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	2	84,020,037 - 84,024,757 (+)	NCBI		UU_Cfam_GSD_1.0

Mad2l2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405058	34,713,906 - 34,718,120 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936474	538,625 - 542,901 (-)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936474	538,703 - 542,901 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

MAD2L2
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	6	71,773,682 - 71,779,183 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	6	71,773,680 - 71,779,192 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	6	65,692,635 - 65,698,160 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

MAD2L2
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	20	120,099,928 - 120,115,954 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	20	120,110,269 - 120,116,083 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666054	23,977,591 - 23,984,254 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Mad2l2
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624818	1,282,082 - 1,286,997 (+)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624818	1,274,553 - 1,286,750 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_005403996	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AGCD01058994	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	GBDI01170196	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSCLAT00000006248 ⟹ ENSCLAP00000006145

Type:

CODING

Position:

Chinchilla Assembly	Chr	Position (strand)	Source
ChiLan1.0 Ensembl	NW_004955486	2,191,903 - 2,198,538 (+)	Ensembl

RefSeq Acc Id:

XM_005403996 ⟹ XP_005404053

Type:

CODING

Position:

Chinchilla Assembly	Chr	Position (strand)	Source
ChiLan1.0	NW_004955486	2,191,903 - 2,197,193 (+)	NCBI

Sequence:

show sequence

ACCGCGGACGTCACCGAGCGGCGCCGAGGCGGCGCGCGGGTTGAGTGGGAGGCGGGAGTGATCG
GTTCGGCGGCTCGCGGCGCTGGGGCTCCGACCCGAACCCAGGCGGGGACGGAGGCCGGAGCCCA
CACCTGGGAGGCGGAAAGGGCGGGATTCCCTCAGGGGAGGGACTCGGCCGGGTAGGAGGCGGGA
CTTCCCCCCGCCGGGCTGCGCTTTCCGCGTGTCCGGCTTTGCGCTCCGGCCCTGCGCCTCCAGG
TGTTTTTCTCCGCGTCCGCGGCCCGGCGCGGCTTGCGCGCACAGCTGGGTTTTTCCCTGCACCC
CGCCCCGGTGGAACGAGGCCGATCGGGGCGCGGCGTTGCCCCCAGGCCGTGACACCGACGTGGG
GGGTCCTCCGCAGCTGTCCTGATCGGGGCAGAGGGGACGCCCTGCCCCGGCCTCCCCACACCGA
GGCGAACCACCTGACCCGCGACGCCAGCTCGCGGCAGGAAGGATGACCACGCTTACGCGACAGG
ACCTCAACTTTGGCCAAGTGGTGGCCGACGTGCTCTGCGAGTTCCTGGAGGTGGCCGTGCACCT
GATCCTGTACGTGCGCGAGGTCTACCCGGTGGGCATCTTCCAAAAGCGCAAGAAGTACAACGTA
CCGGTGCAGATGTCCTGCCATCCGGAGCTGAATCAGTACATCCAGGACACGCTGCACTGTGTCA
AGCCACTCCTGGAGAAGAACGATGTGGAAAAAGTGGTGGTGGTGATTTTGGATAAAGAGCATCG
ACCCGTGGAGAAGTTCGTCTTTGAGATCACTCAGCCTCCCTTGCTGTCTATCAGCTCTGACTCT
TTGCTGTCCCATGTGGAGCAGCTGCTCCGAGCCTTCATCCTGAAGATCAGTGTGTGTGATGCCG
TCCTGGACCACAATCCACCAGGCTGCACTTTCACCGTCCTGGTGCACACGAGAGAAGCTGCCAC
TCGAAACATGGAGAAGATCCAGGTCATCAAGGACTTCCCTTGGATCCTAGCAGACGAGCAGGAC
GTCCACATGCATGACCCCCGGCTGATACCCCTGAAAACCATGACGTCGGACATTTTAAAGATGC
AGCTCTATGTTGAAGAGCGAGCTCATAAAAGCAGCTGAGGATGAGCCTGCACCCACCGATGATG
CCACGACTGTCTGACCAGGGACCCGGCTGCGGACAGCGCCGCGGGCCCCACCTCCAAGTGCTCT
TCCTGCTCCTCACAGGCGCCTGCCCGCCATCTGGGGCTGCTTAGGTCTGCCTGGCTTCGTGGAG
GAGGCGTCCCCAGGAAGGCAGTGAGAGACGCTGGGACCTCAATTTCTCATCTCTTGGGGCTCAG
CCGGCTAACACTGTCTGTCTCAAATACTGTGAGTTGTTTCAATAAAGTGCCCCAAGGGCTGGCT
GGGGTGTCCCTCTCCAGAATGAAAGGGACAGGTGCAGCCGGGTGAA

hide sequence

Protein Sequences


Protein RefSeqs	XP_005404053	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSCLAP00000006145
	ENSCLAP00000006145.1

RefSeq Acc Id:

XP_005404053 ⟸ XM_005403996

- UniProtKB:

A0A8C2V1A3 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MTTLTRQDLNFGQVVADVLCEFLEVAVHLILYVREVYPVGIFQKRKKYNVPVQMSCHPELNQYI
QDTLHCVKPLLEKNDVEKVVVVILDKEHRPVEKFVFEITQPPLLSISSDSLLSHVEQLLRAFIL
KISVCDAVLDHNPPGCTFTVLVHTREAATRNMEKIQVIKDFPWILADEQDVHMHDPRLIPLKTM
TSDILKMQLYVEERAHKSS

hide sequence

Ensembl Acc Id:

ENSCLAP00000006145 ⟸ ENSCLAT00000006248

Protein Domains

HORMA

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSCLAG00000004348	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSCLAT00000006248	ENTREZGENE
	ENSCLAT00000006248.1	UniProtKB/TrEMBL
Gene3D-CATH	3.30.900.10	UniProtKB/TrEMBL
InterPro	HORMA_dom	UniProtKB/TrEMBL
	HORMA_dom_sf	UniProtKB/TrEMBL
	Mad2-like	UniProtKB/TrEMBL
NCBI Gene	Mad2l2	ENTREZGENE
PANTHER	MITOTIC SPINDLE ASSEMBLY CHECKPOINT PROTEIN MAD2B	UniProtKB/TrEMBL
	PTHR11842	UniProtKB/TrEMBL
Pfam	HORMA	UniProtKB/TrEMBL
PROSITE	HORMA	UniProtKB/TrEMBL
Superfamily-SCOP	SSF56019	UniProtKB/TrEMBL
UniProt	A0A8C2V1A3	ENTREZGENE, UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2017-02-28	Mad2l2	mitotic arrest deficient 2 like 2		MAD2 mitotic arrest deficient-like 2 (yeast)	Symbol and/or name change	5135510	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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