Mad2l2 (mitotic arrest deficient 2 like 2) - Rat Genome Database

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Gene: Mad2l2 (mitotic arrest deficient 2 like 2) Heterocephalus glaber
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Symbol: Mad2l2
Name: mitotic arrest deficient 2 like 2
RGD ID: 18912115
Description: ENCODES a protein that exhibits JUN kinase binding (ortholog); RNA polymerase II-specific DNA-binding transcription factor binding (ortholog); INVOLVED IN actin filament organization (ortholog); DNA damage response, signal transduction resulting in transcription (ortholog); double-strand break repair (ortholog); ASSOCIATED WITH Charcot-Marie-Tooth disease type 2 (ortholog); chromosome 1p36 deletion syndrome (ortholog); Familial Atrial Fibrillation 6 (ortholog); FOUND IN anaphase-promoting complex (ortholog); nucleoplasm (ortholog); nucleus (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: MAD2 mitotic arrest deficient-like 2; mitotic spindle assembly checkpoint protein MAD2B
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Alliance Orthologs
More Info more info ...
Latest Assembly: HetGla 1.0 - Naked Mole-Rat female 1.0 Assembly
Position:
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248181,282,082 - 1,286,997 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248181,274,553 - 1,286,750 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References
Additional References at PubMed
PMID:30032202  


Genomics

Comparative Map Data
Mad2l2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248181,282,082 - 1,286,997 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248181,274,553 - 1,286,750 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2
MAD2L2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38111,674,480 - 11,691,830 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl111,657,230 - 11,691,811 (-)EnsemblGRCh38hg38GRCh38
GRCh37111,734,537 - 11,751,616 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36111,657,124 - 11,663,780 (-)NCBINCBI36Build 36hg18NCBI36
Build 34111,668,802 - 11,675,459NCBI
Celera110,846,601 - 10,863,739 (-)NCBICelera
Cytogenetic Map1p36.22NCBI
HuRef110,888,642 - 10,905,769 (-)NCBIHuRef
CHM1_1111,722,539 - 11,739,685 (-)NCBICHM1_1
T2T-CHM13v2.0111,218,548 - 11,235,917 (-)NCBIT2T-CHM13v2.0
Mad2l2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm394148,214,615 - 148,230,161 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl4148,214,841 - 148,230,156 (+)EnsemblGRCm39 Ensembl
GRCm384148,130,158 - 148,145,704 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl4148,130,384 - 148,145,699 (+)EnsemblGRCm38mm10GRCm38
MGSCv374147,514,599 - 147,519,805 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv364146,984,290 - 146,989,496 (+)NCBIMGSCv36mm8
Celera4150,401,823 - 150,407,027 (+)NCBICelera
Cytogenetic Map4E2NCBI
cM Map478.67NCBI
Mad2l2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr85163,846,678 - 163,859,851 (+)NCBIGRCr8
mRatBN7.25158,563,545 - 158,576,698 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl5158,563,567 - 158,576,693 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx5161,288,790 - 161,293,471 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.05163,110,607 - 163,115,262 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.05163,066,954 - 163,071,609 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.05164,943,183 - 164,956,255 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl5164,950,917 - 164,956,255 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.05168,601,233 - 168,614,293 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.45165,218,362 - 165,222,828 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.15165,228,549 - 165,233,014 (+)NCBI
Celera5156,851,516 - 156,855,981 (+)NCBICelera
Cytogenetic Map5q36NCBI
Mad2l2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554862,191,903 - 2,198,538 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554862,191,903 - 2,197,193 (+)NCBIChiLan1.0ChiLan1.0
MAD2L2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21216,532,737 - 216,550,231 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11215,178,858 - 215,196,364 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0110,436,532 - 10,454,023 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1111,654,963 - 11,671,364 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl111,654,963 - 11,661,526 (-)Ensemblpanpan1.1panPan2
MAD2L2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1284,539,724 - 84,549,402 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl284,545,226 - 84,549,356 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha281,076,962 - 81,081,699 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0285,207,730 - 85,212,516 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl285,201,068 - 85,212,508 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1281,956,536 - 81,961,266 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0282,957,166 - 82,961,884 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0284,020,037 - 84,024,757 (+)NCBIUU_Cfam_GSD_1.0
Mad2l2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440505834,713,906 - 34,718,120 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936474538,625 - 542,901 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936474538,703 - 542,901 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
MAD2L2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl671,773,682 - 71,779,183 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1671,773,680 - 71,779,192 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2665,692,635 - 65,698,160 (-)NCBISscrofa10.2Sscrofa10.2susScr3
MAD2L2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.120120,099,928 - 120,115,954 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl20120,110,269 - 120,116,083 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605423,977,591 - 23,984,254 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSHGLT00000012628   ⟹   ENSHGLP00000012492
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla_female_1.0 EnsemblNW_0046248181,282,082 - 1,286,997 (+)Ensembl
RefSeq Acc Id: XM_004863571   ⟹   XP_004863628
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_0046248181,282,157 - 1,286,750 (+)NCBI
RefSeq Acc Id: XM_021243366   ⟹   XP_021099025
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_0046248181,282,145 - 1,286,052 (+)NCBI
RefSeq Acc Id: XM_021243367   ⟹   XP_021099026
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_0046248181,274,553 - 1,286,052 (+)NCBI
RefSeq Acc Id: XM_021243368   ⟹   XP_021099027
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_0046248181,282,148 - 1,286,052 (+)NCBI
RefSeq Acc Id: XM_021243369   ⟹   XP_021099028
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_0046248181,282,154 - 1,286,750 (+)NCBI
Protein Sequences
Protein RefSeqs XP_004863628 (Get FASTA)   NCBI Sequence Viewer  
  XP_021099025 (Get FASTA)   NCBI Sequence Viewer  
  XP_021099026 (Get FASTA)   NCBI Sequence Viewer  
  XP_021099027 (Get FASTA)   NCBI Sequence Viewer  
  XP_021099028 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSHGLP00000012492
GenBank Protein JAN98268 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: XP_021099026   ⟸   XM_021243367
- Peptide Label: isoform X1
RefSeq Acc Id: XP_021099025   ⟸   XM_021243366
- Peptide Label: isoform X1
RefSeq Acc Id: XP_021099027   ⟸   XM_021243368
- Peptide Label: isoform X2
RefSeq Acc Id: XP_021099028   ⟸   XM_021243369
- Peptide Label: isoform X3
- UniProtKB: G5C511 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_004863628   ⟸   XM_004863571
- Peptide Label: isoform X4
- UniProtKB: A0A0P6J1U3 (UniProtKB/TrEMBL),   G5C511 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSHGLP00000012492   ⟸   ENSHGLT00000012628


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSHGLG00000008925 Ensembl, ENTREZGENE
Ensembl Transcript ENSHGLT00000012628 ENTREZGENE
Gene3D-CATH 3.30.900.10 UniProtKB/TrEMBL
InterPro HORMA_dom UniProtKB/TrEMBL
  HORMA_dom_sf UniProtKB/TrEMBL
  Mad2-like UniProtKB/TrEMBL
KEGG Report hgl:101721329 UniProtKB/TrEMBL
NCBI Gene Mad2l2 ENTREZGENE
PANTHER MITOTIC SPINDLE ASSEMBLY CHECKPOINT PROTEIN MAD2B UniProtKB/TrEMBL
  PTHR11842 UniProtKB/TrEMBL
Pfam HORMA UniProtKB/TrEMBL
PROSITE HORMA UniProtKB/TrEMBL
Superfamily-SCOP SSF56019 UniProtKB/TrEMBL
UniProt A0A0P6J1U3 ENTREZGENE, UniProtKB/TrEMBL
  G5C511 ENTREZGENE, UniProtKB/TrEMBL