MAD2L2 (mitotic arrest deficient 2 like 2) - Rat Genome Database

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Gene: MAD2L2 (mitotic arrest deficient 2 like 2) Canis lupus familiaris
Analyze
Symbol: MAD2L2
Name: mitotic arrest deficient 2 like 2
RGD ID: 12101076
Description: ENCODES a protein that exhibits JUN kinase binding (inferred); RNA polymerase II-specific DNA-binding transcription factor binding (inferred); INVOLVED IN positive regulation of epithelial to mesenchymal transition (ortholog); positive regulation of extracellular matrix assembly (ortholog); positive regulation of gene expression (ortholog); ASSOCIATED WITH Charcot-Marie-Tooth disease type 2 (ortholog); chromosome 1p36 deletion syndrome (ortholog); Familial Atrial Fibrillation 6 (ortholog); FOUND IN anaphase-promoting complex (ortholog); zeta DNA polymerase complex (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: MAD2 mitotic arrest deficient-like 2; MAD2 mitotic arrest deficient-like 2 (yeast); mitotic spindle assembly checkpoint protein MAD2B
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1284,539,724 - 84,549,402 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl284,545,226 - 84,549,356 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha281,076,962 - 81,081,699 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0285,207,730 - 85,212,516 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl285,201,068 - 85,212,508 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1281,956,536 - 81,961,266 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0282,957,166 - 82,961,884 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0284,020,037 - 84,024,757 (+)NCBIUU_Cfam_GSD_1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References
Additional References at PubMed
PMID:30032202  


Genomics

Comparative Map Data
MAD2L2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1284,539,724 - 84,549,402 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl284,545,226 - 84,549,356 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha281,076,962 - 81,081,699 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0285,207,730 - 85,212,516 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl285,201,068 - 85,212,508 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1281,956,536 - 81,961,266 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0282,957,166 - 82,961,884 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0284,020,037 - 84,024,757 (+)NCBIUU_Cfam_GSD_1.0
MAD2L2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38111,674,480 - 11,691,830 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl111,658,918 - 11,691,811 (-)EnsemblGRCh38hg38GRCh38
GRCh37111,734,537 - 11,751,616 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36111,657,124 - 11,663,780 (-)NCBINCBI36Build 36hg18NCBI36
Build 34111,668,802 - 11,675,459NCBI
Celera110,846,601 - 10,863,739 (-)NCBICelera
Cytogenetic Map1p36.22NCBI
HuRef110,888,642 - 10,905,769 (-)NCBIHuRef
CHM1_1111,722,539 - 11,739,685 (-)NCBICHM1_1
T2T-CHM13v2.0111,218,548 - 11,235,917 (-)NCBIT2T-CHM13v2.0
Mad2l2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm394148,214,615 - 148,230,161 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl4148,214,841 - 148,230,156 (+)EnsemblGRCm39 Ensembl
GRCm384148,130,158 - 148,145,704 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl4148,130,384 - 148,145,699 (+)EnsemblGRCm38mm10GRCm38
MGSCv374147,514,599 - 147,519,805 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv364146,984,290 - 146,989,496 (+)NCBIMGSCv36mm8
Celera4150,401,823 - 150,407,027 (+)NCBICelera
Cytogenetic Map4E2NCBI
cM Map478.67NCBI
Mad2l2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr85163,846,678 - 163,859,851 (+)NCBIGRCr8
mRatBN7.25158,563,545 - 158,576,698 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl5158,563,567 - 158,576,693 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx5161,288,790 - 161,293,471 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.05163,110,607 - 163,115,262 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.05163,066,954 - 163,071,609 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.05164,943,183 - 164,956,255 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl5164,950,917 - 164,956,255 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.05168,601,233 - 168,614,293 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.45165,218,362 - 165,222,828 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.15165,228,549 - 165,233,014 (+)NCBI
Celera5156,851,516 - 156,855,981 (+)NCBICelera
Cytogenetic Map5q36NCBI
Mad2l2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554862,191,903 - 2,198,538 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554862,191,903 - 2,197,193 (+)NCBIChiLan1.0ChiLan1.0
MAD2L2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21216,532,737 - 216,550,231 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11215,178,858 - 215,196,364 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0110,436,532 - 10,454,023 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1111,654,963 - 11,671,364 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl111,654,963 - 11,661,526 (-)Ensemblpanpan1.1panPan2
Mad2l2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440505834,713,906 - 34,718,120 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936474538,625 - 542,901 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936474538,703 - 542,901 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
MAD2L2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl671,773,682 - 71,779,183 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1671,773,680 - 71,779,192 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2665,692,635 - 65,698,160 (-)NCBISscrofa10.2Sscrofa10.2susScr3
MAD2L2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.120120,099,928 - 120,115,954 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl20120,110,269 - 120,116,083 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605423,977,591 - 23,984,254 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Mad2l2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248181,282,082 - 1,286,997 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248181,274,553 - 1,286,750 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in MAD2L2
240 total Variants

Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system reproductive system respiratory system adipose tissue
High
Medium 2 1 1 8 3
Low 5 3 21 6 6 6 6 5 12 10 3
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSCAFT00000026256   ⟹   ENSCAFP00000024383
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl284,545,226 - 84,549,356 (+)Ensembl
RefSeq Acc Id: ENSCAFT00845003986   ⟹   ENSCAFP00845003184
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl285,201,068 - 85,212,508 (+)Ensembl
RefSeq Acc Id: XM_038464722   ⟹   XP_038320650
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
Dog10K_Boxer_Tasha281,076,962 - 81,081,699 (+)NCBI
RefSeq Acc Id: XM_038471104   ⟹   XP_038327032
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.1281,956,536 - 81,961,266 (+)NCBI
RefSeq Acc Id: XM_038532018   ⟹   XP_038387946
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.0284,020,037 - 84,024,757 (+)NCBI
RefSeq Acc Id: XM_038596281   ⟹   XP_038452209
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.0282,957,166 - 82,961,884 (+)NCBI
RefSeq Acc Id: XM_038660355   ⟹   XP_038516283
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0285,207,730 - 85,212,516 (+)NCBI
Reference Protein Sequences
RefSeq Acc Id: ENSCAFP00000024383   ⟸   ENSCAFT00000026256
RefSeq Acc Id: XP_038327032   ⟸   XM_038471104
RefSeq Acc Id: XP_038452209   ⟸   XM_038596281
RefSeq Acc Id: XP_038516283   ⟸   XM_038660355
- UniProtKB: A0A8C0K6Q6 (UniProtKB/TrEMBL),   A0A8P0NHT1 (UniProtKB/TrEMBL),   A0A8C0K3M6 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038320650   ⟸   XM_038464722
- UniProtKB: A0A8C0K6Q6 (UniProtKB/TrEMBL),   A0A8P0NHT1 (UniProtKB/TrEMBL),   A0A8C0K3M6 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038387946   ⟸   XM_038532018
- UniProtKB: A0A8C0K3M6 (UniProtKB/TrEMBL),   A0A8C0K6Q6 (UniProtKB/TrEMBL),   A0A8P0NHT1 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSCAFP00845003184   ⟸   ENSCAFT00845003986
Protein Domains
HORMA


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000016583 Ensembl, UniProtKB/TrEMBL
  ENSCAFG00845002275 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSCAFT00000026256.5 UniProtKB/TrEMBL
  ENSCAFT00845003986.1 UniProtKB/TrEMBL
Gene3D-CATH 3.30.900.10 UniProtKB/TrEMBL
InterPro HORMA_dom UniProtKB/TrEMBL
  HORMA_dom_sf UniProtKB/TrEMBL
  Mad2-like UniProtKB/TrEMBL
NCBI Gene MAD2L2 ENTREZGENE
PANTHER MITOTIC SPINDLE ASSEMBLY CHECKPOINT PROTEIN MAD2B UniProtKB/TrEMBL
  PTHR11842 UniProtKB/TrEMBL
Pfam HORMA UniProtKB/TrEMBL
PROSITE HORMA UniProtKB/TrEMBL
Superfamily-SCOP SSF56019 UniProtKB/TrEMBL
UniProt A0A8C0K3M6 ENTREZGENE
  A0A8C0K6Q6 ENTREZGENE
  A0A8I3N1K2_CANLF UniProtKB/TrEMBL
  A0A8P0NHT1 ENTREZGENE, UniProtKB/TrEMBL
VGNC ID VGNC:52216 ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2017-02-28 MAD2L2  mitotic arrest deficient 2 like 2    MAD2 mitotic arrest deficient-like 2 (yeast)  Symbol and/or name change 5135510 APPROVED