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ONTOLOGY REPORT - ANNOTATIONS

Term:NLRP3 inflammasome complex assembly
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Accession:GO:0044546 term browser browse the term
Definition:The aggregation, arrangement and bonding together of a set of components to form the NLRP3 inflammasome complex, occurring at the level of an individual cell.
Synonyms:exact_synonym: NALP3 inflammasome complex assembly
 related_synonym: NLRP3 inflammasome activation

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NLRP3 inflammasome complex assembly term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Atat1 alpha tubulin acetyltransferase 1 acts_upstream_of ISO (PMID:23502856) MGI PMID:23502856 NCBI chrNW_004624754:25,058,312...25,069,052
Ensembl chrNW_004624754:25,058,204...25,069,561 		JBrowse link
G Kcnj8 potassium inwardly rectifying channel subfamily J member 8 acts_upstream_of_or_within
involved_in		 ISO
IEA		 (PMID:28928055) MGI
Ensembl		 PMID:28928055 GO_REF:0000107 NCBI chrNW_004624752:16,939,289...16,945,692
Ensembl chrNW_004624752:16,939,384...16,946,723 		JBrowse link
G Nlrp3 NLR family pyrin domain containing 3 involved_in
acts_upstream_of_or_within		 ISO (MGI:5492224|PMID:23582325), (MGI:5792478|PMID:27043286), (MGI:5913002|PMID:28716882), (MGI:5921465|PMID:28656979), (MGI:6106673|PMID:28943315), (MGI:6260219|PMID:30487600), (MGI:6787653|PMID:34615873), (MGI:6844859|PMID:34861190), (MGI:6859739|PMID:28465465), (PMID:26173909)
(PMID:17483456), (PMID:23582325), (PMID:25686105), (PMID:27043286), (PMID:27432880), (PMID:28465465), (PMID:28656979), (PMID:28943315), (PMID:30487600), (PMID:31189953), (PMID:33231615), (PMID:34554188), (PMID:34615873), (PMID:35114687), (PMID:35254907), (PMID:35559676), (PMID:36442502)
(PMID:22753929)		 UniProt
MGI		 PMID:17483456 PMID:22753929 PMID:23582325 PMID:25686105 PMID:26173909 More... MGI:5492224 MGI:5792478 MGI:5913002 MGI:5921465 MGI:6106673 MGI:6260219 MGI:6787653 MGI:6844859 MGI:6859739 NCBI chrNW_004624937:564,191...584,470 JBrowse link
G Pycard PYD and CARD domain containing involved_in ISO (PMID:27432880) UniProt PMID:27432880 NCBI chrNW_004624782:14,247,333...14,249,861
Ensembl chrNW_004624782:14,247,864...14,249,000 		JBrowse link
G Sirt2 sirtuin 2 acts_upstream_of ISO (PMID:23502856) MGI PMID:23502856 NCBI chrNW_004624794:12,239,363...12,259,561
Ensembl chrNW_004624794:12,235,263...12,259,276 		JBrowse link
negative regulation of NLRP3 inflammasome complex assembly term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abhd17a abhydrolase domain containing 17A, depalmitoylase involved_in ISO (PMID:38092000) UniProt PMID:38092000 NCBI chrNW_004624828:6,915,126...6,923,433
Ensembl chrNW_004624828:6,917,061...6,923,433 		JBrowse link
G Cptp ceramide-1-phosphate transfer protein involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004624818:8,283,925...8,287,410
Ensembl chrNW_004624818:8,283,926...8,287,274 		JBrowse link
G Csnk1a1 casein kinase 1 alpha 1 involved_in ISO (MGI:6787653|PMID:34615873) UniProt PMID:34615873 MGI:6787653 NCBI chrNW_004624774:8,815,021...8,862,657
Ensembl chrNW_004624774:8,815,023...8,862,878 		JBrowse link
G Fbxl2 F-box and leucine rich repeat protein 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004624788:11,253,912...11,350,045
Ensembl chrNW_004624788:11,253,934...11,349,137 		JBrowse link
G Hspa8 heat shock protein family A (Hsp70) member 8 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004624880:2,070,410...2,075,069
Ensembl chrNW_004624880:2,070,523...2,079,421 		JBrowse link
G Irgm immunity related GTPase M involved_in ISO (MGI:6282153|PMID:30612879)
(PMID:30612879)		 UniProt PMID:30612879 MGI:6282153 NCBI chrNW_004624733:41,241,488...41,248,162 JBrowse link
G Lamp2 lysosomal associated membrane protein 2 involved_in ISO (PMID:36586411) UniProt PMID:36586411 NCBI chrNW_004624931:297,864...343,314
Ensembl chrNW_004624931:298,328...343,915 		JBrowse link
G Mefv MEFV innate immunity regulator, pyrin involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004624824:1,035,172...1,047,632
Ensembl chrNW_004624824:1,035,094...1,047,678 		JBrowse link
G Nlrc3 NLR family CARD domain containing 3 involved_in ISO (PMID:25277106) UniProt PMID:25277106 NCBI chrNW_004624824:1,356,587...1,375,403
Ensembl chrNW_004624824:1,357,326...1,375,688 		JBrowse link
G Sirt2 sirtuin 2 acts_upstream_of_or_within ISO (PMID:23502856) MGI PMID:23502856 NCBI chrNW_004624794:12,239,363...12,259,561
Ensembl chrNW_004624794:12,235,263...12,259,276 		JBrowse link
G Trem2 triggering receptor expressed on myeloid cells 2 acts_upstream_of_or_within ISO (MGI:6391726|PMID:29887864)
(PMID:32514138)		 ARUK-UCL PMID:29887864 PMID:32514138 MGI:6391726 NCBI chrNW_004624754:17,643,397...17,649,255
Ensembl chrNW_004624754:17,643,363...17,648,231 		JBrowse link
G Zdhhc12 zinc finger DHHC-type palmitoyltransferase 12 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004624760:6,273,989...6,276,788
Ensembl chrNW_004624760:6,273,994...6,276,776 		JBrowse link
positive regulation of NLRP3 inflammasome complex assembly term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Atat1 alpha tubulin acetyltransferase 1 acts_upstream_of_or_within ISO (PMID:23502856) MGI PMID:23502856 NCBI chrNW_004624754:25,058,312...25,069,052
Ensembl chrNW_004624754:25,058,204...25,069,561 		JBrowse link
G Brcc3 BRCA1/BRCA2-containing complex subunit 3 involved_in ISO (MGI:7387171|PMID:23246432)
(PMID:28943315)		 UniProt PMID:23246432 PMID:28943315 MGI:7387171 NCBI chrNW_004624963:142,987...212,190
Ensembl chrNW_004624963:145,580...212,064 		JBrowse link
G Btk Bruton tyrosine kinase involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004624902:1,173,101...1,216,662
Ensembl chrNW_004624902:1,182,682...1,216,171 		JBrowse link
G Casp4 caspase 4 involved_in ISO (MGI:5780643|PMID:26173909) UniProt PMID:26173909 MGI:5780643 NCBI chrNW_004624918:145,661...187,006 JBrowse link
G Cd36 CD36 molecule (CD36 blood group) involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004624739:29,341,620...29,441,232
Ensembl chrNW_004624739:29,407,568...29,441,333 		JBrowse link
G Ddx3x DEAD-box helicase 3 X-linked involved_in ISO (MGI:6368386|PMID:31511697) UniProt PMID:31511697 MGI:6368386 NCBI chrNW_004624762:14,290,267...14,305,437
Ensembl chrNW_004624762:14,290,267...14,305,633 		JBrowse link
G Dhx33 DEAH-box helicase 33 involved_in ISO (PMID:23871209) UniProt PMID:23871209 NCBI chrNW_004624786:9,247,294...9,266,645
Ensembl chrNW_004624786:9,248,382...9,266,519 		JBrowse link
G Gbp5 guanylate binding protein 5 involved_in ISO (PMID:22461501) UniProt PMID:22461501 NCBI chrNW_004624742:8,324,902...8,335,965 JBrowse link
G Mapk8 mitogen-activated protein kinase 8 involved_in ISO (MGI:6106673|PMID:28943315)
(PMID:28943315)		 UniProt PMID:28943315 MGI:6106673 NCBI chrNW_004624928:1,442,216...1,494,275
Ensembl chrNW_004624928:1,439,146...1,494,266 		JBrowse link
G Mark4 microtubule affinity regulating kinase 4 involved_in ISO (PMID:28656979)
(MGI:5921465|PMID:28656979)		 UniProt PMID:28656979 MGI:5921465 NCBI chrNW_004624907:2,184,702...2,212,673
Ensembl chrNW_004624907:2,184,729...2,212,666 		JBrowse link
G Mavs mitochondrial antiviral signaling protein involved_in ISO (PMID:23582325)
(MGI:5492224|PMID:23582325)		 UniProt PMID:23582325 MGI:5492224 NCBI chrNW_004624741:4,936,556...4,951,081
Ensembl chrNW_004624741:4,939,040...4,954,058 		JBrowse link
G Myd88 MYD88 innate immune signal transduction adaptor involved_in ISO (PMID:33718825) UniProt PMID:33718825 NCBI chrNW_004624731:2,677,259...2,681,408
Ensembl chrNW_004624731:2,677,290...2,681,489 		JBrowse link
G Nek7 NIMA related kinase 7 involved_in ISO (MGI:5751332|PMID:26814970)
(MGI:5698271|PMID:26642356)
(PMID:31189953), (PMID:36442502)		 UniProt PMID:26642356 PMID:26814970 PMID:31189953 PMID:36442502 MGI:5698271 MGI:5751332 NCBI chrNW_004624798:2,116,888...2,283,061
Ensembl chrNW_004624798:2,116,900...2,198,999 		JBrowse link
G Plcg2 phospholipase C gamma 2 acts_upstream_of_or_within ISO (PMID:32514138) ARUK-UCL PMID:32514138 NCBI chrNW_004624746:5,678,057...5,824,663
Ensembl chrNW_004624746:5,682,666...5,821,855 		JBrowse link
G Ppp2ca protein phosphatase 2 catalytic subunit alpha involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004624733:38,012,694...38,033,745
Ensembl chrNW_004624733:38,012,392...38,036,914 		JBrowse link
G Prkd1 protein kinase D1 involved_in ISO (MGI:5913002|PMID:28716882) UniProt PMID:28716882 MGI:5913002 NCBI chrNW_004624820:2,408,562...2,726,199
Ensembl chrNW_004624820:2,408,360...2,726,606 		JBrowse link
G Ptpn22 protein tyrosine phosphatase non-receptor type 22 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004624772:9,472,869...9,552,751
Ensembl chrNW_004624772:9,472,913...9,550,990 		JBrowse link
G Stmp1 short transmembrane mitochondrial protein 1 involved_in ISO (MGI:6384515|PMID:31836654) UniProt PMID:31836654 MGI:6384515 NCBI chrNW_004624765:15,941,281...15,969,027 JBrowse link
G Tlr4 toll like receptor 4 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004624760:17,596,516...17,608,955
Ensembl chrNW_004624760:17,598,630...17,609,120 		JBrowse link
G Tlr6 toll like receptor 6 involved_in ISO (MGI:5546292|PMID:23812099) UniProt PMID:23812099 MGI:5546292 NCBI chrNW_004624840:7,323,022...7,349,334 JBrowse link
G Zdhhc5 zinc finger DHHC-type palmitoyltransferase 5 involved_in ISO (PMID:38092000) UniProt PMID:38092000 NCBI chrNW_004624864:3,027,537...3,049,567
Ensembl chrNW_004624864:3,028,170...3,048,945 		JBrowse link
regulation of NLRP3 inflammasome complex assembly term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Eif2ak2 eukaryotic translation initiation factor 2 alpha kinase 2 involved_in ISO (MGI:5432942|PMID:22801494) UniProt PMID:22801494 MGI:5432942 NCBI chrNW_004624738:18,716,623...18,764,243
Ensembl chrNW_004624738:18,717,092...18,758,457 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 15093
    cellular process 14237
      cellular component organization or biogenesis 6217
        cellular component organization 6020
          cellular component assembly 2852
            protein-containing complex assembly 1407
              canonical inflammasome complex assembly 38
                NLRP3 inflammasome complex assembly 37
                  negative regulation of NLRP3 inflammasome complex assembly 12
                  positive regulation of NLRP3 inflammasome complex assembly 21
                  regulation of NLRP3 inflammasome complex assembly + 34
Path 2
Term Annotations click to browse term
  biological_process 15093
    response to stimulus 8161
      response to biotic stimulus 1361
        response to external biotic stimulus 1317
          response to other organism 1314
            defense response to other organism 906
              defense response to symbiont 802
                innate immune response 664
                  regulation of innate immune response 371
                    positive regulation of innate immune response 309
                      activation of innate immune response 253
                        innate immune response-activating signaling pathway 237
                          pattern recognition receptor signaling pathway 235
                            cytoplasmic pattern recognition receptor signaling pathway 151
                              inflammasome-mediated signaling pathway 39
                                canonical inflammasome complex assembly 38
                                  NLRP3 inflammasome complex assembly 37
                                    negative regulation of NLRP3 inflammasome complex assembly 12
                                    positive regulation of NLRP3 inflammasome complex assembly 21
                                    regulation of NLRP3 inflammasome complex assembly + 34
paths to the root