Dhx33 (DEAH-box helicase 33) - Rat Genome Database

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Gene: Dhx33 (DEAH-box helicase 33) Heterocephalus glaber
Analyze
Symbol: Dhx33
Name: DEAH-box helicase 33
RGD ID: 18906150
Description: ENCODES a protein that exhibits DNA-binding transcription factor binding (ortholog); mRNA binding (ortholog); rDNA binding (ortholog); INVOLVED IN positive regulation of MAPK cascade (ortholog); positive regulation of NF-kappaB transcription factor activity (ortholog); positive regulation of NLRP3 inflammasome complex assembly (ortholog); ASSOCIATED WITH developmental and epileptic encephalopathy 25 (ortholog); FOUND IN cytoplasm (ortholog); NLRP3 inflammasome complex (ortholog); nucleoplasm (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: putative ATP-dependent RNA helicase DHX33
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Alliance Orthologs
More Info more info ...
Latest Assembly: HetGla 1.0 - Naked Mole-Rat female 1.0 Assembly
Position:
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247869,248,382 - 9,266,519 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247869,247,294 - 9,266,645 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
Dhx33
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247869,248,382 - 9,266,519 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247869,247,294 - 9,266,645 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2
DHX33
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38175,440,917 - 5,468,982 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl175,440,917 - 5,468,982 (-)EnsemblGRCh38hg38GRCh38
GRCh37175,344,237 - 5,372,302 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36175,286,299 - 5,312,905 (-)NCBINCBI36Build 36hg18NCBI36
Build 34175,286,314 - 5,312,905NCBI
Celera175,361,948 - 5,388,553 (-)NCBICelera
Cytogenetic Map17p13.2NCBI
HuRef175,234,760 - 5,262,848 (-)NCBIHuRef
CHM1_1175,353,926 - 5,382,059 (-)NCBICHM1_1
T2T-CHM13v2.0175,334,655 - 5,362,725 (-)NCBIT2T-CHM13v2.0
Dhx33
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391170,874,917 - 70,895,258 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1170,874,917 - 70,895,263 (-)EnsemblGRCm39 Ensembl
GRCm381170,984,091 - 71,004,533 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1170,984,091 - 71,004,437 (-)EnsemblGRCm38mm10GRCm38
MGSCv371170,797,593 - 70,817,934 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361170,800,286 - 70,820,627 (-)NCBIMGSCv36mm8
Celera1178,538,505 - 78,558,847 (-)NCBICelera
Cytogenetic Map11B4NCBI
cM Map1143.21NCBI
Dhx33
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81056,206,680 - 56,223,189 (-)NCBIGRCr8
mRatBN7.21055,708,102 - 55,724,618 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1055,705,756 - 55,724,567 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1060,387,811 - 60,404,254 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01059,876,330 - 59,892,773 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01055,375,420 - 55,391,863 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01057,622,022 - 57,638,485 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1057,622,022 - 57,638,485 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01057,367,234 - 57,383,697 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41057,889,929 - 57,906,392 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11057,904,115 - 57,934,844 (-)NCBI
Celera1054,853,790 - 54,870,250 (-)NCBICelera
Cytogenetic Map10q24NCBI
Dhx33
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495546710,793,934 - 10,818,898 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495546710,797,464 - 10,819,083 (-)NCBIChiLan1.0ChiLan1.0
DHX33
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21913,051,397 - 13,079,461 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11715,019,627 - 15,047,677 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0175,490,642 - 5,517,192 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1175,484,093 - 5,508,927 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl175,484,093 - 5,508,926 (-)Ensemblpanpan1.1panPan2
DHX33
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1531,337,447 - 31,351,447 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl531,338,620 - 31,346,422 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha531,474,469 - 31,489,480 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0531,441,081 - 31,456,107 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl531,441,042 - 31,456,107 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1531,406,643 - 31,421,660 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0531,365,553 - 31,380,549 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0531,541,969 - 31,556,986 (+)NCBIUU_Cfam_GSD_1.0
Dhx33
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440560253,530,788 - 53,555,817 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366772,345,315 - 2,364,802 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049366772,345,153 - 2,367,247 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
DHX33
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1251,527,083 - 51,546,448 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11251,527,071 - 51,547,334 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
DHX33
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1164,855,374 - 4,879,892 (-)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366605916,707,433 - 16,736,209 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0


Expression

RNA-SEQ Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts XM_004857339 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AHKG01062227 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSHGLT00000020824   ⟹   ENSHGLP00000020622
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla_female_1.0 EnsemblNW_0046247869,248,382 - 9,266,519 (-)Ensembl
Ensembl Acc Id: ENSHGLT00000020825   ⟹   ENSHGLP00000020623
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla_female_1.0 EnsemblNW_0046247869,248,382 - 9,266,519 (-)Ensembl
Ensembl Acc Id: ENSHGLT00000020826   ⟹   ENSHGLP00000020624
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla_female_1.0 EnsemblNW_0046247869,248,382 - 9,266,519 (-)Ensembl
RefSeq Acc Id: XM_004857339   ⟹   XP_004857396
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_0046247869,247,294 - 9,266,645 (-)NCBI
Protein Sequences
Protein RefSeqs XP_004857396 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSHGLP00000020622
RefSeq Acc Id: XP_004857396   ⟸   XM_004857339
- UniProtKB: G5BW79 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSHGLP00000020622   ⟸   ENSHGLT00000020824
Ensembl Acc Id: ENSHGLP00000020623   ⟸   ENSHGLT00000020825
Ensembl Acc Id: ENSHGLP00000020624   ⟸   ENSHGLT00000020826


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSHGLG00000014753 Ensembl, ENTREZGENE
Ensembl Transcript ENSHGLT00000020824 ENTREZGENE
Gene3D-CATH 1.20.120.1080 UniProtKB/TrEMBL
  P-loop containing nucleotide triphosphate hydrolases UniProtKB/TrEMBL
InterPro DEAD-box_helicase_OB_fold UniProtKB/TrEMBL
  DEAD/DEAH_box_helicase_dom UniProtKB/TrEMBL
  DNA/RNA_helicase_DEAH_CS UniProtKB/TrEMBL
  HA2_WH UniProtKB/TrEMBL
  Helicase-assoc_dom UniProtKB/TrEMBL
  Helicase_ATP-bd UniProtKB/TrEMBL
  Helicase_C UniProtKB/TrEMBL
  P-loop_NTPase UniProtKB/TrEMBL
NCBI Gene Dhx33 ENTREZGENE
PANTHER ATP-DEPENDENT RNA HELICASE UniProtKB/TrEMBL
  ATP-DEPENDENT RNA HELICASE DHX33 UniProtKB/TrEMBL
Pfam DEAD UniProtKB/TrEMBL
  HA2 UniProtKB/TrEMBL
  HA2_C UniProtKB/TrEMBL
  Helicase_C UniProtKB/TrEMBL
  OB_NTP_bind UniProtKB/TrEMBL
PROSITE DEAH_ATP_HELICASE UniProtKB/TrEMBL
  HELICASE_ATP_BIND_1 UniProtKB/TrEMBL
  HELICASE_CTER UniProtKB/TrEMBL
SMART DEXDc UniProtKB/TrEMBL
  HA2 UniProtKB/TrEMBL
  HELICc UniProtKB/TrEMBL
Superfamily-SCOP P-loop containing nucleoside triphosphate hydrolases UniProtKB/TrEMBL
UniProt G5BW79 ENTREZGENE, UniProtKB/TrEMBL