DHX33 (DEAH-box helicase 33) - Rat Genome Database

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Gene: DHX33 (DEAH-box helicase 33) Canis lupus familiaris
Analyze
Symbol: DHX33
Name: DEAH-box helicase 33
RGD ID: 12056120
Description: ENCODES a protein that exhibits ATP binding (inferred); DNA-binding transcription factor binding (inferred); double-stranded RNA binding (inferred); INVOLVED IN positive regulation of MAPK cascade (inferred); positive regulation of NLRP3 inflammasome complex assembly (inferred); positive regulation of transcription by RNA polymerase I (inferred); ASSOCIATED WITH developmental and epileptic encephalopathy 25 (ortholog); genetic disease (ortholog); FOUND IN cytoplasm (inferred); NLRP3 inflammasome complex (inferred); nucleolus (inferred)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: ATP-dependent RNA helicase DHX33; putative ATP-dependent RNA helicase DHX33
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1531,337,447 - 31,351,447 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl531,338,620 - 31,346,422 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha531,474,469 - 31,489,480 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0531,441,081 - 31,456,107 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl531,441,042 - 31,456,107 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1531,406,643 - 31,421,660 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0531,365,553 - 31,380,549 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0531,541,969 - 31,556,986 (+)NCBIUU_Cfam_GSD_1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
DHX33
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1531,337,447 - 31,351,447 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl531,338,620 - 31,346,422 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha531,474,469 - 31,489,480 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0531,441,081 - 31,456,107 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl531,441,042 - 31,456,107 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1531,406,643 - 31,421,660 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0531,365,553 - 31,380,549 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0531,541,969 - 31,556,986 (+)NCBIUU_Cfam_GSD_1.0
DHX33
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38175,440,917 - 5,468,982 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl175,440,917 - 5,468,982 (-)EnsemblGRCh38hg38GRCh38
GRCh37175,344,237 - 5,372,302 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36175,286,299 - 5,312,905 (-)NCBINCBI36Build 36hg18NCBI36
Build 34175,286,314 - 5,312,905NCBI
Celera175,361,948 - 5,388,553 (-)NCBICelera
Cytogenetic Map17p13.2NCBI
HuRef175,234,760 - 5,262,848 (-)NCBIHuRef
CHM1_1175,353,926 - 5,382,059 (-)NCBICHM1_1
T2T-CHM13v2.0175,334,655 - 5,362,725 (-)NCBIT2T-CHM13v2.0
Dhx33
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391170,874,917 - 70,895,258 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1170,874,917 - 70,895,263 (-)EnsemblGRCm39 Ensembl
GRCm381170,984,091 - 71,004,533 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1170,984,091 - 71,004,437 (-)EnsemblGRCm38mm10GRCm38
MGSCv371170,797,593 - 70,817,934 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361170,800,286 - 70,820,627 (-)NCBIMGSCv36mm8
Celera1178,538,505 - 78,558,847 (-)NCBICelera
Cytogenetic Map11B4NCBI
cM Map1143.21NCBI
Dhx33
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81056,206,680 - 56,223,189 (-)NCBIGRCr8
mRatBN7.21055,708,102 - 55,724,618 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1055,705,756 - 55,724,567 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1060,387,811 - 60,404,254 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01059,876,330 - 59,892,773 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01055,375,420 - 55,391,863 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01057,622,022 - 57,638,485 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1057,622,022 - 57,638,485 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01057,367,234 - 57,383,697 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41057,889,929 - 57,906,392 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11057,904,115 - 57,934,844 (-)NCBI
Celera1054,853,790 - 54,870,250 (-)NCBICelera
Cytogenetic Map10q24NCBI
Dhx33
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495546710,793,934 - 10,818,898 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495546710,797,464 - 10,819,083 (-)NCBIChiLan1.0ChiLan1.0
DHX33
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21913,051,397 - 13,079,461 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11715,019,627 - 15,047,677 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0175,490,642 - 5,517,192 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1175,484,093 - 5,508,927 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl175,484,093 - 5,508,926 (-)Ensemblpanpan1.1panPan2
Dhx33
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440560253,530,788 - 53,555,817 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366772,345,315 - 2,364,802 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049366772,345,153 - 2,367,247 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
DHX33
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1251,527,083 - 51,546,448 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11251,527,071 - 51,547,334 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
DHX33
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1164,855,374 - 4,879,892 (-)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366605916,707,433 - 16,736,209 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Dhx33
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247869,248,382 - 9,266,519 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247869,247,294 - 9,266,645 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in DHX33
125 total Variants

Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system reproductive system respiratory system adipose tissue
High
Medium 8 1 5 2 9
Low 5 5 14 6 5 6 1 6 10 8 1 6
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSCAFT00000024626   ⟹   ENSCAFP00000022848
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl531,338,620 - 31,346,422 (+)Ensembl
RefSeq Acc Id: ENSCAFT00845004735   ⟹   ENSCAFP00845003785
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl531,441,042 - 31,456,107 (+)Ensembl
RefSeq Acc Id: ENSCAFT00845004747   ⟹   ENSCAFP00845003796
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl531,441,119 - 31,456,107 (+)Ensembl
RefSeq Acc Id: XM_038475301   ⟹   XP_038331229
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.1531,406,643 - 31,421,660 (+)NCBI
RefSeq Acc Id: XM_038513447   ⟹   XP_038369375
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
Dog10K_Boxer_Tasha531,474,469 - 31,489,480 (+)NCBI
RefSeq Acc Id: XM_038536471   ⟹   XP_038392399
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.0531,541,969 - 31,556,986 (+)NCBI
RefSeq Acc Id: XM_038600670   ⟹   XP_038456598
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.0531,365,553 - 31,380,549 (+)NCBI
RefSeq Acc Id: XM_038665195   ⟹   XP_038521123
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0531,441,081 - 31,456,107 (+)NCBI
Reference Protein Sequences
RefSeq Acc Id: ENSCAFP00000022848   ⟸   ENSCAFT00000024626
RefSeq Acc Id: XP_038331229   ⟸   XM_038475301
RefSeq Acc Id: XP_038456598   ⟸   XM_038600670
RefSeq Acc Id: XP_038521123   ⟸   XM_038665195
- UniProtKB: A0A8I3MQB8 (UniProtKB/TrEMBL),   A0A8C0PMH9 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038369375   ⟸   XM_038513447
- UniProtKB: A0A8C0KV95 (UniProtKB/TrEMBL),   A0A8P0SJY7 (UniProtKB/TrEMBL),   A0A8C0PMH9 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038392399   ⟸   XM_038536471
- UniProtKB: A0A8C0KV95 (UniProtKB/TrEMBL),   A0A8C0PMH9 (UniProtKB/TrEMBL),   A0A8P0SJY7 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSCAFP00845003796   ⟸   ENSCAFT00845004747
RefSeq Acc Id: ENSCAFP00845003785   ⟸   ENSCAFT00845004735
Protein Domains
Helicase ATP-binding   Helicase C-terminal   Helicase-associated


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000015535 Ensembl, UniProtKB/TrEMBL
  ENSCAFG00030020465 UniProtKB/TrEMBL
  ENSCAFG00040000856 UniProtKB/TrEMBL
  ENSCAFG00845002655 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCAFT00000024626.5 UniProtKB/TrEMBL
  ENSCAFT00030037798.1 UniProtKB/TrEMBL
  ENSCAFT00040001553.1 UniProtKB/TrEMBL
  ENSCAFT00845004735 ENTREZGENE
  ENSCAFT00845004735.1 UniProtKB/TrEMBL
  ENSCAFT00845004747.1 UniProtKB/TrEMBL
Gene3D-CATH 1.20.120.1080 UniProtKB/TrEMBL
  3.40.50.300 UniProtKB/TrEMBL
InterPro DEAD-box_helicase_OB_fold UniProtKB/TrEMBL
  DEAD/DEAH_box_helicase_dom UniProtKB/TrEMBL
  DNA/RNA_helicase_DEAH_CS UniProtKB/TrEMBL
  HA2_WH UniProtKB/TrEMBL
  Helicase-assoc_dom UniProtKB/TrEMBL
  Helicase_ATP-bd UniProtKB/TrEMBL
  Helicase_C UniProtKB/TrEMBL
  P-loop_NTPase UniProtKB/TrEMBL
NCBI Gene DHX33 ENTREZGENE
PANTHER ATP-DEPENDENT RNA HELICASE UniProtKB/TrEMBL
  ATP-DEPENDENT RNA HELICASE DHX33 UniProtKB/TrEMBL
Pfam DEAD UniProtKB/TrEMBL
  HA2 UniProtKB/TrEMBL
  HA2_C UniProtKB/TrEMBL
  Helicase_C UniProtKB/TrEMBL
  OB_NTP_bind UniProtKB/TrEMBL
PROSITE DEAH_ATP_HELICASE UniProtKB/TrEMBL
  HELICASE_ATP_BIND_1 UniProtKB/TrEMBL
  HELICASE_CTER UniProtKB/TrEMBL
SMART DEXDc UniProtKB/TrEMBL
  HA2 UniProtKB/TrEMBL
  HELICc UniProtKB/TrEMBL
Superfamily-SCOP SSF52540 UniProtKB/TrEMBL
UniProt A0A8C0KV95 ENTREZGENE
  A0A8C0PMH9 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I3MQB8 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I3N2X3_CANLF UniProtKB/TrEMBL
  A0A8P0SJY7 ENTREZGENE, UniProtKB/TrEMBL
VGNC ID VGNC:39943 ENTREZGENE