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ONTOLOGY REPORT - ANNOTATIONS

Term:toll-like receptor 4 signaling pathway
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Accession:GO:0034142 term browser browse the term
Definition:The series of molecular signals initiated by a ligand binding to toll-like receptor 4.
Synonyms:exact_synonym: TLR4 signaling pathway;   toll-like receptor 4 signalling pathway
 xref: Reactome:R-HSA-166016 "Toll Like Receptor 4 (TLR4) Cascade"


show annotations for term's descendants           Sort by:
toll-like receptor 4 signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CD14 CD14 molecule involved_in IEA
IBA		 Ensembl
GO_Central		 GO_REF:0000033 GO_REF:0000107 NCBI chr 2:142,348,036...142,349,686
Ensembl chr 2:142,346,360...142,349,581 		JBrowse link
G CHUK component of inhibitor of nuclear factor kappa B kinase complex involved_in IEA Ensembl GO_REF:0000107 NCBI chr14:111,316,178...111,351,669
Ensembl chr14:111,315,141...111,351,868 		JBrowse link
G ECSIT ECSIT signaling integrator involved_in IEA Ensembl GO_REF:0000107 NCBI chr 2:70,154,861...70,170,762
Ensembl chr 2:70,154,843...70,170,744 		JBrowse link
G HMGB1 high mobility group box 1 involved_in IDA (PMID:14660645) UniProt PMID:14660645 NCBI chr11:7,195,556...7,321,071 JBrowse link
G IRAK1 interleukin 1 receptor associated kinase 1 acts_upstream_of_or_within
involved_in		 ISO
IBA		 (PMID:10549626) MGI
GO_Central		 PMID:10549626 GO_REF:0000033 NCBI chr  X:124,717,604...124,724,855
Ensembl chr  X:124,717,612...124,724,860 		JBrowse link
G IRAK2 interleukin 1 receptor associated kinase 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr13:66,350,606...66,416,834
Ensembl chr13:66,350,606...66,416,827 		JBrowse link
G IRF3 interferon regulatory factor 3 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 6:54,701,733...54,706,079
Ensembl chr 6:54,701,668...54,707,151 		JBrowse link
G LETMD1 LETM1 domain containing 1 acts_upstream_of_or_within ISO (PMID:31980577) MGI PMID:31980577
G LGALS9 galectin 9 NOT|involved_in ISO (PMID:16116184) UniProt PMID:16116184 NCBI chr12:44,155,079...44,173,634 JBrowse link
G LY96 lymphocyte antigen 96 involved_in IEA
IBA		 Ensembl
GO_Central		 GO_REF:0000033 GO_REF:0000107 NCBI chr 4:61,919,806...61,950,712
Ensembl chr 4:61,926,064...61,950,697 		JBrowse link
G LYN LYN proto-oncogene, Src family tyrosine kinase involved_in IEA Ensembl GO_REF:0000107 NCBI chr 4:75,793,273...75,903,710
Ensembl chr 4:75,793,492...75,903,496 		JBrowse link
G MAP3K7 mitogen-activated protein kinase kinase kinase 7 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 1:58,482,046...58,548,087
Ensembl chr 1:58,481,956...58,548,057 		JBrowse link
G MYD88 MYD88 innate immune signal transduction adaptor involved_in IEA
IBA		 Ensembl
GO_Central		 GO_REF:0000033 GO_REF:0000107 NCBI chr13:22,976,951...22,979,568
Ensembl chr13:22,966,137...22,983,109 		JBrowse link
G NAGLU N-acetyl-alpha-glucosaminidase involved_in IEA Ensembl GO_REF:0000107 Ensembl chr12:20,271,351...20,279,777 JBrowse link
G NFKBIA NFKB inhibitor alpha acts_upstream_of_or_within
involved_in		 ISO
IEA		 (PMID:18261938) MGI
Ensembl		 PMID:18261938 GO_REF:0000107 NCBI chr 7:64,508,119...64,510,754
Ensembl chr 7:64,507,822...64,511,277 		JBrowse link
G NMI N-myc and STAT interactor involved_in IEA Ensembl GO_REF:0000107 NCBI chr15:941,379...966,519
Ensembl chr15:941,475...967,321 		JBrowse link
G OAS1 2'-5'-oligoadenylate synthetase 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr14:38,851,083...38,867,427
Ensembl chr14:38,851,918...38,859,409 		JBrowse link
G PIK3AP1 phosphoinositide-3-kinase adaptor protein 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr14:108,038,396...108,303,942
Ensembl chr14:108,039,431...108,303,929 		JBrowse link
G RELA RELA proto-oncogene, NF-kB subunit involved_in IEA Ensembl GO_REF:0000107 NCBI chr 2:6,594,869...6,602,684
Ensembl chr 2:6,593,969...6,603,469 		JBrowse link
G RIPK2 receptor interacting serine/threonine kinase 2 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:11894098) Ensembl
MGI		 PMID:11894098 GO_REF:0000107 NCBI chr 4:47,026,558...47,075,133
Ensembl chr 4:47,027,098...47,074,704 		JBrowse link
G S100A14 S100 calcium binding protein A14 involved_in IEA
IBA		 Ensembl
GO_Central		 GO_REF:0000033 GO_REF:0000107 NCBI chr 4:96,027,746...96,029,878
Ensembl chr 4:96,027,639...96,029,869 		JBrowse link
G SCIMP SLP adaptor and CSK interacting membrane protein involved_in IEA Ensembl GO_REF:0000107 NCBI chr12:51,772,635...51,794,107
Ensembl chr12:51,773,448...51,794,104 		JBrowse link
G TBK1 TANK binding kinase 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 5:28,880,210...28,929,964
Ensembl chr 5:28,880,205...28,929,963 		JBrowse link
G TICAM1 TIR domain containing adaptor molecule 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 2:74,004,566...74,021,100
Ensembl chr 2:74,004,308...74,021,873 		JBrowse link
G TICAM2 toll like receptor adaptor molecule 2 involved_in ISO (PMID:28630139) UniProt PMID:28630139 NCBI chr 2:119,758,622...119,778,650 JBrowse link
G TIRAP TIR domain containing adaptor protein involved_in IEA
IBA		 Ensembl
GO_Central		 GO_REF:0000033 GO_REF:0000107 NCBI chr 9:53,374,559...53,394,172
Ensembl chr 9:53,375,644...53,394,165 		JBrowse link
G TLR4 toll like receptor 4 involved_in
acts_upstream_of_or_within		 IEA
ISO
IBA		 (PMID:25549946) Ensembl
MGI
GO_Central		 PMID:25549946 GO_REF:0000033 GO_REF:0000107 NCBI chr 1:258,044,610...258,054,641
Ensembl chr 1:258,044,610...258,058,970 		JBrowse link
G TMEM126A transmembrane protein 126A involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:25549946) Ensembl
MGI		 PMID:25549946 GO_REF:0000107 NCBI chr 9:19,576,241...19,585,869
Ensembl chr 9:19,576,295...19,585,277 		JBrowse link
G TNIP3 TNFAIP3 interacting protein 3 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 8:102,892,427...102,990,902
Ensembl chr 8:102,892,366...102,991,848 		JBrowse link
G TRAF3 TNF receptor associated factor 3 involved_in IEA Ensembl GO_REF:0000107
G TRAF6 TNF receptor associated factor 6 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 2:24,602,749...24,628,263
Ensembl chr 2:24,602,804...24,626,072 		JBrowse link
G TRIL TLR4 interactor with leucine rich repeats involved_in ISO (PMID:19710467) UniProt PMID:19710467 NCBI chr18:43,725,910...43,833,993 JBrowse link
MyD88-dependent toll-like receptor 4 signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G LRRFIP2 LRR binding FLII interacting protein 2 acts_upstream_of_or_within ISO (PMID:19265123) MGI PMID:19265123 NCBI chr13:21,666,896...21,790,352
Ensembl chr13:21,670,424...21,793,043 		JBrowse link
negative regulation of toll-like receptor 4 signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ACOD1 aconitate decarboxylase 1 involved_in ISO (PMID:23609450) UniProt PMID:23609450 NCBI chr11:49,077,152...49,088,218
Ensembl chr11:49,077,492...49,087,104 		JBrowse link
G BPIFB1 BPI fold containing family B member 1 involved_in IEA
IBA		 Ensembl
GO_Central		 GO_REF:0000033 GO_REF:0000107 NCBI chr17:36,782,307...36,809,756
Ensembl chr17:36,782,307...36,809,754 		JBrowse link
G DAB2IP DAB2 interacting protein involved_in IEA Ensembl GO_REF:0000107 NCBI chr 1:261,732,280...261,859,833
Ensembl chr 1:261,659,785...261,859,830 		JBrowse link
G LYN LYN proto-oncogene, Src family tyrosine kinase involved_in IEA Ensembl GO_REF:0000107 NCBI chr 4:75,793,273...75,903,710
Ensembl chr 4:75,793,492...75,903,496 		JBrowse link
G MFHAS1 multifunctional ROCO family signaling regulator 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr15:56,200,455...56,296,151
Ensembl chr15:56,200,455...56,295,064 		JBrowse link
G MIR140 microRNA mir-140 involved_in ISO (PMID:30233718)
(PMID:30321456)		 ARUK-UCL PMID:30233718 PMID:30321456 NCBI chr 6:17,077,530...17,077,599
Ensembl chr 6:17,077,507...17,077,620 		JBrowse link
G MIR20A microRNA mir-20a involved_in ISO (PMID:29653364) ARUK-UCL PMID:29653364 NCBI chr11:60,735,109...60,735,179
Ensembl chr11:60,735,099...60,735,196 		JBrowse link
G MIR708 microRNA mir-708 involved_in ISO (PMID:31599428) ARUK-UCL PMID:31599428 NCBI chr 9:13,780,171...13,780,250
Ensembl chr 9:13,780,171...13,780,250 		JBrowse link
G NR1D1 nuclear receptor subfamily 1 group D member 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr12:22,263,549...22,274,131
Ensembl chr12:22,263,657...22,271,643 		JBrowse link
G RAB7B RAB7B, member RAS oncogene family involved_in IEA Ensembl GO_REF:0000107 NCBI chr 9:66,635,636...66,666,034
Ensembl chr 9:66,635,638...66,666,036 		JBrowse link
G SQSTM1 sequestosome 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 2:78,752,768...78,763,998
Ensembl chr 2:78,752,771...78,763,938 		JBrowse link
G TAX1BP1 Tax1 binding protein 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr18:44,827,908...44,910,265
Ensembl chr18:44,827,095...44,910,235 		JBrowse link
G TICAM2 toll like receptor adaptor molecule 2 involved_in ISO (PMID:19412184) UniProt PMID:19412184 NCBI chr 2:119,758,622...119,778,650 JBrowse link
G TREM2 triggering receptor expressed on myeloid cells 2 involved_in ISO (PMID:29407460)
(PMID:31134514)		 ARUK-UCL PMID:29407460 PMID:31134514 NCBI chr 7:36,465,921...36,471,509
Ensembl chr 7:36,465,324...36,471,516 		JBrowse link
G TRIM32 tripartite motif containing 32 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 1:257,051,421...257,066,911
Ensembl chr 1:257,054,228...257,066,909 		JBrowse link
positive regulation of toll-like receptor 4 signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CD14 CD14 molecule involved_in IEA Ensembl GO_REF:0000107 NCBI chr 2:142,348,036...142,349,686
Ensembl chr 2:142,346,360...142,349,581 		JBrowse link
G F2RL1 F2R like trypsin receptor 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 2:85,732,082...85,747,552
Ensembl chr 2:85,732,189...85,750,858 		JBrowse link
G HMGB1 high mobility group box 1 involved_in ISO (PMID:16267105) UniProt PMID:16267105 NCBI chr11:7,195,556...7,321,071 JBrowse link
G IFI35 interferon induced protein 35 involved_in IEA Ensembl GO_REF:0000107 NCBI chr12:19,879,386...19,890,330
Ensembl chr12:19,879,387...19,890,314 		JBrowse link
G LBP lipopolysaccharide binding protein involved_in IEA Ensembl GO_REF:0000107 NCBI chr17:41,398,935...41,429,467
Ensembl chr17:41,398,791...41,429,551 		JBrowse link
G LTF lactotransferrin involved_in IEA Ensembl GO_REF:0000107 NCBI chr13:29,413,886...29,445,751
Ensembl chr13:29,413,886...29,445,739 		JBrowse link
G NINJ1 ninjurin 1 involved_in ISO (PMID:25860173) UniProt PMID:25860173 NCBI chr 3:42,654,536...42,672,830
Ensembl chr 3:42,654,228...42,672,778 		JBrowse link
G NR1H3 nuclear receptor subfamily 1 group H member 3 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 2:15,315,283...15,336,785
Ensembl chr 2:15,315,282...15,334,820 		JBrowse link
G PELI1 pellino E3 ubiquitin protein ligase 1 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:19734906) Ensembl
MGI		 PMID:19734906 GO_REF:0000107 NCBI chr 3:77,740,460...77,796,911
Ensembl chr 3:77,713,489...77,796,914 		JBrowse link
G PTPN22 protein tyrosine phosphatase non-receptor type 22 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 4:106,692,102...106,758,101
Ensembl chr 4:106,686,604...106,758,099 		JBrowse link
G TICAM2 toll like receptor adaptor molecule 2 involved_in ISO (PMID:22685567)
(PMID:19412184)		 UniProt PMID:19412184 PMID:22685567 NCBI chr 2:119,758,622...119,778,650 JBrowse link
G TIRAP TIR domain containing adaptor protein involved_in IEA Ensembl GO_REF:0000107 NCBI chr 9:53,374,559...53,394,172
Ensembl chr 9:53,375,644...53,394,165 		JBrowse link
G WDFY1 WD repeat and FYVE domain containing 1 involved_in IEA
IBA		 Ensembl
GO_Central		 GO_REF:0000033 GO_REF:0000107 NCBI chr15:125,674,142...125,720,187
Ensembl chr15:125,669,842...125,720,158 		JBrowse link
G ZNRF1 zinc and ring finger 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 6:12,555,655...12,668,807 JBrowse link
G ZNRF1 zinc and ring finger 1 involved_in IEA Ensembl GO_REF:0000107 Ensembl chr 6:12,555,664...12,668,804 JBrowse link
regulation of toll-like receptor 4 signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G APPL1 adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr13:39,089,157...39,124,969
Ensembl chr13:39,089,077...39,129,781 		JBrowse link
G APPL2 adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 2 involved_in ISO (PMID:27219021) UniProt PMID:27219021 NCBI chr 5:79,356,046...79,412,235
Ensembl chr 5:79,356,067...79,412,235 		JBrowse link
G FLOT1 flotillin 1 NOT|involved_in ISO (PMID:25204797) UniProt PMID:25204797 NCBI chr 7:23,253,157...23,265,165
Ensembl chr 7:23,252,326...23,265,145 		JBrowse link
G PIK3R1 phosphoinositide-3-kinase regulatory subunit 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr16:46,434,757...46,523,626
Ensembl chr16:46,511,521...46,523,609 		JBrowse link
TIRAP-dependent toll-like receptor 4 signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G TIRAP TIR domain containing adaptor protein involved_in IEA Ensembl GO_REF:0000107 NCBI chr 9:53,374,559...53,394,172
Ensembl chr 9:53,375,644...53,394,165 		JBrowse link
TRAM-dependent toll-like receptor 4 signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G PRKCE protein kinase C epsilon involved_in IEA Ensembl GO_REF:0000107 NCBI chr 3:94,351,277...94,864,549
Ensembl chr 3:94,349,889...94,866,306 		JBrowse link
G RAB11FIP2 RAB11 family interacting protein 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr14:128,068,085...128,110,949
Ensembl chr14:128,068,959...128,110,512 		JBrowse link
G TICAM2 toll like receptor adaptor molecule 2 involved_in ISO (PMID:19412184)
(PMID:22685567)		 UniProt PMID:19412184 PMID:22685567 NCBI chr 2:119,758,622...119,778,650 JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 18954
    immune system process 2582
      activation of immune response 533
        immune response-activating signaling pathway 470
          immune response-activating cell surface receptor signaling pathway 280
            innate immune response activating cell surface receptor signaling pathway 84
              cell surface pattern recognition receptor signaling pathway 77
                cell surface toll-like receptor signaling pathway 72
                  toll-like receptor 4 signaling pathway 63
                    MyD88-dependent toll-like receptor 4 signaling pathway 1
                    TIRAP-dependent toll-like receptor 4 signaling pathway 1
                    TRAM-dependent toll-like receptor 4 signaling pathway 3
                    TRIF-dependent toll-like receptor 4 signaling pathway 0
                    negative regulation of toll-like receptor 4 signaling pathway 15
                    positive regulation of toll-like receptor 4 signaling pathway 15
                    regulation of toll-like receptor 4 signaling pathway + 33
Path 2
Term Annotations click to browse term
  biological_process 18954
    response to stimulus 10124
      response to external stimulus 2590
        response to external biotic stimulus 1715
          response to other organism 1698
            defense response to other organism 1183
              defense response to symbiont 984
                innate immune response 907
                  regulation of innate immune response 449
                    positive regulation of innate immune response 365
                      activation of innate immune response 302
                        innate immune response-activating signaling pathway 280
                          innate immune response activating cell surface receptor signaling pathway 84
                            cell surface pattern recognition receptor signaling pathway 77
                              cell surface toll-like receptor signaling pathway 72
                                toll-like receptor 4 signaling pathway 63
                                  MyD88-dependent toll-like receptor 4 signaling pathway 1
                                  TIRAP-dependent toll-like receptor 4 signaling pathway 1
                                  TRAM-dependent toll-like receptor 4 signaling pathway 3
                                  TRIF-dependent toll-like receptor 4 signaling pathway 0
                                  negative regulation of toll-like receptor 4 signaling pathway 15
                                  positive regulation of toll-like receptor 4 signaling pathway 15
                                  regulation of toll-like receptor 4 signaling pathway + 33
paths to the root