PIK3R1 (phosphoinositide-3-kinase regulatory subunit 1) - Rat Genome Database

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Gene: PIK3R1 (phosphoinositide-3-kinase regulatory subunit 1) Sus scrofa
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Symbol: PIK3R1
Name: phosphoinositide-3-kinase regulatory subunit 1
RGD ID: 14209962
Description: ENCODES a protein that exhibits 1-phosphatidylinositol-3-kinase activity (ortholog); 1-phosphatidylinositol-3-kinase regulator activity (ortholog); ATPase binding (ortholog); INVOLVED IN aging (ortholog); B cell differentiation (ortholog); cellular response to fatty acid (ortholog); PARTICIPATES IN E-cadherin signaling pathway; ephrin - ephrin receptor bidirectional signaling axis; epidermal growth factor/neuregulin signaling pathway; ASSOCIATED WITH Agammaglobulinemia 7, Autosomal Recessive (ortholog); Alzheimer's disease (ortholog); Animal Mammary Neoplasms (ortholog); FOUND IN cytoplasm (ortholog); membrane (ortholog); neuron projection (ortholog); INTERACTS WITH S-nitrosoglutathione
Type: protein-coding
RefSeq Status: MODEL
Also known as: phosphatidylinositol 3-kinase regulatory subunit alpha; phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Sscrofa11.1 - Pig Sscrofa11.1 Assembly
Position:
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1646,434,873 - 46,523,609 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11646,434,757 - 46,523,626 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21650,135,837 - 50,148,434 (-)NCBISscrofa10.2Sscrofa10.2susScr3
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
aging  (ISO)
B cell differentiation  (IEA,ISO)
cellular glucose homeostasis  (IEA)
cellular response to fatty acid  (ISO)
cellular response to insulin stimulus  (ISO)
cellular response to UV  (IEA,ISO)
extrinsic apoptotic signaling pathway via death domain receptors  (IEA,ISO)
glucose metabolic process  (ISO)
growth hormone receptor signaling pathway  (IEA)
insulin receptor signaling pathway  (IBA,ISO)
insulin-like growth factor receptor signaling pathway  (IEA,ISO)
intrinsic apoptotic signaling pathway in response to DNA damage  (IEA,ISO)
negative regulation of apoptotic process  (IEA,ISO)
negative regulation of blood pressure  (ISO)
negative regulation of cell adhesion  (ISO)
negative regulation of cell-cell adhesion  (ISO)
negative regulation of cell-matrix adhesion  (IEA,ISO)
negative regulation of heart rate  (ISO)
negative regulation of muscle cell apoptotic process  (ISO)
negative regulation of osteoclast differentiation  (IEA,ISO)
negative regulation of proteolysis  (ISO)
negative regulation of smooth muscle cell proliferation  (ISO)
negative regulation of stress fiber assembly  (IEA)
phosphatidylinositol 3-kinase signaling  (IEA)
phosphatidylinositol phosphate biosynthetic process  (IBA)
positive regulation of cell migration  (IEA,ISO)
positive regulation of endoplasmic reticulum unfolded protein response  (IEA)
positive regulation of filopodium assembly  (IEA)
positive regulation of focal adhesion disassembly  (IEA)
positive regulation of gene expression  (ISO)
positive regulation of lamellipodium assembly  (IEA)
positive regulation of myoblast differentiation  (ISO)
positive regulation of protein import into nucleus  (IEA)
positive regulation of protein phosphorylation  (ISO)
positive regulation of RNA splicing  (IEA)
positive regulation of synapse assembly  (ISO)
positive regulation of transcription by RNA polymerase II  (IEA,ISO)
positive regulation of tumor necrosis factor production  (IEA,ISO)
protein import into nucleus  (IEA,ISO)
protein phosphorylation  (IEA,ISO)
protein stabilization  (IEA)
protein transport  (IEA)
regulation of insulin receptor signaling pathway  (IEA,ISO)
regulation of phosphatidylinositol 3-kinase activity  (IBA,ISO)
regulation of protein localization to plasma membrane  (IEA,ISO)
regulation of stress fiber assembly  (ISO)
response to amino acid  (ISO)
response to cAMP  (ISO)
response to dexamethasone  (ISO)
response to drug  (ISO)
response to endoplasmic reticulum stress  (IEA)
response to estradiol  (ISO)
response to ethanol  (ISO)
response to fatty acid  (ISO)
response to fructose  (ISO)
response to glucocorticoid  (ISO)
response to growth factor  (ISO)
response to insulin  (ISO)
response to iron(II) ion  (ISO)
response to nutrient  (ISO)
response to progesterone  (ISO)
response to testosterone  (ISO)
response to yeast  (ISO)
signal transduction  (IEA)

References
Additional References at PubMed
PMID:12873230   PMID:14681463   PMID:16284184   PMID:18420583  


Genomics

Comparative Map Data
PIK3R1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1646,434,873 - 46,523,609 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11646,434,757 - 46,523,626 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21650,135,837 - 50,148,434 (-)NCBISscrofa10.2Sscrofa10.2susScr3
PIK3R1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl568,215,756 - 68,301,821 (+)EnsemblGRCh38hg38GRCh38
GRCh38568,215,737 - 68,301,821 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh37567,511,584 - 67,597,649 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36567,558,218 - 67,633,405 (+)NCBINCBI36hg18NCBI36
Build 34567,622,250 - 67,633,403NCBI
Celera564,520,829 - 64,597,175 (+)NCBI
Cytogenetic Map5q13.1NCBI
HuRef564,468,818 - 64,555,164 (+)NCBIHuRef
CHM1_1567,511,846 - 67,597,747 (+)NCBICHM1_1
Pik3r1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3913101,817,269 - 101,904,725 (-)NCBIGRCm39mm39
GRCm39 Ensembl13101,817,071 - 101,904,725 (-)Ensembl
GRCm3813101,680,761 - 101,768,217 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl13101,680,563 - 101,768,217 (-)EnsemblGRCm38mm10GRCm38
MGSCv3713102,450,716 - 102,538,172 (-)NCBIGRCm37mm9NCBIm37
MGSCv3613102,781,018 - 102,792,904 (-)NCBImm8
Celera13105,285,857 - 105,373,612 (-)NCBICelera
Cytogenetic Map13D1NCBI
cM Map1353.92NCBI
Pik3r1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2232,878,942 - 32,963,611 (-)NCBI
Rnor_6.0 Ensembl231,745,088 - 31,826,867 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.0231,742,326 - 31,826,882 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0250,891,225 - 50,965,217 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4232,602,673 - 32,675,350 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1232,523,041 - 32,595,719 (-)NCBI
Celera228,878,690 - 28,948,863 (-)NCBICelera
RH 3.4 Map2111.0RGD
Cytogenetic Map2q12NCBI
Pik3r1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554461,020,043 - 1,098,820 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554461,020,707 - 1,098,327 (-)NCBIChiLan1.0ChiLan1.0
PIK3R1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1547,268,477 - 47,350,960 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl547,267,286 - 47,350,960 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0545,701,219 - 45,786,652 (-)NCBIMhudiblu_PPA_v0panPan3
PIK3R1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1253,447,802 - 53,527,563 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl253,448,286 - 53,524,970 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha250,408,936 - 50,489,628 (+)NCBI
ROS_Cfam_1.0253,951,256 - 54,032,010 (+)NCBI
UMICH_Zoey_3.1251,011,708 - 51,092,420 (+)NCBI
UNSW_CanFamBas_1.0251,791,194 - 51,871,863 (+)NCBI
UU_Cfam_GSD_1.0252,678,736 - 52,759,442 (+)NCBI
Pik3r1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024407213192,252,011 - 192,336,736 (-)NCBI
SpeTri2.0NW_0049364801,188,408 - 1,273,210 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PIK3R1
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1464,321,296 - 64,406,188 (+)NCBI
ChlSab1.1 Ensembl464,321,078 - 64,406,519 (+)Ensembl
Pik3r1
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046248151,290,106 - 1,376,961 (-)NCBI


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system hemolymphoid system musculoskeletal system nervous system renal system reproductive system respiratory system
High
Medium 10 3 1 5 2 21 2 3 3
Low 1 2 2
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSSSCT00000030461   ⟹   ENSSSCP00000024885
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl1646,434,873 - 46,523,284 (+)Ensembl
RefSeq Acc Id: ENSSSCT00000033882   ⟹   ENSSSCP00000030884
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl1646,511,499 - 46,520,660 (+)Ensembl
RefSeq Acc Id: ENSSSCT00000042717   ⟹   ENSSSCP00000058661
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl1646,446,383 - 46,523,287 (+)Ensembl
RefSeq Acc Id: ENSSSCT00000058089   ⟹   ENSSSCP00000043773
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl1646,511,521 - 46,523,609 (+)Ensembl
RefSeq Acc Id: XM_005672504   ⟹   XP_005672561
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.11646,511,757 - 46,520,673 (+)NCBI
Sequence:
RefSeq Acc Id: XM_021076847   ⟹   XP_020932506
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.11646,434,757 - 46,523,626 (+)NCBI
Sequence:
RefSeq Acc Id: XM_021076848   ⟹   XP_020932507
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.11646,435,555 - 46,523,626 (+)NCBI
Sequence:
RefSeq Acc Id: XM_021076849   ⟹   XP_020932508
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.11646,503,653 - 46,523,626 (+)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: XP_020932506   ⟸   XM_021076847
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_020932507   ⟸   XM_021076848
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_020932508   ⟸   XM_021076849
- Peptide Label: isoform X3
- Sequence:
RefSeq Acc Id: XP_005672561   ⟸   XM_005672504
- Peptide Label: isoform X2
- UniProtKB: F1SKR9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSSSCP00000024885   ⟸   ENSSSCT00000030461
RefSeq Acc Id: ENSSSCP00000043773   ⟸   ENSSSCT00000058089
RefSeq Acc Id: ENSSSCP00000058661   ⟸   ENSSSCT00000042717
RefSeq Acc Id: ENSSSCP00000030884   ⟸   ENSSSCT00000033882
Protein Domains
PI3K_P85_iSH2   Rho-GAP   SH2   SH3


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSSCG00000016958 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCG00070017653 UniProtKB/TrEMBL
Ensembl Protein ENSSSCP00000024885 ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCP00000030884 ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCP00000043773 ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCP00000058661 UniProtKB/TrEMBL
  ENSSSCP00070029204 UniProtKB/TrEMBL
  ENSSSCP00070029206 UniProtKB/TrEMBL
  ENSSSCP00070029214 UniProtKB/TrEMBL
  ENSSSCP00070029218 UniProtKB/TrEMBL
  ENSSSCP00070029226 UniProtKB/TrEMBL
Ensembl Transcript ENSSSCT00000030461 ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCT00000033882 ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCT00000042717 UniProtKB/TrEMBL
  ENSSSCT00000058089 ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCT00070034948 UniProtKB/TrEMBL
  ENSSSCT00070034954 UniProtKB/TrEMBL
  ENSSSCT00070034963 UniProtKB/TrEMBL
  ENSSSCT00070034970 UniProtKB/TrEMBL
  ENSSSCT00070034980 UniProtKB/TrEMBL
Gene3D-CATH 1.10.555.10 UniProtKB/TrEMBL
  3.30.505.10 UniProtKB/TrEMBL
InterPro ISH2_PIK3R1 UniProtKB/TrEMBL
  PI3K_P85_iSH2 UniProtKB/TrEMBL
  PI3K_p85alpha_SH3 UniProtKB/TrEMBL
  PI3kinase_P85_cSH2 UniProtKB/TrEMBL
  PI3kinase_P85_nSH2 UniProtKB/TrEMBL
  Rho_GTPase_activation_prot UniProtKB/TrEMBL
  RhoGAP_dom UniProtKB/TrEMBL
  SH2 UniProtKB/TrEMBL
  SH2_dom_sf UniProtKB/TrEMBL
  SH3-like_dom_sf UniProtKB/TrEMBL
  SH3_domain UniProtKB/TrEMBL
KEGG Report ssc:100623707 UniProtKB/TrEMBL
NCBI Gene PIK3R1 ENTREZGENE
Pfam PI3K_P85_iSH2 UniProtKB/TrEMBL
  RhoGAP UniProtKB/TrEMBL
  SH2 UniProtKB/TrEMBL
PRINTS SH2DOMAIN UniProtKB/TrEMBL
PROSITE RHOGAP UniProtKB/TrEMBL
  SH2 UniProtKB/TrEMBL
  SH3 UniProtKB/TrEMBL
SMART RhoGAP UniProtKB/TrEMBL
  SH2 UniProtKB/TrEMBL
  SH3 UniProtKB/TrEMBL
Superfamily-SCOP SSF48350 UniProtKB/TrEMBL
  SSF50044 UniProtKB/TrEMBL
  SSF55550 UniProtKB/TrEMBL
UniProt A0A287AIC1_PIG UniProtKB/TrEMBL
  A0A287BQF3_PIG UniProtKB/TrEMBL
  A0A4X1UGZ9_PIG UniProtKB/TrEMBL
  A0A4X1UJ28_PIG UniProtKB/TrEMBL
  A0A4X1ULC7_PIG UniProtKB/TrEMBL
  A0A4X1UM36_PIG UniProtKB/TrEMBL
  F1SKR9 ENTREZGENE, UniProtKB/TrEMBL
  I3LLB7_PIG UniProtKB/TrEMBL
  Q864U2_PIG UniProtKB/TrEMBL
  Q864U3_PIG UniProtKB/TrEMBL
VGNC ID VGNC:91445 ENTREZGENE