LTF (lactotransferrin) - Rat Genome Database

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Gene: LTF (lactotransferrin) Sus scrofa
Analyze
Symbol: LTF
Name: lactotransferrin
RGD ID: 13886816
Description: ENCODES a protein that exhibits peptidase activity (ortholog); INVOLVED IN antibacterial humoral response (ortholog); antifungal humoral response (ortholog); bone morphogenesis (ortholog); ASSOCIATED WITH Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis (ortholog); candidiasis (ortholog); Carbon Tetrachloride Poisoning (ortholog); FOUND IN cytoplasm (ortholog); secretory granule (ortholog); specific granule (ortholog); INTERACTS WITH bis(2-chloroethyl) sulfide
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: lactoferrin; PLF
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Sscrofa11.1 - Pig Sscrofa11.1 Assembly
Position:
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1329,413,886 - 29,445,737 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11329,413,886 - 29,445,751 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21332,577,743 - 32,609,425 (-)NCBISscrofa10.2Sscrofa10.2susScr3
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
antibacterial humoral response  (IBA,IEA,ISS)
antifungal humoral response  (IEA,ISS)
antimicrobial humoral immune response mediated by antimicrobial peptide  (IEA)
bone morphogenesis  (IEA,ISS)
defense response to Gram-negative bacterium  (IEA)
defense response to Gram-positive bacterium  (ISO)
innate immune response  (ISO)
innate immune response in mucosa  (IEA,ISS)
iron ion homeostasis  (IEA)
iron ion transport  (IBA)
killing of cells of other organism  (IEA)
membrane disruption in other organism  (IEA)
negative regulation by host of viral process  (IEA)
negative regulation of apoptotic process  (ISS)
negative regulation of ATPase activity  (IEA)
negative regulation of cysteine-type endopeptidase activity  (IEA)
negative regulation of lipopolysaccharide-mediated signaling pathway  (IEA,ISS)
negative regulation of membrane potential  (ISO)
negative regulation of osteoclast development  (ISS)
negative regulation of single-species biofilm formation in or on host organism  (IEA,ISS)
negative regulation of tumor necrosis factor (ligand) superfamily member 11 production  (ISS)
negative regulation of viral genome replication  (IEA)
negative regulation of viral process  (ISO)
ossification  (IEA)
positive regulation of bone mineralization involved in bone maturation  (ISS)
positive regulation of chondrocyte proliferation  (IEA,ISS)
positive regulation of I-kappaB kinase/NF-kappaB signaling  (IEA)
positive regulation of NF-kappaB transcription factor activity  (IEA)
positive regulation of osteoblast differentiation  (IEA,ISS)
positive regulation of osteoblast proliferation  (IEA,ISS)
positive regulation of protein serine/threonine kinase activity  (IEA)
positive regulation of toll-like receptor 4 signaling pathway  (IEA)
proteolysis  (IEA)
regulation of cytokine production  (ISS)
regulation of tumor necrosis factor production  (IEA,ISS)
retina homeostasis  (ISO)

Cellular Component

References
Additional References at PubMed
PMID:1503259   PMID:1511016   PMID:2605266   PMID:14681463   PMID:15777643   PMID:16244999   PMID:17145712   PMID:17489602   PMID:20541878   PMID:20607309   PMID:27487204  


Genomics

Comparative Map Data
LTF
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1329,413,886 - 29,445,737 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11329,413,886 - 29,445,751 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21332,577,743 - 32,609,425 (-)NCBISscrofa10.2Sscrofa10.2susScr3
LTF
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl346,435,645 - 46,485,234 (-)EnsemblGRCh38hg38GRCh38
GRCh38346,435,645 - 46,485,234 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh37346,477,136 - 46,526,724 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36346,452,500 - 46,481,399 (-)NCBINCBI36hg18NCBI36
Build 34346,452,500 - 46,481,399NCBI
Celera346,414,868 - 46,443,775 (-)NCBI
Cytogenetic Map3p21.31NCBI
HuRef346,519,882 - 46,548,964 (-)NCBIHuRef
CHM1_1346,427,517 - 46,456,606 (-)NCBICHM1_1
Ltf
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm399110,848,360 - 110,871,834 (+)NCBIGRCm39mm39
GRCm39 Ensembl9110,848,339 - 110,871,835 (+)Ensembl
GRCm389111,019,292 - 111,042,766 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl9111,019,271 - 111,042,767 (+)EnsemblGRCm38mm10GRCm38
MGSCv379110,921,796 - 110,945,270 (+)NCBIGRCm37mm9NCBIm37
MGSCv369110,864,108 - 110,887,582 (+)NCBImm8
Celera9110,742,738 - 110,766,162 (+)NCBICelera
Cytogenetic Map9F2NCBI
cM Map960.79NCBI
Ltf
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.28110,999,948 - 111,022,795 (+)NCBImRatBN7.2
mRatBN7.2 Ensembl8110,999,948 - 111,022,795 (+)Ensembl
Rnor_6.08119,290,416 - 119,313,261 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl8119,290,416 - 119,313,261 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.08118,632,730 - 118,655,575 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.48115,417,764 - 115,440,609 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.18115,437,256 - 115,458,062 (+)NCBI
Celera8110,282,264 - 110,305,105 (+)NCBICelera
Cytogenetic Map8q32NCBI
Ltf
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542025,580,359 - 25,604,331 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495542025,580,449 - 25,604,277 (+)NCBIChiLan1.0ChiLan1.0
LTF
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1347,442,440 - 47,471,532 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl347,442,440 - 47,471,532 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0346,337,738 - 46,367,476 (-)NCBIMhudiblu_PPA_v0panPan3
LTF
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12042,231,994 - 42,263,202 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2042,231,994 - 42,263,202 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2042,147,994 - 42,179,342 (+)NCBI
ROS_Cfam_1.02042,714,382 - 42,745,648 (+)NCBI
UMICH_Zoey_3.12041,955,622 - 41,986,941 (+)NCBI
UNSW_CanFamBas_1.02042,357,046 - 42,388,364 (+)NCBI
UU_Cfam_GSD_1.02042,637,942 - 42,669,274 (+)NCBI
Ltf
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118200,795,136 - 200,824,718 (-)NCBI
SpeTri2.0NW_004936596344,287 - 373,788 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
LTF
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1227,867,332 - 7,896,403 (-)NCBIChlSab1.1chlSab2
ChlSab1.1 Ensembl227,867,286 - 7,894,521 (-)EnsemblChlSab1.1chlSab2
Vero_WHO_p1.0NW_023666041159,254,403 - 159,283,476 (+)NCBIVero_WHO_p1.0
Ltf
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462473074,636,554 - 74,656,817 (+)NCBIHetGla_female_1.0hetGla2


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system hemolymphoid system nervous system renal system reproductive system respiratory system
High
Medium 1 1
Low 2 2 3 6 1
Below cutoff 2 2 1 1 13 1 1 2

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_214362 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_021068563 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AEMK02000085 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF044256 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF222916 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK237898 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK238358 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK351012 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK397900 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK398010 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK399757 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AP006185 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AP006435 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY306198 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  EF012241 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FP325142 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  GFLN01042181 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  L77887 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M81327 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M92089 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSSSCT00000030564   ⟹   ENSSSCP00000026769
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl1329,413,887 - 29,445,737 (-)Ensembl
RefSeq Acc Id: ENSSSCT00000089932   ⟹   ENSSSCP00000068563
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl1329,413,886 - 29,443,683 (-)Ensembl
RefSeq Acc Id: NM_214362   ⟹   NP_999527
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.11329,413,886 - 29,445,739 (-)NCBI
Sequence:
RefSeq Acc Id: XM_021068563   ⟹   XP_020924222
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.11329,413,886 - 29,445,751 (-)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: XP_020924222   ⟸   XM_021068563
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: NP_999527   ⟸   NM_214362
- Peptide Label: precursor
- Sequence:
RefSeq Acc Id: ENSSSCP00000026769   ⟸   ENSSSCT00000030564
RefSeq Acc Id: ENSSSCP00000068563   ⟸   ENSSSCT00000089932
Protein Domains
Transferrin-like


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSSCG00000029879 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCG00070007434 UniProtKB/TrEMBL
Ensembl Protein ENSSSCP00000026769 ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCP00000068563 ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCP00070011865 UniProtKB/TrEMBL
  ENSSSCP00070011871 UniProtKB/TrEMBL
Ensembl Transcript ENSSSCT00000030564 ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCT00000089932 ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCT00070014377 UniProtKB/TrEMBL
  ENSSSCT00070014383 UniProtKB/TrEMBL
InterPro Lactotransferrin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Transferrin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Transferrin-like_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Transferrin_Fe_BS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report ssc:397649 UniProtKB/Swiss-Prot
NCBI Gene LTF ENTREZGENE
Pfam Transferrin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PIRSF Lactotransferrin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Transferrin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PRINTS TRANSFERRIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE TRANSFERRIN_LIKE_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TRANSFERRIN_LIKE_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TRANSFERRIN_LIKE_3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TRANSFERRIN_LIKE_4 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART TR_FER UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A4X1T9C7_PIG UniProtKB/TrEMBL
  A0A4X1T9V8_PIG UniProtKB/TrEMBL
  A0A5G2QUQ4_PIG UniProtKB/TrEMBL
  P14632 ENTREZGENE
  Q6YST2_PIG UniProtKB/TrEMBL
  Q6YT39_PIG UniProtKB/TrEMBL
  Q8WMN8_PIG UniProtKB/TrEMBL
  Q9GKJ4_PIG UniProtKB/TrEMBL
  TRFL_PIG UniProtKB/Swiss-Prot
UniProt Secondary Q29557 UniProtKB/Swiss-Prot
VGNC ID VGNC:89891 ENTREZGENE