IRAK1 (interleukin 1 receptor associated kinase 1) - Rat Genome Database

Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Gene: IRAK1 (interleukin 1 receptor associated kinase 1) Sus scrofa
Analyze
Symbol: IRAK1
Name: interleukin 1 receptor associated kinase 1
RGD ID: 13941400
Description: ENCODES a protein that exhibits heat shock protein binding (ortholog); interleukin-1 receptor binding (ortholog); protein kinase activity (ortholog); INVOLVED IN aging (ortholog); cellular response to heat (ortholog); cellular response to hypoxia (ortholog); PARTICIPATES IN interleukin-1 signaling pathway; Toll-like receptor signaling pathway; ASSOCIATED WITH adrenoleukodystrophy (ortholog); ankylosing spondylitis (ortholog); autistic disorder (ortholog); FOUND IN lipid droplet (ortholog); membrane (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: interleukin receptor associated kinase 1; interleukin-1 receptor-associated kinase 1
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Sscrofa11.1 - Pig Sscrofa11.1 Assembly
Position:
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 EnsemblX124,717,612 - 124,724,860 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1X124,717,604 - 124,724,855 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2X142,283,035 - 142,290,286 (-)NCBISscrofa10.2Sscrofa10.2susScr3
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
activation of NF-kappaB-inducing kinase activity  (IEA)
aging  (ISO)
cellular response to heat  (ISO)
cellular response to hypoxia  (ISO)
cellular response to lipopolysaccharide  (IBA,ISO)
cellular response to organic substance  (IEA)
cytokine-mediated signaling pathway  (IBA,ISO)
innate immune response  (IBA,IEA,ISO)
interleukin-1-mediated signaling pathway  (IBA,IEA,ISO)
intracellular signal transduction  (IBA)
JNK cascade  (ISO)
lipopolysaccharide-mediated signaling pathway  (IEA,ISO)
macromolecule metabolic process  (IEA)
negative regulation of cholesterol efflux  (ISO)
negative regulation of DNA-templated transcription  (ISO)
negative regulation of NF-kappaB transcription factor activity  (IEA)
nitrogen compound metabolic process  (IEA)
phosphorylation  (IEA)
positive regulation of I-kappaB kinase/NF-kappaB signaling  (IBA,IEA,ISO)
positive regulation of JUN kinase activity  (ISO)
positive regulation of leukocyte adhesion to vascular endothelial cell  (IEA)
positive regulation of MAP kinase activity  (IBA)
positive regulation of NF-kappaB transcription factor activity  (IBA,IEA,ISO)
positive regulation of NIK/NF-kappaB signaling  (IEA)
positive regulation of smooth muscle cell proliferation  (ISO)
positive regulation of type I interferon production  (IEA)
primary metabolic process  (IEA)
protein autophosphorylation  (IEA,ISO)
protein phosphorylation  (IEA,ISO)
regulation of cytokine-mediated signaling pathway  (IEA)
response to interleukin-1  (IEA)
response to lipopolysaccharide  (IEA,ISO)
response to peptidoglycan  (ISO)
signal transduction  (IEA)
toll-like receptor 2 signaling pathway  (IBA,IEA,ISO)
toll-like receptor 4 signaling pathway  (IBA,ISO)
type I interferon-mediated signaling pathway  (IEA)

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:14681463   PMID:17145712  


Genomics

Comparative Map Data
IRAK1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 EnsemblX124,717,612 - 124,724,860 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1X124,717,604 - 124,724,855 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2X142,283,035 - 142,290,286 (-)NCBISscrofa10.2Sscrofa10.2susScr3
IRAK1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38X154,010,507 - 154,019,902 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 EnsemblX154,010,506 - 154,019,902 (-)EnsemblGRCh38hg38GRCh38
GRCh37X153,275,958 - 153,285,353 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36X152,929,151 - 152,938,536 (-)NCBINCBI36hg18NCBI36
Build 34X152,796,808 - 152,806,189NCBI
CeleraX153,509,662 - 153,519,047 (-)NCBI
Cytogenetic MapXq28NCBI
HuRefX141,927,208 - 141,942,770 (-)NCBIHuRef
CHM1_1X153,150,366 - 153,159,748 (-)NCBICHM1_1
T2T-CHM13v2.0X152,284,194 - 152,293,583 (-)NCBI
Irak1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39X73,057,520 - 73,067,527 (-)NCBIGRCm39mm39
GRCm39 EnsemblX73,057,520 - 73,067,524 (-)Ensembl
GRCm38X74,013,914 - 74,023,921 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 EnsemblX74,013,914 - 74,023,918 (-)EnsemblGRCm38mm10GRCm38
MGSCv37X71,259,253 - 71,269,260 (-)NCBIGRCm37mm9NCBIm37
MGSCv36X70,267,692 - 70,276,641 (-)NCBImm8
CeleraX65,266,305 - 65,276,311 (-)NCBICelera
Cytogenetic MapXA7.3NCBI
cM MapX37.61NCBI
Irak1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2X151,768,621 - 151,778,521 (-)NCBImRatBN7.2
mRatBN7.2 EnsemblX151,768,777 - 151,778,521 (-)Ensembl
Rnor_6.0X156,716,469 - 156,726,367 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 EnsemblX156,716,604 - 156,725,977 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01152,464,303 - 152,474,397 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4X159,960,184 - 159,969,180 (-)NCBIRGSC3.4rn4RGSC3.4
Celera1136,116,523 - 136,125,519 (+)NCBICelera
Cytogenetic MapXq37NCBI
Irak1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955580661,609 - 668,622 (-)EnsemblChiLan1.0
ChiLan1.0NW_004955580663,651 - 668,622 (-)NCBIChiLan1.0ChiLan1.0
IRAK1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1X153,446,827 - 153,458,189 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 EnsemblX153,446,827 - 153,460,602 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0X143,560,802 - 143,570,185 (-)NCBIMhudiblu_PPA_v0panPan3
IRAK1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1X121,853,340 - 121,862,582 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 EnsemblX121,819,432 - 121,862,576 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_TashaX107,180,516 - 107,191,312 (-)NCBI
ROS_Cfam_1.0X124,993,051 - 125,003,852 (-)NCBI
ROS_Cfam_1.0 EnsemblX124,995,644 - 125,003,858 (-)Ensembl
UMICH_Zoey_3.1X120,762,292 - 120,773,086 (-)NCBI
UNSW_CanFamBas_1.0X123,277,991 - 123,288,705 (-)NCBI
UU_Cfam_GSD_1.0X123,039,025 - 123,049,823 (-)NCBI
Irak1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2X119,153,636 - 119,162,536 (-)NCBI
SpeTri2.0NW_004936809891,407 - 900,311 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
IRAK1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1X128,433,462 - 128,443,126 (-)NCBIChlSab1.1chlSab2
ChlSab1.1 EnsemblX128,433,465 - 128,443,043 (-)EnsemblChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366606566,307,276 - 66,317,037 (-)NCBIVero_WHO_p1.0
Irak1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624946613,890 - 618,445 (-)EnsemblHetGla_female_1.0hetGla2
HetGla 1.0NW_004624946613,392 - 618,459 (-)NCBIHetGla_female_1.0hetGla2


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system hemolymphoid system musculoskeletal system nervous system renal system reproductive system respiratory system
High
Medium 1
Low 10 4 3 4 2 23 2 3 3
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSSSCT00000013987   ⟹   ENSSSCP00000013604
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 EnsemblX124,717,612 - 124,724,860 (-)Ensembl
RefSeq Acc Id: XM_003135490   ⟹   XP_003135538
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1X124,717,604 - 124,724,855 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_003135538 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein CAE47756 (Get FASTA)   NCBI Sequence Viewer  
  JAA74211 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: XP_003135538   ⟸   XM_003135490
- Sequence:
RefSeq Acc Id: ENSSSCP00000013604   ⟸   ENSSSCT00000013987
Protein Domains
Protein kinase


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSSCG00000012795 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCG00015012653 UniProtKB/TrEMBL
  ENSSSCG00025043453 UniProtKB/TrEMBL
  ENSSSCG00055007093 UniProtKB/TrEMBL
Ensembl Protein ENSSSCP00000013604 ENTREZGENE
  ENSSSCP00000013604.4 UniProtKB/TrEMBL
  ENSSSCP00015006525.1 UniProtKB/TrEMBL
  ENSSSCP00025025091.1 UniProtKB/TrEMBL
  ENSSSCP00055010825.1 UniProtKB/TrEMBL
  ENSSSCP00055010912.1 UniProtKB/TrEMBL
Ensembl Transcript ENSSSCT00000013987 ENTREZGENE
  ENSSSCT00000013987.5 UniProtKB/TrEMBL
  ENSSSCT00015016737.1 UniProtKB/TrEMBL
  ENSSSCT00025059150.1 UniProtKB/TrEMBL
  ENSSSCT00055013749.1 UniProtKB/TrEMBL
  ENSSSCT00055013860.1 UniProtKB/TrEMBL
Gene3D-CATH 1.10.533.10 UniProtKB/TrEMBL
InterPro DEATH-like_dom_sf UniProtKB/TrEMBL
  Death_domain UniProtKB/TrEMBL
  Death_IRAK1 UniProtKB/TrEMBL
  IRAK1 UniProtKB/TrEMBL
  Kinase-like_dom_sf UniProtKB/TrEMBL
  Prot_kinase_dom UniProtKB/TrEMBL
  Protein_kinase_ATP_BS UniProtKB/TrEMBL
  Ser/Thr_kinase_AS UniProtKB/TrEMBL
KEGG Report ssc:396606 UniProtKB/TrEMBL
NCBI Gene IRAK1 ENTREZGENE
PANTHER PTHR24419:SF1 UniProtKB/TrEMBL
Pfam Death UniProtKB/TrEMBL
  Pkinase UniProtKB/TrEMBL
PROSITE PROTEIN_KINASE_ATP UniProtKB/TrEMBL
  PROTEIN_KINASE_DOM UniProtKB/TrEMBL
  PROTEIN_KINASE_ST UniProtKB/TrEMBL
SMART S_TKc UniProtKB/TrEMBL
Superfamily-SCOP SSF47986 UniProtKB/TrEMBL
  SSF56112 UniProtKB/TrEMBL
UniProt A0A8D0MRU1_PIG UniProtKB/TrEMBL
  A0A8D0URX2_PIG UniProtKB/TrEMBL
  A0A8D1PYI5_PIG UniProtKB/TrEMBL
  F1RZU1_PIG UniProtKB/TrEMBL
  M3TYR1_PIG UniProtKB/TrEMBL
  Q70EK3_PIG UniProtKB/TrEMBL
VGNC ID VGNC:89198 ENTREZGENE