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ONTOLOGY REPORT - ANNOTATIONS

Term:negative regulation of tumor necrosis factor-mediated signaling pathway
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Accession:GO:0010804 term browser browse the term
Definition:Any process that decreases the rate or extent of the tumor necrosis factor-mediated signaling pathway. The tumor necrosis factor-mediated signaling pathway is the series of molecular signals generated as a consequence of tumor necrosis factor binding to a cell surface receptor.
Synonyms:exact_synonym: negative regulation of TNF signaling;   negative regulation of TNF-mediated signaling pathway;   negative regulation of tumor necrosis factor-mediated signalling pathway


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negative regulation of tumor necrosis factor-mediated signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ADIPOQ adiponectin, C1Q and collagen domain containing involved_in IEA
ISS		 Ensembl
UniProt		 GO_REF:0000024 GO_REF:0000107 NCBI chr34:19,398,310...19,410,519
Ensembl chr34:19,354,825...19,409,844 		JBrowse link
G APOA1 apolipoprotein A1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 5:16,740,071...16,742,081
Ensembl chr 5:16,740,130...16,741,943 		JBrowse link
G BIRC7 baculoviral IAP repeat containing 7 involved_in ISO (PMID:11865055) UniProt PMID:11865055 NCBI chr24:46,950,700...46,956,375
Ensembl chr24:46,952,474...46,955,495 		JBrowse link
G CCDC3 coiled-coil domain containing 3 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 2:23,477,696...23,593,107
Ensembl chr 2:23,477,696...23,591,036 		JBrowse link
G CLDN18 claudin 18 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:22437732) Ensembl
MGI		 PMID:22437732 GO_REF:0000107 NCBI chr23:34,229,115...34,257,431
Ensembl chr23:34,228,992...34,255,650 		JBrowse link
G DICER1 dicer 1, ribonuclease III involved_in
acts_upstream_of		 IEA
ISO		 (PMID:26435691) Ensembl
ARUK-UCL		 PMID:26435691 GO_REF:0000107 NCBI chr 8:63,970,245...64,029,438
Ensembl chr 8:63,972,027...64,019,879 		JBrowse link
G F2RL1 F2R like trypsin receptor 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 3:29,801,119...29,810,006
Ensembl chr 3:29,800,211...29,810,180 		JBrowse link
G GAS6 growth arrest specific 6 involved_in IEA Ensembl GO_REF:0000107 NCBI chr22:60,975,196...61,005,869
Ensembl chr22:60,974,849...61,005,875 		JBrowse link
G GPS2 G protein pathway suppressor 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 5:32,273,169...32,275,915
Ensembl chr 5:32,273,173...32,275,580 		JBrowse link
G H2BC11 H2B clustered histone 11 involved_in ISO (PMID:11859126) UniProt PMID:11859126 NCBI chr35:24,540,629...24,543,786 JBrowse link
G HSF4 heat shock transcription factor 4 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 5:82,190,996...82,201,224
Ensembl chr 5:82,196,500...82,201,151
Ensembl chr 5:82,196,500...82,201,151 		JBrowse link
G LOC119876002 caspase recruitment domain-containing protein 8-like involved_in IEA Ensembl GO_REF:0000107
G LOC491519 caspase recruitment domain family, member 8 involved_in ISO (PMID:11821383) UniProt PMID:11821383 NCBI chr 1:107,994,215...108,025,875 JBrowse link
G MIR125B-1 microRNA mir-125b-1 acts_upstream_of ISO (PMID:26435691) ARUK-UCL PMID:26435691 NCBI chr 5:12,097,672...12,097,732
Ensembl chr 5:12,097,658...12,097,745 		JBrowse link
G MIR125B-2 microRNA mir-125b-2 acts_upstream_of ISO (PMID:26435691) ARUK-UCL PMID:26435691 NCBI chr31:13,304,980...13,305,040
Ensembl chr31:13,304,964...13,305,052 		JBrowse link
G MIR130A microRNA mir-130a acts_upstream_of ISO (PMID:26435691) ARUK-UCL PMID:26435691 NCBI chr18:38,543,618...38,543,679
Ensembl chr18:38,543,618...38,543,681 		JBrowse link
G MIR152 microRNA mir-152 involved_in ISO (PMID:24813629) BHF-UCL PMID:24813629 NCBI chr 9:24,335,161...24,335,219
Ensembl chr 9:24,335,146...24,335,225 		JBrowse link
G MIR27B microRNA mir-27b acts_upstream_of_or_within ISO (PMID:31124343) ARUK-UCL PMID:31124343 NCBI chr 1:71,678,117...71,678,179
Ensembl chr 1:71,678,105...71,678,191 		JBrowse link
G NR1H4 nuclear receptor subfamily 1 group H member 4 involved_in IEA Ensembl GO_REF:0000107 NCBI chr15:39,497,313...39,608,120
Ensembl chr15:39,536,290...39,608,116 		JBrowse link
G PELI3 pellino E3 ubiquitin protein ligase family member 3 acts_upstream_of_or_within
involved_in		 ISO
IEA		 (PMID:24113711)
(PMID:23950925)		 MGI
Ensembl		 PMID:23950925 PMID:24113711 GO_REF:0000107 NCBI chr18:50,870,483...50,881,089
Ensembl chr18:50,872,426...50,879,826 		JBrowse link
G PIAS4 protein inhibitor of activated STAT 4 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:20054338) Ensembl
MGI		 PMID:20054338 GO_REF:0000107 NCBI chr20:55,529,841...55,553,604
Ensembl chr20:55,524,443...55,553,525 		JBrowse link
G PPP2CB protein phosphatase 2 catalytic subunit beta acts_upstream_of
involved_in		 ISO
IEA		 (PMID:28159925) ARUK-UCL
Ensembl		 PMID:28159925 GO_REF:0000107 NCBI chr16:33,532,703...33,567,011
Ensembl chr16:33,532,958...33,566,640 		JBrowse link
G PTPN2 protein tyrosine phosphatase non-receptor type 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 7:78,160,564...78,252,382
Ensembl chr 7:78,160,589...78,252,719 		JBrowse link
G RFFL ring finger and FYVE like domain containing E3 ubiquitin protein ligase involved_in ISO (PMID:18450452) UniProt PMID:18450452 NCBI chr 9:38,271,419...38,346,103
Ensembl chr 9:38,222,051...38,365,621 		JBrowse link
G TANK TRAF family member associated NFKB activator involved_in IEA Ensembl GO_REF:0000107 NCBI chr36:6,732,507...6,826,762
Ensembl chr36:6,750,265...6,826,486 		JBrowse link
G TJP2 tight junction protein 2 acts_upstream_of_or_within ISO (PMID:22437732) MGI PMID:22437732 NCBI chr 1:88,126,134...88,251,018
Ensembl chr 1:88,126,136...88,230,654 		JBrowse link
G TNFRSF11B TNF receptor superfamily member 11b involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:29415886) Ensembl
MGI		 PMID:29415886 GO_REF:0000107 NCBI chr13:18,155,765...18,183,263
Ensembl chr13:18,156,367...18,183,444 		JBrowse link
G TRAIP TRAF interacting protein involved_in IEA Ensembl GO_REF:0000107 NCBI chr20:39,430,109...39,454,437
Ensembl chr20:39,430,489...39,453,933 		JBrowse link
G XIAP X-linked inhibitor of apoptosis involved_in IEA Ensembl GO_REF:0000107 NCBI chr  X:95,300,234...95,356,103
Ensembl chr  X:95,331,827...95,351,582 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 17925
    negative regulation of biological process 5776
      negative regulation of response to stimulus 1872
        negative regulation of response to cytokine stimulus 103
          negative regulation of cytokine-mediated signaling pathway 96
            negative regulation of tumor necrosis factor-mediated signaling pathway 29
Path 2
Term Annotations click to browse term
  biological_process 17925
    biological regulation 12446
      regulation of biological process 12082
        signaling 6866
          signal transduction 6317
            cell surface receptor signaling pathway 2807
              cytokine-mediated signaling pathway 493
                regulation of cytokine-mediated signaling pathway 166
                  negative regulation of cytokine-mediated signaling pathway 96
                    negative regulation of tumor necrosis factor-mediated signaling pathway 29
paths to the root