GAS6 (growth arrest specific 6) - Rat Genome Database

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Gene: GAS6 (growth arrest specific 6) Canis lupus familiaris
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Symbol: GAS6
Name: growth arrest specific 6
RGD ID: 12340481
Description: ENCODES a protein that exhibits signaling receptor binding (ortholog); INVOLVED IN activation of protein kinase B activity (ortholog); animal organ regeneration (ortholog); apoptotic cell clearance (ortholog); PARTICIPATES IN Gas6 - Axl signaling axis; ASSOCIATED WITH acute kidney failure (ortholog); adenoid cystic carcinoma (ortholog); Cardiomegaly (ortholog); FOUND IN cytoplasm (inferred); extracellular region (inferred); extracellular space (inferred)
Type: protein-coding
RefSeq Status: MODEL
Also known as: growth arrest-specific protein 6; LOW QUALITY PROTEIN: growth arrest-specific protein 6
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12260,975,196 - 61,005,869 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2260,974,849 - 61,005,875 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2260,684,745 - 60,717,508 (-)NCBI
ROS_Cfam_1.02261,659,911 - 61,692,783 (-)NCBI
UMICH_Zoey_3.12261,097,815 - 61,130,605 (-)NCBI
UNSW_CanFamBas_1.02261,099,052 - 61,131,978 (-)NCBI
UU_Cfam_GSD_1.02261,131,260 - 61,164,234 (-)NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
activation of protein kinase B activity  (ISO)
animal organ regeneration  (ISO)
apoptotic cell clearance  (IEA,ISO)
apoptotic process  (IEA)
B cell chemotaxis  (IEA)
blood coagulation  (IEA,ISO)
calcium ion transmembrane transport  (IEA)
cell-substrate adhesion  (IEA,ISO)
cellular response to drug  (IEA)
cellular response to glucose stimulus  (ISO)
cellular response to growth factor stimulus  (IEA,ISO)
cellular response to interferon-alpha  (IEA)
cellular response to starvation  (IEA,ISO)
cellular response to vitamin K  (IEA)
dendritic cell differentiation  (IEA)
enzyme linked receptor protein signaling pathway  (IEA,ISO)
extracellular matrix assembly  (ISO)
fusion of virus membrane with host plasma membrane  (IEA)
hematopoietic stem cell migration to bone marrow  (IEA)
negative regulation of apoptotic process  (ISO)
negative regulation of biomineral tissue development  (IEA)
negative regulation of cysteine-type endopeptidase activity involved in apoptotic process  (IEA)
negative regulation of dendritic cell apoptotic process  (IEA)
negative regulation of DNA-binding transcription factor activity  (IEA)
negative regulation of endothelial cell apoptotic process  (IEA)
negative regulation of fibroblast apoptotic process  (IEA)
negative regulation of interferon-gamma production  (IEA)
negative regulation of interleukin-1 production  (IEA)
negative regulation of interleukin-6 production  (IEA)
negative regulation of oligodendrocyte apoptotic process  (IEA)
negative regulation of renal albumin absorption  (ISO)
negative regulation of transcription, DNA-templated  (IEA)
negative regulation of tumor necrosis factor production  (IEA)
negative regulation of tumor necrosis factor-mediated signaling pathway  (IEA)
neuron migration  (IEA,ISO)
peptidyl-serine phosphorylation  (IEA)
phagocytosis  (ISO)
positive regulation of cytokine-mediated signaling pathway  (IEA)
positive regulation of dendritic cell chemotaxis  (IEA)
positive regulation of ERK1 and ERK2 cascade  (IEA,ISO)
positive regulation of fibroblast proliferation  (IEA,ISO)
positive regulation of gene expression  (IEA)
positive regulation of glomerular filtration  (ISO)
positive regulation of natural killer cell differentiation  (IEA)
positive regulation of peptidyl-serine phosphorylation  (IEA)
positive regulation of phagocytosis  (IEA)
positive regulation of protein export from nucleus  (IEA)
positive regulation of protein kinase activity  (ISO)
positive regulation of protein kinase B signaling  (IEA)
positive regulation of protein phosphorylation  (ISO)
positive regulation of protein tyrosine kinase activity  (IEA)
positive regulation of TOR signaling  (ISO)
protein kinase B signaling  (IBA,IEA,ISO)
protein localization to plasma membrane  (IEA)
protein phosphorylation  (ISO)
receptor-mediated virion attachment to host cell  (IEA)
signal transduction  (ISO)
viral entry into host cell  (ISO)
viral genome replication  (IEA)

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References

Genomics

Comparative Map Data
GAS6
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12260,975,196 - 61,005,869 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2260,974,849 - 61,005,875 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2260,684,745 - 60,717,508 (-)NCBI
ROS_Cfam_1.02261,659,911 - 61,692,783 (-)NCBI
UMICH_Zoey_3.12261,097,815 - 61,130,605 (-)NCBI
UNSW_CanFamBas_1.02261,099,052 - 61,131,978 (-)NCBI
UU_Cfam_GSD_1.02261,131,260 - 61,164,234 (-)NCBI
GAS6
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl13113,820,549 - 113,864,076 (-)EnsemblGRCh38hg38GRCh38
GRCh3813113,820,549 - 113,864,076 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh3713114,523,522 - 114,567,049 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 3613113,546,913 - 113,590,396 (+)NCBINCBI36hg18NCBI36
Build 3413113,546,912 - 113,590,396NCBI
Celera1395,265,581 - 95,312,916 (-)NCBI
Cytogenetic Map13q34NCBI
HuRef1394,864,702 - 94,908,220 (+)NCBIHuRef
CHM1_113114,491,807 - 114,536,236 (-)NCBICHM1_1
Gas6
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39813,515,374 - 13,544,535 (-)NCBIGRCm39mm39
GRCm39 Ensembl813,515,374 - 13,544,490 (-)Ensembl
GRCm38813,465,374 - 13,494,535 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl813,465,374 - 13,494,490 (-)EnsemblGRCm38mm10GRCm38
MGSCv37813,465,374 - 13,494,535 (-)NCBIGRCm37mm9NCBIm37
MGSCv36813,465,351 - 13,494,483 (-)NCBImm8
Celera813,633,535 - 13,662,710 (-)NCBICelera
Cytogenetic Map8A1.1NCBI
cM Map86.06NCBI
Gas6
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21676,045,430 - 76,075,904 (+)NCBI
Rnor_6.0 Ensembl1681,213,364 - 81,243,757 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.01681,213,364 - 81,243,824 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01680,701,559 - 80,732,410 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41680,900,159 - 80,930,929 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11680,900,528 - 80,930,916 (+)NCBI
Celera1673,852,900 - 73,883,275 (+)NCBICelera
Cytogenetic Map16q12.5NCBI
Gas6
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955404275,946 - 304,809 (+)EnsemblChiLan1.0
ChiLan1.0NW_004955404276,397 - 303,864 (+)NCBIChiLan1.0ChiLan1.0
Gas6
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404945195,897,815 - 195,920,260 (-)NCBI
SpeTri2.0NW_00493647227,116 - 57,158 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
GAS6
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1178,848,794 - 78,881,272 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11178,848,797 - 78,880,733 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21186,582,221 - 86,614,062 (-)NCBISscrofa10.2Sscrofa10.2susScr3
LOC103214855
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1391,720,871 - 91,762,712 (-)NCBI
Vero_WHO_p1.0NW_02366604648,879,389 - 48,960,473 (-)NCBI
Gas6
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_004624793385,846 - 410,934 (+)NCBI


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system reproductive system respiratory system adipose tissue
High
Medium 5 5 16 6 6 1 12 8 10 6
Low 6 6 6 5
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSCAFT00000010387   ⟹   ENSCAFP00000009630
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl2260,974,849 - 61,005,875 (-)Ensembl
RefSeq Acc Id: ENSCAFT00000071322   ⟹   ENSCAFP00000048221
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl2260,975,230 - 61,005,869 (-)Ensembl
RefSeq Acc Id: ENSCAFT00000075209   ⟹   ENSCAFP00000045406
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl2260,975,230 - 61,005,869 (-)Ensembl
RefSeq Acc Id: XM_038431542   ⟹   XP_038287470
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.02261,659,911 - 61,692,783 (-)NCBI
RefSeq Acc Id: XM_038431543   ⟹   XP_038287471
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.02261,659,911 - 61,692,775 (-)NCBI
RefSeq Acc Id: XM_038456606   ⟹   XP_038312534
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
Dog10K_Boxer_Tasha2260,684,745 - 60,717,508 (-)NCBI
RefSeq Acc Id: XM_038456607   ⟹   XP_038312535
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
Dog10K_Boxer_Tasha2260,684,745 - 60,717,500 (-)NCBI
RefSeq Acc Id: XM_038506922   ⟹   XP_038362850
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.12261,097,815 - 61,130,605 (-)NCBI
RefSeq Acc Id: XM_038570136   ⟹   XP_038426064
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.02261,131,260 - 61,164,234 (-)NCBI
RefSeq Acc Id: XM_038570137   ⟹   XP_038426065
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.02261,131,260 - 61,164,226 (-)NCBI
RefSeq Acc Id: XM_038634309   ⟹   XP_038490237
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.02261,099,052 - 61,131,978 (-)NCBI
RefSeq Acc Id: XM_038634310   ⟹   XP_038490238
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.02261,099,052 - 61,131,970 (-)NCBI
RefSeq Acc Id: XM_844530   ⟹   XP_849623
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.12260,975,196 - 61,005,869 (-)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: XP_849623   ⟸   XM_844530
- Sequence:
RefSeq Acc Id: ENSCAFP00000009630   ⟸   ENSCAFT00000010387
RefSeq Acc Id: ENSCAFP00000045406   ⟸   ENSCAFT00000075209
RefSeq Acc Id: ENSCAFP00000048221   ⟸   ENSCAFT00000071322
RefSeq Acc Id: XP_038362850   ⟸   XM_038506922
- Peptide Label: isoform X3
RefSeq Acc Id: XP_038490237   ⟸   XM_038634309
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038490238   ⟸   XM_038634310
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038287470   ⟸   XM_038431542
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038287471   ⟸   XM_038431543
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038312534   ⟸   XM_038456606
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038312535   ⟸   XM_038456607
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038426064   ⟸   XM_038570136
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038426065   ⟸   XM_038570137
- Peptide Label: isoform X2
Protein Domains
EGF-like   Gla   LAM_G_DOMAIN

Promoters
RGD ID:13687368
Promoter ID:EPDNEW_C5436
Type:single initiation site
Name:GAS6_1
Description:growth arrest specific 6
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.12261,005,844 - 61,005,904EPDNEW

Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000006421 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSCAFP00000009630 UniProtKB/TrEMBL
  ENSCAFP00000045406 UniProtKB/TrEMBL
  ENSCAFP00000048221 UniProtKB/TrEMBL
Ensembl Transcript ENSCAFT00000010387 UniProtKB/TrEMBL
  ENSCAFT00000071322 UniProtKB/TrEMBL
  ENSCAFT00000075209 UniProtKB/TrEMBL
Gene3D-CATH 4.10.740.10 UniProtKB/TrEMBL
InterPro Coagulation_fac-like_Gla_dom UniProtKB/TrEMBL
  ConA-like_dom_sf UniProtKB/TrEMBL
  EGF-like_Ca-bd_dom UniProtKB/TrEMBL
  EGF-like_dom UniProtKB/TrEMBL
  EGF-type_Asp/Asn_hydroxyl_site UniProtKB/TrEMBL
  EGF_Ca-bd_CS UniProtKB/TrEMBL
  GLA-like_dom_SF UniProtKB/TrEMBL
  GLA_domain UniProtKB/TrEMBL
  Growth_fac_rcpt_cys_sf UniProtKB/TrEMBL
  Laminin_G UniProtKB/TrEMBL
NCBI Gene GAS6 ENTREZGENE
Pfam EGF_CA UniProtKB/TrEMBL
  Gla UniProtKB/TrEMBL
  Laminin_G_1 UniProtKB/TrEMBL
  Laminin_G_2 UniProtKB/TrEMBL
PRINTS GLABLOOD UniProtKB/TrEMBL
PROSITE ASX_HYDROXYL UniProtKB/TrEMBL
  EGF_1 UniProtKB/TrEMBL
  EGF_2 UniProtKB/TrEMBL
  EGF_3 UniProtKB/TrEMBL
  EGF_CA UniProtKB/TrEMBL
  GLA_1 UniProtKB/TrEMBL
  GLA_2 UniProtKB/TrEMBL
  LAM_G_DOMAIN UniProtKB/TrEMBL
SMART EGF UniProtKB/TrEMBL
  EGF_CA UniProtKB/TrEMBL
  GLA UniProtKB/TrEMBL
  LamG UniProtKB/TrEMBL
Superfamily-SCOP SSF49899 UniProtKB/TrEMBL
  SSF57184 UniProtKB/TrEMBL
  SSF57630 UniProtKB/TrEMBL
UniProt A0A5F4BU83_CANLF UniProtKB/TrEMBL
  A0A5F4C5G7_CANLF UniProtKB/TrEMBL
  F1PZR6_CANLF UniProtKB/TrEMBL
VGNC ID VGNC:41118 ENTREZGENE