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ONTOLOGY REPORT - ANNOTATIONS

Term:complement activation
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Accession:GO:0006956 term browser browse the term
Definition:Any process involved in the activation of any of the steps of the complement cascade, which allows for the direct killing of microbes, the disposal of immune complexes, and the regulation of other immune processes; the initial steps of complement activation involve one of three pathways, the classical pathway, the alternative pathway, and the lectin pathway, all of which lead to the terminal complement pathway.
Synonyms:exact_synonym: complement cascade;   complement response
 related_synonym: complement activity

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complement activation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G C1r complement C1r involved_in IEA InterPro GO_REF:0000002 NCBI chrNW_004936709:709,001...719,758
Ensembl chrNW_004936709:708,968...720,478 		JBrowse link
G C1s complement C1s involved_in IEA InterPro GO_REF:0000002 NCBI chrNW_004936709:731,211...742,583
Ensembl chrNW_004936709:731,165...742,686 		JBrowse link
G C2 complement C2 involved_in IEA Ensembl
TreeGrafter
InterPro		 GO_REF:0000002 GO_REF:0000107 GO_REF:0000118 NCBI chrNW_004936727:1,602,400...1,615,974
Ensembl chrNW_004936727:1,602,398...1,616,060 		JBrowse link
G C3 complement C3 acts_upstream_of_or_within
involved_in		 ISO (PMID:25284781)
(PMID:18947875)
(PMID:19302245)		 RGD
MGI
BHF-UCL		 PMID:18947875 PMID:19302245 PMID:20712003 PMID:25284781 RGD:5129529 NCBI chrNW_004936588:3,985,732...4,023,221 JBrowse link
G C6 complement C6 involved_in IEA Ensembl
TreeGrafter		 GO_REF:0000107 GO_REF:0000118 NCBI chrNW_004936518:1,471,116...1,532,733
Ensembl chrNW_004936518:1,471,355...1,532,439 		JBrowse link
G C7 complement C7 involved_in IEA TreeGrafter GO_REF:0000118 NCBI chrNW_004936518:1,687,482...1,736,463
Ensembl chrNW_004936518:1,689,328...1,731,770 		JBrowse link
G C8a complement C8 alpha chain acts_upstream_of_or_within
involved_in		 ISO
IEA		 (PMID:12413696) MGI
TreeGrafter
Ensembl		 PMID:12413696 GO_REF:0000107 GO_REF:0000118 NCBI chrNW_004936522:4,686,306...4,745,175
Ensembl chrNW_004936522:4,686,081...4,745,175 		JBrowse link
G C8b complement C8 beta chain involved_in IEA TreeGrafter GO_REF:0000118 NCBI chrNW_004936522:4,638,111...4,673,388
Ensembl chrNW_004936522:4,644,047...4,673,615 		JBrowse link
G C8g complement C8 gamma chain involved_in IEA InterPro GO_REF:0000002 NCBI chrNW_004936669:985,318...988,600
Ensembl chrNW_004936669:985,295...988,726
Ensembl chrNW_004936669:985,295...988,726 		JBrowse link
G C9 complement C9 involved_in IEA TreeGrafter GO_REF:0000118 NCBI chrNW_004936518:2,947,956...2,994,892
Ensembl chrNW_004936518:2,958,995...2,994,880 		JBrowse link
G Cfb complement factor B involved_in ISO
IEA		 RGD
TreeGrafter
InterPro		 PMID:6906329 GO_REF:0000002 GO_REF:0000118 RGD:2311339 NCBI chrNW_004936727:1,595,872...1,602,274
Ensembl chrNW_004936727:1,595,499...1,602,215 		JBrowse link
G Cfi complement factor I involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936563:960,883...998,136
Ensembl chrNW_004936563:960,883...988,634 		JBrowse link
G Colec11 collectin subfamily member 11 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936532:1,757,288...1,776,053
Ensembl chrNW_004936532:1,749,894...1,776,001 		JBrowse link
G Fcn3 ficolin 3 involved_in ISO (PMID:22851708) UniProt PMID:22851708 NCBI chrNW_004936474:11,680,166...11,685,214 JBrowse link
G LOC101975827 complement C4-A involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:1438267), (PMID:8133084) InterPro
TreeGrafter
MGI		 PMID:1438267 PMID:8133084 GO_REF:0000002 GO_REF:0000118 NCBI chrNW_004936727:1,556,204...1,570,084 JBrowse link
G Masp1 MBL associated serine protease 1 involved_in IEA InterPro GO_REF:0000002 NCBI chrNW_004936578:2,804,460...2,857,731
Ensembl chrNW_004936578:2,804,460...2,869,582 		JBrowse link
G Masp2 MBL associated serine protease 2 involved_in IEA InterPro GO_REF:0000002 NCBI chrNW_004936474:100,584...113,781
Ensembl chrNW_004936474:101,402...114,313 		JBrowse link
G Rgcc regulator of cell cycle involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936667:232,807...245,131
Ensembl chrNW_004936667:232,782...245,131 		JBrowse link
complement activation, alternative pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G C5 complement C5 involved_in IEA UniProt GO_REF:0000043 NCBI chrNW_004936487:9,391,774...9,474,168
Ensembl chrNW_004936487:9,391,804...9,474,159 		JBrowse link
G C8a complement C8 alpha chain involved_in IEA UniProt GO_REF:0000043 NCBI chrNW_004936522:4,686,306...4,745,175
Ensembl chrNW_004936522:4,686,081...4,745,175 		JBrowse link
G C8b complement C8 beta chain involved_in IEA UniProt GO_REF:0000043 NCBI chrNW_004936522:4,638,111...4,673,388
Ensembl chrNW_004936522:4,644,047...4,673,615 		JBrowse link
G C9 complement C9 involved_in IEA UniProt GO_REF:0000043 NCBI chrNW_004936518:2,947,956...2,994,892
Ensembl chrNW_004936518:2,958,995...2,994,880 		JBrowse link
G Cfb complement factor B involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:27564415)
(PMID:9238044)		 UniProt
MGI		 PMID:9238044 PMID:27564415 GO_REF:0000043 NCBI chrNW_004936727:1,595,872...1,602,274
Ensembl chrNW_004936727:1,595,499...1,602,215 		JBrowse link
G Cfd complement factor D involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:27564415) Ensembl
MGI		 PMID:27564415 GO_REF:0000107 NCBI chrNW_004936588:350,925...352,732
Ensembl chrNW_004936588:350,921...355,582 		JBrowse link
G Cfp complement factor properdin involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936502:13,391,613...13,398,723
Ensembl chrNW_004936502:13,391,535...13,397,440 		JBrowse link
G Cr2 complement C3d receptor 2 involved_in
acts_upstream_of_or_within_negative_effect		 ISO (PMID:11981823)
(PMID:19828624)		 ARUK-UCL
MGI		 PMID:11981823 PMID:19828624 NCBI chrNW_004936557:5,246,770...5,256,608 JBrowse link
G LOC101964865 complement receptor type 1 involved_in ISO (PMID:11981823) ARUK-UCL PMID:11981823 NCBI chrNW_004936557:5,185,831...5,284,999 JBrowse link
complement activation, classical pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G C1qa complement C1q A chain involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:11901193) Ensembl
UniProt
MGI		 PMID:11901193 GO_REF:0000043 GO_REF:0000107 NCBI chrNW_004936474:8,007,953...8,010,591
Ensembl chrNW_004936474:8,008,534...8,010,191 		JBrowse link
G C1qbp complement C1q binding protein involved_in IEA UniProt GO_REF:0000043 NCBI chrNW_004936677:2,371,400...2,376,608
Ensembl chrNW_004936677:2,371,418...2,376,608 		JBrowse link
G C1r complement C1r involved_in IEA UniProt GO_REF:0000043 NCBI chrNW_004936709:709,001...719,758
Ensembl chrNW_004936709:708,968...720,478 		JBrowse link
G C2 complement C2 involved_in IEA UniProt GO_REF:0000043 NCBI chrNW_004936727:1,602,400...1,615,974
Ensembl chrNW_004936727:1,602,398...1,616,060 		JBrowse link
G C5 complement C5 involved_in IEA UniProt GO_REF:0000043 NCBI chrNW_004936487:9,391,774...9,474,168
Ensembl chrNW_004936487:9,391,804...9,474,159 		JBrowse link
G C6 complement C6 involved_in IEA UniProt GO_REF:0000043 NCBI chrNW_004936518:1,471,116...1,532,733
Ensembl chrNW_004936518:1,471,355...1,532,439 		JBrowse link
G C7 complement C7 involved_in IEA UniProt GO_REF:0000043 NCBI chrNW_004936518:1,687,482...1,736,463
Ensembl chrNW_004936518:1,689,328...1,731,770 		JBrowse link
G C8a complement C8 alpha chain involved_in IEA UniProt GO_REF:0000043 NCBI chrNW_004936522:4,686,306...4,745,175
Ensembl chrNW_004936522:4,686,081...4,745,175 		JBrowse link
G C8b complement C8 beta chain involved_in IEA UniProt GO_REF:0000043 NCBI chrNW_004936522:4,638,111...4,673,388
Ensembl chrNW_004936522:4,644,047...4,673,615 		JBrowse link
G C9 complement C9 involved_in IEA UniProt GO_REF:0000043 NCBI chrNW_004936518:2,947,956...2,994,892
Ensembl chrNW_004936518:2,958,995...2,994,880 		JBrowse link
G Crp C-reactive protein ISO RGD PMID:16367929 RGD:1580273 NCBI chrNW_004936740:885,855...888,854
Ensembl chrNW_004936740:883,272...890,606 		JBrowse link
G LOC101960229 complement C1q subcomponent subunit C involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936474:8,013,395...8,016,937
Ensembl chrNW_004936474:8,013,359...8,016,959 		JBrowse link
G LOC101975827 complement C4-A involved_in IEA UniProt GO_REF:0000043 NCBI chrNW_004936727:1,556,204...1,570,084 JBrowse link
G LOC101977501 mannose-binding protein A-like involved_in IEA UniProt GO_REF:0000043 NCBI chrNW_004936716:89,232...91,728 JBrowse link
G Otol1 otolin 1 involved_in IEA UniProt GO_REF:0000043 NCBI chrNW_004936708:1,417,801...1,426,386
Ensembl chrNW_004936708:1,417,801...1,426,386 		JBrowse link
complement activation, lectin pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Colec10 collectin subfamily member 10 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936470:27,416,471...27,449,206
Ensembl chrNW_004936470:27,416,494...27,449,206 		JBrowse link
G Colec11 collectin subfamily member 11 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936532:1,757,288...1,776,053
Ensembl chrNW_004936532:1,749,894...1,776,001 		JBrowse link
G Fcn3 ficolin 3 involved_in ISO (PMID:11907111) UniProt PMID:11907111 NCBI chrNW_004936474:11,680,166...11,685,214 JBrowse link
G Krt1 keratin 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936512:10,084,764...10,090,312
Ensembl chrNW_004936512:10,084,763...10,090,414 		JBrowse link
G LOC101965964 ficolin-1 involved_in IEA Ensembl
TreeGrafter		 GO_REF:0000107 GO_REF:0000118 NCBI chrNW_004936669:2,421,092...2,428,240
Ensembl chrNW_004936669:2,421,087...2,431,714 		JBrowse link
G LOC101977501 mannose-binding protein A-like involved_in IEA Ensembl
UniProt		 GO_REF:0000043 GO_REF:0000107 NCBI chrNW_004936716:89,232...91,728 JBrowse link
G Masp1 MBL associated serine protease 1 involved_in IEA Ensembl
TreeGrafter		 GO_REF:0000107 GO_REF:0000118 NCBI chrNW_004936578:2,804,460...2,857,731
Ensembl chrNW_004936578:2,804,460...2,869,582 		JBrowse link
G Masp2 MBL associated serine protease 2 involved_in IEA Ensembl
TreeGrafter		 GO_REF:0000107 GO_REF:0000118 NCBI chrNW_004936474:100,584...113,781
Ensembl chrNW_004936474:101,402...114,313 		JBrowse link
negative regulation of activation of membrane attack complex term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cd59 CD59 molecule (CD59 blood group) acts_upstream_of_or_within ISO (PMID:10946279), (PMID:11471050) RGD
MGI		 PMID:10946279 PMID:11471050 PMID:15843577 RGD:1600482 NCBI chrNW_004936533:4,242,589...4,263,136 JBrowse link
G LOC101964865 complement receptor type 1 acts_upstream_of ISO (PMID:31862673) ARUK-UCL PMID:31862673 NCBI chrNW_004936557:5,185,831...5,284,999 JBrowse link
negative regulation of complement activation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cd55 CD55 molecule (Cromer blood group) involved_in ISO (PMID:6211481)
(PMID:28657829)		 RGD
UniProt		 PMID:6211481 PMID:10929073 PMID:28657829 RGD:2326180 NCBI chrNW_004936557:5,344,373...5,364,234 JBrowse link
G Cd59 CD59 molecule (CD59 blood group) acts_upstream_of_or_within ISO (PMID:10946279) MGI PMID:10946279 NCBI chrNW_004936533:4,242,589...4,263,136 JBrowse link
G LOC101964865 complement receptor type 1 involved_in ISO (PMID:31862673) ARUK-UCL PMID:31862673 NCBI chrNW_004936557:5,185,831...5,284,999 JBrowse link
G Masp1 MBL associated serine protease 1 involved_in ISO (PMID:11485744) UniProt PMID:11485744 NCBI chrNW_004936578:2,804,460...2,857,731
Ensembl chrNW_004936578:2,804,460...2,869,582 		JBrowse link
negative regulation of complement activation, alternative pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cd46 CD46 molecule involved_in ISO (PMID:9029106) AgBase PMID:9029106 NCBI chrNW_004936557:5,136,784...5,175,543 JBrowse link
G LOC101964865 complement receptor type 1 involved_in ISO (PMID:10531307) UniProt PMID:10531307 NCBI chrNW_004936557:5,185,831...5,284,999 JBrowse link
G Susd4 sushi domain containing 4 involved_in IEA TreeGrafter GO_REF:0000118 NCBI chrNW_004936526:488,604...615,265
Ensembl chrNW_004936526:485,348...615,265 		JBrowse link
G Vsig4 V-set and immunoglobulin domain containing 4 involved_in IEA Ensembl
TreeGrafter		 GO_REF:0000107 GO_REF:0000118 NCBI chrNW_004936635:2,167,633...2,191,725
Ensembl chrNW_004936635:2,167,617...2,191,740 		JBrowse link
negative regulation of complement activation, classical pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G C4bpb complement component 4 binding protein beta involved_in ISO (PMID:22333221) BHF-UCL PMID:22333221 NCBI chrNW_004936557:5,546,692...5,561,531 JBrowse link
G Cd46 CD46 molecule involved_in ISO (PMID:9029106) AgBase PMID:9029106 NCBI chrNW_004936557:5,136,784...5,175,543 JBrowse link
G LOC101964865 complement receptor type 1 involved_in ISO (PMID:10531307), (PMID:6910481) UniProt PMID:6910481 PMID:10531307 NCBI chrNW_004936557:5,185,831...5,284,999 JBrowse link
G LOC101973539 C4b-binding protein alpha chain involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936557:5,511,372...5,535,158
Ensembl chrNW_004936557:5,511,320...5,542,713 		JBrowse link
G Susd4 sushi domain containing 4 involved_in IEA TreeGrafter GO_REF:0000118 NCBI chrNW_004936526:488,604...615,265
Ensembl chrNW_004936526:485,348...615,265 		JBrowse link
negative regulation of complement activation, lectin pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G LOC101959212 alpha-2-macroglobulin involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936870:424,832...468,303
Ensembl chrNW_004936870:424,951...468,167 		JBrowse link
G Serping1 serpin family G member 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936581:4,911,403...4,924,484
Ensembl chrNW_004936581:4,908,458...4,924,645 		JBrowse link
positive regulation of activation of membrane attack complex term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G C3 complement C3 involved_in ISO (PMID:15611275) BHF-UCL PMID:15611275 NCBI chrNW_004936588:3,985,732...4,023,221 JBrowse link
G LOC101964865 complement receptor type 1 involved_in ISO (PMID:11981823) ARUK-UCL PMID:11981823 NCBI chrNW_004936557:5,185,831...5,284,999 JBrowse link
positive regulation of complement activation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Il1b interleukin 1 beta involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936783:1,251,678...1,256,807
Ensembl chrNW_004936783:1,252,158...1,257,165 		JBrowse link
G Phb1 prohibitin 1 involved_in ISO (PMID:17070910) UniProt PMID:17070910 NCBI chrNW_004936490:12,127,065...12,138,870
Ensembl chrNW_004936490:12,127,065...12,138,870 		JBrowse link
positive regulation of complement activation, classical pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Trem2 triggering receptor expressed on myeloid cells 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936476:18,659,725...18,665,406
Ensembl chrNW_004936476:18,659,815...18,663,940 		JBrowse link
regulation of complement activation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G C1qbp complement C1q binding protein involved_in IEA Ensembl
TreeGrafter		 GO_REF:0000107 GO_REF:0000118 NCBI chrNW_004936677:2,371,400...2,376,608
Ensembl chrNW_004936677:2,371,418...2,376,608 		JBrowse link
G Cd55 CD55 molecule (Cromer blood group) acts_upstream_of_or_within ISO (PMID:25284781) MGI PMID:25284781 NCBI chrNW_004936557:5,344,373...5,364,234 JBrowse link
G Cd59 CD59 molecule (CD59 blood group) acts_upstream_of_or_within ISO (PMID:25284781) MGI PMID:25284781 NCBI chrNW_004936533:4,242,589...4,263,136 JBrowse link
G Phb2 prohibitin 2 NOT|involved_in ISO (PMID:17070910) UniProt PMID:17070910 NCBI chrNW_004936709:854,493...859,182
Ensembl chrNW_004936709:854,698...858,851 		JBrowse link
G Susd4 sushi domain containing 4 involved_in IEA Ensembl
InterPro		 GO_REF:0000002 GO_REF:0000107 NCBI chrNW_004936526:488,604...615,265
Ensembl chrNW_004936526:485,348...615,265 		JBrowse link
regulation of complement activation, classical pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cd55 CD55 molecule (Cromer blood group) acts_upstream_of_or_within ISO (PMID:9892684) MGI PMID:9892684 NCBI chrNW_004936557:5,344,373...5,364,234 JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 16037
    immune system process 2299
      immune effector process 609
        complement activation 45
          activation of membrane attack complex + 3
          complement activation, alternative pathway + 12
          complement activation, classical pathway + 22
          complement activation, lectin pathway + 10
          negative regulation of complement activation + 11
          positive regulation of complement activation + 5
          regulation of complement activation + 17
Path 2
Term Annotations click to browse term
  biological_process 16037
    biological regulation 11269
      regulation of biological process 10908
        positive regulation of biological process 6170
          positive regulation of response to stimulus 2301
            positive regulation of immune response 688
              activation of immune response 504
                complement activation 45
                  activation of membrane attack complex + 3
                  complement activation, alternative pathway + 12
                  complement activation, classical pathway + 22
                  complement activation, lectin pathway + 10
                  negative regulation of complement activation + 11
                  positive regulation of complement activation + 5
                  regulation of complement activation + 17
paths to the root