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ONTOLOGY REPORT - ANNOTATIONS

Term:regulation of complement activation
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Accession:GO:0030449 term browser browse the term
Definition:Any process that modulates the frequency, rate or extent of complement activation.
Synonyms:exact_synonym: regulation of complement cascade

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regulation of complement activation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G C1qbp complement C1q binding protein involved_in IEA Ensembl
TreeGrafter		 GO_REF:0000107 GO_REF:0000118 NCBI chrNW_004936677:2,371,400...2,376,608
Ensembl chrNW_004936677:2,371,418...2,376,608 		JBrowse link
G Cd55 CD55 molecule (Cromer blood group) acts_upstream_of_or_within ISO (PMID:25284781) MGI PMID:25284781 NCBI chrNW_004936557:5,344,373...5,364,234 JBrowse link
G Cd59 CD59 molecule (CD59 blood group) acts_upstream_of_or_within ISO (PMID:25284781) MGI PMID:25284781 NCBI chrNW_004936533:4,242,589...4,263,136 JBrowse link
G Phb2 prohibitin 2 NOT|involved_in ISO (PMID:17070910) UniProt PMID:17070910 NCBI chrNW_004936709:854,493...859,182
Ensembl chrNW_004936709:854,698...858,851 		JBrowse link
G Susd4 sushi domain containing 4 involved_in IEA Ensembl
InterPro		 GO_REF:0000002 GO_REF:0000107 NCBI chrNW_004936526:488,604...615,265
Ensembl chrNW_004936526:485,348...615,265 		JBrowse link
negative regulation of activation of membrane attack complex term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cd59 CD59 molecule (CD59 blood group) acts_upstream_of_or_within ISO (PMID:10946279), (PMID:11471050) RGD
MGI		 PMID:10946279 PMID:11471050 PMID:15843577 RGD:1600482 NCBI chrNW_004936533:4,242,589...4,263,136 JBrowse link
G LOC101964865 complement receptor type 1 acts_upstream_of ISO (PMID:31862673) ARUK-UCL PMID:31862673 NCBI chrNW_004936557:5,185,831...5,284,999 JBrowse link
negative regulation of complement activation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cd55 CD55 molecule (Cromer blood group) involved_in ISO (PMID:6211481)
(PMID:28657829)		 RGD
UniProt		 PMID:6211481 PMID:10929073 PMID:28657829 RGD:2326180 NCBI chrNW_004936557:5,344,373...5,364,234 JBrowse link
G Cd59 CD59 molecule (CD59 blood group) acts_upstream_of_or_within ISO (PMID:10946279) MGI PMID:10946279 NCBI chrNW_004936533:4,242,589...4,263,136 JBrowse link
G LOC101964865 complement receptor type 1 involved_in ISO (PMID:31862673) ARUK-UCL PMID:31862673 NCBI chrNW_004936557:5,185,831...5,284,999 JBrowse link
G Masp1 MBL associated serine protease 1 involved_in ISO (PMID:11485744) UniProt PMID:11485744 NCBI chrNW_004936578:2,804,460...2,857,731
Ensembl chrNW_004936578:2,804,460...2,869,582 		JBrowse link
negative regulation of complement activation, alternative pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cd46 CD46 molecule involved_in ISO (PMID:9029106) AgBase PMID:9029106 NCBI chrNW_004936557:5,136,784...5,175,543 JBrowse link
G LOC101964865 complement receptor type 1 involved_in ISO (PMID:10531307) UniProt PMID:10531307 NCBI chrNW_004936557:5,185,831...5,284,999 JBrowse link
G Susd4 sushi domain containing 4 involved_in IEA TreeGrafter GO_REF:0000118 NCBI chrNW_004936526:488,604...615,265
Ensembl chrNW_004936526:485,348...615,265 		JBrowse link
G Vsig4 V-set and immunoglobulin domain containing 4 involved_in IEA Ensembl
TreeGrafter		 GO_REF:0000107 GO_REF:0000118 NCBI chrNW_004936635:2,167,633...2,191,725
Ensembl chrNW_004936635:2,167,617...2,191,740 		JBrowse link
negative regulation of complement activation, classical pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Apoh apolipoprotein H involved_in IEA TreeGrafter GO_REF:0000118 NCBI chrNW_004936541:6,683,483...6,695,094
Ensembl chrNW_004936541:6,683,534...6,695,066 		JBrowse link
G C4bpb complement component 4 binding protein beta involved_in ISO (PMID:22333221) BHF-UCL PMID:22333221 NCBI chrNW_004936557:5,546,692...5,561,531 JBrowse link
G Cd46 CD46 molecule involved_in ISO (PMID:9029106) AgBase PMID:9029106 NCBI chrNW_004936557:5,136,784...5,175,543 JBrowse link
G Cd55 CD55 molecule (Cromer blood group) involved_in IEA TreeGrafter GO_REF:0000118 NCBI chrNW_004936557:5,344,373...5,364,234 JBrowse link
G LOC101964865 complement receptor type 1 involved_in ISO (PMID:10531307), (PMID:6910481) UniProt PMID:6910481 PMID:10531307 NCBI chrNW_004936557:5,185,831...5,284,999 JBrowse link
G LOC101965450 zona pellucida sperm-binding protein 3 receptor-like involved_in IEA TreeGrafter GO_REF:0000118 NCBI chrNW_004936557:5,459,285...5,500,034 JBrowse link
G LOC101973539 C4b-binding protein alpha chain involved_in IEA Ensembl
TreeGrafter		 GO_REF:0000107 GO_REF:0000118 NCBI chrNW_004936557:5,511,372...5,535,158
Ensembl chrNW_004936557:5,511,320...5,542,713 		JBrowse link
G Susd4 sushi domain containing 4 involved_in IEA TreeGrafter GO_REF:0000118 NCBI chrNW_004936526:488,604...615,265
Ensembl chrNW_004936526:485,348...615,265 		JBrowse link
negative regulation of complement activation, lectin pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G LOC101959212 alpha-2-macroglobulin involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936870:424,832...468,303
Ensembl chrNW_004936870:424,951...468,167 		JBrowse link
G Serping1 serpin family G member 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936581:4,911,403...4,924,484
Ensembl chrNW_004936581:4,908,458...4,924,645 		JBrowse link
positive regulation of activation of membrane attack complex term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G C3 complement C3 involved_in ISO (MGI:4430818|PMID:15611275) BHF-UCL PMID:15611275 MGI:4430818 NCBI chrNW_004936588:3,985,732...4,023,221 JBrowse link
G C6 complement C6 involved_in ISO (MGI:4430818|PMID:15611275) BHF-UCL PMID:15611275 MGI:4430818 NCBI chrNW_004936518:1,471,116...1,532,733
Ensembl chrNW_004936518:1,471,355...1,532,439 		JBrowse link
G LOC101964865 complement receptor type 1 involved_in ISO (PMID:11981823) ARUK-UCL PMID:11981823 NCBI chrNW_004936557:5,185,831...5,284,999 JBrowse link
positive regulation of complement activation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G C6 complement C6 involved_in ISO (MGI:4430818|PMID:15611275) BHF-UCL PMID:15611275 MGI:4430818 NCBI chrNW_004936518:1,471,116...1,532,733
Ensembl chrNW_004936518:1,471,355...1,532,439 		JBrowse link
G Il1b interleukin 1 beta involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936783:1,251,678...1,256,807
Ensembl chrNW_004936783:1,252,158...1,257,165 		JBrowse link
G Phb1 prohibitin 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936490:12,127,065...12,138,870 JBrowse link
positive regulation of complement activation, classical pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Trem2 triggering receptor expressed on myeloid cells 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936476:18,659,725...18,665,406
Ensembl chrNW_004936476:18,659,815...18,663,940 		JBrowse link
regulation of complement activation, classical pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cd55 CD55 molecule (Cromer blood group) acts_upstream_of_or_within ISO (PMID:9892684) MGI PMID:9892684 NCBI chrNW_004936557:5,344,373...5,364,234 JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 15969
    immune system process 2209
      activation of immune response 488
        complement activation 46
          regulation of complement activation 20
            negative regulation of complement activation + 13
            positive regulation of complement activation + 6
            regulation of activation of membrane attack complex + 4
            regulation of complement activation, alternative pathway + 4
            regulation of complement activation, classical pathway + 9
            regulation of complement activation, lectin pathway + 2
Path 2
Term Annotations click to browse term
  biological_process 15969
    biological regulation 11154
      regulation of biological process 10818
        regulation of response to stimulus 3768
          positive regulation of response to stimulus 2252
            positive regulation of immune response 666
              activation of immune response 488
                complement activation 46
                  regulation of complement activation 20
                    negative regulation of complement activation + 13
                    positive regulation of complement activation + 6
                    regulation of activation of membrane attack complex + 4
                    regulation of complement activation, alternative pathway + 4
                    regulation of complement activation, classical pathway + 9
                    regulation of complement activation, lectin pathway + 2
paths to the root