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ONTOLOGY REPORT - ANNOTATIONS


Term:complement activation, alternative pathway
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Accession:GO:0006957 term browser browse the term
Definition:Any process involved in the activation of any of the steps of the alternative pathway of the complement cascade which allows for the direct killing of microbes and the regulation of other immune processes.
Synonyms:exact_synonym: complement cascade, alternative pathway



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complement activation, alternative pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G C3 complement C3 involved_in IEA GO_REF:0000043 UniProt GO_REF:0000043 NCBI chr 9:2,087,437...2,114,366
Ensembl chr 9:2,087,437...2,114,429
JBrowse link
G C5 complement C5 involved_in IEA GO_REF:0000043 UniProt GO_REF:0000043 NCBI chr 3:18,270,696...18,361,994
Ensembl chr 3:18,270,696...18,361,994
JBrowse link
G C8b complement C8 beta chain involved_in IEA GO_REF:0000043 UniProt GO_REF:0000043 NCBI chr 5:119,535,009...119,572,565
Ensembl chr 5:119,535,146...119,572,565
JBrowse link
G C9 complement C9 involved_in IEA GO_REF:0000043 UniProt GO_REF:0000043 NCBI chr 2:55,573,094...55,621,345
Ensembl chr 2:55,572,992...55,621,338
JBrowse link
G Cfb complement factor B acts_upstream_of_or_within ISO MGI:1861129 (MGI:1096110|PMID:9238044), (MGI:6100611|PMID:27564415) RGD PMID:9238044 PMID:27564415 MGI:1096110 MGI:6100611 NCBI chr20:3,970,643...3,976,510
Ensembl chr20:3,951,474...3,976,505
JBrowse link
G Cfd complement factor D involved_in
acts_upstream_of_or_within
IEA
ISO
GO_REF:0000107
(MGI:6100611|PMID:27564415)
Ensembl
RGD
PMID:27564415 GO_REF:0000107 MGI:6100611 NCBI chr 7:9,813,148...9,814,871
Ensembl chr 7:9,813,150...9,815,053
JBrowse link
G Cfh complement factor H acts_upstream_of_or_within_negative_effect ISO (MGI:4421084|PMID:19828624)
(MGI:6100611|PMID:27564415)
RGD PMID:19828624 PMID:27564415 MGI:4421084 MGI:6100611 NCBI chr13:51,512,376...51,613,829
Ensembl chr13:51,511,828...51,613,838
JBrowse link
G Cfp complement factor properdin involved_in ISO MGI:3774548 (MGI:3773929|PMID:18292556) RGD PMID:18292556 MGI:3773929 NCBI chr  X:1,162,014...1,167,576
Ensembl chr  X:1,161,979...1,167,573
JBrowse link
G Cr2 complement C3d receptor 2 involved_in
acts_upstream_of_or_within_negative_effect
ISO (PMID:11981823)
(MGI:4421084|PMID:19828624)
RGD PMID:11981823 PMID:19828624 MGI:4421084 NCBI chr13:106,678,579...106,716,595
Ensembl chr13:106,685,413...106,716,235
JBrowse link
negative regulation of complement activation, alternative pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cd46 CD46 molecule involved_in ISO (PMID:9029106) RGD PMID:9029106 NCBI chr13:106,575,586...106,606,325
Ensembl chr13:106,574,858...106,660,445
JBrowse link
G Susd4 sushi domain containing 4 involved_in ISO
IBA
(PMID:23482636)
PMID:21873635
RGD PMID:23482636 PMID:21873635 RGD:13792537 NCBI chr13:94,455,180...94,577,773
Ensembl chr13:94,455,165...94,577,750
JBrowse link
G Vsig4 V-set and immunoglobulin domain containing 4 involved_in IBA
ISO
PMID:21873635
UniProtKB:P01024 (PMID:17051150)
RGD PMID:17051150 PMID:21873635 RGD:13792537 NCBI chr  X:61,144,926...61,170,212
Ensembl chr  X:61,144,928...61,170,212
JBrowse link
regulation of complement activation, alternative pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G C3 complement C3 involved_in ISO (PMID:28671664) RGD PMID:28671664 NCBI chr 9:2,087,437...2,114,366
Ensembl chr 9:2,087,437...2,114,429
JBrowse link
G Cfh complement factor H involved_in ISO (PMID:20378178), (PMID:28671664) RGD PMID:20378178 PMID:28671664 NCBI chr13:51,512,376...51,613,829
Ensembl chr13:51,511,828...51,613,838
JBrowse link
G Cfi complement factor I involved_in ISO (PMID:28671664) RGD PMID:28671664 NCBI chr 2:218,389,079...218,430,565
Ensembl chr 2:218,387,990...218,430,561
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 19812
    immune system process 2880
      immune effector process 728
        complement activation 165
          complement activation, alternative pathway 13
            negative regulation of complement activation, alternative pathway + 3
            positive regulation of complement activation, alternative pathway + 0
            regulation of complement activation, alternative pathway + 6
Path 2
Term Annotations click to browse term
  biological_process 19812
    biological regulation 13762
      regulation of biological process 13019
        positive regulation of biological process 6733
          positive regulation of immune system process 1020
            positive regulation of immune response 640
              activation of immune response 413
                complement activation 165
                  complement activation, alternative pathway 13
                    negative regulation of complement activation, alternative pathway + 3
                    positive regulation of complement activation, alternative pathway + 0
                    regulation of complement activation, alternative pathway + 6
paths to the root