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ONTOLOGY REPORT - ANNOTATIONS


Term:complement activation, alternative pathway
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Accession:GO:0006957 term browser browse the term
Definition:Any process involved in the activation of any of the steps of the alternative pathway of the complement cascade which allows for the direct killing of microbes and the regulation of other immune processes.
Synonyms:exact_synonym: complement cascade, alternative pathway



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complement activation, alternative pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G C3 complement C3 involved_in IEA GO_REF:0000043 UniProt GO_REF:0000043 NCBI chr 9:2,087,437...2,114,366
Ensembl chr 9:2,087,437...2,114,429
JBrowse link
G C5 complement C5 involved_in IEA GO_REF:0000043 UniProt GO_REF:0000043 NCBI chr 3:18,270,696...18,361,994
Ensembl chr 3:18,270,696...18,361,994
JBrowse link
G C5l1 complement C5 like 1 involved_in IEA GO_REF:0000043 UniProt GO_REF:0000043 NCBI chr 3:18,401,716...18,420,064
Ensembl chr 3:18,404,899...18,420,054
JBrowse link
G C8a complement C8 alpha chain involved_in IEA GO_REF:0000043 UniProt GO_REF:0000043 NCBI chr 5:119,583,168...119,637,675
Ensembl chr 5:119,583,174...119,637,754
JBrowse link
G C8b complement C8 beta chain involved_in IEA GO_REF:0000043 UniProt GO_REF:0000043 NCBI chr 5:119,535,009...119,572,565
Ensembl chr 5:119,535,146...119,572,565
JBrowse link
G C9 complement C9 involved_in IEA GO_REF:0000043 UniProt GO_REF:0000043 NCBI chr 2:55,573,094...55,621,345
Ensembl chr 2:55,572,992...55,621,338
JBrowse link
G Cfb complement factor B acts_upstream_of_or_within ISO MGI:1861129 (MGI:1096110|PMID:9238044), (MGI:6100611|PMID:27564415) RGD PMID:9238044 PMID:27564415 MGI:1096110 MGI:6100611 NCBI chr20:3,970,643...3,976,510
Ensembl chr20:3,951,474...3,976,505
JBrowse link
G Cfd complement factor D involved_in
acts_upstream_of_or_within
IEA
ISO
GO_REF:0000107
(MGI:6100611|PMID:27564415)
Ensembl
RGD
PMID:27564415 GO_REF:0000107 MGI:6100611 NCBI chr 7:9,813,148...9,814,871
Ensembl chr 7:9,813,150...9,815,053
JBrowse link
G Cfh complement factor H acts_upstream_of_or_within_negative_effect ISO (MGI:4421084|PMID:19828624)
(MGI:6100611|PMID:27564415)
RGD PMID:19828624 PMID:27564415 MGI:4421084 MGI:6100611 NCBI chr13:51,512,376...51,613,829
Ensembl chr13:51,511,828...51,613,838
JBrowse link
G Cfp complement factor properdin involved_in ISO MGI:3774548 (MGI:3773929|PMID:18292556) RGD PMID:18292556 MGI:3773929 NCBI chr  X:1,162,014...1,167,576
Ensembl chr  X:1,161,979...1,167,573
JBrowse link
G Cr2 complement C3d receptor 2 involved_in
acts_upstream_of_or_within_negative_effect
ISO (PMID:11981823)
(MGI:4421084|PMID:19828624)
RGD PMID:11981823 PMID:19828624 MGI:4421084 NCBI chr13:106,678,579...106,716,595
Ensembl chr13:106,685,413...106,716,235
JBrowse link
negative regulation of complement activation, alternative pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cd46 CD46 molecule involved_in ISO (PMID:9029106) RGD PMID:9029106 NCBI chr13:106,575,586...106,606,325
Ensembl chr13:106,574,858...106,660,445
JBrowse link
G Susd4 sushi domain containing 4 involved_in ISO
IBA
(PMID:23482636)
GO_REF:0000033
RGD
GO_Central
PMID:23482636 GO_REF:0000033 NCBI chr13:94,455,180...94,577,773
Ensembl chr13:94,455,165...94,577,750
JBrowse link
G Vsig4 V-set and immunoglobulin domain containing 4 involved_in ISO
IBA
UniProtKB:P01024 (PMID:17051150)
GO_REF:0000033
RGD
GO_Central
PMID:17051150 GO_REF:0000033 NCBI chr  X:61,144,926...61,170,212
Ensembl chr  X:61,144,928...61,170,212
JBrowse link
regulation of complement activation, alternative pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cfh complement factor H involved_in ISO (PMID:20378178), (PMID:28671664) RGD PMID:20378178 PMID:28671664 NCBI chr13:51,512,376...51,613,829
Ensembl chr13:51,511,828...51,613,838
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20325
    immune system process 2984
      immune response 2077
        innate immune response 978
          complement activation, alternative pathway 14
            negative regulation of complement activation, alternative pathway 3
            positive regulation of complement activation, alternative pathway 0
            regulation of complement activation, alternative pathway + 4
Path 2
Term Annotations click to browse term
  biological_process 20325
    biological regulation 13633
      regulation of biological process 13227
        positive regulation of biological process 6791
          positive regulation of response to stimulus 2525
            positive regulation of immune response 795
              activation of immune response 566
                complement activation 72
                  complement activation, alternative pathway 14
                    negative regulation of complement activation, alternative pathway 3
                    positive regulation of complement activation, alternative pathway 0
                    regulation of complement activation, alternative pathway + 4
paths to the root