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ONTOLOGY REPORT - ANNOTATIONS


Term:complement activation, lectin pathway
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Accession:GO:0001867 term browser browse the term
Definition:Any process involved in the activation of any of the steps of the lectin pathway of the complement cascade which allows for the direct killing of microbes and the regulation of other immune processes.
Comment:Note that proteins such as mannose-binding lectin (MBL) and certain serum ficolins can activate the lectin complement pathway.
Synonyms:exact_synonym: complement cascade, lectin pathway



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complement activation, lectin pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AABR07006691.1 involved_in IEA GO_REF:0000043 UniProt GO_REF:0000043 Ensembl chr 1:228,016,498...228,043,066 JBrowse link
G Cd69 Cd69 molecule TAS RGD PMID:11034393 PMID:15506986 RGD:1354527, RGD:1354528 NCBI chr 4:162,725,446...162,733,364
Ensembl chr 4:162,725,446...162,733,542
JBrowse link
G Colec10 collectin subfamily member 10 involved_in ISO
IEA
(PMID:24174618)
GO_REF:0000107
RGD
Ensembl
PMID:24174618 GO_REF:0000107 NCBI chr 7:85,744,895...85,806,368
Ensembl chr 7:85,744,895...85,805,675
JBrowse link
G Colec11 collectin sub-family member 11 involved_in ISO (PMID:24174618), (PMID:25912189) RGD PMID:24174618 PMID:25912189 NCBI chr 6:45,223,974...45,256,640
Ensembl chr 6:45,223,980...45,271,145
JBrowse link
G Fcna ficolin A involved_in
acts_upstream_of_or_within
IBA
ISO
PMID:21873635
(MGI:5473786|PMID:16328467)
(PMID:11907111)
RGD PMID:11907111 PMID:16328467 PMID:21873635 MGI:5473786, RGD:13792537 NCBI chr 3:8,445,904...8,449,128
Ensembl chr 3:8,445,907...8,449,105
JBrowse link
G Fcnb ficolin B involved_in IBA
ISO
PMID:21873635
(PMID:16116205)
RGD PMID:16116205 PMID:21873635 RGD:13792537 NCBI chr 3:11,393,771...11,402,198
Ensembl chr 3:11,393,739...11,402,151
JBrowse link
G Krt1 keratin 1 involved_in ISO
IEA
UniProtKB:P11226 (PMID:11549596)
GO_REF:0000107
RGD
Ensembl
PMID:11549596 GO_REF:0000107 NCBI chr 7:132,976,618...132,981,844
Ensembl chr 7:132,976,620...132,981,844
JBrowse link
G Masp1 MBL associated serine protease 1 involved_in IBA
ISO
IEA
ISS
PMID:21873635
(PMID:10679061), (PMID:11907111), (PMID:16116205), (PMID:22691502), (PMID:24174618)
(MGI:3789229|PMID:18424734)
GO_REF:0000107
(PMID:17182967)
GO_REF:0000024
RGD
Ensembl
UniProt
PMID:10679061 PMID:11907111 PMID:16116205 PMID:17182967 PMID:18424734 More... GO_REF:0000024 GO_REF:0000107 MGI:3789229, RGD:13792537 NCBI chr11:77,334,794...77,405,271
Ensembl chr11:77,334,859...77,402,974
JBrowse link
G Masp2 MBL associated serine protease 2 involved_in
acts_upstream_of_or_within
IBA
ISO
IEA
PMID:21873635
(PMID:10679061), (PMID:11907111), (PMID:16116205), (PMID:22691502), (PMID:24174618)
(MGI:5473786|PMID:16328467)
GO_REF:0000107
GO_REF:0000002
(PMID:17182967), (PMID:9087411)
RGD
Ensembl
InterPro
PMID:9087411 PMID:10679061 PMID:11907111 PMID:16116205 PMID:16328467 More... GO_REF:0000002 GO_REF:0000107 MGI:5473786, RGD:13792537 NCBI chr 5:159,035,892...159,049,561
Ensembl chr 5:159,035,911...159,049,580
JBrowse link
G Mbl1 mannose binding lectin 1 acts_upstream_of_or_within IDA
ISO
MGI:96924 (MGI:3577322|PMID:15148336) RGD PMID:15148336 PMID:16272342 MGI:3577322, RGD:1582134 NCBI chr16:17,029,146...17,035,187
Ensembl chr16:17,029,118...17,035,174
JBrowse link
G Mbl2 mannose binding lectin 2 acts_upstream_of_or_within
involved_in
ISO MGI:3577339|MGI:96923 (MGI:3577322|PMID:15148336)
UniProtKB:P04264 (PMID:11549596), (PMID:22691502)
(PMID:15148336)
RGD PMID:11549596 PMID:15148336 PMID:22691502 MGI:3577322 NCBI chr 1:228,016,439...228,024,736 JBrowse link
G Mfap4 microfibril associated protein 4 involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr10:46,167,158...46,170,176
Ensembl chr10:46,167,217...46,170,155
JBrowse link
negative regulation of complement activation, lectin pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G A2m alpha-2-macroglobulin involved_in ISO (PMID:12538697) RGD PMID:12538697 NCBI chr 4:154,897,770...154,947,787
Ensembl chr 4:154,897,877...154,947,786
JBrowse link
G Serping1 serpin family G member 1 involved_in ISS
ISO
GO_REF:0000024
(PMID:10946292)
UniProt
RGD
PMID:10946292 GO_REF:0000024 NCBI chr 3:69,842,726...69,852,583
Ensembl chr 3:69,842,739...69,852,034
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 19812
    immune system process 2880
      immune effector process 728
        complement activation 165
          complement activation, lectin pathway 14
            negative regulation of complement activation, lectin pathway + 2
            positive regulation of complement activation, lectin pathway + 0
            regulation of complement activation, lectin pathway + 2
Path 2
Term Annotations click to browse term
  biological_process 19812
    biological regulation 13762
      regulation of biological process 13019
        positive regulation of biological process 6733
          positive regulation of immune system process 1020
            positive regulation of immune response 640
              activation of immune response 413
                complement activation 165
                  complement activation, lectin pathway 14
                    negative regulation of complement activation, lectin pathway + 2
                    positive regulation of complement activation, lectin pathway + 0
                    regulation of complement activation, lectin pathway + 2
paths to the root