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ONTOLOGY REPORT - ANNOTATIONS


Term:activation of membrane attack complex
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Accession:GO:0001905 term browser browse the term
Definition:The activation of the membrane attack complex components of the complement cascade which can result in death of a target cell through cytolysis.
Synonyms:exact_synonym: MAC assembly;   MAC formation;   activation of MAC;   membrane attack complex assembly;   membrane attack complex formation
 narrow_synonym: activation of TCC;   activation of terminal complement complex;   activation of the terminal complement cascade



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activation of membrane attack complex term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cfh complement factor H acts_upstream_of_or_within ISO (MGI:4837299|PMID:20813971) RGD PMID:20813971 MGI:4837299 NCBI chr13:51,512,376...51,613,829
Ensembl chr13:51,511,828...51,613,838
JBrowse link
negative regulation of activation of membrane attack complex term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cd59 CD59 molecule involved_in
acts_upstream_of_or_within
IDA
IBA
ISO
PMID:21873635
(MGI:1888643|PMID:10946279), (MGI:2148385|PMID:11471050)
RGD PMID:10946279 PMID:11471050 PMID:15843577 PMID:21873635 MGI:1888643 MGI:2148385, RGD:1600482, RGD:13792537 NCBI chr 3:90,459,085...90,477,571
Ensembl chr 3:90,459,162...90,478,847
JBrowse link
positive regulation of activation of membrane attack complex term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G C3 complement C3 involved_in IEA
ISO
GO_REF:0000107
(MGI:4430818|PMID:15611275)
Ensembl
RGD
PMID:15611275 GO_REF:0000107 MGI:4430818 NCBI chr 9:2,087,437...2,114,366
Ensembl chr 9:2,087,437...2,114,429
JBrowse link
G C6 complement C6 involved_in ISO (MGI:4430818|PMID:15611275) RGD PMID:15611275 MGI:4430818 NCBI chr 2:53,846,027...53,921,279
Ensembl chr 2:53,851,985...53,921,275
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 19497
    immune system process 2829
      immune effector process 724
        complement activation 164
          activation of membrane attack complex 4
            negative regulation of activation of membrane attack complex 1
            positive regulation of activation of membrane attack complex 2
            regulation of activation of membrane attack complex + 3
Path 2
Term Annotations click to browse term
  biological_process 19497
    biological regulation 13606
      regulation of biological process 12866
        positive regulation of biological process 6686
          positive regulation of response to stimulus 2354
            positive regulation of immune response 632
              activation of immune response 405
                complement activation 164
                  activation of membrane attack complex 4
                    negative regulation of activation of membrane attack complex 1
                    positive regulation of activation of membrane attack complex 2
                    regulation of activation of membrane attack complex + 3
paths to the root