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RGD DISEASE ONTOLOGY - ANNOTATIONS

RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.
Term:Gliosis
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Accession:DOID:9007402 term browser browse the term
Definition:The production of a dense fibrous network of neuroglia; includes astrocytosis, which is a proliferation of astrocytes in the area of a degenerative lesion.
Synonyms:exact_synonym: Astrocytosis;   Glioses;   astrogliosis;   reactive astrogliosis
 primary_id: MESH:D005911;   RDO:0005678


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Gliosis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ADK adenosine kinase ISO associated with status epilepticus;protein:increased expression:brain RGD PMID:21964979 RGD:6482650 NCBI chr10:74,151,221...74,709,290
Ensembl chr10:74,151,202...74,709,963 		JBrowse link
G ANGPT1 angiopoietin 1 EXP CTD Direct Evidence: therapeutic CTD PMID:30476904 NCBI chr 8:107,249,482...107,497,918
Ensembl chr 8:107,249,482...107,498,055 		JBrowse link
G APP amyloid beta precursor protein EXP CTD Direct Evidence: marker/mechanism CTD PMID:27567873 NCBI chr21:25,880,550...26,171,128
Ensembl chr21:25,880,535...26,171,128 		JBrowse link
G BDNF brain derived neurotrophic factor EXP CTD Direct Evidence: therapeutic CTD PMID:21087489 NCBI chr11:27,654,893...27,722,030
Ensembl chr11:27,654,893...27,722,058 		JBrowse link
G BMP4 bone morphogenetic protein 4 ISO protein:increased expression:spinal cord RGD PMID:17696121 RGD:1643225 NCBI chr14:53,949,736...53,956,891
Ensembl chr14:53,949,736...53,958,761 		JBrowse link
G BMP7 bone morphogenetic protein 7 ISO protein:increased expression:spinal cord RGD PMID:17696121 RGD:1643225 NCBI chr20:57,168,753...57,266,641
Ensembl chr20:57,168,753...57,266,641 		JBrowse link
G CD82 CD82 molecule ISO mRNA:increased expression:retina RGD PMID:15277499 RGD:2289406 NCBI chr11:44,564,409...44,620,358
Ensembl chr11:44,564,427...44,620,358 		JBrowse link
G EPHA4 EPH receptor A4 no_association ISO associated with spinal cord injuries; RGD PMID:15537875 PMID:20170651 RGD:5688771, RGD:5688772 NCBI chr 2:221,418,027...221,574,202
Ensembl chr 2:221,418,027...221,574,202 		JBrowse link
G FGF2 fibroblast growth factor 2 EXP CTD Direct Evidence: therapeutic CTD PMID:21087489 NCBI chr 4:122,826,682...122,898,236
Ensembl chr 4:122,826,682...122,898,236 		JBrowse link
G GFAP glial fibrillary acidic protein EXP CTD Direct Evidence: marker/mechanism CTD PMID:12183020 NCBI chr17:44,903,159...44,915,500
Ensembl chr17:44,903,159...44,916,937 		JBrowse link
G GRM8 glutamate metabotropic receptor 8 EXP CTD Direct Evidence: marker/mechanism CTD PMID:11226630 NCBI chr 7:126,438,598...127,252,941
Ensembl chr 7:126,438,598...127,253,093 		JBrowse link
G ITGA1 integrin subunit alpha 1 EXP CTD Direct Evidence: marker/mechanism CTD PMID:12851778 NCBI chr 5:52,787,916...52,959,209
Ensembl chr 5:52,787,916...52,959,209 		JBrowse link
G ITGA2 integrin subunit alpha 2 EXP CTD Direct Evidence: marker/mechanism CTD PMID:12851778 NCBI chr 5:52,989,352...53,094,779
Ensembl chr 5:52,989,340...53,094,779 		JBrowse link
G ITGA4 integrin subunit alpha 4 EXP CTD Direct Evidence: marker/mechanism CTD PMID:12851778 NCBI chr 2:181,457,205...181,538,940
Ensembl chr 2:181,457,202...181,538,940 		JBrowse link
G ITGA5 integrin subunit alpha 5 EXP CTD Direct Evidence: marker/mechanism CTD PMID:12851778 NCBI chr12:54,395,261...54,419,266
Ensembl chr12:54,395,261...54,419,266 		JBrowse link
G ITGB1 integrin subunit beta 1 EXP CTD Direct Evidence: marker/mechanism CTD PMID:12851778 NCBI chr10:32,900,318...32,958,230
Ensembl chr10:32,887,273...33,005,792 		JBrowse link
G ITGB3 integrin subunit beta 3 EXP CTD Direct Evidence: marker/mechanism CTD PMID:12851778 NCBI chr17:47,253,827...47,313,743
Ensembl chr17:47,253,827...47,313,743 		JBrowse link
G ITGB4 integrin subunit beta 4 EXP CTD Direct Evidence: marker/mechanism CTD PMID:12851778 NCBI chr17:75,721,459...75,757,818
Ensembl chr17:75,721,328...75,757,818 		JBrowse link
G KCNK3 potassium two pore domain channel subfamily K member 3 EXP CTD Direct Evidence: marker/mechanism CTD PMID:18671295 NCBI chr 2:26,692,722...26,733,420
Ensembl chr 2:26,692,722...26,733,420 		JBrowse link
G KCNN4 potassium calcium-activated channel subfamily N member 4 ameliorates ISO associated with diabetic ketoacidosis RGD PMID:27174668 RGD:401784498 NCBI chr19:43,766,533...43,780,973
Ensembl chr19:43,766,533...43,780,976 		JBrowse link
G LAMC1 laminin subunit gamma 1 EXP CTD Direct Evidence: therapeutic CTD PMID:30476904 NCBI chr 1:183,023,420...183,145,592
Ensembl chr 1:183,023,420...183,145,592 		JBrowse link
G LEPR leptin receptor EXP CTD Direct Evidence: marker/mechanism CTD PMID:29191728 NCBI chr 1:65,420,652...65,641,559
Ensembl chr 1:65,420,652...65,641,559 		JBrowse link
G MAPK1 mitogen-activated protein kinase 1 EXP CTD Direct Evidence: marker/mechanism CTD PMID:19402951 NCBI chr22:21,759,657...21,867,680
Ensembl chr22:21,759,657...21,867,680 		JBrowse link
G MAPK3 mitogen-activated protein kinase 3 EXP CTD Direct Evidence: marker/mechanism CTD PMID:19402951 NCBI chr16:30,114,105...30,123,220
Ensembl chr16:30,114,105...30,123,506 		JBrowse link
G MAPT microtubule associated protein tau IDA RGD PMID:19155101 RGD:8158112 NCBI chr17:45,894,554...46,028,334
Ensembl chr17:45,894,527...46,028,334 		JBrowse link
G POMGNT1 protein O-linked mannose N-acetylglucosaminyltransferase 1 (beta 1,2-) ISO RGD PMID:21970971 RGD:11532765 NCBI chr 1:46,188,683...46,220,305
Ensembl chr 1:46,188,683...46,220,305 		JBrowse link
G PSEN1 presenilin 1 EXP CTD Direct Evidence: marker/mechanism CTD PMID:27567873 NCBI chr14:73,136,417...73,223,691
Ensembl chr14:73,136,418...73,223,691 		JBrowse link
G SNCG synuclein gamma ISO RGD PMID:19246516 RGD:6478696 NCBI chr10:86,955,759...86,963,258
Ensembl chr10:86,958,599...86,963,258 		JBrowse link
G SOD1 superoxide dismutase 1 EXP CTD Direct Evidence: marker/mechanism CTD PMID:24918341 PMID:29434186 NCBI chr21:31,659,693...31,668,931
Ensembl chr21:31,659,666...31,668,931 		JBrowse link
G TNFRSF21 TNF receptor superfamily member 21 EXP CTD Direct Evidence: marker/mechanism CTD PMID:24113175 NCBI chr 6:47,231,532...47,309,905
Ensembl chr 6:47,231,532...47,309,905 		JBrowse link
G TNR tenascin R EXP CTD Direct Evidence: marker/mechanism CTD PMID:15120744 NCBI chr 1:175,315,194...175,743,595
Ensembl chr 1:175,315,194...175,743,595 		JBrowse link
G VIM vimentin ISO associated with alcohol-induced disorders, nervous system;protein:increased expression:astrocyte
associated with head injuries, penetrating		 RGD PMID:21958862 PMID:15684657 RGD:6480622, RGD:6480626 NCBI chr10:17,228,241...17,237,593
Ensembl chr10:17,228,241...17,237,593 		JBrowse link
G VIP vasoactive intestinal peptide ISO RGD PMID:21281617 RGD:5685382 NCBI chr 6:152,750,797...152,759,760
Ensembl chr 6:152,750,797...152,759,765 		JBrowse link
G ZEB2 zinc finger E-box binding homeobox 2 ISO RGD PMID:34852714 RGD:155882542 NCBI chr 2:144,384,081...144,520,119
Ensembl chr 2:144,364,364...144,521,057 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  disease 35753
    Pathological Conditions, Signs and Symptoms 21489
      Pathologic Processes 13190
        Gliosis 34
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