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RGD DISEASE ONTOLOGY - ANNOTATIONS

RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.
Term:morphine dependence
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Accession:DOID:2560 term browser browse the term
Definition:An opiate dependence that involves the continued use of morphine despite despite problems related to use of the substance. (DO)
Synonyms:exact_synonym: morphine abuse;   morphine addiction
 primary_id: MESH:D009021
 xref: EFO:0005612
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morphine dependence term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adra2a adrenoceptor alpha 2A ISO mRNA:increases expression:cerebral cortex (rat) RGD PMID:9105684 RGD:401976538 NCBI chrNW_004955485:384,405...387,332
Ensembl chrNW_004955485:385,800...387,240 		JBrowse link
G Ago2 argonaute RISC catalytic component 2 ISO RGD PMID:23927484 RGD:401900655 NCBI chrNW_004955461:14,194,268...14,260,949
Ensembl chrNW_004955461:14,205,748...14,253,861 		JBrowse link
G Arc activity regulated cytoskeleton associated protein ameliorates ISO RGD PMID:21549764 PMID:25746394 RGD:11087075 RGD:401851922 NCBI chrNW_004955454:1,379,998...1,383,414
Ensembl chrNW_004955454:1,379,998...1,383,414 		JBrowse link
G Bax BCL2 associated X, apoptosis regulator treatment ISO RGD PMID:24906198 RGD:10054248 NCBI chrNW_004955559:1,695,960...1,700,246
Ensembl chrNW_004955559:1,695,960...1,700,244 		JBrowse link
G Bcl2 BCL2 apoptosis regulator treatment ISO RGD PMID:24906198 RGD:10054248 NCBI chrNW_004955402:46,911,125...47,084,214
Ensembl chrNW_004955402:46,916,266...47,084,485 		JBrowse link
G Bdnf brain derived neurotrophic factor treatment ISO protein:decreased expression:nucleus accumbens RGD PMID:27461790 PMID:32428531 RGD:401940145 RGD:401959372 NCBI chrNW_004955476:6,773,244...6,822,201
Ensembl chrNW_004955476:6,772,088...6,822,588 		JBrowse link
G Cnr1 cannabinoid receptor 1 treatment ISO RGD PMID:27461790 RGD:401940145 NCBI chrNW_004955411:15,052,151...15,077,320
Ensembl chrNW_004955411:15,052,163...15,077,320 		JBrowse link
G Comt catechol-O-methyltransferase susceptibility ISO DNA:SNP:cd: (rs4680) p.V158M (human) RGD PMID:30211780 RGD:401940137 NCBI chrNW_004955442:18,130,282...18,152,153
Ensembl chrNW_004955442:18,130,987...18,137,412 		JBrowse link
G Creb1 cAMP responsive element binding protein 1 treatment ISO CTD Direct Evidence: marker/mechanism
protein:increased phosphorylation:central amygdaloid nucleus
protein:increased expression:neuron, brain
protein:increased phosphorylation:hypothalamus, ventral tegmental area
mRNA, protein:increased expression:hippocampus, prefrontal cortex		 CTD
RGD		 PMID:11717377 PMID:18772347 PMID:19052216 PMID:19108758 PMID:19341783 More... RGD:401940119 RGD:401940121 RGD:401940122 RGD:401940145 RGD:401940182 RGD:401940184 RGD:401950487 RGD:401959374 RGD:401959375 RGD:401959607 RGD:401959748 NCBI chrNW_004955457:7,424,403...7,490,630
Ensembl chrNW_004955457:7,431,736...7,491,149 		JBrowse link
G Drd2 dopamine receptor D2 ISO protein:decreased expression:hippocampus (rat) RGD PMID:18276072 RGD:2311587 NCBI chrNW_004955412:15,054,255...15,114,558
Ensembl chrNW_004955412:15,054,038...15,114,573 		JBrowse link
G Fadd Fas associated via death domain severity ISO RGD PMID:21088039 RGD:11341805 NCBI chrNW_004955422:16,026,323...16,035,808
Ensembl chrNW_004955422:16,031,280...16,036,281 		JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit treatment ISO RGD PMID:10998122 PMID:12225868 PMID:27053349 RGD:401959748 RGD:405100721 RGD:405255651 NCBI chrNW_004955523:307,181...310,728
Ensembl chrNW_004955523:305,728...310,728 		JBrowse link
G Fosb FosB proto-oncogene, AP-1 transcription factor subunit ameliorates ISO protein:increased expression:brain (rat)
associated with pregnancy complications; protein:increased expression:brain (rat)		 RGD PMID:23185589 PMID:33592274 RGD:401851068 RGD:401901281 NCBI chrNW_004955555:2,438,864...2,445,846
Ensembl chrNW_004955555:2,438,864...2,445,846 		JBrowse link
G Gad1 glutamate decarboxylase 1 ISO mRNA:increased expression:dentate gyrus granule cell layer RGD PMID:15673448 RGD:401900167 NCBI chrNW_004955449:3,964,006...4,001,850
Ensembl chrNW_004955449:3,963,705...4,001,850 		JBrowse link
G Gria1 glutamate ionotropic receptor AMPA type subunit 1 treatment
exacerbates		 ISO CTD Direct Evidence: marker/mechanism
protein:decreased phosphorylation:caudate-putamen, nucleus accumbens (rat)
protein:altered expression:prefrontal cortex, membrane (rat)
rat gene in a mouse model
protein:increased phosphorylation:nucleus accumbens (rat)		 CTD
RGD		 PMID:11404432 PMID:15287884 PMID:16775132 PMID:22072679 PMID:24201449 More... RGD:401976466 RGD:405096668 RGD:405100238 RGD:405100728 RGD:405101690 RGD:405649739 RGD:405649863 RGD:405650198 NCBI chrNW_004955408:7,912,223...8,226,241
Ensembl chrNW_004955408:7,912,592...8,223,570 		JBrowse link
G Grin2a glutamate ionotropic receptor NMDA type subunit 2A ISO CTD Direct Evidence: marker/mechanism CTD PMID:12878694 NCBI chrNW_004955442:8,171,114...8,565,187
Ensembl chrNW_004955442:8,174,232...8,562,059 		JBrowse link
G Htr2a 5-hydroxytryptamine receptor 2A ISO protein:increased expression:prefrontal cortex RGD PMID:28082900 RGD:401900741 NCBI chrNW_004955431:583,165...646,991
Ensembl chrNW_004955431:580,713...647,345 		JBrowse link
G Mapk1 mitogen-activated protein kinase 1 treatment ISO protein:increased phosphorylation:central amygdaloid nucleus RGD PMID:18772347 PMID:19052216 PMID:27461790 PMID:29024786 PMID:33609567 RGD:401940121 RGD:401940145 RGD:401950487 RGD:401959374 RGD:401959607 NCBI chrNW_004955442:17,284,232...17,380,026
Ensembl chrNW_004955442:17,284,232...17,380,020 		JBrowse link
G Mapk3 mitogen-activated protein kinase 3 treatment ISO protein:increased phosphorylation:central amygdaloid nucleus RGD PMID:18772347 PMID:19052216 PMID:27461790 PMID:29024786 PMID:33609567 RGD:401940121 RGD:401940145 RGD:401950487 RGD:401959374 RGD:401959607 NCBI chrNW_004955493:6,870,699...6,876,836
Ensembl chrNW_004955493:6,869,668...6,879,152 		JBrowse link
G Mmp9 matrix metallopeptidase 9 ISO CTD Direct Evidence: marker/mechanism CTD PMID:20519536 NCBI chrNW_004955445:11,295,500...11,303,322
Ensembl chrNW_004955445:11,295,448...11,303,288 		JBrowse link
G Ncam1 neural cell adhesion molecule 1 ISO protein:decreased expression, altered form:hippocampus (rat) RGD PMID:15673448 RGD:401900167 NCBI chrNW_004955412:14,630,109...14,923,847
Ensembl chrNW_004955412:14,630,443...14,923,926 		JBrowse link
G Ngf nerve growth factor ISO mRNA,protein:increased expression:central amygdaloid nucleus RGD PMID:22871918 RGD:401965392 NCBI chrNW_004955435:18,581,889...18,633,330
Ensembl chrNW_004955435:18,581,808...18,601,059 		JBrowse link
G Nos1 nitric oxide synthase 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:17989510 NCBI chrNW_004955455:13,797,557...13,978,402
Ensembl chrNW_004955455:13,797,545...13,972,566 		JBrowse link
G Npsr1 neuropeptide S receptor 1 ISO RGD PMID:23684726 RGD:9831198 NCBI chrNW_004955560:1,069,651...1,243,111
Ensembl chrNW_004955560:1,069,651...1,243,111 		JBrowse link
G Nr3c2 nuclear receptor subfamily 3 group C member 2 treatment ISO RGD PMID:22304485 RGD:401965468 NCBI chrNW_004955471:3,059,210...3,397,894
Ensembl chrNW_004955471:3,061,735...3,395,520 		JBrowse link
G Oprl1 opioid related nociceptin receptor 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:11027224 NCBI chrNW_004955528:161,673...184,515
Ensembl chrNW_004955528:161,673...167,937 		JBrowse link
G Oprm1 opioid receptor mu 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:3720824 NCBI chrNW_004955439:7,870,563...7,923,817
Ensembl chrNW_004955439:7,757,569...7,923,817 		JBrowse link
G Pdyn prodynorphin treatment ISO RGD PMID:15976090 RGD:401850590 NCBI chrNW_004955415:13,106,087...13,119,497
Ensembl chrNW_004955415:13,106,062...13,119,515 		JBrowse link
G Rack1 receptor for activated C kinase 1 ISO mRNA, protein:increased expression:hippocampus, prefrontal cortex RGD PMID:19341783 RGD:401940119 NCBI chrNW_004955530:78,488...83,297
Ensembl chrNW_004955530:78,426...83,297 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  disease 16063
    Chemically-Induced Disorders 1090
      substance-related disorder 545
        Narcotic-Related Disorders 69
          opiate dependence 67
            morphine dependence 29
Path 2
Term Annotations click to browse term
  disease 16063
    disease of anatomical entity 13822
      nervous system disease 12089
        central nervous system disease 10855
          brain disease 10187
            disease of mental health 7328
              substance-related disorder 545
                substance dependence 121
                  drug dependence 84
                    opiate dependence 67
                      morphine dependence 29
paths to the root